Tag: M.W=300-400

58446-52-9, Name is 1-Phenylicosane-1,3-dione, molecular formula is C26H42O2, belongs to isothiazole compound, is a common compound. In a patnet, author is Kiselyov, Alex S., once mentioned the new application about 58446-52-9, Name: 1-Phenylicosane-1,3-dione.

Novel derivatives of 1,3,4-oxadiazoles are potent mitostatic agents featuring strong microtubule depolymerizing activity in the sea urchin embryo and cell culture assays

A series of novel 1,3,4-oxadiazole derivatives based on structural and electronic overlap with combretastatins have been designed and synthesized. Initially, we tested all new compounds in vivo using the phenotypic sea urchin embryo assay to yield a number of agents with anti-proliferative, anti-mitotic, and microtubule destabilizing activities. The experimental data led to identification of 1,3,4-oxadiazole derivatives with isothiazole (5-8) and phenyl (9-12) pharmacophores featuring activity profiles comparable to that of combretastatins, podophyllotoxin and nocodazole. Cytotoxic effects of the two lead molecules, namely 6 and 12, were further confirmed and evaluated by conventional assays with the A549 human cancer cell line including cell proliferation, cell cycle arrest at the G2/M phase, cellular microtubule distribution, and finally in vitro microtubule assembly with purified tubulin. The modeling results using 3D similarity (ROCS) and docking (FRED) correlated well with the observed activity of the molecules. Docking data suggested that the most potent molecules are likely to target the colchicine binding site. (C) 2010 Elsevier Masson SAS. All rights reserved.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 58446-52-9. The above is the message from the blog manager. Name: 1-Phenylicosane-1,3-dione.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

 

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 1235-74-1, Name is (1R,4aS,10aR)-methyl 7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxylate, molecular formula is C21H30O2. In an article, author is CLERICI, F,once mentioned of 1235-74-1, Category: isothiazole.

ISOTHIAZOLES .5. CYCLOADDITION REACTION OF NITRILE OXIDES TO 3-DIETHYLAMINO-4-(4-METHOXYPHENYL)-ISOTHIAZOLE 1,1-DIOXIDE – AN ENTRY TO 5-ACYL-ISOTHIAZOLE 1,1-DIOXIDE AND 5-CYANO-ISOTHIAZOLE 1,1-DIOXIDE DERIVATIVES

Nitrile oxides 2 reacted with 3-diethylamino-4-(4-methoxyphenyl)-isothiazole 1,1-dioxide (1) affording through a highly regioselective 1,3-dipolar cycloaddition reaction isothiazolo[5,4-d]isoxazoline 4,4-dioxides 3. Reduction of 3 afforded a mixture of the E and Z forms of the corresponding 5-(amino-arylmethylene)-dihydro-isothiazole 1,1-dioxides 4/5 which were transformed into 5-acyl-dihydro-isothiazole 1,1-dioxides 6 and the corresponding dehydrated products 7. Compound 3 f was easily transformed into 5-cyanoisothiazole 1,1-dioxide 11.

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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

 

118727-34-7, Name is 1,3,5-Tris(4-aminophenyl)benzene, molecular formula is C24H21N3, Recommanded Product: 118727-34-7, belongs to isothiazole compound, is a common compound. In a patnet, author is Amati, Mario, once mentioned the new application about 118727-34-7.

Tandem Photoarylation-Photoisomerization of Halothiazoles: Synthesis, Photophysical and Singlet Oxygen Activation Properties of Ethyl 2-Arylthiazole-5-carboxylates

The photochemical reaction between ethyl 2-chlorothiazole-5-carboxylate and benzene gave no product. In contrast, the reaction with ethyl 2-iodothiazole-5-carboxylate gave ethyl 3-phenylisothiazole-4-carboxylate. The same behaviour was observed if the reaction was performed in the presence of furan, thiophene and 2-bromothiophene. The products thus obtained were studied for their photophysical properties and it was found that the observed absorptions [lambda(max)=257 nm (epsilon = 7000 M-1 cm(-1)) for ethyl 3-phenylisothiazole-4-carboxylate, 278 nm (a = 7000 M-1 cm(-1)) for ethyl 3-(2-furyl)isothiazole-4-carboxylate, 269 and 285 nm (a = 7500 M-1 cm(-1)) for ethyl 3(2-thienyl)isothiazole-4-carboxylate] are mainly due to pi -> pi* transitions from the HOMO to the LUMO+1 orbital. The tested compounds showed fluorescence [lambda(em) = 350-400 (lambda(exc) = 300 nm), 360 and 410 nm (lambda(exc) = 320 nm), 412 nm (lambda(exc) 340 nm) for ethyl 3-phenylisothiazole-4-carboxylate, 397 and 460 nm (lambda(exc) = 300 nm), 381, 394 and 460 nm (lambda(exc) = 320 nm), 381, 398 and 466 rim (lambda(exc) = 340 nm) for ethyl 3-(2-furyl)isothiazole-4-carboxylate, 372, 377 and 414 nm (lambda(exc) = 300, 320 and 340 nm respectively) for ethyl 3-(2-thienyl)isothiazole-4carboxylate], possibly due to dual emission from different excited states. The use of the compound obtained as a sensitizer in the photo-oxidation of trans-alpha,alpha’-dimethylstilbene showed that all the new compounds are singlet-oxygen sensitizers.

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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

 

Synthetic Route of 209911-63-7, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 209911-63-7, Name is 4′-(Dibromomethyl)-[1,1′-biphenyl]-2-carbonitrile, SMILES is N#CC1=CC=CC=C1C2=CC=C(C(Br)Br)C=C2, belongs to isothiazole compound. In a article, author is Gedi, Vinayakumar, introduce new discover of the category.

Identification and characterization of inhibitors of Haemophilus influenzae acetohydroxyacid synthase

Acetohydroxyacid synthase (AHAS), a potential target for antimicrobial agents, catalyzes the first common step in the biosynthesis of branched-chain amino acids. The gene coding for the AHAS catalytic subunit from Haemophilus influenzae (Hi) was cloned, overexpressed in Escherichia coli, and purified. To identify new inhibitory scaffolds, we used a high-throughput screen to test 221 small diverse chemical compounds against Hi-AHAS. Compounds were selected for their ability to inhibit AHAS in vitro. The screen identified 3 compounds, each representing a structural class, as Hi-AHAS inhibitors with an IC(50) in the low micromolar range (4.4-14.6 mu M). The chemical scaffolds of the three compounds were oxa-1-thia-4-aza-cyclopenta[b]naphthalene (KHG25229), phenyl-2,3-dihydro-isothiazole (KHG25386), and phenyl-pyrrolidine-3-carboxylic acid phenylamide (KHG25056). Further, molecular docking of the two most potent chemicals, KHG25229 and KHG25386, in Hi-AHAS yielded binding energies of -10.41 and -9.21 kcal/mol, respectively. The binding modes were consistent with inhibition mechanisms, as both chemicals oriented outside the active site. As the need for novel antibiotic classes to combat drug resistant bacteria increases, screening compounds that act against Hi-AHAS may assist in the identification of potential new anti-Hi drugs. (C) 2011 Elsevier Inc. All rights reserved.

Synthetic Route of 209911-63-7, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 209911-63-7 is helpful to your research.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com