In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Quality Control of 3-Piperazinobenzisothiazole hydrochloride, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 87691-88-1, name is 3-Piperazinobenzisothiazole hydrochloride. In an article£¬Which mentioned a new discovery about 87691-88-1
New disulfide route to 3-(1-piperazinyl)-1,2-benzisothiazole. Nucleus for atypical antipsychotic drugs
A new, one-step commercial process for the preparation of 3-(1-piperazinyl)-l,2-benzisothiazole hydrochloride, a key intermediate for the syntheses of some new, “atypical antipsychotic” drugs, was developed. Reaction of bis(2-cyanophenyl) disulfide with excess piperazine at 120-140 C for 3-24 h in the presence of small amounts of DMSO and 2-propanol formed 3-(l-piperazinyl)-l,2-benzisothiazole in 75-80% yields. The DMSO oxidized the liberated 2-mercaptobenzonitrile to regenerate bis(2-cyanophenyl) disulfide, thereby enabling the utilization of both halves of the symmetrical disulfide to generate product. The reaction mechanism for the conversion of the bis(2-cyanophenyl) disulfide to 3-amino-1,2-benzisothiazole involves the formation of ring-opened sulfenamide and benzamidine intermediates and then their subsequent ring closure to regenerate the 1,2-benzisothiazole nucleus. A safe, efficient, and robust process to prepare 3-(l-piperazinyl)-1,2-benzisothiazole under very concentrated reaction conditions was developed and successfully scaled up in the pilot plant to support the development of ziprasidone.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Quality Control of 3-Piperazinobenzisothiazole hydrochloride, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 87691-88-1, in my other articles.
Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com