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107869-45-4, Name is (3aR,6S)-8,8-Dimethyl-4,5,6,7-tetrahydro-3H-3a,6-methanobenzo[c]isothiazole 2,2-dioxide, belongs to isothiazole compound, is a common compound. Safety of (3aR,6S)-8,8-Dimethyl-4,5,6,7-tetrahydro-3H-3a,6-methanobenzo[c]isothiazole 2,2-dioxideIn an article, once mentioned the new application about 107869-45-4.

A convenient, improved synthesis of (camphoryl)sulfonyl oxaziridines

A convenient, efficient procedure for the large scale synthesis of chiral oxidizing reagents (+), and (-)-((8,8-dichlorocamphory)sulfonyl)oxaziridine, 5, as well as of 8,8 unsubstituted (+), and (-) (camphoryl)sulfonyl oxaziridine, 4, from (+), or (-) (camphoryl)imine, 2, in step yields of 83% to 95%, is reported.

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Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

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Indole – aryl heterocyclic piperazine (acridine) derivatives and their use in anti-depression (by machine translation)

The invention discloses a indole – aryl heterocyclic piperazine (acridine) compound or its pharmaceutically acceptable salt, has the following structure: The compounds and compositions containing the same to the 5 – HT reuptake, 5 – HT1 A Receptor and 5 – HT7 Receptor has activity, it can be applied to the preparation of novel anti-depression drug. (by machine translation)

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Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

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PHENYLALKYL AND PYRIDYLALKYL PIPERAZINE DERIVATIVES

This invention relates to compounds of the formula (1) wherein R1, R3, R4, X1 , and X2 are defined as in the specification, pharmaceutical compositions containing them and their use in the treatment of central nervous system and other disorders.

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Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

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87691-88-1, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 87691-88-1, molcular formula is C11H14ClN3S, introducing its new discovery.

Method for preparing Perospirone is (by machine translation)

The invention discloses a new method for preparing Perospirone is of the, type I and along link oneself dimethyl ester imide reaction, produce Perospirone is, the method avoids the alkylation intermediate, has the advantages of simple process, raw materials are easy, is suitable for industrial production, the product yield and purity are, and the like. (by machine translation)

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Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

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Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In a patent, 87691-88-1, molecular formula is C11H14ClN3S, introducing its new discovery. 87691-88-1

PROCESSES FOR PREPARATION OF ZIPRASIDONE

Provided are processes for preparing ziprasidone from CEI and BIPT.

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Isothiazole – Wikipedia,
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107869-45-4, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.107869-45-4, Name is (3aR,6S)-8,8-Dimethyl-4,5,6,7-tetrahydro-3H-3a,6-methanobenzo[c]isothiazole 2,2-dioxide, molecular formula is C10H15NO2S. In a article£¬once mentioned of 107869-45-4

IRIDOIDS : ENANTIOSELECTIVE SYNTHESIS OF LOGANIN VIA AN ASYMMETRIC DIELS-ALDER REACTION

Starting from (-)-camphor-10-sulfonic acid (5) the crystalline sultam 9 was readily prepared.TiCl4-mediated Diels-Alder addition of the N-crotonyl sultam 11 to cyclopentadiene, crystallization of the resulrting adduct 12 and subsequent reduction gave virtually pure (1S, 4R,5R, 6S)-1 together with recovered auxiliary 9.The loganin precursor 1 was transformed into norbonanone 20, which upon Baeyer-Villiger oxidation led to the suitably substituted cyclopentane 22 from which 1-B-O-methyl loganin aglucone (2) was readily available.

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Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

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HETEROCYCLIC SUBSTITUTED PIPERAZINES FOR THE TREATMENT OF SCHIZOPHRENIA

This invention relates to compounds of the formula 1 wherein Ar, A, R2, R3, Y and ring Q are defined as in the specification, pharmaceutical compositions containing them and their use in the treatment of central nervous system disorders.

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Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

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PROCESS FOR THE PREPARATION OF ZIPRASIDONE (5-[2-[4-(1,2-BENZISOTHIAZOL-3-Y1)-1-PIPERAZINY1]ETHY1]-6-CHLORO-1,3-DIHYDRO-2H-INDOL-2-ONE)

The present invention provides a new and useful process for preparing 5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3?dihydro-2H-indol-2-one (ziprasidone) and methods for its purification. The process comprises the steps of: (i) mixing 6-chloro-5-(2-chloroethyl)-1,3-dihydro-2H-indol-2-one with either a free base or salt form of 3-(1-piperazinyl)-1,2?benzoisothiazole, in the presence of an alkaline compound and a high-boiling polar organic solvent or mixture of high boiling polar organic solvents, (ii) heating the mixture and stirring for a sufficient amount of time to obtain ziprasidone formation, (iii) cooling the mixture, adding it to water and filtering off the product, (iv) adding water to the product and stirring the suspension, and (v) isolating crude ziprasidone.

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Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

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87691-88-1, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.87691-88-1, Name is 3-Piperazinobenzisothiazole hydrochloride, molecular formula is C11H14ClN3S. In a Article, authors is Sharma£¬once mentioned of 87691-88-1

Novel urea and thiourea derivatives of thiazole-glutamic acid conjugate as potential inhibitors of microbes and fungi

Since discovery and development of effective as well as safe drugs has brought a progressive era in human healthcare that is accompanied by the appearance of drug resistant bacterial strains, there is constant need of new antibacterial agent having novel mechanisms of action to act against the harmful pathogens. In the present study, several N-terminal substituted urea/thiourea derivatives were synthesized by the reaction of glutamic acid and 3-(1-piperazinyl)-1,2-benzisothiazole with various substituted phenyl isocyanates/isothiocyanates. Elemental analysis, IR, 1H NMR, 13C NMR and mass spectral data confirmed the structure of the newly synthesized compounds. The derivatives were investigated for their antibacterial and antifungal activities against various pathogens of human origin by agar well diffusion method and microdilution method. The preliminary antimicrobial bioassay reveals that the compounds containing fluoro and bromo as substituents showed promising antimicrobial activity. Pleiades Publishing, Ltd., 2013.

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Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

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A and Cefotetan disodium method for the preparation of intermediates (by machine translation)

The invention discloses a Cefotetan disodium method for the preparation of intermediates thereof, the commercial raw material 4 – (1-amino-3-tert-butoxy -1,3-dioxo-2-ene yl) – 1,3-dithio-azetidine-2-carboxylic acid (2) and 7-MAC (3) for a condensation reaction to make compound 4, after deprotection, salification Cefotetan disodium (1). The invention also provides the compound 2 preparation method. The conventional route of the route to avoid pollution of the environment of the use of chloride reagent, with simple process route, process cost reduction, the overall yield of product is improved, friendly characteristic of the environment, is suitable for industrial production. (by machine translation)

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Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com