Tag: M.W:200-300

Chemistry is traditionally divided into organic and inorganic chemistry. COA of Formula: C8H4BrNO2S, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 677304-75-5

CINNOLINE AND QUINAZOLINE DERIVATES AS PHOSPHODIESTERASE 10 INHIBITORS

The present invention is directed to cinnoline and quinazoline compounds of formula (I) that are PDE10 inhibitors, pharmaceutical compounds containing the same and processes for preparing the same. The invention is also directed to methods of treating diseases mediated by PDE10 enzyme such as obesity, non-insulin dependent diabetes, schizophrenia or bipolar disorder, obsessive-compulsive disorder, and the like.

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Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Formula: C11H14ClN3S. Introducing a new discovery about 87691-88-1, Name is 3-Piperazinobenzisothiazole hydrochloride

Synthesis and Biological Evaluation of 1-(1,2-Benzisothiazol-3-yl)- and (1,2-Benzisoxazol-3-yl)piperazine Derivatives as Potential Antipsychotic Agents

Members of the series of title compounds were tested for potential antipsychotic activity in relevant receptor binding assays and behavioral screens.Structure-activity relationships within the series are discussed.Compound 24 (BMY 13859-1), a (1,2-benzisothiazol-3-yl)piperazine derivative, was selected for further study because of its potent and selective profile in primary CNS tests.It was active in the Sidman avoidance paradigm and blocked amphetamine-induced stereotyped behavior in dogs for up to 7 h.The compound’s lack of typical neuroleptic-like effects in therat catalepsy test and its failure to produce dopamine receptor supersensitivity following chronic administration indicate that it should not cause the movement disorders commonly associated with antipsychotic therapy.Although 24 has potent affinity for dopaminergic binding sites, its even greater affinity for serotonin receptors suggests that a serotonergic component may be relevant to its atypical profile.Compound 24 is currently undergoing clinical evaluation in schizophrenic patients.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Formula: C11H14ClN3S, you can also check out more blogs about87691-88-1

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Reference of 87691-88-1, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 87691-88-1, Name is 3-Piperazinobenzisothiazole hydrochloride,introducing its new discovery.

Orally-effective, long-acting sorbitol dehydrogenase inhibitors: Synthesis, structure – Activity relationships, and in vivo evaluations of novel heterocycle-substituted piperazino-pyrimidines

Optimization of a previously disclosed sorbitol dehydrogenase inhibitor (SDI, II) for potency and duration of action was achieved by replacing the metabolically labile N,N-dimethylsulfamoyl group with a variety of heterocycles. Specifically, this effort led to a series of novel, in vitro potent SDIs with longer serum half-lives and acceptable in vivo activity in acutely diabetic rats (e.g., 62, 67, and 69). However, the desired in vivo potency in chronically diabetic rats, ED90 ? 5 mg/kg/day, was achieved only through further modification of the piperazine linker. Several members of this family, including 86, showed better than the targeted potency with ED90 values of 1-2 mg/kg/day. Compound 86 was further profiled and found to be a selective inhibitor of sorbitol dehydrogenase, with excellent pharmacodynamic/pharmacokinetic properties, demonstrating normalization of sciatic nerve fructose in a chronically diabetic rat model for ?17 h, when administered orally at a single dose of 2 mg/kg/day.

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In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 87691-88-1, name is 3-Piperazinobenzisothiazole hydrochloride, introducing its new discovery. category: isothiazole

A process for the preparation of intermediates […] (by machine translation)

The invention relates to a process for the preparation of intermediates […], the intermediate body is (3aR, 7aR) – 4 ? – (1,2-benzisothiazol-3-yl) eight hydrogen spiral [2H-isoindole -2,1 ?-piperazine] a sulfonate. The (1R, 2R) – 1,2-cyclohexane dimethanol as raw materials, dialkyltinacetal after armor is a sulfonic acid ester, with the 3 – (1-piperazinyl) – 1,2 benzothiazin hydrochloride reaction to obtain the required intermediate. (by machine translation)

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Reference of 76857-14-2, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.76857-14-2, Name is Sodium 3-oxido-5-sulfidoisothiazole-4-carboxylate, molecular formula is C4NNa3O3S2. In a Patent£¬once mentioned of 76857-14-2

A head spore for the Tanzania acid new crystalline and its preparation method (by machine translation)

A head spore for the Tanzania acid new crystalline and its preparation method. The present invention provides a [6R – (6a, 7 alpha)] – 7 – [[ [4 – (2 – amino – 1 – carboxyl – 2 – oxo ethylidene) – 1, 3 – dithio-azetidine – 2 – yl] carbonyl] amino] – 7 – methoxy – 3 – [[ (1 – methyl – 1H – tetrazol – 5 – yl) thio] methyl] – 8 – oxo – 5 – thia – 1 – azabicyclo [4, 2, 0] Oct – 2 – ene – 2 – carboxylic acid the new crystalline form, this crystalline form X – ray powder diffraction pattern of a reflection angle of the 2 theta in the 11.66 ¡À 0.1 , 17 . 53 ¡À 0.1 , 17 . 72 ¡À 0.1 , 18 . 91 ¡À 0.1 , 20 . 01 ¡À 0.1 , 21 . 02 ¡À 0.1 , 22 . 24 ¡À 0.1 , 23 . 33 ¡À 0.1 and has a characteristic peak. Such a compound is crystalline form has good stability, and its preparation process is simple, lower cost, can be used in industrial production. (by machine translation)

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Reference of 76857-14-2, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 76857-14-2, Name is Sodium 3-oxido-5-sulfidoisothiazole-4-carboxylate, molecular formula is C4NNa3O3S2. In a Patent£¬once mentioned of 76857-14-2

Process for obtaining compounds usable in the production of cefotetan, and new compounds obtained thereby

A process for obtaining salts of 4-carboxy-3-hydroxy-5-mercapto-isothiazole which are compounds usable in the production of Cefotetan, and new compounds obtained thereby, in which R1 = R2 = R3 = Na or K; R1 = Na or K and R2 = R3 = H; or R1 = R2 = Na or K and R3 = H.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Reference of 76857-14-2. In my other articles, you can also check out more blogs about 76857-14-2

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One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Formula: C10H15NO2S, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 107869-45-4, Name is (3aR,6S)-8,8-Dimethyl-4,5,6,7-tetrahydro-3H-3a,6-methanobenzo[c]isothiazole 2,2-dioxide, molecular formula is C10H15NO2S

Methods and systems for evaluating and predicting the reactivity of monooxygenase enzymes

Methods and systems for evaluating and predicting the reactivity of natural and engineered monooxygenase enzymes are provided. Methods are provided for acquiring a functional profile (fingerprint) of monooxygenases that encode information regarding the active site configuration of such monooxygenases. Methods are also provided for carrying out analysis of a monooxygenase fingerprint, to formulate predictions regarding the reactivity properties (e.g., substrate reactivity, chemo-, regio, and stereoselectivity properties) of the fingerprinted monooxygenases.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Formula: C10H15NO2S, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 107869-45-4, in my other articles.

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87691-88-1, Name is 3-Piperazinobenzisothiazole hydrochloride, belongs to isothiazole compound, is a common compound. Safety of 3-Piperazinobenzisothiazole hydrochlorideIn an article, once mentioned the new application about 87691-88-1.

[1,3,4] OXADIAZOLE DERIVATIVE AND APPLICATION THEREOF

The present invention belongs to the medicinal chemistry field, and specifically discloses a [1,3,4]oxadiazole derivative with the structure of general formula (I) and pharmaceutically acceptable salt thereof. The compound can be used to prepare a medicine for preventing or treating a disease of the central nervous system.

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Application of 87691-88-1, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 87691-88-1, molcular formula is C11H14ClN3S, introducing its new discovery.

1,2,4-TRIAZOL-3-ONE ANTIDEPRESSANTS

Phenoxyalkyl substituted-1,2,4-triazolones having anti-depressant properties typified by 2-3-4-(3-chlorophenyl)-1-piperazinyl!propyl!-5-ethyl-4-(2-phenoxyethyl)-2H-1,2, 4-triazol-3(4H)-one are disclosed.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 87691-88-1 is helpful to your research. Application of 87691-88-1

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Isothiazole – ScienceDirect.com

 

Electric Literature of 87691-88-1, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.87691-88-1, Name is 3-Piperazinobenzisothiazole hydrochloride, molecular formula is C11H14ClN3S. In a Patent£¬once mentioned of 87691-88-1

PROCESS FOR PREPARING ZIPRASIDONE

The present invention concerns a process for the preparation of 5-(2-(4-(1,2- 5 benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-2H-indol-2-one of the formula (I), or a pharmaceutically acceptable acid addition salt, solvate, hydrates or clathrate thereof, said process comprising reacting a compound of formula (II) wherein X is a halogen atom, with a compound of formula (III), said compound of formula (III) being the free base or an addition salt with an organic or inorganic acid, wherein said process is characterized in that said compounds according to formulas (II) and (III) are reacted in the presence of a neutralizing agent, and are reacted in a solvent comprising acetonitrile.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 87691-88-1

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