Tag: M.W=150-200

An article Design, green one-pot synthesis and molecular docking study of novel N,N-bis(cyanoacetyl)hydrazines and bis-coumarins as effective inhibitors of DNA gyrase and topoisomerase IV WOS:000521282300012 published article about CYANOACETIC ACID HYDRAZIDE; HETEROCYCLIC-COMPOUNDS; ANTICANCER ACTIVITY; ESCHERICHIA-COLI; DERIVATIVES; PYRIDINE; ANTIBACTERIAL; THIOPHENE; THIAZOLE; PYRAZOLE in [Metwally, Nadia Hanafy; Abdallah, Sanaa Osman; Mohsen, Marwa Maher Abdel] Cairo Univ, Fac Sci, Chem Dept, Giza, Egypt in 2020.0, Cited 42.0. Formula: C9H10O3. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7

A novel, quick, environmentally safe, and one-pot synthesis of a series of N,N-bis(cyanoacetyl)hydrazine derivatives, bis-imino-2H-chromenes and bis-2-oxo-2H-chromene derivatives have been designed. Some selected newly synthesized compounds were investigated in vitro for their antibacterial activity. Compound 5j is the most toxic compound against Staphylococcus aureus with activity index 171%, followed by compound 15b with activity index 136% compared to standard drug ampicillin. Moreover, compound 15a is the most toxic compound against Escherichia coli with activity index 111% compared to standard drug gentamicin. Minimum inhibitory concentration (MIC) was carried out for compounds with high antibacterial activity. Compound 5j has good MIC (7.8 mu g/ml) against Staphylococcus aureus while 15a has good MIC (31.25 mu g/ml) against Streptococcus mutans which is better than MIC of the standard drug ampicillin (MIC = 62.5 mu g/ml). Compounds 5j, 5k, 15a, 15b and 15e which have good MIC values were introduced to enzyme assay against DNA gyrase and topoisomerase IV. The results showed that compound 15a can strongly inhibit DNA gyrase and topoisomerase IV (IC50 = 27.30 and 25.52 mu M respectively), compared to methotrexate as the standard drug (IC50 = 29.01 and 23.55 mu M respectively). Structure-activity relationships were also discussed based on the biological and docking simulation results.

Formula: C9H10O3. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Metwally, NH; Abdallah, SO; Mohsen, MMA or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Quality Control of 2,6-Difluorobenzoic acid. In 2019 LUMINESCENCE published article about PHOTOCHEMICALLY-INDUCED FLUORESCENCE; LIQUID-CHROMATOGRAPHY; PHENYLUREA HERBICIDES; EXPOSURE; HEALTH; WATER; DEGRADATION; RESIDUES; SAMPLES in [Diaw, Pape A.] Univ Alioune Diop, Lab Mat Electrochim & Photochim Analyt, Bambey, Senegal; [Diaw, Pape A.; Mbaye, Olivier M. A.; Thiare, Diene D.; Gaye-Seye, Mame Diabou; Coly, Atanasse] Univ Cheikh Anta Diop, Lab Photochim & Anal, Dakar, Senegal; [Oturan, Nihal; Gaye-Seye, Mame Diabou; Oturan, Mehmet A.; Aaron, Jean-Jacques] Univ Paris Est Mame la Vallee, LGE, 5 Blvd Descartes, F-77454 Champs Sur Marne 2, Marne La Vallee, France; [Le Jeune, Bernard; Giamarchi, Philippe] Univ Brest, Lab OPTIMAG, Fac Sci, EA 938, 6 Ave Victor le Gorgeu, Brest, France in 2019, Cited 35. The Name is 2,6-Difluorobenzoic acid. Through research, I have a further understanding and discovery of 385-00-2.

Diflubenzuron (DFB) and fenuron (FEN) are benzoylurea and phenylurea pesticides, widely used in Senegal, that do not exhibit any natural fluorescence, but can be determined by means of photoinduced fluorescence (PIF) methods. Photodegradation of DFB and FEN yielded a number of fluorescent and non-fluorescent photoproducts. For both pesticides, at least 10 photoproducts were detected and identified by gas chromatography-mass spectrometry (GC/MS). To identify the formed fluorescent DFB and FEN photoproducts, their fluorescence spectra were compared with those of standard compounds, including phenol and p-hydroxyaniline.

Quality Control of 2,6-Difluorobenzoic acid. About 2,6-Difluorobenzoic acid, If you have any questions, you can contact Diaw, PA; Mbaye, OMA; Thiare, DD; Oturan, N; Gaye-Seye, MD; Coly, A; Le Jeune, B; Giamarchi, P; Oturan, MA; Aaron, JJ or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com