Tag: M.W:100-200

Application of 119639-24-6. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 2-(tert-Butyl)isothiazol-3(2H)-one 1,1-dioxide, is researched, Molecular C7H11NO3S, CAS is 119639-24-6, about Tilcotil studies. Part 2. [4 + 2] Additions with isothiazol-3(2H)-one 1,1-dioxide. Author is Burri, Kaspar F..

The isothiazoles I (R = CMe3, CH2CO2Et, R1 = Br) are not only dipolarophiles but also reactive and versatile dienophiles, especially with oxy-substituted 1,3-butadienes, I readily combine in Diels-Alder fashion; the regiospecificity of the addition is governed by the carbonyl group of the dienophile, whereas the SO2 group can be ignored for the purpose of predicting regioselectivity. Upon dehydrobromination of the [4 + 2] adducts with DBN, the cycloaromatization process is completed, generating saccharin-like compounds Besides the parent saccharin, several hydroxylated derivatives, e.g., II (R2 = OH, R3 = H; R2 = R3 = OH) have been synthesized by this new method. II are of potential interest as non-nutritive sweetening agents. In an alternative version of this principle, the isothiazole I (R = CMe3, CH2CO2Et, CH2C6H4OMe-4, R1 = H) is reacted with the oxazole III, affording, after acid-promoted rearrangement, pyrido-annulated isothiazoles IV. Since both processes generate saccharin-related structures, they may serve in syntheses of oxicams and analogs of ipsapirone. To demonstrate the viability of the approach one representative of each series, has been converted to an oxicam.

Compounds in my other articles are similar to this one(2-(tert-Butyl)isothiazol-3(2H)-one 1,1-dioxide)Application of 119639-24-6, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (Piperidinium-1-ylmethyl)trifluoroborate, is researched, Molecular C6H13BF3N, CAS is 1268340-93-7, about Reinvestigation of Aminomethyltrifluoroborates and Their Application in Suzuki-Miyaura Cross-Coupling Reactions.Application of 1268340-93-7.

A reinvestigation into the chem. composition of potassium aminomethyltrifluoroborates is reported. These trifluoroborato salts have been reassigned as zwitterionic ammoniomethyltrifluoroborates. Minor adjustments to the previously disclosed reaction conditions are reported that permit a similar level of activity as nucleophiles in Suzuki-Miyaura cross-coupling reactions.

Compounds in my other articles are similar to this one((Piperidinium-1-ylmethyl)trifluoroborate)Application of 1268340-93-7, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Waldner, Adrian published an article about the compound: 2-(tert-Butyl)isothiazol-3(2H)-one 1,1-dioxide( cas:119639-24-6,SMILESS:O=C(C=C1)N(C(C)(C)C)S1(=O)=O ).Formula: C7H11NO3S. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:119639-24-6) through the article.

The [4 + 2] cycloaddition of α,β-unsaturated hydrazones, Me2NN:CHCR:CHR1 (R = Me, Et, CHMe2, R1 = H; R = R1 = Me), (1-azabuta-1,3-dienes) with isothiazol-3(2H)-one 1,1-dioxide derivatives I (R2 = H, CMe3, Me3CCH2CMe2, 4-ClC6H4, PhCH2, 4-MeOC6H4CH2) affords, depending on the solvent used, picolinamides II or III, and 4-azasaccharin derivatives IV or V. The course of the reaction is mainly influenced by the substituent R2 of the dienophile I.

Compounds in my other articles are similar to this one(2-(tert-Butyl)isothiazol-3(2H)-one 1,1-dioxide)Formula: C7H11NO3S, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 119639-24-6, is researched, Molecular C7H11NO3S, about Palladium-Catalyzed [3 + 2] Cycloaddition via Twofold 1,3-C(sp3)-H Activation, the main research direction is palladium catalyzed cycloaddition carbon hydrogen bond activation; amide lactam cycloaddition maleimide.Category: isothiazole.

Cycloaddition reactions provide an expeditious route to construct ring systems in a highly convergent and stereoselective manner. For a typical cycloaddition reaction to occur, however, the installation of multiple reactive functional groups (π-bonds, leaving group, etc.) are required within the substrates, compromising the overall efficiency or scope of the cycloaddition reaction. Here, we report a palladium-catalyzed [3 + 2] reaction that utilizes C(sp3)-H activation to generate the three-carbon unit for formal cycloaddition with maleimides. We implemented a strategy where the initial C(sp3)-H activation/olefin insertion would trigger a relayed, second remote C(sp3)-H activation to complete a formal [3 + 2] cycloaddition The diastereoselectivity profile of this reaction resembles that of a typical pericyclic cycloaddition reaction in that the relationships between multiple stereocenters are exquisitely controlled in a single reaction. The key to success was the use of weakly coordinating amides as the directing group, as undesired Heck or alkylation pathways were preferred with other types of directing groups. The use of the pyridine-3-sulfonic acid ligands is critical to enable C(sp3)-H activation directed by this weak coordination. The method is compatible with a wide range of amide substrates, including lactams, which lead to novel spiro-bicyclic products. The [3 + 2] product is also shown to undergo a reductive desymmetrization process to access chiral cyclopentane bearing multiple stereocenters with excellent enantioselectivity. Cycloaddition reactions provide an expeditious route to construct ring systems in a highly convergent and stereoselective manner. For a typical cycloaddition reaction to occur, however, the installation of multiple reactive functional groups (π-bonds, leaving group, etc.) is required within the substrates, compromising the overall efficiency or scope of the cycloaddition reaction. Here, we report a palladium-catalyzed [3 + 2] reaction that utilizes twofold C(sp3)-H activation to generate the three-carbon unit for formal cycloaddition The initial β-C(sp3)-H activation of aliphatic amide, followed by maleimide insertion, triggers a relayed, second C(sp3)-H activation to complete a formal [3 + 2] cycloaddition The key to success was the use of weakly coordinating amide as the directing group, as previous studies have shown that Heck or alkylation pathways are preferred when stronger-coordinating directing groups are used with maleimide coupling partners [e.g., N,N-dimethylpivalamide + N-(4-nitrophenyl)maleimide → I (87%, dr 6:1)]. To promote the amide-directed C(sp3)-H activation step, the use of pyridine-3-sulfonic acid ligands is crucial. This method is compatible with a wide range of amide substrates, including lactams, which lead to spiro-bicyclic products. The [3 + 2] product is also shown to undergo a reductive desymmetrization process to access chiral cyclopentane bearing multiple stereocenters with excellent enantioselectivity.

Compounds in my other articles are similar to this one(2-(tert-Butyl)isothiazol-3(2H)-one 1,1-dioxide)Category: isothiazole, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Pyrimidines. I. Synthesis of pyrimidinethiols, published in 1961, which mentions a compound: 6307-44-4, mainly applied to , Recommanded Product: 6307-44-4.

cf. CA 54, 6747a. The 9 previously unknown isomers of the 22 possible substituted pyrimidinethiols, containing H, HO, NH2, and SH as substituents were synthesized and methods for preparation of some of the previously reported compounds were improved. Various derivatives of RC:N.CR1:N.CR2:CH (I) were prepared for preliminary screening as antitumor agents. HOCH2CH2OH (200 ml.), 125 g. 4,5-Cl(MeS)C4H2N2, and 200 g. NaSH heated slowly to 100° with frothing and bubbling, the mixture carefully heated to 150° and kept 30 min., the solution poured into 1500 ml. H2O and the boiled, decolorized hot filtrate acidified with AcOH, the precipitate reprecipitated from hot dilute aqueous NH4OH with AcOH gave 85 g. I (R = H, R1 = R2 = SH), converted by concentrated HBr to I (R = R1 = H, R2 = SH). NaHS (42 g.) and 13 g. 4,6,2-Cl(HO)(MeS)C4HN2 in 120 ml. HOCH2CH2OH heated 30 min. at 150°, the cooled mixture poured into 500 ml. H2O and the boiled decolorized solution filtered, acidified with AcOH to pH 5 and the refiltered solution adjusted to pH 1.0 with dilute HCl, the product reprecipitated from solution in dilute NH4OH with HCl, and the product recrystallized from HCONMe2-H2O gave 9.0 g. I (R = OH, R1 = R2 = SH), m. 262-4° (method A). The appropriate chloropyrimidine (60 g.) in 500 ml. absolute alc. refluxed 3 hrs. with 150 g. NaHS, the chilled mixture filtered and the alc. washed precipitate boiled in 1 l. H2O, the decolorized solution filtered, the filtrate acidified and the precipitate recrystallized from the appropriate solvent gave RC:N.CR1: N.CR2:CR3 (II) (method B). In method C the procedure was the same but no precipitate was formed. The light yellow alc. solution was diluted with 1 l. boiling H2O and acidified and the precipitate recrystallized The appropriate chloropyrimidine (40 g.) and 40 g. (H2N)2CS in 500 ml. absolute alc refluxed 2 hrs. the mixture chilled and the precipitated ligroine-washed product purified by reprecipitation and recrystallization gave II (method D). The appropriate chloropyrimidine (35 g.) and 70 g. powd. NaHS in 400 ml. H2O was autoclaved 4 hrs. at 150°/8 atm., the solution boiled and the decolorized solution filtered, acidified with AcOH [for the preparation of I (R = NH2, R1 = SH, R2 = OH)] or dilute HCl [for the preparation of I (R = SH, R1 = R2 = OH)], and the products purified by recrystallization (method E). I (R = NH2, R1 = SH, R2 = OH) (50 g. finely powd. and dried at 100°) refluxed 2 hrs. with 150 g. P2S5 in 1.5 l. dry C5H5N, excess C5H5N evaporated in vacuo and the residue diluted cautiously with 750 ml. H2O, the mixture refluxed 2 hrs. on a steam bath with evolution of H2S, the chilled mixture filtered and adjusted to pH 2, the volume reduced to 33% in vacuo and the cooled concentrate filtered, the residue taken up in dilute NH4OH and the boiled decolorized solution filtered, acidified with dilute HCl and the precipitate recrystallized from HCONMe2-H2O gave 35 g. I (R = H2N, R1 = R2 = SH). Purified P2S5 (125 g.) and 52 g. I (R = R1 = H, R2 = OH) refluxed 1 hr. with stirring in l. C5H5N, the hot solution poured into 1 l. H2O and the solution heated on a steam bath 3 hrs., the filtered solution evaporated in vacuo to 200 ml., refrigerated and the H2O-washed product recrystallized from 500 ml. boiling H2O gave 42 g. I (R = R1 = H, R2 = SH). I(R = R2 = Cl, R1 = NH2) (33 g.) added to 1 l. 4:1 alc.-H2O containing 40 g. NaOH saturated with H2S, the mixture refluxed with stirring 2 hrs. with passage of H2S, treated with C and the filtered solution acidified with AcOH gave 42 g. I (R = SH, R1 = NH2, R2 = Cl), m. 302° (decomposition), λ 260 mμ (ε 9800, pH 1), λ 280 mμ (ε 12,500, pH 11), converted by autoclaving with NaHS to I (R = SH, R1 = R2 = OH). I (R = R2 = OH, R1 = SH)(60 g.)in 1 l. 2N NaOH stirred 3 hrs. with dropwise addition of 50 g. Me2SO4, the solution boiled with addition of C and the decolorized filtered solution acidified to pH 1.0 with HCl gave 50 g. I (R = R1 = OH, R1 = MeS) (III), m. above 360° (H2O). III (80 g.) refluxed 2 hrs. with 500 ml. POCl3, excess POCl3 removed in vacuo and the residue poured with stirring over crushed ice, the mixture stirred 20 min. at 0°, filtered and the precipitate washed in ice H2O until the pH of the washings was no longer below 5, the material dried 16 hrs. in vacuo and recrystallized from MeOH and H2O gave 64 g. I (R = R2 = Cl, R1 = MeS) (IV), m 43°. Treatment of IV with NaHS at 150° in HOCH2CH2OH gave I (R = R1 = R2 = SH). NaHS (75 g.) in 500 ml. MeOH at 50° stirred with portionwise addition of 50 g. IV, the mixture stirred 30 min. before dilution with 1 l. H2O, the solution boiled with C and the filtered solution acidified, the product reprecipitated from dilute NH4OH with AcOH, and recrystallized from HCONMe2-H2O gave 40 g. I (R = R2 = HS, R1 = MeS), m. above 360°. IV (50 g.) refluxed with stirring 4 hrs. in 500 ml. 2N NaOH, the solution decolorized and the filtered solution acidified with AcOH, the precipitate purified by reprecipitation and recrystallized from HCONMe2-H2O gave 40 g. I (R = Cl, R1 = MeS, R2 = OH), m. 208°. Absolute MeOH (150 ml.) at 0° treated with 30 g. finely powd. IV, the mixture stirred 45 min. with passage of dry Cl, filtered from 8 g. product, and the filtrate evaporated at 20° in a stream of dry air gave 12 g. product; the crops combined and recrystallized from EtOAc and C7H16 gave 17 g. I (R = R2 = Cl, R1 = MeSO2) (V), m. 119°. V (15 g.) warmed in 200 ml. N NaOH, the filtered solution chilled and the precipitate washed with cold H2O and alc., the dry salt (11.6 g.) in 150 ml. H2O carefully neutralized with HCl and the solution evaporated in vacuo, the residue taken up in boiling Me2CHOH and diluted with C7H16 gave 5 g. I (R = R2 = Cl, R1 = OH), m. 262° (Me2CHOHC7H16). The ultraviolet absorption spectra of the completed series of I showed the approx. maximum of the major peak of I in solutions at pH 1.0 were 280, 300-20, 320-40, and 360-70 mμ for 2-pyrimidinethiols, 4-pyrimidinethiols, 2,4-pyrimidinedithiols, and 4,6-pyrimidinedithiols, resp. Data for I and for a number of known thiopyrimidines, II, not previously published are recorded for comparison [R, R1, R2, R3, m.p. (solvents), and % yield given]: H, SH, H, H, 229-30° (alc.), 70; H, H, SH, H, 190-2° (H2O), 69; H, OH, SH, H, 298-300° (H2O-HCONMe2), 88; H, SH, OH, H, 310-12° (H2O), 73; H, NH2, SH, H, 231-3° (H2O-HCONMe2), 68; OH, H, SH, H, 247° (H2O), 79; H2N, H, SH, H, 306° (H2O-HCONMe2), 61; H, SH, SH, H, 300° (H2O), 70; HS, H, SH, H, 250-2° (H2O), 70; OH, SH, OH, H, above 360° (H2O-HCONMe2), 84; OH, OH, SH, H, 245° (H2O), 54; H2N, OH, SH, H, 355° (H2O-HCONMe2), 43; OH, H2N, SH, H, above 360° (H2O-HCONMe2), 82; H2N, H2N, SH, H, above 360° (reprecipitation), 50; H2N, SH, OH, H, above 360° (reprecipitation), 91; H2N, SH, H2N, H, above 360° (reprecipitation), 93; OH, SH, SH, H, 262-4° (H2O-HCONMe2), 79; H2N, SH, SH, H, above 360° (H2O-HCONMe2), 60; SH, OH, SH, H, 266-7° (H2O-HCONMe2), 46; SH, H2N, SH, H, 267° (H2O), 76; SH, SH, SH, H, above 360° (reprecipitation), 70; Cl, H2N, H, Cl, above 360° (reprecipitation), 63; Me, H2N, SH, H, 321° (reprecipitation), 84; Me, H2N, SH, Br, 207° (H2O-HCONMe2), 98; Me, SH, SH, H, above 360° (H2O-HCONMe2), 70; H, SH, SH, CO2H, 261-3° (H2O-HCONMe2), 63; SH, H, SH, Cl, 215-17° (reprecipitation), 70; SH, H, SH, Br, 213° (reprecipitation), 92; SH, H2N, SH, Ph, 266-8° (H2O-HCONMe2), 60; H, MeS, SH, H, 203° (H2O-HCONMe2), 96; Me, MeS, SH, H, 239° (H2O-HCONMe2), 78; SH, MeS, SH, H, above 360° (H2O-alc.), 80. For comparison of structure and biol. activities in pyrimidine thiols, a number of new related 4-pyrimidine thiols substituted in position 5 were synthesized. Thiopyrimidine (0.08 mole) stirred in 250 ml. N NaOH treated with a stoichiometric amount of the appropriate alkyl halide, the mixture stirred 3 hrs. and the H2O-washed precipitate recrystallized gave the corresponding alkylthiopyrimidine (method A). Similarly, the above reaction mixture on failure to give a precipitate was acidified with AcOH and the product recrystallized to yield the required alkyl thiopyrimidine (method B). The yields ranged from 80 to 95%. Phys. data for alkylthio- and aralkylthiopyrimidines are listed [R, R1, R2, R3 of formula II, method of synthesis, m.p. (solvent, if other than HCONMe2 + H2O) given]: MeS, H, OH, H, B, 230° (H2O); PhCH2S, H, OH, H, B, 238-9°; 2,4-Cl2C6H3CH2S, H, OH, H, B, 191.3°; MeS, H, H2 N, H, A, 168-70°; EtS, H, H2N, H, A, 147-9°; PhCH2S, H, H2N, H, A, 140°; 2,4-Cl2C6H3CH2S, H, H2N, H, A, 184-6°; p-O2NC6H4CH2S, H, H2N, H, A, 165-7°; MeS, H, MeS, H, A, 52-4° (C7H16); MeS, H, MeS, H2N, A, 79°; MeS, H, MeS, Cl, A, 118-20°; EtS, H, EtS, Cl, A, 58-9°; PhCH2S, H, PhCH2S, Cl, A, 86-8°; 2,4-Cl2C6H3CH2S, H 2,4-Cl2C6H3CH2S, Cl, A, 155°; MeS, H, MeS, Br, A, 155°; PrS, H, PrS, Br, A, 44-6°; PhCH2S, H, PhCH2S, Br, A, 95-7°; 2,4-Cl2C6H3CH2S, H, 2,4-Cl2C6H3CH2S, Br, A, 149°; p-O2NC6H4CH2S, H, p-O2NC6H4CH2S, Br, A, 168-70°; PhCH2S, OH, OH, H, B, 242°; H, OH, o-ClC6H4CH2S, H, A, 174-6°; H, OH, 2,4-Cl2C6H3CH2S, H, A, 193-4°; MeS, H2N, H, H, A, 150-3°; Et, H2N, H, H, A, 155°; PhCH2S, H2N, H, H, A, 178-80°; 2,4-Cl2C6H3CH2S, H2N, H, H, A, 155-7°; o-ClC6H4CH2S, H2N, Me, H, A, 143-5°; MeS, H2N, Cl, H, A, 106-8°; EtS, H2N, Cl, H, A, 109-10°; PrS, H2N, Cl, H, A, 105-6°; PrS, H2N, Me, Br, A, 95-7°; o-ClC6H4CH2S, H2N, Me, Br, A, 138-40°; p-O2NC6H4CH2S, H2N, Me, Br, A, 226-8°; EtS, H2N, EtS, H, A, 54°; PrS, H2N, PrS, H, A, 85-7°; PhCH2S, H2N, PhCH2S, H, A, 134-6°; 2,4-Cl2C6H3CH2S, H2N, 2,4-Cl2C6H3CH2S, H, A, 159-61°; MeS, H2N, MeS, Ph, A, 128-9° (C7H15); PhCH2S, H2N, PhCH2S, Ph, A, 207-9° (C7H15); o-ClC6H4CH2S, H2N, o-ClC6H4CH2S, Ph, A, 174-5° (EtOAc); 2,4-Cl2C6H3CH2S, H2N, 2,4-Cl2C6H3CH2S, Ph, A, 164-7° (PhMe); MeS, MeS, Me, H, A, 43-5° (C7H15); 2,4-Cl2C6H3CH2S, MeS, Me, H, A, 100-2°; H2N, MeS, MeS, H, A, 121-3°; MeS, MeS, MeS, H, A, 114-16°; H, MeS, MeS, CO2H, B, 201-3°; PhCH2S, PhCH2S, Me, H, A, 37-9° (C7H15); o-ClC6H4CH2S, o-ClC6H4CH2S, o-ClC6H4CH2S, H, A, 117-18° (H2O-alc.); 2,4-Cl2C6H3CH2S, 2,4-Cl2C6H3CH2S, H, H, A, 94-6° (C7H15); 2,4-Cl2C6H3CH2S, 2,4-Cl2C6H3CH2S, Me, H, A, 107-9° (C7H15); H2N, 2,4-Cl2C6H3CH2S, 2,4-Cl2C6H3CH2S, H, A, 125-7° (C7H15); 2,4-Cl2C6H3CH2S, 2,4-Cl2C6H3CH2S, 2,4-Cl2C6H3CH2S, H, A, 120-4°. Other II prepared were (R, R1, R2, R3, method of synthesis, and m.p. (solvent) given): MeS, OH, H2N, H, B, 294° (H2O); MeS, H2N, Me, H, A, 152°; EtS, H2N, Me, H, A, 122-4°; BuS, H2N, Me, H, A, 70-2°; PhCH2S, H2N, Me, H, A, 118-20°; 2,4-Cl2C6H3CH2S, H2N, Me, H, A, 157-60°; p-O2NC6H4CH2S, H2N, Me, H, A, 157-9°; MeS, H2N, OH, H, B, 274-6°; EtS, H2N, OH, H, B, 248°; PrS, H2N, OH, H, B, 228-32°; BuS, H2N, OH, H, B, 240-2°; C6H11S, H2N, OH, H, B, 185°; MeS, H2N, Me, Br, A, 140-2°; PhCH2S, H2N, Me, Br, A, 135-7°; MeS, H2N, MeS, H, A, 116-18°; OH, MeS, MeS, H, B, 197° (H2O). Ultraviolet maximum at pH 1 and 11 were given for the II prepared

In some applications, this compound(6307-44-4)Recommanded Product: 6307-44-4 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Journal of Medicinal Chemistry called Potent Benzimidazole Sulfonamide Protein Tyrosine Phosphatase 1B Inhibitors Containing the Heterocyclic (S)-Isothiazolidinone Phosphotyrosine Mimetic, Author is Combs, Andrew P.; Zhu, Wenyu; Crawley, Matthew L.; Glass, Brian; Polam, Padmaja; Sparks, Richard B.; Modi, Dilip; Takvorian, Amy; McLaughlin, Erin; Yue, Eddy W.; Wasserman, Zelda; Bower, Michael; Wei, Min; Rupar, Mark; Ala, Paul J.; Reid, Brian M.; Ellis, Dawn; Gonneville, Lucie; Emm, Thomas; Taylor, Nancy; Yeleswaram, Swamy; Li, Yanlong; Wynn, Richard; Burn, Timothy C.; Hollis, Gregory; Liu, Phillip C. C.; Metcalf, Brian, which mentions a compound: 119639-24-6, SMILESS is O=C(C=C1)N(C(C)(C)C)S1(=O)=O, Molecular C7H11NO3S, Recommanded Product: 2-(tert-Butyl)isothiazol-3(2H)-one 1,1-dioxide.

Potent nonpeptidic benzimidazole sulfonamide inhibitors of protein tyrosine phosphatase 1B (PTP1B) were derived from the optimization of a tripeptide containing the novel (S)-isothiazolidinone ((S)-IZD) phosphotyrosine (pTyr) mimetic. An x-ray cocrystal structure of inhibitor 46/PTP1B at 1.8 Å resolution demonstrated that the benzimidazole sulfonamides form a bidentate H bond to Asp-48 as designed, although the aryl group of the sulfonamide unexpectedly interacts intramolecularly in a pi-stacking manner with the benzimidazole. The ortho substitution to the (S)-IZD on the aryl ring afforded low nanomolar enzyme inhibitors of PTP1B that also displayed low caco-2 permeability and cellular activity in an insulin receptor (IR) phosphorylation assay and an Akt phosphorylation assay. The design, synthesis, and SAR of this novel series of benzimidazole sulfonamide containing (S)-IZD inhibitors of PTP1B are presented herein.

In some applications, this compound(119639-24-6)Recommanded Product: 2-(tert-Butyl)isothiazol-3(2H)-one 1,1-dioxide is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Bromination of pyrimidines by N-bromosuccinimide》. Authors are Nishiwaki, Tarozaemon.The article about the compound:2-Amino-6-methylpyrimidine-4-thiolcas:6307-44-4,SMILESS:SC1=CC(C)=NC(N)=N1).Category: isothiazole. Through the article, more information about this compound (cas:6307-44-4) is conveyed.

cf. CA 54, 24777h. Pyrimidines having potentially tautomeric groups at the 2-, 4-, or 6-position were brominated preferentially at the 5-position by N-bromosuccinimide (I) in HOAc. Thus, 0.01 mole pyrimidine in 20 ml. HOAc was treated with 0.01 mole I 1 hr. at 100°. The precipitate was collected and crystallized to give N:CR1N:CR2.CBr:CR3 (R1, R2, R3, m.p., and % yield given): OH, OH, H, 295° 59; OH, OH, Me, 248°, 76; H, OH, OH, 264°, 61; NH2, OH, H, 275°, 83; NH2, OH, Me, 249°, 61; NH2, H, H, 239-40°, 62; NH2, Cl, Cl, 235-6°, 63; NH2, Me, Me, 183-4°, 75; NH2, Ph, Me, 125-8°, 70; Cl, Cl, NH2, 155-7°, 79; SMe, OH, H, 252°, 41; SMe, OH, Me, 246°, 21; SMe, OH, NH2, -, 60; SMe, Cl, NH2, 164-5°, 66; SEt, OH, H, 185-7.5°, 47. An ionic mechanism was postulated as yields were improved by addition of AlCl3, FeCl3, SnCl4, and picric acid and not reduced by radical inhibitors. The bromination by I of O- and S-alkylpyrimidines, 1,3,4-trimethyluracil, and 2,4-dichloro-6-methylpyrimidine by this method was not successful.

In some applications, this compound(6307-44-4)Category: isothiazole is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Molander, Gary A.; Beaumard, Floriane published the article 《Cross-Coupling of Mesylated Phenol Derivatives with Potassium Ammonio- and Amidomethyltrifluoroborates》. Keywords: Suzuki Miyaura cross coupling mesylated phenol amidomethyltrifluoroborate.They researched the compound: (Piperidinium-1-ylmethyl)trifluoroborate( cas:1268340-93-7 ).Electric Literature of C6H13BF3N. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1268340-93-7) here.

A large array of aryl and heteroaryl mesylates have been successfully employed as electrophiles in a Csp2-Csp3 Suzuki-Miyaura cross-coupling with potassium ammonio- and amidomethyltrifluoroborates to afford the corresponding products in high yields.

In some applications, this compound(1268340-93-7)Electric Literature of C6H13BF3N is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

HPLC of Formula: 1268340-93-7. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: (Piperidinium-1-ylmethyl)trifluoroborate, is researched, Molecular C6H13BF3N, CAS is 1268340-93-7, about Cross-Coupling of Mesylated Phenol Derivatives with Potassium Ammonio- and Amidomethyltrifluoroborates. Author is Molander, Gary A.; Beaumard, Floriane.

A large array of aryl and heteroaryl mesylates have been successfully employed as electrophiles in a Csp2-Csp3 Suzuki-Miyaura cross-coupling with potassium ammonio- and amidomethyltrifluoroborates to afford the corresponding products in high yields.

Compounds in my other articles are similar to this one((Piperidinium-1-ylmethyl)trifluoroborate)HPLC of Formula: 1268340-93-7, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Amino-6-methylpyrimidine-4-thiol( cas:6307-44-4 ) is researched.Quality Control of 2-Amino-6-methylpyrimidine-4-thiol.Felczak, Krzysztof; Bretner, Maria; Kulikowski, Tadeusz; Shugar, David published the article 《High-yield regioselective thiation of biologically important pyrimidinones, dihydropyrimidinones and their ribo, 2′-deoxyribo and 2′,3′-dideoxyribo nucleosides》 about this compound( cas:6307-44-4 ) in Nucleosides & Nucleotides. Keywords: pyrimidinone regioselective thiation Lawesson reagent; nucleoside pyrimidinone regioselective thiation Lawesson reagent. Let’s learn more about this compound (cas:6307-44-4).

Convenient and high-yield regioselective thiation procedures based on the use of the Lawesson reagent in different solvents, are described for conversion of the 2- and 4-keto, and 2,4-diketo pyrimidines to the corresponding 2(4)-thio, and 2,4-dithio, derivatives This method is applicable to thiation of the 4-keto groups of 5,6-dihydropyrimidinones and pyrimidine nucleosides. The mild reaction conditions employed are such that it is the method of choice for compounds with labile glycosidic bonds, of choice for compounds with labile glycosidic bonds, such as 5,6-dihydropyrimidine nucleosides and the 2′,3′-dideoxynucleosides currently of interest as antiretroviral, including anti-HIV, agents.

When you point to this article, it is believed that you are also very interested in this compound(6307-44-4)Quality Control of 2-Amino-6-methylpyrimidine-4-thiol and due to space limitations, I can only present the most important information.

Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com