Tag: M.W=100-150

Inagaki, Masanao published the artcileShort Synthesis of tert-Butyl-Hydroxylated 3,5-Di-tert-butyl-4-hydroxybenzaldehyde: Synthesis of tert-Butyl-Hydroxylated S-2474, Formula: C5H11NO2S, the main research area is hydroxybenzaldehyde hydroxybutyl preparation; oxidizing agent hydrobromic acid DMSO; antiarthritic drug S2474 metabolite preparation.

We have developed a very short synthesis of tert-butyl-hydroxylated di-tert-butyl-4-hydroxybenzaldehyde (I) in which the HBr-DMSO system is used as an effective oxidant (overall yield of 45% for the entire four-step process from 2-tert-butyl-p-cresol). We also accomplished the synthesis of a major metabolite (II) of the antiarthritic drug candidate S-2474.

Journal of Organic Chemistry published new progress about Oxidizing agents (hydrobromic acid-DMSO). 73343-04-1 belongs to class isothiazole, name is 2-Ethylisothiazolidine 1,1-dioxide, and the molecular formula is C5H11NO2S, Formula: C5H11NO2S.

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Oda, Katsuo published the artcileDevelopment of One-Pot Synthesis of New Antiarthritic Drug Candidate S-2474 with High E-Selectivity, Product Details of C5H11NO2S, the main research area is antiarthritic drug candidate S2474 high E selectivity preparation.

A one-pot synthesis of S-2474 was developed to overcome the problems of a large number of steps, low stereoselectivity, low yield, a large amount of waste, and severe reaction conditions. Aldol-type condensation of 3,5-di-tert-butyl-4-hydroxybenzaldehyde and N-ethyl-γ-sultam was carried out with LDA and then quenched with water. Dehydration proceeded under basic conditions, providing S-2474 directly as a single isomer on the benzylidene double bond. The reaction mechanism appears to involve a quinone methide intermediate. Environmental assessment of the development of this compound is also discussed.

Organic Process Research & Development published new progress about Antiarthritics. 73343-04-1 belongs to class isothiazole, name is 2-Ethylisothiazolidine 1,1-dioxide, and the molecular formula is C5H11NO2S, Product Details of C5H11NO2S.

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Inagaki, Masanao published the artcileNovel Antiarthritic Agents with 1,2-Isothiazolidine-1,1-dioxide (γ-Sultam) Skeleton: Cytokine Suppressive Dual Inhibitors of Cyclooxygenase-2 and 5-Lipoxygenase, Formula: C5H11NO2S, the main research area is antiarthritic isothiazolidine dioxide sultam preparation; structure activity antiarthritic isothiazolidine dioxide sultam.

Various 1,2-isothiazolidine 1,1-dioxide (γ-sultam) derivatives containing an antioxidant moiety, 2,6-di-tert-butylphenol substituent, were prepared Some compounds, which have a lower alkyl group at the 2-position of the γ-sultam skeleton, showed potent inhibitory effects on both cyclooxygenase (COX)-2 and 5-lipoxygenase (5-LO), as well as production of interleukin (IL)-1 in in vitro assays. They also proved to be effective in several animal arthritic models without any ulcerogenic activities. Among these compounds, (E)-(5)-(3,5-di-tert-butyl-4-hydroxybenzylidene)-2-ethyl-1,2-isothiazolidine-1,1-dioxide (S-2474) (I) was selected as an antiarthritic drug candidate and is now under clin. trials. The structure-activity relationships (SAR) examined and some pharmacol. evaluations are described.

Journal of Medicinal Chemistry published new progress about Antiarthritics. 73343-04-1 belongs to class isothiazole, name is 2-Ethylisothiazolidine 1,1-dioxide, and the molecular formula is C5H11NO2S, Formula: C5H11NO2S.

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Inagaki, Masanao published the artcileHighly E-Selective and Effective Synthesis of Antiarthritic Drug Candidate S-2474 Using Quinone Methide Derivatives, Application In Synthesis of 73343-04-1, the main research area is ditertbutylhydroxybenzylideneethylisothiazolidine dioxide preparation; isothiazolidine ditertbutylhydroxybenzylideneethyl dioxide preparation.

We have developed an efficient and E-selective synthesis of an antiarthritic drug candidate (E)-(5)-(3,5-di-tert-butyl-4-hydroxybenzylidene)-2-ethyl-1,2-isothiazolidine-1,1-dioxide (S-2474), in which α-methoxy-p-quinone methide is used as a key intermediate. α-Methoxy-p-quinone methide was revealed to be an equivalent to a p-hydroxy protected benzaldehyde. It reacts smoothly with α-sulfonyl carbanion to give 1,6-addition intermediates, which can be further processed to provide S-2474 directly in the presence of a base. This procedure gives S-2474 as an almost single isomer on the benzylidene double bond in excellent yield and thus is a very practical method adaptable to large-scale synthesis. The detailed mechanistic aspects are studied and discussed.

Journal of Organic Chemistry published new progress about ditertbutylhydroxybenzylideneethylisothiazolidine dioxide preparation; isothiazolidine ditertbutylhydroxybenzylideneethyl dioxide preparation. 73343-04-1 belongs to class isothiazole, name is 2-Ethylisothiazolidine 1,1-dioxide, and the molecular formula is C5H11NO2S, Application In Synthesis of 73343-04-1.

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Product Details of 99-04-7. In 2019 ASIAN J ORG CHEM published article about METAL-FREE CATALYST; AEROBIC OXIDATION; OXYGEN REDUCTION; CARBOXYLIC-ACIDS; PALLADIUM NANOPARTICLES; GOLD NANOPARTICLES; ACTIVATED CARBON; ELECTROCATALYSTS; PERFORMANCE; REAGENT in [Yang, Fan; Xu, Chong; Xia, Yan; Chen, Zhuo; He, Xing; Li, Yun; Yang, Wang; Li, Yongfeng] China Univ Petr, State Key Lab Heavy Oil Proc, Beijing 102249, Changping, Peoples R China; [Cao, Yan] China Petr Engn & Construct North China Co, 3 Jianshe Rd, Renqiu, Hebei, Peoples R China in 2019, Cited 47. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7.

The nitrogen and phosphorus co-doped graphene-like carbon (NPG) is cost-effective fabricated by simple ball-milling and thermal treatment. The as-prepared NPG can be used as a metal-free catalyst for selective catalytic oxidation of aromatic alcohols to their corresponding acids by using TBHP and O-2 as the oxidant in water. It is observed that various aromatic alcohols bearing electron-donating/withdrawing groups can be oxidized to the corresponding acids in excellent yields. No dehalogenation and steric-hindrance effects are detected in this oxidation process. In addition, the NPG catalyst can be easily separated and efficiently reused seven times, showing good recyclability.

Product Details of 99-04-7. Bye, fridends, I hope you can learn more about C8H8O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article Cooperativity within the catalyst: alkoxyamide as a catalyst for bromocyclization and bromination of (hetero)aromatics WOS:000573314500029 published article about PHASE-TRANSFER CATALYSIS; ENANTIOSELECTIVE BROMOCYCLIZATION; SELECTIVE HALOGENATION; N-BROMOSUCCINIMIDE; HALOFUNCTIONALIZATION; HALOCYCLIZATION; TRYPTAMINE; REAGENT; ARENES; MILD in [Mondal, Haripriyo; Sk, Md Raja; Maji, Modhu Sudan] Indian Inst Technol Kharagpur, Dept Chem, Kharagpur 721302, W Bengal, India in 2020, Cited 48. Product Details of 151-10-0. The Name is 1,3-Dimethoxybenzene. Through research, I have a further understanding and discovery of 151-10-0

Alkoxyamide has been reported as a catalyst for the activation ofN-bromosuccinimide to perform bromocyclization and bromination of a wide range of substrates in a lipophilic solvent, where adequate suppression of the background reactions was observed. The key feature of the active site is the alkoxy group attached to the sulfonamide moiety, which facilitates the acceptance as well as the delivery of bromonium species from the bromine source to the substrates.

Welcome to talk about 151-10-0, If you have any questions, you can contact Mondal, H; Sk, MR; Maji, MS or send Email.. Product Details of 151-10-0

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article Green, Mild, and Efficient Friedel-Crafts Benzylation of Scarcely Reactive Arenes and Heteroarenes under On-Water Conditions WOS:000466387800014 published article about PROTON ACCEPTOR GROUPS; X-RAY-DIFFRACTION; HYDROPHOBIC AMPLIFICATION; ORGANIC-REACTIONS; MICHAEL ADDITION; ALKYL; CATALYST; BENZENE; DIARYLMETHANES; ACCELERATION in [La Manna, Pellegrino; Soriente, Annunziata; De Rosa, Margherita; Buonerba, Antonio; Talotta, Carmen; Gaeta, Carmine; Neri, Placido] Univ Salerno, Dipartimento Chim & Biol A Zambelli, Via Giovanni Paolo II, I-84084 Salerno, Italy in 2019, Cited 98. The Name is 1,3-Dimethoxybenzene. Through research, I have a further understanding and discovery of 151-10-0. Product Details of 151-10-0

Metal-free Friedel-Crafts benzylation (FCB) of scarcely reactive arenes and heteroarenes was performed under on-water conditions by an environmentally sustainable procedure. The catalytic strategy exploits the hydrophobicity of the resorcinarene macrocycle 1 a. The proposed mechanism is based on the activation of benzyl chloride by H-bonding interactions with catalyst 1 a. In fact, under on-water conditions the hydrophobic amplification of the strength of the H-bonding interactions between the OH groups of the resorcinarene catalyst and the chlorine atom of benzyl chloride leads to polarization of the C-Cl bond, which consequently promotes electrophilic attack of the pi nucleophile. Thus, many arenes and heteroarenes were efficiently benzylated under mild on-water conditions by using resorcinarene 1 a as catalyst. The FCB of benzene is industrially relevant for the synthesis of diphenylmethane, and hence the on-water procedure was extended to the gram-scale synthesis of diphenylmethane, starting from benzene and benzyl chloride in the presence of resorcinarene catalyst 1 a.

Product Details of 151-10-0. Welcome to talk about 151-10-0, If you have any questions, you can contact La Manna, P; Soriente, A; De Rosa, M; Buonerba, A; Talotta, C; Gaeta, C; Neri, P or send Email.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Safety of 1,3-Dimethoxybenzene. Authors Kaur, J; Shahin, A; Barham, JP in AMER CHEMICAL SOC published article about in [Kaur, Jaspreet; Shahin, Ahmed; Barham, Joshua P.] Univ Regensburg, Fak Chem & Pharm, D-93040 Regensburg, Germany; [Shahin, Ahmed] Benha Univ, Fac Sci, Chem Dept, Banha 13518, Egypt in 2021, Cited 46. The Name is 1,3-Dimethoxybenzene. Through research, I have a further understanding and discovery of 151-10-0

A photocatalyst-free and mild visible light photochemical procedure for C(sp(3))-H arylation of amides is described. The reaction proceeds via an electron donor-acceptor (EDA) complex between an electron-rich arene substrate and electron-poor persulfate oxidant. C(sp(3))-H arylation of the amide occurs selectively with the most electron-rich arene of the substrate. Mechanistic studies corroborate the reaction taking place in a solvent cage holding components in a close proximity.

Safety of 1,3-Dimethoxybenzene. Bye, fridends, I hope you can learn more about C8H10O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article Ipso-nitration of carboxylic acids using a mixture of nitronium tetrafluoroborate, base and 1-hexyl-3,4,5-trimethyl-1H-imidazolium tetrafluoroborate WOS:000474499200008 published article about PHOSPHONIUM IONIC LIQUIDS; AROMATIC-COMPOUNDS; SOLVOLYTIC BEHAVIOR; SELECTIVE NITRATION; ARYLBORONIC ACIDS; HIGHLY EFFICIENT; SULFONIC-ACID; METAL; CHEMISTRY; CATALYST in [Natarajan, Palani] Panjab Univ, Dept Chem, Chandigarh 160014, India; Panjab Univ, Ctr Adv Studies Chem, Chandigarh 160014, India in 2019.0, Cited 83.0. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7. Safety of 3-Methylbenzoic acid

An eco-friendly and a simple ipso-nitration protocol for a series of aliphatic and (hetero)aromatic carboxylic acids using nitronium tetrafluoroborate, 1-hexyl-3,4,5-trimethyl-1H-imidazolium tetrafluoroborate and base is reported. While contrasted with recently known decarboxylative ipso-nitration strategies for the preparation of nitro compounds, this protocol does not require a toxic metal catalyst and harmful volatile organic solvents. Moreover, this method is perfect for a broad range of functional groups and affords exclusively the ipso-nitrated product in moderate to good yields. (C) 2019 Elsevier Ltd. All rights reserved.

Welcome to talk about 99-04-7, If you have any questions, you can contact Natarajan, P; Chaudhary, R; Venugopalan, P or send Email.. Safety of 3-Methylbenzoic acid

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Recently I am researching about HIGHLY SELECTIVE OXIDATION; PLATINUM CATALYST; MOLECULAR-OXYGEN; ALLYLIC ALCOHOLS; PORE STRUCTURE; POROUS CARBON; ALDEHYDES; EFFICIENT; NANOPARTICLES; SURFACE, Saw an article supported by the Institute for Advanced Studies in Basic Science (IASBS) Research Council [G2019IASBS31100]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Ganji, N; Karimi, B; Najafvand-Derikvandi, S; Vali, H. The CAS is 99-04-7. Through research, I have a further understanding and discovery of 3-Methylbenzoic acid. Name: 3-Methylbenzoic acid

Preparation of an ordered mesoporous polypyrrole/carbon (PPy/OMC) composite has been described through a two-step nanocasting process using KIT-6 as a template. Characterization of the PPy/OMC nanocomposite by various analysis methods such as TEM, XRD, TGA, SEM and N-2 sorption confirmed the preparation of a material with ordered mesoporous structure, uniform pore size distribution, high surface area and high stability. This nanocomposite was then used for the immobilization of palladium nanoparticles. The nanoparticles were almost uniformly distributed on the support with a narrow particle size of 20-25 nm, confirmed by various analysis methods. Performance of the Pd@PPy/OMC catalyst was evaluated in the aerobic oxidation of various primary and secondary alcohols on water as a green solvent, giving the corresponding carboxylic acids and ketones in high yields and excellent selectivity. The catalyst could also be reused for at least 10 reaction runs without losing its catalytic activity and selectivity. High catalytic efficiency of the catalyst can be attributed to a strong synergism between the PPy/OMC and that of supported Pd nanoparticles.

Name: 3-Methylbenzoic acid. Welcome to talk about 99-04-7, If you have any questions, you can contact Ganji, N; Karimi, B; Najafvand-Derikvandi, S; Vali, H or send Email.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com