Tag: M.W:0-100

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Quality Control of Isothiazole, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 288-16-4, Name is Isothiazole, molecular formula is C3H3NS

A Synopsis of the Properties and Applications of Heteroaromatic Rings in Medicinal Chemistry

Five- and six-membered heteroaromatic rings and their benzo-fused homologues are well established as important structural elements in drug design and are well represented in approved drugs. The key properties of these heterocycles that are of?interest to medicinal chemists include lipophilicity, pKa, aromaticity, ionization potential, H-bond acceptor, and H-bond donor (N?H, O?H, C?H) capability, electron withdrawing effects, dipole values, and bond angles. The judicious and productive application of azoles and azines in drug design requires an understanding of the intrinsic physical chemical properties of the individual heterocycles and how these interact with substituents. In this article, the key properties of azole and azine heterocycles are summarized followed by a synopsis of applications where some of these factors play a role in drug?target interactions and/or potency.

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Reference of 288-16-4, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.288-16-4, Name is Isothiazole, molecular formula is C3H3NS. In a Article£¬once mentioned of 288-16-4

One-step synthesis of 2-alkenecarbodithioate esters from substituted propargyl ethers, and their conversion into isothiazole ring through a [4+1] type oxidative ring closure

Treatment of substituted propargyl methyl ethers with a base and elemental sulfur in the presence of a thiolate ion afforded 2-alkenecarbodithioate esters in good yields. The reaction is assumed to proceed through a pathway involving in situ generation of propadienethione intermediates. Further conversion of 2-alkenecarbodithioate esters into 2,3-dihydroisothiazoles were efficiently performed by treating with chloramine-T through a [4+1] type oxidative ring closure via thiocarbonyl S-tosylimides.

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Synthetic Route of 288-16-4, Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about Synthetic Route of 288-16-4

Solvent effect on nitrogen NMR shieldings in thiazole and thiadiazole systems

High precision 14N NMR measurements are reported for all six possible thiazole and thiadiazole molecules in a variety of solvents.Both solvent polarity and hydrogen bonding effects on the nitrogen nuclear shielding of the solutes are significant.Both types of effect produce an increase in the solute nitrogen shielding.Analysis of experimental data, and molecular orbital studies, indicate that an increase in the polarity of the solvent favours the delocalization of the lone pair electrons from the sulfur atoms into the conjugated rings.This leads to an increase in electronic charge at the nitrogen atom(s) concerned.This effect is more pronounced than analogous effects observed for pyridine type nitrogen atoms in the corresponding diazole and triazole systems.The significant shielding effects which result from solvent to solute hydrogen bonding to ring nitrogen atoms are shown to be essentially local in origin.Thus the shielding concerned is that of the nitrogen atom directly involved in the hydrogen bonding.

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Isothiazole – ScienceDirect.com

 

Electric Literature of 288-16-4, Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about Electric Literature of 288-16-4

Golden Jubilee for Scorpionates. Recent Advances in Organometallic Chemistry and Their Role in Catalysis

This review aims to describe some recent trends in organometallic complexes containing scorpionate ligands. Particular attention will be paid to the ligands structure, reagents, and methods developed during the past decade and contextualize them within the broad field of organometallic chemistry. In fact, novel ligand design has itself become a fundamental part of most organometallic researches and many catalytic conversions have been attained by subtle modification of the metal environment through a careful choice of the ancillary ligands. This review, which is necessarily limited in scope, reports the organometallic complexes with azolylborate and azolylalkane ligands from 2008 until today and it is organized according to the metal center.

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Isothiazole – ScienceDirect.com

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Safety of Isothiazole, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 288-16-4, Name is Isothiazole, molecular formula is C3H3NS

A preparation N-methyl thiazoline-2-ketone compound by the method (by machine translation)

The invention discloses a method for preparing an N-Methylthiazoline-2-ketone compound. In an inert atmosphere, an organic solvent is taken as a reaction medium, copper salt and an antioxidant are taken as a catalytic system, and a thiazole compound is oxidized into the N-Methylthiazoline-2-ketone compound through an oxidative methylation reaction. The preparation method disclosed by the invention is higher in reactivity, mild in reaction conditions, short in reaction time and high in yield; used catalysts are low in price and toxicity, and less in use amount, a multi-step reaction is shortened to a one-step reaction, and the treatment is simple, thereby being beneficial to purifying products; most importantly, the use of a toxic and volatile methylation reagent is avoided. The catalyst system disclosed by the invention has universality for a variety of reactants. Raw materials of the invention are readily available, and the reaction process is simple and controllable, so that the method is suitable for the industrialized production.

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Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, category: isothiazole, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 288-16-4, Name is Isothiazole, molecular formula is C3H3NS

gamma-Secretase Modulators: Current status and future directions

This chapter reviews the current status of gamma-secretase modulators, highlighting key compounds by each company involved in the area. The review focuses on the three main chemotypes: acids, imidazoles and related derivatives and natural products. A section on chemical biology and ligand-binding site elucidation studies is also included. The primary source of information is drawn from peer reviewed literature as this permits analysis of PK-PD relationships and subsequent comment. Discussion of the patent literature is included for completeness. From this analysis, the key issues and challenges in the area are highlighted. The review concludes with a summary of the clinical development status and comment on future prospects of the field.

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Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

Synthetic Route of 288-16-4, Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about Synthetic Route of 288-16-4

Synthesis and biological evaluation of novel 1beta-methylcarbapenems with isothiazoloethenyl side chains

The synthesis of novel 1beta-methylcarbapenems 1a,b bearing isothiazoloethenyl moieties at C-5 position of pyrrolidine ring and their biological evaluation are described. Both compounds showed potent and well-balanced antibacterial activity as well as high stability to DHP-I. Especially, 5-isothiazole derivative 1a exhibited excellent DHP-I stability and advanced pharmacokinetics profiles, compared to 5-isoxazole derivative 2, imipenem, and meropenem.

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Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

Application of 288-16-4, Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter. In a Review£¬Which mentioned a new discovery about 288-16-4

Imidazo[1,2-a]pyridines: Promising drug candidate for antitumor therapy

Imidazo[1,2-a]pyridine has been shown to be an important biologically active moiety. This review is a compilation of the scattered output of results of the anticancer activities of the imidazo[ 1,2-a]pyridine system since 2001, which have been classified as inhibition of CDK, VEGFR, PI3K, EGFR, RGGT etc. along with inhibition against different tumor cell lines. Various imidazo[ 1,2-a]pyridine based analogues have been used as lead molecules and are now under human clinical trials. This review will help the wider scientific community in the area of drug discovery of imidazo[1,2-a]pyridines as novel anticancer agents.

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Isothiazole – Wikipedia,
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4,6-Dinitrobenzo[c]isothiazole: Synthesis and 1,3-dipolar cycloaddition to azomethine ylide

1,3-Dipolar cycloaddition of 4,6-dinitrobenzo[c]isothiazole to (N-methyl-N-methylideneammonio)methanide (2 equiv.) gives 5,8-dimethyl-3b,6b- dinitrodecahydroisothiazolo[3,4-e]pyrrolo[3,4-g]isoindole, whose structure was confirmed by X-ray diffraction analysis.

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Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

288-16-4, Name is Isothiazole, belongs to isothiazole compound, is a common compound. Application In Synthesis of IsothiazoleIn an article, once mentioned the new application about 288-16-4.

Synthesis, fungicidal activity and SAR of 3,4-dichloroisothiazole-based cycloalkylsulfonamides

To develop more valuable and effective fungicide candidates, a novel series of 3,4-dichloroisothioxazole-based cycloalkylsulfonamides were synthesized and their structures were identified by 1H NMR, 13C NMR, MS and elemental analysis. Compound 3k was further confirmed by X-ray single crystal diffraction. The in vitro bioassay results demonstrated that the target compounds showed significant fungicidal activity on mycelial growth and spore germination of Botrytis cinerea. Especially, compound 3j, with prominent inhibition effect on mycelial with EC50 and EC80 values of 1.4 and 23.7 mug/mL respectively, was comparable to the selected commercial fungicide. Moreover, at 50 mug/mL, the inhibition rate of compound 3j on spore germination was recorded up to 89.7%. The further in vivo bioassay results indicated compound 3j continued to show high control effect on tomato leaves, flowers and fruit at 200 mug/mL, with control efficiencies of 94.3%, 89.3% and 91.9%, respectively. The structure?activity relationship showed that the compound with a five-membered ring possessed the best activity after the introduction of the active fragment of the 3,4-dichloroisothioxazole, provided a valuable idea for further creation of new fungicides.

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Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com