Tag: 94594-90-8

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.94594-90-8,(3aS,6S,7aS)-8,8-Dimethylhexahydro-1H-3a,6-methanobenzo[c]isothiazole 2,2-dioxide,as a common compound, the synthetic route is as follows.

[00124] [3aS-[1(E),3a,6,7a]]-1-[3-(3,4-difluorophenyl)-1-oxo-2-propenyl]-hexahydro-8,8-dimethyl-3H-3a,6-methano-2,l-benzisothiazole-2,2-dioxide: At 0-5 0C, a solution of 3-(3,4-difluoro-phenyl)-acryloyl chloride in dichloromethane (30 mL) was added to a mixture of (2R)-bornane-10,2-sultam (14.5 g, 67.35 mmol, 1.00 equiv), triethylamine (20.4 g, 201.98 mmol, 3.00 equiv), and dichloromethane (120 mL). The resulting solution was stirred at ambient temperature for about 3 hours and then water (40 mL) was added. Standard extractive workup with dichloromethane (2 x 40 mL) gave the title product as an off-white solid (18.5 g; yield = 72 percent). 1H NMR (300 MHz, CDCl3) delta: 7.68 (d, / = 15.6 Hz, 1 H), 7.15- 7.45 (m, 3 H), 7.19 (d, J = 15.6 Hz, 1 H), 4.00 (m, 1 H), 3.55 (q, J1 =13.8 Hz, J2 = 24.0 Hz ), 2.18 (m, 2 H), 1.93 (m, 2 H), 1.37-1.48 (m, 2 H), 1.22 (s, 3 H), 0.96 (s, 3 H).

94594-90-8 (3aS,6S,7aS)-8,8-Dimethylhexahydro-1H-3a,6-methanobenzo[c]isothiazole 2,2-dioxide 6916014, aisothiazole compound, is more and more widely used in various.

Reference£º
Patent; AUSPEX PHARMACEUTICALS, INC.; RAO, Tadimeti; ZHANG, Chengzhi; WO2011/17108; (2011); A2;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

94594-90-8, (3aS,6S,7aS)-8,8-Dimethylhexahydro-1H-3a,6-methanobenzo[c]isothiazole 2,2-dioxide is a isothiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Take 30 g of the resulting intermediate, add 250 mL of dichloromethane. After stirring to clarify,37 g of camphorsulfonamide and 9. 6 g of N, N’-4-dimethylaminopyridine (DMAP) were added and the reaction was cooled to 10 ¡ã C. A solution of 75 g of N, N’-dicyclohexylcarbodiimide (DCC) and 50 mL of DCM was added dropwise, and the temperature of the dropping process was below 20 ¡ã C. After completion of the dropwise addition, the reaction was carried out at 20 ¡ã C to 25 ¡ã C for 18 hours. After completion of the reaction, the reaction solution was filtered and the resulting filtrate was washed once with 50 mL of water and once with 25 mL of saturated brine. After the dichloromethane phase was concentrated, 300 mL of n-heptane was added to precipitate a solid. Filtered and then dried to give 56 g of a solid, 99.8percent purity, 91percent yield.

The synthetic route of 94594-90-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Dalian Honkai Chemical Development Co., Ltd; Sun, Liquan; Zhao, xinjun; Feng, Yan-shu; Gao, Hanrong; cornille, Fabrice; Canevotti, Renato; (12 pag.)CN106588841; (2017); A;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com