Tag: 269.3599

New ligands with a wide bite angle. Efficient catalytic activity in the Rh(I)-catalyzed hydroformylation of olefins was written by Yamamoto, Keiji;Momose, Satoru;Funahashi, Masakazu;Ebata, Satoshi;Ohmura, Hideaki;Komatsu, Hiroshi;Miyazawa, Masahiro. And the article was included in Chemistry Letters in 1994.Recommanded Product: 1-((3aS,6R,7aR)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one This article mentions the following:

The relevance of a new diphosphinite (I), which holds a natural bite angle around 120° in a catalyst complex, to the Rh(I)-catalyzed hydroformylation of certain olefins is examined, exhibiting a high turnover frequency (TOF) as compared with a typical 1,2-bis(diphenylphosphino)ethane with a bite angle around 85°. In the experiment, the researchers used many compounds, for example, 1-((3aS,6R,7aR)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one (cas: 94594-91-9Recommanded Product: 1-((3aS,6R,7aR)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one).

1-((3aS,6R,7aR)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one (cas: 94594-91-9) belongs to isothiazole derivatives. Isothiazoles and isothiazolium cations are attacked by carbanions at sulfur and on recyclization can give thiophenes. Many compounds with an isothiazole scaffold demonstrated a wide range of biological profiles, including antiinflammatory, antithrombotic, and anticonvulsive agents.Recommanded Product: 1-((3aS,6R,7aR)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Copper-Catalyzed Intermolecular Trifluoromethylazidation of Alkenes: Convenient Access to CF₃-Containing Alkyl Azides was written by Wang, Fei;Qi, Xiaoxu;Liang, Zhaoli;Chen, Pinhong;Liu, Guosheng. And the article was included in Angewandte Chemie, International Edition in 2014.SDS of cas: 119944-89-7 This article mentions the following:

A novel copper-catalyzed intermol. trifluoromethylazidation of alkenes has been developed under mild reaction conditions. A variety of CF₃-containing azides were directly synthesized from a wide range of olefins, including activated and un-activated alkenes, and the resulting products can be easily transformed into the corresponding CF₃-containing amine derivatives Under optimized reaction conditions the synthesis of the target compounds was achieved using tetrakis(acetonitrile)copper hexafluorophosphate as a catalyst for a reaction of alkenes with trimethylsilyl azide and 3,3-dimethyl-1-(trifluoromethyl)-1,2-benzodioxol. Alkene reactants included (ethenyl)benzene derivatives (styrene), cyclopentene, cyclohexene, indene, cyclooctene, dihydroquinoline, (3β)-3-(acetyloxy)pregn-5-en-20-one, 4-methoxyphenyl 4,6-O-[(S)-phenylmethylene]-3-O-2-propen-1-yl-β-δ-galactopyranose (monosaccharide O-allyl ether), terpene derivatives In the experiment, the researchers used many compounds, for example, 1-((3aR,6S,7aS)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one (cas: 119944-89-7SDS of cas: 119944-89-7).

1-((3aR,6S,7aS)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one (cas: 119944-89-7) belongs to isothiazole derivatives. Isothiazoles and isothiazolium cations are attacked by carbanions at sulfur and on recyclization can give thiophenes. Various penicillins and cephalosporins having an isothiazole ring system have shown considerable antibacterial efficacy against Gram-positive and Gram-negative bacteria.SDS of cas: 119944-89-7

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

The use of vicinal twofold Heck reaction products in diastereoselective sequential Michael additions. A convenient access to enantiomerically pure six-ring annulated cispentacin derivatives was written by Voigt, Katharina;Lansky, Annegret;Noltemeyer, Mathias;de Meijere, Armin. And the article was included in Liebigs Annalen in 1996.Quality Control of 1-((3aS,6R,7aR)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one This article mentions the following:

The Pd-catalyzed coupling reactions of various acrylic acid derivatives with 1,2-dibromobenzene, 1,2,3-tribromobenzene, and 1,2-dibromocyclohexene yielded the corresponding diethenylarenes I (R = OMe, OCMe₃, OCH₂Ph, O-menthyl, O-camphorsultamyl; R¹ = H; R²R³, R⁴R⁵ = bond), triethenylarenes I [R = OMe, OCMe₃; R¹ = (E)-CH:CHCOR; R²R³, R⁴R⁵ = bond], and hexatrienes I (R = OMe, OCMe₃; R¹, R², R³, R⁴, R⁵ = H). Some of these compounds were converted to 1,2,3-trisubstituted trans,trans-indane- and tetrahydroindane derivatives by domino conjugate additions of N, C, and S nucleophiles. With PhCH₂NHSiMe₃ as an NH₃ equivalent, the relative configuration of all 3 newly formed stereogenic centers was controlled (d.e. >90%). With chiral non-racemic ammonia equivalent like benzyl[(S)-phenylethyl]amine and TMS-(R)-AMP, protected diastereomerically pure β-amino esters were obtained, which could easily be deprotected by standard methods to yield the enantiomerically pure β-amino acids II and III. In the experiment, the researchers used many compounds, for example, 1-((3aS,6R,7aR)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one (cas: 94594-91-9Quality Control of 1-((3aS,6R,7aR)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one).

1-((3aS,6R,7aR)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one (cas: 94594-91-9) belongs to isothiazole derivatives. Isothiazoles and their saturated and/or oxygenated analogs play an important role in pharmaceutical research. Many compounds with an isothiazole scaffold demonstrated a wide range of biological profiles. Some of these molecules have been efficiently used in the treatment of Alzheimer’s disease.Quality Control of 1-((3aS,6R,7aR)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On the scope of diastereoselective epoxidation of various chiral auxiliaries derived enones: The conformational analysis of camphor derived N- and O-enones was written by Lee, Wei-Der;Chiu, Ching-Chen;Hsu, Hua-Lin;Chen, Kwunmin. And the article was included in Tetrahedron in 2004.Electric Literature of C13H19NO3S This article mentions the following:

Various camphor derived N- and O-enones were treated with selected oxidants to provide the corresponding epoxides in a wide range of diastereoselectivity. For camphorsultam derived activated alkenes, high to excellent stereoselectivities were obtained when the s-trans enones were treated with methyl(trifluoromethyl)dioxirane. On the other hand, for exo-10,10-diphenyl-2,10-camphanediol and exo-10,10-diphenyl-10-methoxy-2-camphanol derived alkenes, the use of s-cis enones gave the desired epoxide with excellent diastereoselectivity under the same reaction conditions. The stereoselectivity was highly dependent on the geometry of the auxiliaries derived enones and the stereochem. induction is discussed. In the experiment, the researchers used many compounds, for example, 1-((3aS,6R,7aR)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one (cas: 94594-91-9Electric Literature of C13H19NO3S).

1-((3aS,6R,7aR)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one (cas: 94594-91-9) belongs to isothiazole derivatives. The chemistry of isothiazoles is being intensively developed, which is evidenced by the wide range of selective transformations involving the isothiazole heterocycle and the high biological activity of its derivatives that can be used as effective new drugs and plant protection chemicals. Various penicillins and cephalosporins having an isothiazole ring system have shown considerable antibacterial efficacy against Gram-positive and Gram-negative bacteria.Electric Literature of C13H19NO3S

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

The Total Synthesis of (-)-Lemonomycin was written by Ashley, Eric R.;Cruz, Ernest G.;Stoltz, Brian M.. And the article was included in Journal of the American Chemical Society in 2003.Synthetic Route of C13H19NO3S This article mentions the following:

The first total synthesis of the novel glycosylated tetrahydroisoquinoline antitumor antibiotic (-)-Lemonomycin I has been accomplished. The highly convergent synthesis relies on a key asym. dipolar cycloaddition to set the stereochem. of the aglycon core, a Suzuki fragment coupling to connect the diazabicycle to the aryl subunit, and a stereoselective Pictet-Spengler reaction that incorporates the aminoglycoside subunit directly into the core structure without the need for late-stage glycosylation or protecting group manipulations. The novel aminoglycoside was prepared using a highly diastereoselective Felkin-controlled acetate aldol addition reaction to a threonine-derived ketone. In the experiment, the researchers used many compounds, for example, 1-((3aR,6S,7aS)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one (cas: 119944-89-7Synthetic Route of C13H19NO3S).

1-((3aR,6S,7aS)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one (cas: 119944-89-7) belongs to isothiazole derivatives. Similar to other five-membered heterocycles, isothiazoles react with a wide range of electrophilic and nucleophilic reagents to form diverse products. It has been found that isothiazole-based compounds show synergistic effects when used with other biocidal compounds.Synthetic Route of C13H19NO3S

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Asymmetric synthesis of chiral piperazinylpropylisoxazoline ligands for dopamine receptors was written by Jung, Ji Young;Jung, Sun Ho;Koh, Hun Yeong. And the article was included in European Journal of Medicinal Chemistry in 2007.SDS of cas: 119944-89-7 This article mentions the following:

The asym. synthesis of chiral piperazinylpropylisoxazoline analogs, e.g., I and II, was accomplished through a seven-step sequence of reactions, which involved asym. 1,3-dipolar cycloaddition, alkyl chain extension, and reductive amination as key reactions. Chiral ligands I and II exhibited the higher binding affinity and selectivity for the D₃ receptor over the D₄ receptor than their enantiomers, resp. In the experiment, the researchers used many compounds, for example, 1-((3aR,6S,7aS)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one (cas: 119944-89-7SDS of cas: 119944-89-7).

1-((3aR,6S,7aS)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one (cas: 119944-89-7) belongs to isothiazole derivatives. Isothiazoles and benzisothiazoles are usually liquids or low-melting-point solids; polar substituents increase the melting points because of the possibility of hydrogen bonding and other interactions in the crystalline state. The ring structure of isothiazole is incorporated into larger compounds with biological activity such as the pharmaceutical drugs ziprasidone and perospirone.SDS of cas: 119944-89-7

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com