Tag: 150.2

Tetrahydro-3H-pyrazolo[4,3-a]phenanthridine-based CDK inhibitor was written by Opoku-Temeng, Clement;Dayal, Neetu;Hernandez, Delmis E.;Naganna, N.;Sintim, Herman O.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2018.Related Products of 53473-85-1 This article mentions the following:

Cyclin-dependent kinases have emerged as important targets for cancer therapy. HSD992, containing a novel scaffold based on the tetrahydro-3H-pyrazolo[4,3-a]phenanthridine core, inhibits CDK2/3 but not other CDKs and also potently inhibits several cancer cell lines. In the experiment, the researchers used many compounds, for example, Benzo[d]isothiazol-5-amine (cas: 53473-85-1Related Products of 53473-85-1).

Benzo[d]isothiazol-5-amine (cas: 53473-85-1) belongs to isothiazole derivatives. Isothiazoles and benzisothiazoles are usually liquids or low-melting-point solids; polar substituents increase the melting points because of the possibility of hydrogen bonding and other interactions in the crystalline state. Many compounds with an isothiazole scaffold demonstrated a wide range of biological profiles, including antiinflammatory, antithrombotic, and anticonvulsive agents.Related Products of 53473-85-1

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

3H-Pyrazolo[4,3-f]quinoline-Based Kinase Inhibitors Inhibit the Proliferation of Acute Myeloid Leukemia Cells In Vivo was written by Dayal, Neetu;Reznickova, Eva;Hernandez, Delmis E.;Perina, Miroslav;Torregrosa-Allen, Sandra;Elzey, Bennett D.;Skerlova, Jana;Ajani, Haresh;Djukic, Stefan;Vojackova, Veronika;Lepsik, Martin;Rezacova, Pavlina;Krystof, Vladimir;Jorda, Radek;Sintim, Herman O.. And the article was included in Journal of Medicinal Chemistry in 2021.Application In Synthesis of Benzo[d]isothiazol-5-amine This article mentions the following:

Herein, various 3H-pyrazolo[4,3-f]quinoline-containing compounds e.g., I were rapidly assembled via the Doebner-Povarov multicomponent reaction from the readily available 5-aminoindazoles, ketones and aldehydes in good yields. The most active compounds potently inhibit the recombinant FLT3 kinase and its mutant forms with nanomolar IC₅₀ values. Docking studies with the FLT3 kinase showed a type I binding mode, where the 3H-pyrazolo group interacts with Cys694 in the hinge region. The compounds blocked the proliferation of AML cell lines harboring oncogenic FLT3-ITD mutations with remarkable IC₅₀ values, which were comparable to the approved FLT3 inhibitor quizartinib. The compounds also inhibited the growth of leukemia in a mouse-disseminated AML model, and hence, the novel 3H-pyrazolo[4,3-f]quinoline-containing kinase inhibitors are potential lead compounds to develop into anticancer agents, especially for kinase-driven cancers. In the experiment, the researchers used many compounds, for example, Benzo[d]isothiazol-5-amine (cas: 53473-85-1Application In Synthesis of Benzo[d]isothiazol-5-amine).

Benzo[d]isothiazol-5-amine (cas: 53473-85-1) belongs to isothiazole derivatives. The chemistry of isothiazoles is being intensively developed, which is evidenced by the wide range of selective transformations involving the isothiazole heterocycle and the high biological activity of its derivatives that can be used as effective new drugs and plant protection chemicals. Various penicillins and cephalosporins having an isothiazole ring system have shown considerable antibacterial efficacy against Gram-positive and Gram-negative bacteria.Application In Synthesis of Benzo[d]isothiazol-5-amine

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

An in Silico Method for Predicting Ames Activities of Primary Aromatic Amines by Calculating the Stabilities of Nitrenium Ions was written by Bentzien, Joerg;Hickey, Eugene R.;Kemper, Raymond A.;Brewer, Mark L.;Dyekjaer, Jane D.;East, Stephen P.;Whittaker, Mark. And the article was included in Journal of Chemical Information and Modeling in 2010.Synthetic Route of C7H6N2S This article mentions the following:

In this paper, the authors describe an in silico first principal approach to predict the mutagenic potential of primary aromatic amines. This approach is based on the so-called “nitrenium hypothesis”, which was developed by Ford et al. in the early 1990s. This hypothesis asserts that the mutagenic effect for this class of mols. is mediated through the transient formation of a nitrenium ion and that the stability of this cation is correlated with the mutagenic potential. Here the authors use quantum mech. calculations at different levels of theory (semiempirical AM1, ab initio HF/3-21G, HF/6-311G(d,p), and DFT/B3LYP/6-311G(d,p)) to compute the stability of nitrenium ions. When applied to a test set of 257 primary aromatic amines, the authors show that this method can correctly differentiate between Ames active and inactive compounds, and furthermore that it is able to rationalize and predict SAR trends within structurally related chem. series. For this test set, the AM1 nitrenium stability calculations are found to provide a good balance between speed and accuracy, resulting in an overall accuracy of 85%, and sensitivity and specificity of 91% and 72%, resp. The nitrenium-based predictions are also compared to the com. software packages DEREK, MULTICASE, and the MOE-Toxicophore descriptor. One advantage of the approach presented here is that the calculation of relative stabilities results in a continuous spectrum of activities and not a simple yes/no answer. This allows the authors to observe and rationalize subtle trends due to the different electrostatic properties of the organic mols. The authors’ results strongly indicate that nitrenium ion stability calculations should be used as a complementary approach to assist the medicinal chemist in prioritizing and selecting nonmutagenic primary aromatic amines during preclin. drug discovery programs. In the experiment, the researchers used many compounds, for example, Benzo[d]isothiazol-5-amine (cas: 53473-85-1Synthetic Route of C7H6N2S).

Benzo[d]isothiazol-5-amine (cas: 53473-85-1) belongs to isothiazole derivatives. Isothiazole is more toxic than pyridine. But the more substituted isothiazoles are usually far less toxic. Various penicillins and cephalosporins having an isothiazole ring system have shown considerable antibacterial efficacy against Gram-positive and Gram-negative bacteria.Synthetic Route of C7H6N2S

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com