101.13 | - Page 2 of 4 - Heterocyclic Building Blocks-Isothiazole

Thyssen, Jacob P. et al. published their research in Contact Dermatitis in 2012 | CAS: 1003-07-2

Isothiazol-3(2H)-one (cas: 1003-07-2) belongs to isothiazole derivatives. Isothiazoles and isothiazolium cations are attacked by carbanions at sulfur and on recyclization can give thiophenes. Many compounds with an isothiazole scaffold demonstrated a wide range of biological profiles. Some of these molecules have been efficiently used in the treatment of Alzheimer’s disease.Formula: C3H3NOS

The critical review of methodologies and approaches to assess the inherent skin sensitization potential (skin allergies) of chemicals. Part III was written by Thyssen, Jacob P.;Gimenez-Arnau, Elena;Lepoittevin, Jean-Pierre;Menne, Torkil;Boman, Anders;Schnuch, Axel. And the article was included in Contact Dermatitis in 2012.Formula: C3H3NOS This article mentions the following:

The statistical evidence on the incidence and morbidity of skin contact allergy (contact dermatitis) cases in the European Union before and after the safety limits were set is presented. The evidence is used to assess the possible effect of the limits in the reduction/prevention of the incidence and morbidity of contact dermatitis. In the experiment, the researchers used many compounds, for example, Isothiazol-3(2H)-one (cas: 1003-07-2Formula: C3H3NOS).

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Xie, Shaowen et al. published their research in Environmental Science and Pollution Research in 2018 | CAS: 1003-07-2

Isothiazol-3(2H)-one (cas: 1003-07-2) belongs to isothiazole derivatives. Similar to other five-membered heterocycles, isothiazoles react with a wide range of electrophilic and nucleophilic reagents to form diverse products. It has been found that isothiazole-based compounds show synergistic effects when used with other biocidal compounds.Quality Control of Isothiazol-3(2H)-one

Arsenic uptake, transformation, and release by three freshwater algae under conditions with and without growth stress was written by Xie, Shaowen;Liu, Jinxin;Yang, Fen;Feng, Hanxiao;Wei, Chaoyang;Wu, Fengchang. And the article was included in Environmental Science and Pollution Research in 2018.Quality Control of Isothiazol-3(2H)-one This article mentions the following:

This study was carried out using indoor controlled experiments to study the arsenic uptake, biotransformation, and release behaviors of freshwater algae under growth stress. Three freshwater algae, Microcystis aeruginosa, Anabaena flosaquae, and Chlorella sp.,Two types of inhibitors, Cu²⁺ and isothiazolinone, inhibit the growth of the algae. The algae were cultivated to a logarithmic stage in growth media containing0.1 mg/L P; then,0.8 mg/LAs in the form of arsenate (iAs^V) was added,while both inhibitors were simultaneously added at dosages of 0.1 and 0.3 mg/LAfter 2 days of exposure, the average growth rate was measured to represent the growth rates of the algae cells; the extra- and intracellular monomethyl arsenic, and di-Me arsenic, were also measured,Without inhibitors,M.aeruginosa significantly higher than that of the other two algae.However, when Cu²⁺ was added as an external inhibitor, the order of the average growth rate for the three algae became partially reversed.The great reduction in M. aeruginosa growth rate was accompanied by increases in extracellular iAs^V and iAs^III and intracellular iAs concentrations The biol.productivity of As by the three algae followed the order of M.aeruginosa, Chlorella sp.,and A.flosaquae,generally consistent with the As transformation and release in conditions with and without inhibitors, suggesting that the As behavior in the algae that was related to growth stress largely differed among algae species. In the experiment, the researchers used many compounds, for example, Isothiazol-3(2H)-one (cas: 1003-07-2Quality Control of Isothiazol-3(2H)-one).

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Vidal, J. et al. published their research in Science of the Total Environment in 2021 | CAS: 1003-07-2

Isothiazol-3(2H)-one (cas: 1003-07-2) belongs to isothiazole derivatives. Isothiazole is a good solvent for many organic substances but should be used with caution because it is more toxic than pyridine. It has been found that isothiazole-based compounds show synergistic effects when used with other biocidal compounds.Related Products of 1003-07-2

Electro-kinetic washing of a soil contaminated with quinclorac and subsequent electro-oxidation of wash water was written by Vidal, J.;Baez, Maria E.;Salazar, R.. And the article was included in Science of the Total Environment in 2021.Related Products of 1003-07-2 This article mentions the following:

This work deals with the remediation of a soil that has been enriched with Quinclorac (QNC), one of the herbicides most used in Chile for weed control in rice fields. Quinclorac damages the microflora and macrofauna of soils and is toxic to some susceptible crops, which results in economic loses during crop rotation. Furthermore, Quinclorac a potential contaminant of water resources and soils, given its high mobility and persistence. This has created the need to lower its concentrations in soils intensively cultivated. In this study, an electro-kinetic soil washing system (EKSW) for mobilizing this pesticide in the soil was explored. The performance of this technol. was compared by assessing the effect of direct (DP) and reverse (RP) polarity during 15 days under potentiostatic conditions and applying an elec. field of 1 V cm-1 between electrodes. Among the main results, the highest removal of QNC was obtained through the EKSW-RP process, which also contributed to the prevention of acidity and alk. fronts in the soil, compared to the EKSW-DP system. In both cases, the highest accumulation of QNC occurred in the cathodic well by mobilizing the non-ionized contaminant through the electroosmotic flow (EOF) from anode to cathode. After the treatment with EKSW, the wash water accumulated in the anodic and cathodic wells, which contained an important concentration of pesticide, was subjected to electro-oxidation (EO) by applying different current densities (j). The high generation of •OH on the surface of a boron-doped diamond electrode (BDD) allowed for the complete degradation and mineralization of QNC and its major intermediate compounds to CO₂. The results of this study show that the application of both coupled stages in this type of remediation technologies would enable the removal of QNC from the soil without altering its chem. and phys. properties, constituting an environmentally friendly process. In the experiment, the researchers used many compounds, for example, Isothiazol-3(2H)-one (cas: 1003-07-2Related Products of 1003-07-2).

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Mardones, Lucas E. et al. published their research in Progress in Organic Coatings in 2018 | CAS: 1003-07-2

Long-lasting isothiazolinone-based biocide obtained by encapsulation in micron-sized mesoporous matrices was written by Mardones, Lucas E.;Legnoverde, Maria S.;Pereyra, Andrea M.;Basaldella, Elena I.. And the article was included in Progress in Organic Coatings in 2018.Product Details of 1003-07-2 This article mentions the following:

The physicochem. properties of the silicas (structure, textural properties) were evaluated by SEM, TEM, XRD and adsorption/desorption of N₂ in order to determine their ability to encapsulate, stabilize and subsequently release a com. biocide used for latex preservation (CMIT/MIT). CMIT/MIT consists of an aqueous solution of the active ingredients CMIT (5-chloro-2-methyl-4-isothiazolin-3-one) and MIT (2-methyl-4-isothiazolin-3-one), present in a CMIT/MIT: 3/1 wt ratio. MCF has less hindered diffusion caused by a short channel length, which facilitates the biocide access to the pores of the matrix. The long pore length of SBA-15 makes the diffusion of CMIT/MIT mixture more difficult. Biocide release tests in aqueous media indicated that the CMIT/MIT concentration in the leaching solution depends on the matrix nature, the smaller values being obtained when the ordered matrix was used. Addnl., biocide delivery could be delayed by increasing the working pH from 7 to 9. Results showed that biocide encapsulation allows maintaining a long-lasting release, even under alk. conditions (pH 9), at which the hydrolysis of non-supported CMIT occur. Several release tests at different temperature (318, 323 and 328 K), were carried out for 20 days at pH 7. The biocide loading after the tests was reflected in the IR spectra, and it has been corroborated that biocide encapsulation allows retarding the fast thermal decomposition of CMIT. In the experiment, the researchers used many compounds, for example, Isothiazol-3(2H)-one (cas: 1003-07-2Product Details of 1003-07-2).

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Gobakken, Lone Ross et al. published their research in Wood Science and Technology in 2010 | CAS: 1003-07-2

Isothiazol-3(2H)-one (cas: 1003-07-2) belongs to isothiazole derivatives. Isothiazoles and their saturated and/or oxygenated analogs play an important role in pharmaceutical research. It has been found that isothiazole-based compounds show synergistic effects when used with other biocidal compounds.Product Details of 1003-07-2

Modeling mould growth on coated modified and unmodified wood substrates exposed outdoors was written by Gobakken, Lone Ross;Lebow, Patricia K.. And the article was included in Wood Science and Technology in 2010.Product Details of 1003-07-2 This article mentions the following:

Mold growth on coated wood is today a genuine challenge for house owners. Environmentally sound wooden facades with long service lives and acceptable appearance are desired. The objective in this study was to investigate the accumulated mold growth on 13 different wood substrates with 3 surface coating systems by identifying the factors that contribute to the variation and to predict future performance. A generalized linear mixed model was fit to the data with the anal. showing that coating and exposure time both had highly significant influences on mold growth. Further, wood substrate was significant, but comparatively less than coating and exposure time. A smaller coefficient for mold coverage in the beginning of the exposure period gave the panels with one of the coating systems, BAP, a delay in mold growth, and the extrapolated values for years 6-12 indicate a longer aesthetic service life than panels with the two other coating systems. Coated heartwood as wood type was less susceptible to mold growth than coated mixed wood and coated sapwood. Acetylated pine as wood substrate and aspen as wood species had lower resistance to mold growth than the other wood substrates and wood species, resp. In the experiment, the researchers used many compounds, for example, Isothiazol-3(2H)-one (cas: 1003-07-2Product Details of 1003-07-2).

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Zhang, Bai-hong et al. published their research in Liaoning Huagong in 2019 | CAS: 1003-07-2

Isothiazol-3(2H)-one (cas: 1003-07-2) belongs to isothiazole derivatives. The chemistry of isothiazoles is being intensively developed, which is evidenced by the wide range of selective transformations involving the isothiazole heterocycle and the high biological activity of its derivatives that can be used as effective new drugs and plant protection chemicals. It has been found that isothiazole-based compounds show synergistic effects when used with other biocidal compounds.Recommanded Product: 1003-07-2

Study on the application of isothiazolinone stabilizer was written by Zhang, Bai-hong;Sun, Hui;Zhang, Chong;Li, Hong;Zhang, Yu;Wang, Kun-peng;Li, Jun-feng;Lu, Peng-cheng. And the article was included in Liaoning Huagong in 2019.Recommanded Product: 1003-07-2 This article mentions the following:

Isothiazolinone has been widely used in circulating cooling water system as an effective broad-spectrum fungicide. Due to the instability of isothiazolinone itself in the application, magnesium salt as stabilizer is usually added in I type products (14%). Application of isothiazolinone with magnesium salt as stabilizer in the closed water system can affect the total hardness of the water system. So bromine compound organic compounds as stabilizer have been developed, and the application of isothiazolinone with bromine compound organic compounds as stabilizer has no significant influence on the water quality parameters of the system, which is beneficial to the stable operation of the system. In the experiment, the researchers used many compounds, for example, Isothiazol-3(2H)-one (cas: 1003-07-2Recommanded Product: 1003-07-2).

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Nagy, Peter I. et al. published their research in International Journal of Molecular Sciences in 2016 | CAS: 1003-07-2

Isothiazol-3(2H)-one (cas: 1003-07-2) belongs to isothiazole derivatives. The chemistry of isothiazoles is being intensively developed, which is evidenced by the wide range of selective transformations involving the isothiazole heterocycle and the high biological activity of its derivatives that can be used as effective new drugs and plant protection chemicals. In general, isothiazole undergoes nitration in the presence of HNO3, sulfuric acid, and sulfonation by using sulfuric acid under thermal conditions to generate corresponding 4-nitro- and 4-sulfonic acid derivatives, respectively.Product Details of 1003-07-2

Replacement of oxygen by sulfur in small organic molecules. 3. Theoretical studies on the tautomeric equilibria of the 2OH and 4OH-substituted oxazole and thiazole and the 3OH and 4OH-substituted isoxazole and isothiazole in the isolated state and in solution was written by Nagy, Peter I.. And the article was included in International Journal of Molecular Sciences in 2016.Product Details of 1003-07-2 This article mentions the following:

This follow-up paper completes the author’s investigations to explore the in-solution structural preferences and relative free energies of all OH-substituted oxazole, thiazole, isoxazole, and isothiazole systems. The polarizable continuum dielec. solvent method calculations in the integral-equation formalism (IEF-PCM) were performed at the DFT/B97D/aug-cc-pv(q+(d))z level for the stable neutral tautomers with geometries optimized in dichloromethane and aqueous solution With the exception of the predictions for the predominant tautomers of the 3OH isoxazole and isothiazole, the results of the IEF-PCM calculations for identifying the most stable tautomer of the given species in the two selected solvents agreed with those from exptl. investigations. The calculations predict that the hydroxy proton, with the exception for the 4OH isoxazole and 4OH isothiazole, moves preferentially to the ring nitrogen or to a ring carbon atom in parallel with the development of a C=O group. The remaining, low-fraction OH tautomers will not be observable in the equilibrium compositions Relative solvation free energies obtained by the free energy perturbation method implemented in Monte Carlo simulations are in moderate accord with the IEF-PCM results, but consideration of the ΔGsolv/MC values in calculating ΔGstot maintains the tautomeric preferences. It was revealed from the Monte Carlo solution structure analyses that the S atom is not a hydrogen-bond acceptor in any OH-substituted thiazole or isothiazole, and the OH-substituted isoxazole and oxazole ring oxygens may act as a weak hydrogen-bond acceptor at most. The mols. form 1.0-3.4 solute-water hydrogen bonds in generally unexplored numbers at some specific solute sites. Nonetheless, hydrogen-bond formation is favorable with the NH, C=O and OH groups. In the experiment, the researchers used many compounds, for example, Isothiazol-3(2H)-one (cas: 1003-07-2Product Details of 1003-07-2).

Isothiazol-3(2H)-one (cas: 1003-07-2) belongs to isothiazole derivatives. The chemistry of isothiazoles is being intensively developed, which is evidenced by the wide range of selective transformations involving the isothiazole heterocycle and the high biological activity of its derivatives that can be used as effective new drugs and plant protection chemicals. In general, isothiazole undergoes nitration in the presence of HNO3, sulfuric acid, and sulfonation by using sulfuric acid under thermal conditions to generate corresponding 4-nitro- and 4-sulfonic acid derivatives, respectively.Product Details of 1003-07-2

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Adibpour, Neda et al. published their research in European Journal of Medicinal Chemistry in 2010 | CAS: 1003-07-2

Isothiazol-3(2H)-one (cas: 1003-07-2) belongs to isothiazole derivatives. Similar to other five-membered heterocycles, isothiazoles react with a wide range of electrophilic and nucleophilic reagents to form diverse products. The isothiazoles can be oxidized to the corresponding sulfoxides on treatment with peracids.Synthetic Route of C3H3NOS

Synthesis and antibacterial activity of isothiazolyl oxazolidinones and analogous 3(2H)-isothiazolones was written by Adibpour, Neda;Khalaj, Ali;Rajabalian, Saeed. And the article was included in European Journal of Medicinal Chemistry in 2010.Synthetic Route of C3H3NOS This article mentions the following:

The synthesis and antibacterial activity of several new 5-((3-oxoisothiazol-2(3H)-yl)methyl)-3-phenyloxazolidin-2-ones, e.g., I, and analogous 2-(4-substituted phenyl)-3(2H)-isothiazolones, e.g., II, substituted at 4 and/or 3-positions of the Ph moiety with different groups of which some have shown to increase the antibacterial activity of both 3-aryl-2-oxazolidinones and 3(2H)-isothiazolones is described. The most active compounds were isothiazolyl oxazolidinones with unsubstituted and 4-F substituted Ph rings which showed activities higher than analogous 3(2H)-isothiazolones and comparable or superior to linezolid, vancomycin, and ciprofloxacin against some tested microorganisms. The change in position of F and/or the use of larger substituents gave compounds with reduced or no activity. Evaluation of cytotoxicity to mouse fibroblast (NIH/3T3) cells indicated that these compounds exhibit antibacterial activity at non-cytotoxic concentrations In the experiment, the researchers used many compounds, for example, Isothiazol-3(2H)-one (cas: 1003-07-2Synthetic Route of C3H3NOS).

Isothiazol-3(2H)-one (cas: 1003-07-2) belongs to isothiazole derivatives. Similar to other five-membered heterocycles, isothiazoles react with a wide range of electrophilic and nucleophilic reagents to form diverse products. The isothiazoles can be oxidized to the corresponding sulfoxides on treatment with peracids.Synthetic Route of C3H3NOS

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Aerts, Olivier et al. published their research in Contact Dermatitis in 2016 | CAS: 1003-07-2

Isothiazol-3(2H)-one (cas: 1003-07-2) belongs to isothiazole derivatives. Some representatives of isothiazoles have proven to be synergists of bioactive substances, which opens the way to lower the doses of drugs used and is especially important in cancer chemotherapy. Many compounds with an isothiazole scaffold demonstrated a wide range of biological profiles. Some of these molecules have been efficiently used in the treatment of Alzheimer’s disease.Synthetic Route of C3H3NOS

Octylisothiazolinone, an additional cause of allergic contact dermatitis caused by leather: case series and potential implications for the study of cross-reactivity with methylisothiazolinone was written by Aerts, Olivier;Meert, Hans;Romaen, Elien;Leysen, Julie;Matthieu, Lucretia;Apers, Sandra;Lambert, Julien;Goossens, An. And the article was included in Contact Dermatitis in 2016.Synthetic Route of C3H3NOS This article mentions the following:

Summary : Background : Octylisothiazolinone (OIT) is used as an antifungal agent by the leather industry. Objectives : To show sensitization to OIT from leather, and to highlight the potential implications when cross-reactivity between OIT and methylisothiazolinone (MI) is studied. Methods : Two patients with allergic contact dermatitis caused by a leather belt and shoes, resp., were patch tested with methylchloroisothiazolinone (MCI)/MI, MI, MCI, OIT, and benzisothiazolinone (BIT). High-performance liquid chromatog. with UV detection (HPLC-UV) was used to detect isothiazolinone derivatives in leather goods. Addnl., files of OIT-sensitized patients, observed at the KU Leuven department during the period 1990-2015, were retrospectively analyzed. Results : Both patients had been primarily sensitized to OIT, but the diagnosis in one of them could be achieved only when a higher patch test concentration of OIT (1000 ppm pet.) was used. HPLC-UV confirmed the presence of OIT in their leather goods. Non-relevant sensitization to MI was noted in both cases. Four addnl. cases of OIT sensitization from leather could be retrieved from the KU Leuven database. Conclusions : Non-occupational sensitization to OIT from leather may occur. Patch test concentrations of >250 ppm pet. may be necessary for diagnosis, and to show cross-reactivity with MI. Safer use limits for OIT in the leather industry may be needed. In the experiment, the researchers used many compounds, for example, Isothiazol-3(2H)-one (cas: 1003-07-2Synthetic Route of C3H3NOS).

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Xiong, Chuanjia et al. published their research in Chunjian Gongye in 2011 | CAS: 1003-07-2

Isothiazol-3(2H)-one (cas: 1003-07-2) belongs to isothiazole derivatives. Isothiazoles and benzisothiazoles are usually liquids or low-melting-point solids; polar substituents increase the melting points because of the possibility of hydrogen bonding and other interactions in the crystalline state. The isothiazoles can be oxidized to the corresponding sulfoxides on treatment with peracids.Name: Isothiazol-3(2H)-one

Application of chlorine dioxide to thermoelectric circulating cooling water in our plant was written by Xiong, Chuanjia. And the article was included in Chunjian Gongye in 2011.Name: Isothiazol-3(2H)-one This article mentions the following:

The author introduced sterilization characteristics of chlorine dioxide and the practical application in circulating cooling water in our thermoelec. plant, and carried out ClO₂ lab experiments The experiment studied the effects of added amount of ClO₂ and pH value on sterilization rate, and carried out algae killing experiment The results showed that ClO₂ had good sterilization and algae killing effect at pH 8-9, the ClO₂-not oxidized isothiazolinone-based biocide composite agent had obvious bacterium killing, and had iron removal and washing effects. The study improves bacterium killing effect for circulating cooling water in our thermoelec. plant and ensures stable operation of cooling water system. In the experiment, the researchers used many compounds, for example, Isothiazol-3(2H)-one (cas: 1003-07-2Name: Isothiazol-3(2H)-one).

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com