Tag: 100-200

On August 29, 1974, Weiler, Ernest D. published a patent.Reference of 2-Methylisothiazol-3(2H)-one hydrochloride The title of the patent was Bactericidal and fungicidal 4,5,5-trichloro-3-isothiazolidinones. And the patent contained the following:

Seventeen isothiazolidinones (I; R = C1-10 alkyl, CH2Ph, Ph, C6H4Cl-3, CHMePh, or cyclohexyl; R1 = Me or Cl) were prepared and used as bactericides and fungicides. Thus, (MeNHCOCHMeCH2S)2 was treated with Cl to give 19% I (R = R1 = Me), which was also prepared in 68% yield by chlorination of 2,4-dimethyl-4-isothiazolin-3-one in AcOEt at ≤67°. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Reference of 2-Methylisothiazol-3(2H)-one hydrochloride

The Article related to chloroisothiazolidinone bactericide fungicide, isothiazolidinone bactericide, fungicides and other aspects.Reference of 2-Methylisothiazol-3(2H)-one hydrochloride

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On October 2, 2001, Onishi, Toshikiyo; Toujou, Tamaki; Noguchi, Keiji published a patent.Application In Synthesis of 2-Methylisothiazol-3(2H)-one hydrochloride The title of the patent was Preparation of metal-free stable liquid compositions containing 3-isothiazolones as industrial bactericides. And the patent contained the following:

The compositions are prepared by dissolving hydrogen halide salts of 3-isothiazolones in PhOH and washing the solution with water to remove the acids. Thus, a mixture of 5-chloro-2-methyl-4-isothiazolin-3-one hydrochloride (I.HCl) and 2-methyl-4-isothiazolin-3-one hydrochloride was dissolved in PhOH, mixed with water, the aqueous phase removed, and the PhOH phase was washed with water to give a solution containing 21.8% I. The solution was left at 40° for 4 wk in a sealed container to show I content 19.6%. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Application In Synthesis of 2-Methylisothiazol-3(2H)-one hydrochloride

The Article related to decomposition chloromethylisothiazolinone hydrochloride bactericide phenol water, industrial antibacterial agents and other aspects.Application In Synthesis of 2-Methylisothiazol-3(2H)-one hydrochloride

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On April 29, 2009, Jin, Yuechun; Li, Kezhong; Lu, Xueting; Zhang, Xiaolin; Wang, Yu; Zhou, Shuailin; Li, Chao published a patent.Application of 26172-54-3 The title of the patent was Method for continuous production of 3-isothiazolinone derivatives. And the patent contained the following:

The method comprises allowing to react Me acrylate (I) with sulfur and H2S in the first reactor, filtering the reaction liquid to obtain solid, water phase and organic phase containing (SCH2CH2CO2CH3)2 (II) and S(SCH2CH2CO2CH3)2 (III), introducing the solid and water phase to the first reactor, introducing the organic phase into the first counter-current extraction tower, allowing to react compound III with Na2SO3 aqueous solution to obtain compound II, aminating compound II with primary amine (compound IV; NH2R; here: R = C1-C18 alkyl or C3-C18 cycloalkyl) to obtain (SCH2CH2CONHR)2 (compound V; R is defined as above); reacting compound V with Cl2 to obtain the title compound VI (IT-HCl; here: IT is 2-R-4-R1-5-R2-3-isothiazolinone; R is defined as above; R1 and R2 are H or Cl). The method has the advantages of less production equipment, low energy consumption, simplified operation, and suitability for industrialized production The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Application of 26172-54-3

The Article related to isothiazolinone derivative preparation, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Application of 26172-54-3

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On August 17, 2016, there was a patent about fireproofing agents.Category: isothiazole The title of the patent was Flame retardant used in waterborne flame-retarding coating. And the patent contained the following:

A cyano- and amino group-containing fireproofing agent is applied in coating material. A coating is prepared from waterborne polyurethane resin 30-80, dispersing wetting agent 10-20, defoaming agent 1-5, antiseptic 1-5, film-forming aid 10-20, flame retardant 1-10, and water 50-150 weight parts. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Category: isothiazole

The Article related to cyano amino containing fireproofing agent coating polyurethane, Coatings, Inks, and Related Products: Drying Oils, Solvents, Plasticizers, and Other Additives and other aspects.Category: isothiazole

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On March 31, 1995, Suzuki, Tetsuya published a patent.Safety of 2-Methylisothiazol-3(2H)-one hydrochloride The title of the patent was Photographic emulsions containing isothiazolin-3-ones. And the patent contained the following:

Photog. emulsions are prepared by addition of isothiazolin-3-ones I (R1 = H, alkyl, cycloalkyl, alkenyl, alkoxy, aryl, heterocycle, CONH2, etc.; R2-3 = H, halo, alkyl,, cycloalkyl, aryl, cyano, alkylthio, etc.; R2 and R3 may form a benzene ring) during the period from nucleation of emulsion grains to the termination of chem. ripening. The photog. materials show little dependence on humidity and little change in sensitivity from the time lapse from exposure to processing. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Safety of 2-Methylisothiazol-3(2H)-one hydrochloride

The Article related to emulsion photog isothiazolinone stabilizer, Radiation Chemistry, Photochemistry, and Photographic and Other Reprographic Processes: Silver Halide Photographic Chemistry and Processes and other aspects.Safety of 2-Methylisothiazol-3(2H)-one hydrochloride

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On July 14, 1995, Takahashi, Shigeaki published a patent.Name: 2-Methylisothiazol-3(2H)-one hydrochloride The title of the patent was High-sensitivity silver halide photographic material. And the patent contained the following:

The material is spectrally sensitized with ≥1 sensitizer which is dispersed in solid fine particles with particle size ≤1 μm and contains ≥1 isothiazolin-3-one compound I (R1 = H, alkyl, alicyclic group, alkenyl, aralkyl, alkoxy, aryl, heterocyclic group, carbamoyl, thiocarbamoyl, sulfamoyl; R2-3 = H, halo, alkyl, alicyclic group, aryl, cyano, alkylthio, arylthio, alkylsulfoxide, alkylsulfonyl, heterocyclic group; R2 and R3 may form benzene ring) between nucleation and chem. sensitization. The material gave stain-free images. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Name: 2-Methylisothiazol-3(2H)-one hydrochloride

The Article related to silver halide photog isothiazolinone sensitizer, Radiation Chemistry, Photochemistry, and Photographic and Other Reprographic Processes: Silver Halide Photographic Chemistry and Processes and other aspects.Name: 2-Methylisothiazol-3(2H)-one hydrochloride

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On May 9, 1990, Metoki, Iku; Sato, Kiyoshi published a patent.Electric Literature of 26172-54-3 The title of the patent was Photographic material with excellent antislatic properties. And the patent contained the following:

A high-sensitivity photog. material having improved antistatic properties at high humidity is composed of a support and ≥1 Ag halide photosensitive layer spectrally sensitized by adding a spectral sensitizer during the grain formation process, the phys. ripening process, and the desalting process, and also containing a 3-isothiazolinone derivative (I; R1 = H, alkyl, cycloalkyl, alkenyl, aralkyl, alkoxy, aryl, heterocyclyl, carbamoyl, thiocarbamoyl, and sulfamoyl; R2, R3 = H, halogen, alkyl, cycloalkyl, aryl, CN, alkylthio, arylthio, alkylsulfoxide, alkylsulfonyl, heterocyclyl, or R2 and R3 together can form a benzene ring). Thus, a PET film was coated with a gelatin-Ag halide emulsion (the spectral sensitizer was added after the grain growth process) containing II. The resultant emulsion showed a relative sensitivity of 130 and a surface sp. resistance (at 20° and 55% relative humidity) of 7 × 1011. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Electric Literature of 26172-54-3

The Article related to isothiazolinone derivative photog antistatic property, film photog antistatic isothiazolinone derivative, Radiation Chemistry, Photochemistry, and Photographic and Other Reprographic Processes: Silver Halide Photographic Chemistry and Processes and other aspects.Electric Literature of 26172-54-3

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On December 21, 1984, Mine, Kyomitsu; Irie, Soichiro; Hirao, Yotaro; Nagumo, Toshio; Kawaguchi, Yasushi; Kobayashi, Yayoi published a patent.SDS of cas: 26172-54-3 The title of the patent was Antiseptic treatment of silver halide photographic hydrophilic colloid layers. And the patent contained the following:

A phenol derivative I (R = halo, C1-6 alkyl, lower alkoxycarbonyl, CO2H; n = 0-5) and a compound of formula II (R1 = H, alkyl, cycloalkyl, alkenyl, aralkyl, aryl, heterocyclyl, alkylamido, arylthioamido, alkylthioamido, alkysulfamido, arylsulfamido; R2,R3 = H, halo, alkyl, cycloalkyl, aryl, heterocyclyl, CN, alkylthio, arylthio, alkylsulfoxy, alkylsulfonyl) are added to Ag halide photog. hydrophilic colloid layers as antiseptic agents. Thus, phenol and II (R1 = CONHMe; R2 = Br; R3 = H) were added to a Ag(Br, I) emulsion for x-ray films. The emulsion showed excellent antiseptic property (tested by using Acinetobacters) without degradation of sensitivity and other photog. characteristics. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).SDS of cas: 26172-54-3

The Article related to antiseptic treatment photog emulsion, phenol photog emulsion antiseptic, isothiazolone photog emulsion antiseptic, Radiation Chemistry, Photochemistry, and Photographic and Other Reprographic Processes: Silver Halide Photographic Chemistry and Processes and other aspects.SDS of cas: 26172-54-3

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On November 23, 1972, Miller, George Allen; Weiler, Ernest Dieter published a patent.Formula: C4H6ClNOS The title of the patent was Pesticidal isothiazolinone metal salt complexes. And the patent contained the following:

Fifty-six title compounds [Im.MXn; R = H or Cl; R1 = H or Me; RR1 = CH:CHCH:CH; R2 = H, C1-10 normal or branched alkyl, Ph, m-ClC6H4, p-MeC6H4CH2, or p-ClC6H4CH2CH2; M = Ca, Cd, Co, Cr, Cu, Fe, Hg, Mg, Mn, Ni, Sn, or Zn; X = e.g., Cl, SO4, or Br; m = 1 or 2; n = 1-3] were prepared in .leq.100% yield by reaction of I or I-HX with MXn or MO, resp. I were used as algicides, bactericides, fungicides, herbicides, insecticides, and slimicides, e.g., in cooling towers and paper mills or against mildew in paints. Thus, 2-methyl-3-isothiazolone [2682-20-4] in EtOH was added to ZnCl2 in EtOH and the mixture stirred 30 min to give 92% bis(2-methyl-3-isothiazolone zinc (II) chloride (II) [38897-06-2]. 2-Methyl-3-isothiazolone-HCl [26172-54-3] and ZnO in MeOH were stirred 24 hr to give 94% II. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Formula: C4H6ClNOS

The Article related to isothiazolinone salt pesticide, algicide isothiazolinone, bactericide isothiazolinone, fungicide isothiazolinone, herbicide isothiazolinone, insecticide isothiazolinone, slimicide isothiazolinone and other aspects.Formula: C4H6ClNOS

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On April 30, 2019, Luna, Breanna L.; Garcia, Javier A.; Huang, Min; Ewing, Peter J.; Valentine, Sonya C.; Chu, Yi-Ming; Ye, Qi-Zhuang; Xu, H. Howard published an article.Quality Control of 2-Methylisothiazol-3(2H)-one hydrochloride The title of the article was Identification and characterization of novel isothiazolones with potent bactericidal activity against multi-drug resistant Acinetobacter baumannii clinical isolates. And the article contained the following:

Acinetobacter baumannii has emerged as a globally important nosocomial pathogen characterized by an increased multi-drug resistance (MDR), leaving limited options for treating its infection. To identify novel antibacterial compounds with activity against clin. isolates of A. baumannii, we performed high-throughput screening against a chem. library of 42,944 compounds using nonpathogenic Escherichia coli MG1655 and identified 55 hit compounds The antibacterial activities of 30 pure compounds were determined against MDR clin. isolates of A. baumannii obtained from Los Angeles County hospitals. Two isothiazolones identified, 5-chloro-2-(4-chloro-3-methylphenyl)-4-methyl-3(2H)-isothiazolone and 5-chloro-2-(4-chlorophenyl)-4-methyl-3(2H)-isothiazolone (I), possess novel structure and exhibited consistent, potent and cidal activity against all 46 MDR A. baumannii clin. isolates and reference strains. Addnl., structure-activity relation anal. involving several addnl. isothiazolones supports the link between a chloro-group on the heterocyclic ring or a fused benzene ring and the cidal activity. Attempts to obtain isothiazolone resistant mutants failed, consistent with the rapid cidal action and indicative of a complex mechanism of action. While cytotoxicity was observed with I, it had a therapeutic index value of 28 suggesting future therapeutic potential. Our results indicate that high-throughput screening of compound libraries followed by in vitro biol. evaluations is a viable approach for the discovery of novel antibacterial agents to contribute in the fight against MDR bacterial pathogens. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Quality Control of 2-Methylisothiazol-3(2H)-one hydrochloride

The Article related to antibacterial activity isothiazolone derivative structure acinetobacter, acinetobacter baumannii, antimicrobial susceptibility testing, cytotoxicity, high-throughput screening, isothiazolone, time-kill assay and other aspects.Quality Control of 2-Methylisothiazol-3(2H)-one hydrochloride

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com