Tag: 100-200

On February 7, 2019, Chou, Stephen Y.; Ding, Wei published a patent.COA of Formula: C4H6ClNOS The title of the patent was Devices and methods for examining drug effects on microorganisms and use of cell viability dye for monitoring microorganism viability. And the patent contained the following:

The present invention provides devices, systems, and methods, for performing biol. and chem. assays, in particular, of microorganisms. One aspect of the present invention uses (a) two plates to compress a sample that comprises the microorganisms to be examined into a thin layer, and (b) after (a), an imaging process to count and/or track the microorganisms over a time period or at discrete time points. Another aspect of the present invention uses spacers to control the final sample thickness and hence to assist a determination of the microorganism concentration Yet another aspect of the present invention provides that the drugs to be examined are coated on one or both of the plates, in that the coated drugs are capable of upon contacting the sample, being dissolved and diffuse in the sample. Yet another aspect of the present invention uses a cell viability dye that is added to the sample when the sample is being loaded between the provided two plates and monitoring the microorganism viability with the aid of the dye. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).COA of Formula: C4H6ClNOS

The Article related to microorganism drug effect determination device cell viability dye, Pharmacology: Effects Of Antimicrobials and Parasiticides and other aspects.COA of Formula: C4H6ClNOS

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On July 23, 2019, Yang, Lu; Chen, Jie; Yu, Wangsheng; Yan, Peiyang; Lu, Hai; Zhuang, Huan published a patent.Application of 26172-54-3 The title of the patent was Paper surface sizing solution treatment method, surface sizing solution and coated paper. And the patent contained the following:

Title method comprises: providing a surface sizing solution, wherein the surface sizing solution comprises a starch liquid; testing the pH of the surface sizing solution; determining a dose of adding first bactericide to the surface sizing solution according to a pH value of the surface sizing solution, and adding the dose of the first bactericide to the surface sizing solution to control the microbial content in surface sizing solution The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Application of 26172-54-3

The Article related to sizing solution coated paper, Cellulose, Lignin, Paper, and Other Wood Products: Paper and other aspects.Application of 26172-54-3

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On March 1, 2021, Wei, Zhengxi; Fang, Yuhong; Gosztyla, Maya L.; Li, Andrew J.; Huang, Wenwei; LeClair, Christopher A.; Simeonov, Anton; Tao, Dingyin; Xia, Menghang published an article.HPLC of Formula: 26172-54-3 The title of the article was A direct peptide reactivity assay using a high-throughput mass spectrometry screening platform for detection of skin sensitizers. And the article contained the following:

Chem.-peptide conjugation is the mol. initiating event in skin sensitization. The OECD test guideline uses a high-performance liquid chromatog./UV (HPLC/UV) detection method to quantify chem.-peptide conjugation in a direct peptide reactivity assay (DPRA), which measures the depletion of two synthetic peptides containing lysine or cysteine residues. To improve assay throughput, sensitivity and accuracy, an automated 384-well plate-based RapidFire solid-phase extraction (SPE) system coupled with tandem mass spectrometry (MS/MS) DPRA was developed and validated in the presence of a newly designed internal standard Compared to the HPLC/UV-based DPRA, the automated SPE-MS/MS-based DPRA improved throughput from 16 min to 10 s per sample, and substrate peptides usage was reduced from 100 mM to 5μM. When implementing the SPE-MS/MS-based DPRA into a high-throughput platform, we found 10 compounds that depleted lysine peptide and 24 compounds that depleted cysteine peptide (including 7 unreported chems. from 55 compounds we tested) in a concentration-response manner. The adduct formation between cysteine and cinnamic aldehyde and ethylene glycol dimethacrylate were further analyzed using high-performance liquid chromatog. time-of-flight mass spectrometry (HPLC-TOF-MS) to confirm the conjugation. Overall, the automated SPE-MS/MS-based platform is an efficient, economic, and accurate way to detect skin sensitizers. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).HPLC of Formula: 26172-54-3

The Article related to skin sensitizer spe msms based dpra, direct peptide reaction assay (dpra), high throughput mass spectrometry, rapidfire-ms/ms, Toxicology: Chemicals (Household, Industrial, General) and other aspects.HPLC of Formula: 26172-54-3

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On January 1, 2007, Cuixart Grande, Jesus Maria published a patent.Quality Control of 2-Methylisothiazol-3(2H)-one hydrochloride The title of the patent was Procedure for preparing 2-alkylisothiazolones and their formulation in stable form alone or in association to other molecules with biocidal activity. And the patent contained the following:

This invention relates to a procedure for preparing 2-alkylisothiazolones of formula I and their formulations in stable forms alone or in association to other mols. with biocidal activity. 2-Alkylisothiazolones may be used as industrial biocides. A procedure for preparing compounds of formula I wherein R is C1-8 alkyl; X and X1 are independently H and Cl; are claimed. These compounds were obtained by cyclization of 3,3′-dithiopropionamides. Several example on formulations of these compounds are also provided. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Quality Control of 2-Methylisothiazol-3(2H)-one hydrochloride

The Article related to alkylisothiazolone preparation formulation, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Quality Control of 2-Methylisothiazol-3(2H)-one hydrochloride

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On January 21, 2009, Li, Shaotong published a patent.SDS of cas: 26172-54-3 The title of the patent was Method for synthesizing alkyl isothiazolone hydrochloride by chlorination-cyclization of alkyl dithiodipropionamide with chlorine and sulfuryl chloride. And the patent contained the following:

The invention relates to a method for synthesizing alkyl isothiazolone hydrochloride by chlorination-cyclization of alkyl dithiodipropionamide or alkyl thiopropionamide with chlorine and sulfuryl chloride. The method has advantages of simple operation, low cost and high conversion rate. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).SDS of cas: 26172-54-3

The Article related to thiazolone methyl hydrochloride preparation, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.SDS of cas: 26172-54-3

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On April 6, 2011, Jiang, Zhikai; Jiang, Yifan published a patent.Electric Literature of 26172-54-3 The title of the patent was A process for preparing isothiazolone derivatives. And the patent contained the following:

The invention relates to a process for the preparation of isothiazolone derivatives I or II, wherein R1 is H, alkyl, cycloalkyl, or (un)substituted aryl; R2 and R3 independently = H or Cl. For instance, 1,2-benzisothiazol-3(2H)-one was prepared from 2-mercapto-benzonitrile in the presence of Cl2 in 82.28% yield. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Electric Literature of 26172-54-3

The Article related to isothiazolone derivative preparation heterocyclization, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Electric Literature of 26172-54-3

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Weiler, E. D.; Miller, G. A.; Hausman, M. published an article in 1976, the title of the article was Isothiazoles. VIII: isothiazolidin-3-one derivatives.Category: isothiazole And the article contains the following content:

The isothiazolidinone I (R = R1 = Me) was prepared by cyclization of (MeNHCOCHMeCH2)2S2 in EtOAc in the presence of Cl and I (R, R1 given: Me, Cl; Bu, Me; Bu, Cl; CH2Ph, Cl; CH2C6H3Cl2-3,4, Cl) were obtained by the addition of Cl to the appropriate isothiazolinones II. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Category: isothiazole

The Article related to isothiazolidinone trichloro, thiazolinone addition chlorine, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Category: isothiazole

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On June 17, 1992, Petigara, Ramesh Balubhai; Horton, Isaac Byron published a patent.Computed Properties of 26172-54-3 The title of the patent was Process for preparing 3-isothiazolone compounds. And the patent contained the following:

A process for the preparation of salt-free, and optionally water-free, isothiazolones comprising treating a solution of an acid salt of an isothiazolone with a basic anion exchange resin, preferably a weak base anion exchange resin, and separating the free base isothiazolone solution from the spent resin is claimed. Five different ion exchange resins were evaluated: two strong base anion exchange resins (Amberlite IRA-9OOC-OH and IRA-420C-OH) and 3 weak base anion exchange resins (Amberlite IRA-68, Amberlyst A21 and Diaion WA-30) were used. Thus, chlorination of N-methyl-3-mercaptopropionamide in EtOAc gave a mixture of HCl salts of 5-chloro-2-methyl-3-isothiazolinone and 2-methyl-3-isothiazolone which were neutralized with the described resins. The resultant salt-free isothiazolones are useful as microbicides in environments where even low concentrations of metal salts are undesirable, for example, latex emulsions and corrosion sensitive aqueous systems. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Computed Properties of 26172-54-3

The Article related to isothiazolone hydrochloride salt preparation neutralization resin, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Computed Properties of 26172-54-3

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On October 25, 1995, Petigara, Ramesh Balubbai published a patent.Synthetic Route of 26172-54-3 The title of the patent was Purification of 3-isothiazolones. And the patent contained the following:

The title process for producing substantially separated 5-chloro-2-methyl-3-isothiazolone (CMI) and 2-methyl-3-isothiazolone (MI) from a mixture of their hydrochloride salts comprises heating a mixture of CMI.HCI and MI.HCI in an org, solvent for a period of time necessary to fully dissociate CMI.HCI but insufficient to fully dissociate MI.HCI. CMI free base dissolves in the solvent and the products may recovered by filtration. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Synthetic Route of 26172-54-3

The Article related to chloromethylisothiazolone purification, methylisothiazolone purification, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Synthetic Route of 26172-54-3

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On November 26, 1992, Hahn, Soon Jong; Kim, Jin Man; Park, Young published a patent.Synthetic Route of 26172-54-3 The title of the patent was Preparation of N-alkyl-4-isothiazolin-3-ones from dithiodipropionamides and sulfuryl halides. And the patent contained the following:

Title compounds [I; R1 = Me, Me(CH2)7; R2 = H, Cl], were prepared by (1) treatment of (SCH2CH2CO2H)2 with SOCl2 to give (SCH2CH2COCl)2, (2) treatment of the latter with R1NH2 to give (SCH2CH2CONHR1)2, and (3) treatment of this with SO2X2 (X = halo) in an organic solvent. Thus, [SCH2CH2CONH(CH2)7Me]2 was treated with SO2Cl2 in CH2Cl2 at 0-25° to give 90.5% title compound II. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Synthetic Route of 26172-54-3

The Article related to dithiodipropionamide sulfuryl halide cyclocondensation alkylisothiazolinone, cyclocondensation reaction and other aspects.Synthetic Route of 26172-54-3

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com