Category: isothiazole

McKinnon, David M.’s team published research in Journal of Heterocyclic Chemistry in 1991 | CAS: 35272-19-6

3-Methyl-5-nitrobenzoisothiazole(cas: 35272-19-6) belongs to isothiazole. Various penicillins and cephalosporins having an isothiazole ring system have shown considerable antibacterial efficacy against Gram-positive and Gram-negative bacteria. Name: 3-Methyl-5-nitrobenzoisothiazoleMany compounds with an isothiazole scaffold demonstrated a wide range of biological profiles, including antiinflammatory, antithrombotic, and anticonvulsive agents.

Name: 3-Methyl-5-nitrobenzoisothiazoleOn May 31, 1991, McKinnon, David M.; Abouzeid, A. A. published an article in Journal of Heterocyclic Chemistry. The article was 《Substituent interaction with ring sulfur in some heterocyclic compounds》. The article mentions the following:

The IR carbonyl absorptions of acetylbenzisothiazoles I (R, R1, R2 = H, COMe, SMe) are similar to 7-acetylbenzo[b]thiophenes, but are lower by approx. 15 cm-1 than the corresponding benzo[b]furans. The reasons for this are discussed. The results came from multiple reactions, including the reaction of 3-Methyl-5-nitrobenzoisothiazole(cas: 35272-19-6Name: 3-Methyl-5-nitrobenzoisothiazole)

3-Methyl-5-nitrobenzoisothiazole(cas: 35272-19-6) belongs to isothiazole. Various penicillins and cephalosporins having an isothiazole ring system have shown considerable antibacterial efficacy against Gram-positive and Gram-negative bacteria. Name: 3-Methyl-5-nitrobenzoisothiazoleMany compounds with an isothiazole scaffold demonstrated a wide range of biological profiles, including antiinflammatory, antithrombotic, and anticonvulsive agents.

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Solovyev, Andrey Y.’s team published research in Journal of Organic Chemistry in 2007 | CAS: 35272-19-6

3-Methyl-5-nitrobenzoisothiazole(cas: 35272-19-6) belongs to isothiazole. It has been found that isothiazole-based compounds show synergistic effects when used with other biocidal compounds. These molecules also act as herbicides and in combination with other herbicidal molecules they often enhance their efficacy.Application In Synthesis of 3-Methyl-5-nitrobenzoisothiazole

《One-Pot Synthesis of Substituted 2-Aminobenzo[b]thiophenes》 was written by Solovyev, Andrey Y.; Androsov, Dmitry A.; Neckers, Douglas C.. Application In Synthesis of 3-Methyl-5-nitrobenzoisothiazole And the article was included in Journal of Organic Chemistry on April 13 ,2007. The article conveys some information:

Reaction of 1-(2-chloro-5-nitrophenyl)ethanone via Willgerodt-Kindler routes using primary and secondary amines resulted in a simple, efficient, three-component one-pot synthesis of 2-aminobenzo[b]thiophenes, e.g., I (R = Me, allyl, Bu, CH2Ph, CHMe2, cyclopentyl, cyclohexyl).3-Methyl-5-nitrobenzoisothiazole(cas: 35272-19-6Application In Synthesis of 3-Methyl-5-nitrobenzoisothiazole) was used in this study.

3-Methyl-5-nitrobenzoisothiazole(cas: 35272-19-6) belongs to isothiazole. It has been found that isothiazole-based compounds show synergistic effects when used with other biocidal compounds. These molecules also act as herbicides and in combination with other herbicidal molecules they often enhance their efficacy.Application In Synthesis of 3-Methyl-5-nitrobenzoisothiazole

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Rais, Afsha’s team published research in Trends in Heterocyclic Chemistry in 2009 | CAS: 35272-19-6

3-Methyl-5-nitrobenzoisothiazole(cas: 35272-19-6) belongs to isothiazole. Various penicillins and cephalosporins having an isothiazole ring system have shown considerable antibacterial efficacy against Gram-positive and Gram-negative bacteria. Related Products of 35272-19-6Many compounds with an isothiazole scaffold demonstrated a wide range of biological profiles, including antiinflammatory, antithrombotic, and anticonvulsive agents.

The author of 《Microwave-assisted synthesis of benzisothiazoles and benzisoselenazoles》 were Rais, Afsha; Ankati, Haribabu; Biehl, Ed. And the article was published in Trends in Heterocyclic Chemistry in 2009. Related Products of 35272-19-6 The author mentioned the following in the article:

A microwave-mediated preparation and possible mechanism of benzisothiazole and benzisoselenazole formation are presented. The synthesis of the target compounds [i.e., 3-methyl-1,2-benzisothiazol-5-amine, 3-methyl-1,2-benzisoselenazol-5-amine] was achieved using sulfur or selenium and 1-(2-chloro-5-nitrophenyl)ethanone and ammonium acetate as starting materials. The experimental process involved the reaction of 3-Methyl-5-nitrobenzoisothiazole(cas: 35272-19-6Related Products of 35272-19-6)

3-Methyl-5-nitrobenzoisothiazole(cas: 35272-19-6) belongs to isothiazole. Various penicillins and cephalosporins having an isothiazole ring system have shown considerable antibacterial efficacy against Gram-positive and Gram-negative bacteria. Related Products of 35272-19-6Many compounds with an isothiazole scaffold demonstrated a wide range of biological profiles, including antiinflammatory, antithrombotic, and anticonvulsive agents.

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Androsov, Dmitry A.’s team published research in Tetrahedron in 2010 | CAS: 35272-19-6

3-Methyl-5-nitrobenzoisothiazole(cas: 35272-19-6) belongs to isothiazole. Various penicillins and cephalosporins having an isothiazole ring system have shown considerable antibacterial efficacy against Gram-positive and Gram-negative bacteria. Synthetic Route of C8H6N2O2SSome of these molecules have been efficiently used in the treatment of Alzheimer’s disease.

Synthetic Route of C8H6N2O2SOn March 27, 2010, Androsov, Dmitry A.; Solovyev, Andrey Y.; Petrov, Mikhail L.; Butcher, Ray J.; Jasinski, Jerry P. published an article in Tetrahedron. The article was 《A convenient approach towards 2- and 3-aminobenzo[b]thiophenes》. The article mentions the following:

Reaction of 1-(2-chloro-5-nitrophenyl)ethanone via Willgerodt-Kindler route with primary or secondary amines and sulfur allows a simple, efficient one-pot synthesis of 3-aminobenzo[b]thiophenes. Base-catalyzed transformation of 4-(2-chloro-5-nitrophenyl)-1,2,3-thiadiazole in the presence of primary and secondary amines offers a convenient approach towards 2-aminobenzo[b]thiophenes. In the experiment, the researchers used 3-Methyl-5-nitrobenzoisothiazole(cas: 35272-19-6Synthetic Route of C8H6N2O2S)

3-Methyl-5-nitrobenzoisothiazole(cas: 35272-19-6) belongs to isothiazole. Various penicillins and cephalosporins having an isothiazole ring system have shown considerable antibacterial efficacy against Gram-positive and Gram-negative bacteria. Synthetic Route of C8H6N2O2SSome of these molecules have been efficiently used in the treatment of Alzheimer’s disease.

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Escalante, Jaime’s team published research in Tetrahedron Letters in 1995-06-19 | 104322-63-6

Tetrahedron Letters published new progress about Amino acids, hydroxy Role: SPN (Synthetic Preparation), PREP (Preparation). 104322-63-6 belongs to class isothiazole, and the molecular formula is C10H15NO3S, Formula: C10H15NO3S.

Escalante, Jaime; Juaristi, Eusebio published the artcile< Enantioselective synthesis of β-amino acids. 6. High 1,2-stereoinduction in the preparation of enantiopure 2(R)-hydroxy-3(R)-N-benzoylamino-3-phenylpropionic acid (like stereoisomer of Taxol's side chain)>, Formula: C10H15NO3S, the main research area is stereoselective hydroxylation phenylperhydropyrimidinone camphor oxaziridine; pyrimidinone phenylperhydro stereoselective hydroxylation oxaziridine; asym synthesis phenylisoserine.

The remarkably high 1,2-stereoinduction encountered in the hydroxylation of 6(S)-phenylperhydropyrimidin-4-one I allows for the preparation of enantiopure N-benzoyl (2R,3R)-3-phenylisoserine (II), the like stereoisomer of taxol’s C-13 side chain.

Tetrahedron Letters published new progress about Amino acids, hydroxy Role: SPN (Synthetic Preparation), PREP (Preparation). 104322-63-6 belongs to class isothiazole, and the molecular formula is C10H15NO3S, Formula: C10H15NO3S.

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Towson, James C’s team published research in Organic Syntheses in 1990 | 104322-63-6

Organic Syntheses published new progress about 104322-63-6. 104322-63-6 belongs to class isothiazole, and the molecular formula is C10H15NO3S, Reference of 104322-63-6.

Towson, James C.; Weismiller, Michael C.; Lal, G. Sankar; Sheppard, Aurelia C.; Kumar, Anil; Davis, Franklin A. published the artcile< Synthesis of (+)-(2R,8aS)-10-(camphorylsulfonyl)oxaziridine>, Reference of 104322-63-6, the main research area is camphorylsulfonyloxaziridine; oxaziridine camphorylsulfonyl.

Amidation of (+)-10-camphosulfonyl chloride by NH4OH in CH2Cl2 gave 90% (+)-(1S)-1-camphorsulfonamide which underwent Amberlyst 15 catalyzed cyclocondensation in PhMe to give 90-95% imine I. The last was treated with aqueous oxone and K2CO3 to give 84% title compound II.

Organic Syntheses published new progress about 104322-63-6. 104322-63-6 belongs to class isothiazole, and the molecular formula is C10H15NO3S, Reference of 104322-63-6.

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

McClure, Cynthia K’s team published research in Tetrahedron Letters in 1991-09-23 | 104322-63-6

Tetrahedron Letters published new progress about 104322-63-6. 104322-63-6 belongs to class isothiazole, and the molecular formula is C10H15NO3S, Safety of (4aS,7R,8aS)-9,9-Dimethyltetrahydro-4H-4a,7-methanobenzo[c][1,2]oxazireno[2,3-b]isothiazole 3,3-dioxide.

McClure, Cynthia K.; Grote, Christopher W. published the artcile< α,β-Functionalization of enones via pentacovalent oxaphospholenes>, Safety of (4aS,7R,8aS)-9,9-Dimethyltetrahydro-4H-4a,7-methanobenzo[c][1,2]oxazireno[2,3-b]isothiazole 3,3-dioxide, the main research area is oxaphospholene functionalization enone; phosphonate keto acylvinyl.

2,2,2-Triethoxy-1,2λ5-oxaphospholene reacts under mild, neutral conditions with bromine, dialkyl azodicarboxylates, and oxaziridines to produce β-heteroatom substituted γ-ketophosphonates and β-acyl vinyl phosphonate in high yields.

Tetrahedron Letters published new progress about 104322-63-6. 104322-63-6 belongs to class isothiazole, and the molecular formula is C10H15NO3S, Safety of (4aS,7R,8aS)-9,9-Dimethyltetrahydro-4H-4a,7-methanobenzo[c][1,2]oxazireno[2,3-b]isothiazole 3,3-dioxide.

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Bunnage, Mark E’s team published research in Synlett in 1993-10-31 | 104322-63-6

Synlett published new progress about Stereoselective synthesis. 104322-63-6 belongs to class isothiazole, and the molecular formula is C10H15NO3S, Computed Properties of 104322-63-6.

Bunnage, Mark E.; Davies, Stephen G.; Goodwin, Christopher J. published the artcile< Asymmetric synthesis of allophenylnorstatine>, Computed Properties of 104322-63-6, the main research area is asym synthesis allophenylnorstatine; norstatine allophenyl asym synthesis.

The title compound (I), a component of the HIV-1 protease inhibitor kynostatin, has been prepared via a tandem conjugate addition-electrophilic hydroxylation strategy using lithium (S)-(α-methylbenzyl)benzylamide and (+)-(camphorsulfonyl)oxaziridine. The effects of mol. recognition and enolate geometry on the selectivity of the reaction are discussed.

Synlett published new progress about Stereoselective synthesis. 104322-63-6 belongs to class isothiazole, and the molecular formula is C10H15NO3S, Computed Properties of 104322-63-6.

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Lal,G.Sankar’s team published research in Tetrahedron Letters in 1988 | 104322-63-6

Tetrahedron Letters published new progress about Oxidation, stereoselective. 104322-63-6 belongs to class isothiazole, and the molecular formula is C10H15NO3S, Electric Literature of 104322-63-6.

Davis, Franklin A.; Lal, G. Sankar; Wei, Jia published the artcile< Stereo- and regioselective formation of silyl enol ethers via oxidation of vinyl anions>, Electric Literature of 104322-63-6, the main research area is silyl enol ether stereoselective preparation; oxidation vinyl bromide derivative stereoselective; vinyllithium stereoselective oxidation.

Oxidation of E- and Z-vinyllithiums, R1CR2:CR3Li (R1-R3 = Ph, Me, Et, etc.), with silyl peroxides, RSiMe2OOSiMe2R (R = Me, Me3C), affords silyl enol ethers, R1CR2:CR3OSiMe2R, in good to excellent yield with retention of configuration. This methodol. represents a useful new procedure for the stereo- and regioselective synthesis of ketone enolates.

Tetrahedron Letters published new progress about Oxidation, stereoselective. 104322-63-6 belongs to class isothiazole, and the molecular formula is C10H15NO3S, Electric Literature of 104322-63-6.

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Davis, Franklin A’s team published research in Journal of the American Chemical Society in 1988-12-07 | 104322-63-6

Journal of the American Chemical Society published new progress about Crystal structure. 104322-63-6 belongs to class isothiazole, and the molecular formula is C10H15NO3S, Recommanded Product: (4aS,7R,8aS)-9,9-Dimethyltetrahydro-4H-4a,7-methanobenzo[c][1,2]oxazireno[2,3-b]isothiazole 3,3-dioxide.

Davis, Franklin A.; Towson, James C.; Weismiller, Michael C.; Lal, Sankar; Carroll, Patrick J. published the artcile< Chemistry of oxaziridines. 11. (Camphorylsulfonyl)oxaziridine: synthesis and properties>, Recommanded Product: (4aS,7R,8aS)-9,9-Dimethyltetrahydro-4H-4a,7-methanobenzo[c][1,2]oxazireno[2,3-b]isothiazole 3,3-dioxide, the main research area is camphorylsulfonyloxaziridine preparation oxidation sulfide; crystal structure camphorylsulfonyloxaziridine; mol structure camphorylsulfonyloxaziridine; oxaziridine camphorylsulfonyl preparation crystal structure; asym synthesis sulfoxide.

(+)- And (-)-(camphorylsulfonyl)oxaziridines (+)- and (-)-I are prepared in 3 steps from (+)- and (-)-camphorsulfonyl chlorides in 67% overall yield. In contrast to other optically active sulfonimines, which give on oxidation mixtures of oxaziridine diastereoisomers, oxidation of camphorsulfonimine (-)-II [the precursor to (+)-I] with oxone produces only a single isomer in >95% yield. In the asym. oxidation of prochiral sulfides by I the enantioselectivities are lower than those reported for oxidation by optically active N-sulfamyloxaziridine (5-73 vs. 35-60% enantiomeric excess). This difference is discussed in terms of different active site structures for the 2 oxaziridines. The configuration of the oxaziridine 3-membered ring in I controls the configuration of the product, with (+)-I and (-)-I giving the opposite senses of asym. induction. I does not readily oxidize amines or epoxidize alkenes. Oppolzer’s sultam chiral auxiliary [(-)-III] is prepared in 92% yield by hydride reduction of (-)-II. The structure of (+)-I was determined by x-ray crystallog.

Journal of the American Chemical Society published new progress about Crystal structure. 104322-63-6 belongs to class isothiazole, and the molecular formula is C10H15NO3S, Recommanded Product: (4aS,7R,8aS)-9,9-Dimethyltetrahydro-4H-4a,7-methanobenzo[c][1,2]oxazireno[2,3-b]isothiazole 3,3-dioxide.

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com