Category: isothiazole

On April 19, 1991, Igarashi, Yoshio; Suzuki, Tetsuya; Chiku, Yukihiro; Tsunoda, Toshimasa published a patent.Recommanded Product: 26172-54-3 The title of the patent was Preparation and purification of antimicrobial 3-isothiazolones.. And the patent contained the following:

Compositions containing biol. effective amounts of 3-isothiazolones I [R, R1 = H, halo, C1-4 alkyl; Y = C1-8 alkyl, C5-6 cycloaralkyl, C≤8 aralkyl, (substituted) C6 aryl] are prepared by (a) heating crude 3-isothiazolone hydrochlorides in organic solvents followed by removal of solids or (b) treatment of crude 3-isothiazolone hydrochloride with nitrate salts under reduced pressure or inert gases. Nitrosamines and their precursors are removed from the compositions by the above process. A slurry of N, N’-dimethyl-3,3′-dithiodipropionamide (preparation given) was diluted with toluene and chlorinated to give a slurry containing I-HCl (R = H, R1 = Cl, Y = Me) (II), I-HCl (R = R1 = H, Y = Me), and 8080 ppm N-methyl-3-(N’-methyl)aminopropionamide (III). The slurry was refluxed in CHCl3 for 4 h to prepare a composition containing 2326 ppm III with 90.4% recovery of II. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Recommanded Product: 26172-54-3

The Article related to isothiazolone microbicide purification, Agrochemical Bioregulators: Microbial and other aspects.Recommanded Product: 26172-54-3

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On March 30, 2021, Xu, Junyan; Zhuang, Luyang; Wang, Dan; Yang, Min published a patent.Category: isothiazole The title of the patent was Chemiluminescence immunoassay detection kit for metanephrine. And the patent contained the following:

The invention relates to a chemiluminescence immunoassay detection kit for metanephrine, which has the advantages of high detection efficiency, high sensitivity and specificity. The kit comprises a sample pretreatment reagent and a detection reagent; the sample pretreatment reagent comprises an acidification solution, an acylation buffer solution and an acylating agent solution; the acylating agent in the acylating agent solution is one or more of acetic anhydride, succinic anhydride, butyric anhydride, caproic anhydride, octanoic anhydride, acetylchloride and glacial acetic acid; the detection reagent comprises a magnetic particle coated with metanephrine, specific antibody solution of metanephrine, enzyme conjugate solution containing horseradish peroxidase labeled antibody, and calibration product. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Category: isothiazole

The Article related to chemiluminescence immunoassay test kit metanephrine diagnosis, Biochemical Methods: Immunological and other aspects.Category: isothiazole

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On November 16, 2016, Yang, Zhiting; Wei, Hong; Liu, Xuemei; Chen, Yong; Gao, Aiju; Xu, Yang published a patent.Electric Literature of 26172-54-3 The title of the patent was A glycocholic acid detection kit capable of eliminating chyle interference. And the patent contained the following:

The present invention discloses a glycocholic acid detection kit capable of eliminating chyle interference. The detection kit comprises reagent R1, reagent R2 and calibrator, and described reagent R1 comprises buffer solution a, chyle elimination agent, stabilizer a, surfactant a, reaction promotor a and preservative a; described reagent R2 comprises buffer solution b, latex particle of anti-human glycocholic acid monoclonal antibody, stabilizer b, surfactant b, preservative b and reaction promotor b; described calibrator comprises buffer solution c, glycocholic acid standard product, stabilizer c, surfactant c, reaction promotor c and preservative c. This detection kit is short in detection time, strong in interference tolerance, good in stability, good in repeatability, high in accuracy and high in detection sensitivity. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Electric Literature of 26172-54-3

The Article related to glycocholic acid kit chyle interference analytical reagent, Biochemical Methods: Immunological and other aspects.Electric Literature of 26172-54-3

Referemce:
Isothiazole – Wikipedia,
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On January 31, 2020, Ma, Lei; Zhuang, Luyang; Chen, Xiaoling; Chen, Fei; Yang, Min; Qiao, Xiaofang; Li, Xiaoxia; Fu, Guangyu; Wu, Xuewei published a patent.Product Details of 26172-54-3 The title of the patent was High precision quantitative detection kit for insulin-like growth factor binding protein 3. And the patent contained the following:

A quant. detection kit having good accuracy, improved sensitivity and detection rate of pos. sample, and shortened detection time is provided. The quant. detection kit comprises: magnetic particles coated with insulin-like growth factor binding protein 3 (IGFBP-3) monoclonal antibody, enzyme-labeled IGFBP-3 monoclonal antibody, sample dilution, wherein sample diluent is any one of hydrochloric acid, citric acid, malic acid, phosphoric acid, and sulfosalicylic acid. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Product Details of 26172-54-3

The Article related to insulin growth factor binding protein 3 detection kit, Biochemical Methods: Apparatus and other aspects.Product Details of 26172-54-3

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On May 12, 2010, Oh, Seok published a patent.Name: 2-Methylisothiazol-3(2H)-one hydrochloride The title of the patent was Purification of 2-methyl-4-isothiazolin-3-one. And the patent contained the following:

The title purification method comprises: (1) dispersing a product containing 2-methyl-4-isothiazolin-3-one (I) salts and 5-chloro-2-methyl-4-isothiazolin-3-one (II) salts (byproduct) in an organic solvent, (2) adding amines to the solution to generate I and II, further decomposing II at (-20)-30° for 3-72 h, and (3) removing II by filtration and distilling the solution to obtain pure I. I is used as a preservative. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Name: 2-Methylisothiazol-3(2H)-one hydrochloride

The Article related to methylisothiazolinone purification, Pharmaceuticals: Pharmaceutics and other aspects.Name: 2-Methylisothiazol-3(2H)-one hydrochloride

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On July 17, 2018, Luo, Weixiao; Hu, Xiaofei; Wang, Meili published a patent.HPLC of Formula: 26172-54-3 The title of the patent was Reagent with high interference resistance for detecting uric acid with enzyme. And the patent contained the following:

The reagent with high interference resistance for detecting uric acid with enzymes comprises reagent R1 and reagent R2. The reagent R1 comprises buffer 20, 4-aminoantipyrine 1.2, sodium nitrite 4-8, ion balancer 5-10 mmol/L, ascorbic acid oxidase 3-5 KU/L, heavy metal ion chelating agent 1-2 mmol/L, bovine serum albumin 1-5 g/L, dodecyl tri-Me betaine 1-3, triton-305 1-3 mL/L, and preservative 0.2-0.5 g/L. The reagent R2 comprises buffer 100, N-ethyl-N-(2-hydroxy-3-sulfopropyl)-3,5-dimethoxyaniline (F-DAOS) 8-12 mmol/L, uricase 1-2 KU/L, bovine serum albumin 1-5 g/L, peroxidase 5-10 KU/L and preservative 0.2-0.5 g/L. The reagent has very good interference resistance, and can realize very accurate detection, especially for newborn samples. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).HPLC of Formula: 26172-54-3

The Article related to interference uric acid ascorbic oxidase uricase peroxidase spectrometry, Biochemical Methods: Reagents and other aspects.HPLC of Formula: 26172-54-3

Referemce:
Isothiazole – Wikipedia,
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On June 20, 2017, Bao, Xingyan; Luo, Weixiao; Tan, Baiqing; Li, Zhiming published a patent.Reference of 2-Methylisothiazol-3(2H)-one hydrochloride The title of the patent was Reagent for detecting glucose by hexokinase method with high stability and low cost. And the patent contained the following:

The present invention relates to the field of detection technol. for detecting blood GLU by hexokinase method, and provides liquid dual reagent composed of reagent 1 and reagent 2. Reagent 1 mainly includes buffer solution, Mg2+, ionic equilibrium agent, preservative, NAD (oxidized coenzyme I), and protective agent, and surfactant, and reagent 2 includes buffer solution, protective agent, surfactant, preservative, hexokinase (HK), glucose-6-phosphate dehydrogenase (G6P-DH) and ATP-Na2. The invention targetedly adds various protective agents including polyethylene glycol, Tween-80 and FAD to ensure stability of enzymes in reagent, adds various surfactants in order to reduce cost, particularly usage of enzymes, and to improve emulsification to enzymes and use efficiency of enzymes, thus greatly reduces reagent cost, and is very convenient for application and promotion clin. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Reference of 2-Methylisothiazol-3(2H)-one hydrochloride

The Article related to blood glucose hexokinase dehydrogenase blood diagnostic reagent, Biochemical Methods: Reagents and other aspects.Reference of 2-Methylisothiazol-3(2H)-one hydrochloride

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Isothiazole – Wikipedia,
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On January 22, 1992, Hoss, Gerhard; Pappert, Gunter; Schmidt, Axel published a patent.Safety of 2-Methylisothiazol-3(2H)-one hydrochloride The title of the patent was Preservation of diagnostic test reagents and kits. And the patent contained the following:

Diagnostic test kits and the reagents therein are preserved from microbial degradation by a combination of ≥2 of 2-methyl-4-isothiazolin-3-one-HCl, 2-hydroxypyridine N-oxide, chloroacetamide, N,N-methylenebis[N-(1-hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]urea (I), and 5-bromo-5-nitro-1,3-dioxane. Thus, the reagents in a kit for automated determination of albumin (succinate buffer, pH 4.2; bromcresol green; Brij 35; and preservatives 2-hydroxypyridine N-oxide and I) were incubated with a mixture of bacteria, fungi, and yeasts for 6 wk at 23°. After this time, the bacterial count was reduced by 1.6 x 104 and the count of fungi and yeasts by 8.3 x 104. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Safety of 2-Methylisothiazol-3(2H)-one hydrochloride

The Article related to preservative diagnostic reagent solution, Biochemical Methods: Reagents and other aspects.Safety of 2-Methylisothiazol-3(2H)-one hydrochloride

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Isothiazole – Wikipedia,
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On October 2, 2001, Onishi, Toshikiyo; Toujou, Tamaki; Noguchi, Keiji published a patent.Application In Synthesis of 2-Methylisothiazol-3(2H)-one hydrochloride The title of the patent was Preparation of metal-free stable liquid compositions containing 3-isothiazolones as industrial bactericides. And the patent contained the following:

The compositions are prepared by dissolving hydrogen halide salts of 3-isothiazolones in PhOH and washing the solution with water to remove the acids. Thus, a mixture of 5-chloro-2-methyl-4-isothiazolin-3-one hydrochloride (I.HCl) and 2-methyl-4-isothiazolin-3-one hydrochloride was dissolved in PhOH, mixed with water, the aqueous phase removed, and the PhOH phase was washed with water to give a solution containing 21.8% I. The solution was left at 40° for 4 wk in a sealed container to show I content 19.6%. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Application In Synthesis of 2-Methylisothiazol-3(2H)-one hydrochloride

The Article related to decomposition chloromethylisothiazolinone hydrochloride bactericide phenol water, industrial antibacterial agents and other aspects.Application In Synthesis of 2-Methylisothiazol-3(2H)-one hydrochloride

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On August 29, 1974, Weiler, Ernest D. published a patent.Reference of 2-Methylisothiazol-3(2H)-one hydrochloride The title of the patent was Bactericidal and fungicidal 4,5,5-trichloro-3-isothiazolidinones. And the patent contained the following:

Seventeen isothiazolidinones (I; R = C1-10 alkyl, CH2Ph, Ph, C6H4Cl-3, CHMePh, or cyclohexyl; R1 = Me or Cl) were prepared and used as bactericides and fungicides. Thus, (MeNHCOCHMeCH2S)2 was treated with Cl to give 19% I (R = R1 = Me), which was also prepared in 68% yield by chlorination of 2,4-dimethyl-4-isothiazolin-3-one in AcOEt at ≤67°. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Reference of 2-Methylisothiazol-3(2H)-one hydrochloride

The Article related to chloroisothiazolidinone bactericide fungicide, isothiazolidinone bactericide, fungicides and other aspects.Reference of 2-Methylisothiazol-3(2H)-one hydrochloride

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Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com