Category: 99-04-7

An article New Group Interaction Parameters of the UNIFAC (Dortmund) Model: Aromatic Dicarboxylic Acid Isomer and Methyl Benzoic Acid Isomer Binaries WOS:000605183600025 published article about SOLID-LIQUID EQUILIBRIA; ACETIC-ACID; PLUS WATER; TEREPHTHALIC ACID; PHTHALIC-ACID; TOLUIC ACID; SOLUBILITIES; MIXTURES; SOLVENTS; SYSTEMS in [Shi, Sile; Shen, Zhipeng; Guan, Aocong; Yang, Lintao; Yang, Weijun] Hunan Univ, Coll Chem & Chem Engn, Changsha 410082, Peoples R China; [Luo, Weiping] Hunan Univ, Coll Chem & Chem Engn, Minist Educ, Adv Catalyt Engineer Res Ctr, Changsha 410082, Peoples R China in 2020, Cited 29. Category: isothiazole. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7

In this work, with the available solid-liquid equilibrium (SLE) data of six aromatic carboxylic acids, aromatic dicarboxylic acid isomers (terephthalic acid (TPA), isophthalic acid (IPA), and phthalic acid (PA)), and methyl benzoic acid isomers (m-toluic acid (m-TA), o-toluic acid (o-TA), and p-toluic acid (p-TA)) in acetic acid (HOAc) + water (H2O) solvent mixtures, the relationship between the molecular structure of the above aromatic carboxylic acids and the solubility of them in HOAc + H2O solvent mixtures is discussed. It could be found that among the aromatic dicarboxylic acid isomers and methyl benzoic acid isomers, TPA and p-TA have the lowest solubility in the same solvent and temperature, respectively. Meanwhile, three new groups, p-ArCOOH, m-ArCOOH, and o-ArCOOH, in the UNIFAC (Dortmund) model were first defined to distinguish the influence of the positions of ArCOOH on the thermodynamic properties of aromatic carboxylic acid isomers, which indicates that ArCOOH is located in the para, meta, and ortho positions of the ArCOOH or ArCH3 groups, respectively. Then, the interaction parameters of ArCOOH, p-ArCOOH, m-ArCOOH, and o-ArCOOH with other involved groups in the solvent systems are first obtained by regressing these available SLE data. By using the new defined group, the UNIFAC (Dortmund) model was used to correlate SLE data for the above ternary systems, and trimesic acid + HOAc + H2O systems agree with the experimentally measured results satisfactorily.

Category: isothiazole. About 3-Methylbenzoic acid, If you have any questions, you can contact Luo, WP; Shi, SL; Shen, ZP; Guan, AC; Yang, LT; Yang, WJ or concate me.

Reference:
Isothiazole – Wikipedia,
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In 2019 ANGEW CHEM INT EDIT published article about TRANSITION-METAL CATALYSIS; NONCOVALENT INTERACTIONS; ARENES; LIGAND; ACTIVATION; HYDROFORMYLATION; CONSTRUCTION; HETEROARENES; INSIGHTS; PHENOLS in [Bai, Shao-Tao; Bheeter, Charles B.; Reek, Joost N. H.] Univ Amsterdam, Vant Hoff Inst Mol Sci HIMS, Supramol & Homogeneous Catalysis Grp, Sci Pk 904, NL-1098 XH Amsterdam, Netherlands in 2019, Cited 76. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7. Category: isothiazole

Reported is an iridium catalyst for ortho-selective C-H borylation of challenging secondary aromatic amide substrates, and the regioselectivity is controlled by hydrogen-bond interactions. The BAIPy-Ir catalyst forms three hydrogen bonds with the substrate during the crucial activation step, and allows ortho-C-H borylation with high selectivity. The catalyst displays unprecedented ortho selectivities for a wide variety of substrates that differ in electronic and steric properties, and the catalyst tolerates various functional groups. The regioselective C-H borylation catalyst is readily accessible and converts substrates on gram scale with high selectivity and conversion.

Category: isothiazole. About 3-Methylbenzoic acid, If you have any questions, you can contact Bai, ST; Bheeter, CB; Reek, JNH or concate me.

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Isothiazole – Wikipedia,
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Category: isothiazole. In 2020 BIOORG CHEM published article about NATURAL-PRODUCT in [Xiao, Shengnan; Wang, Xude; Xu, Lei; Li, Tao; Cao, Jiaqing; Zhao, Yuqing] Shenyang Pharmaceut Univ, Sch Funct Food & Wine, Shenyang 110016, Peoples R China; [Zhao, Yuqing] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Peoples R China in 2020, Cited 33. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7.

In this study, we introduced 1, 2, 4-triazole groups into panaxadiol (PD) to obtain 18 panaxadiol triazole derivatives. Five cancer cells and one normal cell were evaluated for cytotoxicity by MTT assay. The results showed that most of the derivatives could inhibit cancer cell proliferation, and the anti-proliferative activity of compound A1 was the most significant. For HepG-2 cells, the IC50 value was 4.21 +/- 0.54 mu M, which was nearly 15 times higher than the activity of PD. Further studies showed that compound A1 could induce apoptosis in HepG-2 cells, and could enhance the expression of Cl-caspase-3, Cl-caspase-9 and Cl-PARP. Moreover, Western blot analysis showed that after treating HepG-2 cells with compound A1, the expression of p53 protein was increased and the ratio of Bax/Bcl-2 was gradually increased. The cytoplasmic Bax is then translocated to the mitochondria, causing the release of Cyt c protein. Therefore, the results indicate that compound A1 induces apoptosis through the mitochondrial pathway and can be used the potential to develop new anti-proliferative agents.

About 3-Methylbenzoic acid, If you have any questions, you can contact Xiao, SN; Wang, XD; Xu, L; Li, T; Cao, JQ; Zhao, YQ or concate me.. Category: isothiazole

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Isothiazole – Wikipedia,
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An article A solid-supported arylboronic acid catalyst for direct amidation WOS:000462657900004 published article about AMIDE BOND FORMATION; CARBOXYLIC-ACIDS; ORGANIC-SYNTHESIS; FLOW; AMINES; CONVENIENT; REAGENTS; POLYMER in [Du, Yihao; Barber, Thomas; Lim, Sot Ee; Baxendale, Ian R.; Whiting, Andrew] Univ Durham, Sci Labs, Ctr Sustainable Chem Proc, Dept Chem, South Rd, Durham DH1 3QZ, England; [Rzepa, Henry S.] Imperial Coll, Dept Chem, South Kensington Campus, London SW7 2AZ, England in 2019, Cited 40. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7. Formula: C8H8O2

An efficient heterogeneous amidation catalyst has been prepared by co-polymerisation of styrene, DVB with 4-styreneboronic acid, which shows wide substrate applicability and higher reactivity than the equivalent homogeneous phenylboronic acid, suggesting potential cooperative catalytic effects. The catalyst can be easily recovered and reused; suitable for use in packed bed flow reactors.

About 3-Methylbenzoic acid, If you have any questions, you can contact Du, YH; Barber, T; Lim, SE; Rzepa, HS; Baxendale, IR; Whiting, A or concate me.. Formula: C8H8O2

Reference:
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Safety of 3-Methylbenzoic acid. Authors Zhou, JY; Liu, RQ; Wang, CY; Zhu, YM in AMER CHEMICAL SOC published article about in [Zhou, Jing-Ya; Liu, Rui-Qing; Wang, Cheng-Yi; Zhu, Yong-Ming] Soochow Univ, Coll Pharmaceut Sci, Suzhou 215123, Peoples R China in 2020, Cited 40. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7

Transition metal-catalyzed cross-couplings have been widely employed in the synthesis of many important molecules in synthetic chemistry for the construction of diverse C-C bonds. Conventional cross-coupling reactions require active electrophilic coupling partners, such as organohalides or sulfonates, which are not environmentally friendly enough. Herein, we disclose the first nickel-catalyzed Suzuki-Miyaura cross-coupling of aryl anhydrides and arylboronic acids for the synthesis of biaryls in a decarbonylation manner. The reaction tolerates a wide range of electron-withdrawing, electron-neutral, and electron-donating substituents in this process.

About 3-Methylbenzoic acid, If you have any questions, you can contact Zhou, JY; Liu, RQ; Wang, CY; Zhu, YM or concate me.. Safety of 3-Methylbenzoic acid

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Authors Song, ZL; Bai, FF; Zhang, BX; Fang, JG in AMER CHEMICAL SOC published article about CUL3-BASED E3 LIGASE; OXIDATIVE STRESS; THERAPEUTIC TARGET; PC12 CELLS; NEURODEGENERATIVE DISEASES; MITOCHONDRIAL DYSFUNCTION; KEAP1-NRF2-ARE PATHWAY; BIOLOGICAL EVALUATION; HYDROGEN-PEROXIDE; CANCER PREVENTION in [Song, Zi-Long; Bai, Feifei; Zhang, Baoxin; Fang, Jianguo] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China; [Song, Zi-Long; Bai, Feifei; Zhang, Baoxin; Fang, Jianguo] Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China in 2020, Cited 70. Category: isothiazole. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7

Oxidative stress is implicated in the pathogenesis of a wide variety of neurodegenerative disorders, and accordingly, dietary supplement of exogenous antioxidants or/and upregulation of the endogenous antioxidant defense system are promising for therapeutic intervention or chemoprevention of neurodegenerative diseases. Nrf2, a master regulator of the cellular antioxidant machinery, cardinally participates in the transcription of cytoprotective genes against oxidative/electrophilic stresses. Herein, we report the synthesis of 59 structurally diverse dithiolethiones and evaluation of their neuroprotection against 6-hydroxydopamine- or H2O2 -induced oxidative damages in PC12 cells, a neuron-like rat pheochromocytoma cell line. Initial screening identified compounds 10 and 11 having low cytotoxicity but conferring remarkable protection on PC12 cells from oxidative-mediated damages. Further studies demonstrated that both compounds upregulated a battery of antioxidant genes as well as corresponding genes’ products. Significantly, silence of Nrf2 expression abolishes cytoprotection of 10 and 11, indicating targeting Nrf2 activation is pivotal for their cellular functions. Taken together, the two lead compounds discovered here with potent neuroprotective functions against oxidative stress via Nrf2 activation merit further development as therapeutic or chemopreventive candidates for neurodegenerative disorders.

About 3-Methylbenzoic acid, If you have any questions, you can contact Song, ZL; Bai, FF; Zhang, BX; Fang, JG or concate me.. Category: isothiazole

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Product Details of 99-04-7. I found the field of Chemistry very interesting. Saw the article Synthesis of Aminated Phenanthridinones via Palladium/Norbornene Catalysis published in 2020, Reprint Addresses Lautens, M (corresponding author), Univ Toronto, Dept Chem, Davenport Res Labs, Toronto, ON M5S 3H6, Canada.. The CAS is 99-04-7. Through research, I have a further understanding and discovery of 3-Methylbenzoic acid.

An ortho-amination, ipso-C-H arylation mediated by palladium/norbornene cooperative catalysis is reported. This reaction proceeds through a sequential intermolecular C-N bond formation process followed by intramolecular C-H activation of a tethered arene. The products, aminated phenanthridinones, were generated in moderate to good yields. This method is also applicable to the formation of dibenzazepinones.

Product Details of 99-04-7. About 3-Methylbenzoic acid, If you have any questions, you can contact Abel-Snape, X; Whyte, A; Lautens, M or concate me.

Reference:
Isothiazole – Wikipedia,
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Authors He, Y; Liao, XZ; Dong, L; Chen, FE in ROYAL SOC CHEMISTRY published article about C-H FUNCTIONALIZATION; BOND FORMATION; NITRATED INDENOISOQUINOLINES; INTERNAL ALKYNES; ACTIVATION; INSERTION; COBALT; PHENYLAZOLES; CYCLIZATION; MULTIPLE in [He, Yuan; Liao, Xian-Zhang; Dong, Lin; Chen, Fen-Er] Sichuan Univ, West China Sch Pharm, Minist Educ, Key Lab Drug Targeting & Drug Delivery Syst, Chengdu 610041, Peoples R China; [Chen, Fen-Er] Fudan Univ, Dept Chem, Engn Ctr Catalysis & Synth Chiral Mol, Shanghai 200433, Peoples R China; [Chen, Fen-Er] Shanghai Engn Ctr Ind Asymmetr Catalysis Chiral D, Shanghai 200433, Peoples R China in 2021.0, Cited 74.0. HPLC of Formula: C8H8O2. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7

Developing powerful methods to introduce versatile functional groups at the N-substituents of isoquinolone scaffolds is still a great challenge. Herein, we report a novel three-component cascade annulation reaction to efficiently construct the N-oxopropyl chain of isoquinolone derivatives via rhodium(iii)-catalyzed C-H activation/cyclization/nucleophilic attack, with oxazoles used both as the directing group and potential functionalized reagents.

HPLC of Formula: C8H8O2. About 3-Methylbenzoic acid, If you have any questions, you can contact He, Y; Liao, XZ; Dong, L; Chen, FE or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Recently I am researching about HEPATOCYTE GROWTH-FACTOR; KINASE INHIBITORS; TYROSINE KINASE; FACTOR-RECEPTOR; SCATTER-FACTOR; CANCER; DISCOVERY; AMPLIFICATION; RESISTANCE; CARCINOMA, Saw an article supported by the Natural Science Foundation of Jiangsu ProvinceNatural Science Foundation of Jiangsu Province [BK2012760]; College Students Innovation Project for the R&D of Novel Drugs [J1310032]; National College Students’ innovation and entrepreneurship training program [201810316057G]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [2632018ZD09]. COA of Formula: C8H8O2. Published in TAYLOR & FRANCIS LTD in ABINGDON ,Authors: Zhang, QW; Ye, ZD; Shen, C; Tie, HX; Wang, L; Shi, L. The CAS is 99-04-7. Through research, I have a further understanding and discovery of 3-Methylbenzoic acid

HGF/c-Met signalling pathway plays an important role in the development of cancers. A series of 6,7-dimethoxy-4-anilinoquinolines possessing benzimidazole moiety were synthesised and identified as potent inhibitors of the tyrosine kinase c-Met. Their in vitro biological activities against three cancer cell lines (A549, MCF-7, and MKN-45) were also evaluated. Most of these compounds exhibited moderate to remarkable potency. Among them, compound 12n showed the most potent inhibitory activity against c-Met with IC50 value of 0.030 +/- 0.008 mu M and it also showed excellent anticancer activity against the tested cancer cell lines at low micromolar concentration. Molecular docking verified the results and revealed the possible binding mode of the most promising compound 12n into the ATP-binding site of c-Met kinase.

COA of Formula: C8H8O2. About 3-Methylbenzoic acid, If you have any questions, you can contact Zhang, QW; Ye, ZD; Shen, C; Tie, HX; Wang, L; Shi, L or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article Coordination-Driven Stereospecific Control Strategy for Pure Cycloisomers in Solid-State Diene Photocycloaddition WOS:000508475100009 published article about 2+2 PHOTODIMERIZATION; PHOTOCHEMISTRY; CHEMISTRY; CYCLOBUTANE; DERIVATIVES; INCREASES; CATALYSIS; POLYMER; CO2 in [Wang, Meng-Fan; Hu, Fei-Long; Niu, Zheng; Wang, Hui-Fang; Lang, Jian-Ping] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Suzhou 215123, Peoples R China; [Wang, Meng-Fan; Mi, Yan; Hu, Fei-Long; Yin, Xian-Hong; Huang, Qin] Guangxi Univ Nationalities, Guangxi Key Lab Chem & Engn Forest Prod, Nanning 530006, Peoples R China in 2020, Cited 49. Computed Properties of C8H8O2. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7

To obtain a pure product without the isomer byproducts is a goal that many chemists are pursuing. As one kind of very important synthesis method, the photochemical reaction is simple and straightforward yet low-selective. In this work, a coordination interaction based oriented synthesis strategy has been proposed to realize the precise stereochemical control of the isomeric cyclic compounds in the photocycloaddition reaction. Through fixing the reactants via coordination interactions, the arrangements and configurations of the reactants can be adjusted, thereby successfully producing all of the related photocycloaddition products without isomer byproducts for the first time. This work not only provides a new route to synthesize the pure cyclic compounds but also expands the application of the photocycloaddition reaction.

Computed Properties of C8H8O2. About 3-Methylbenzoic acid, If you have any questions, you can contact Wang, MF; Mi, Y; Hu, FL; Niu, Z; Yin, XH; Huang, Q; Wang, HF; Lang, JP or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com