Category: 99-04-7

Authors Liu, Z; Bian, M; Ma, QQ; Zhang, Z; Du, HH; Wei, CX in MDPI published article about NF-KAPPA-B; ALZHEIMERS-DISEASE; A-BETA; INHIBITION; RECEPTOR; GSK-3-BETA; APOPTOSIS; RAGE; TRANSLOCATION; DEGRADATION in [Liu, Zheng; Bian, Ming; Ma, Qian-Qian; Du, Huan-Huan; Wei, Cheng-Xi] Inner Mongolia Univ Nationalities, Med Chem & Pharmacol Inst, Tongliao 028000, Peoples R China; [Bian, Ming; Ma, Qian-Qian; Du, Huan-Huan; Wei, Cheng-Xi] Inner Mongolia Key Lab Mongolian Med Pharmacol Ca, Tongliao 028000, Peoples R China; [Zhang, Zhuo] Yanbian Univ, Coll Pharmaceut Sci, Yanji 133022, Peoples R China in 2020, Cited 58. Recommanded Product: 99-04-7. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7

A series of novel synthetic substituted benzo[d]oxazole-based derivatives (5a-5v) exerted neuroprotective effects on beta-amyloid (A beta)-induced PC12 cells as a potential approach for the treatment of Alzheimer’s disease (AD). In vitro studies show that most of the synthesized compounds were potent in reducing the neurotoxicity of A beta(25-35)-induced PC12 cells at 5 mu g/mL. We found that compound 5c was non-neurotoxic at 30 mu g/mL and significantly increased the viability of A beta(25-35)-induced PC12 cells at 1.25, 2.5 and 5 mu g/mL. Western blot analysis showed that compound 5c promoted the phosphorylation of Akt and glycogen synthase kinase (GSK-3 beta) and decreased the expression of nuclear factor-kappa B (NF-kappa B) in A beta(25-35)-induced PC12 cells. In addition, our findings demonstrated that compound 5c protected PC12 cells from A beta(25-35)-induced apoptosis and reduced the hyperphosphorylation of tau protein, and decreased the expression of receptor for AGE (RAGE), beta-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1), inducible nitric oxide synthase (iNOS) and Bcl-2-associated X protein/B-cell lymphoma 2 (Bax/Bcl-2) via Akt/GSK-3 beta/NF-kappa B signaling pathway. In vivo studies suggest that compound 5c shows less toxicity than donepezil in the heart and nervous system of zebrafish.

Recommanded Product: 99-04-7. About 3-Methylbenzoic acid, If you have any questions, you can contact Liu, Z; Bian, M; Ma, QQ; Zhang, Z; Du, HH; Wei, CX or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Category: isothiazole. Recently I am researching about CORRELATED MOLECULAR CALCULATIONS; INDEPENDENT CHEMICAL-SHIFTS; PI-ELECTRON DELOCALIZATION; GAUSSIAN-BASIS SETS; THEORETICAL CALCULATION; IONIZATION-POTENTIALS; OVERTONE SPECTROSCOPY; QUANTITATIVE CONCEPT; AB-INITIO; RESONANCE, Saw an article supported by the SERB from the Department of Science and Technology (DST) Government of India, New Delhi [EMR/2016/001090]; UGC, Government of IndiaUniversity Grants Commission, India; DST, Government of IndiaDepartment of Science & Technology (India); U.S. National Science FoundationNational Science Foundation (NSF) [CHE-1661604]; IITK. Published in AMER INST PHYSICS in MELVILLE ,Authors: Dey, S; Manogaran, D; Manogaran, S; Schaefer, HF. The CAS is 99-04-7. Through research, I have a further understanding and discovery of 3-Methylbenzoic acid

Benzene and 23 monosubstituted and 32 disubstituted derivatives of benzene were optimized for minimum energy structures using the B3LYP/cc-pVTZ method. The force fields of all the compounds were evaluated at their optimized geometries using the same method and basis set. In order to understand the effect of substitution(s) on the aromaticity of benzene, the aromaticity index based on interaction coordinates (AIBIC) values were computed for each and the change from the benzene value was obtained. This difference, the substituent effect based on interaction coordinates (SEBIC), quantifies the effect of the substituent on the aromaticity of benzene ring satisfactorily. It is found that the AIBIC of disubstituted benzenes (XC6H4Y) could be predicted well by adding the respective SEBIC(C6H5X) and SEBIC(C6H5Y) values to the AIBIC of benzene. The projected force fields of the meta and para fragments of the monosubstituted benzenes when chosen properly contain the information about the directing influence of the substituent in terms of the electron density based on interaction coordinates (EDBIC). When the EDBIC(para) > EDBIC(meta) relative to benzene, the substituent is ortho-para directing, while when the reverse is true, it is meta directing. The effect of conformational changes on aromaticity has been studied using aminophenols and dihydroxybenzenes. The additivity rule and the EDBIC concept work adequately well in that the methods can have several useful practical applications that will benefit various areas of science. A good understanding of the substituent effects and the ability to predict them should add a new dimension to the applications of AIBIC.

Category: isothiazole. About 3-Methylbenzoic acid, If you have any questions, you can contact Dey, S; Manogaran, D; Manogaran, S; Schaefer, HF or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article Complete biodegradation of azo dye in an integrated microbial fuel cell-aerobic system using novel bacterial consortium WOS:000457290400039 published article about BIOELECTRICITY GENERATION; WASTE-WATER; DECOLORIZATION in [Das, A.; Mishra, S.] Natl Inst Technol, Dept Chem Engn, Biochem Engn Lab, Rourkela 769008, India in 2019.0, Cited 31.0. Formula: C8H8O2. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7

In the present work, a commercially used azo dye Remazol navy blue was completely degraded into less toxic intermediates in an integrated microbial fuel cell-aerobic system. A novel defined bacterial consortium comprising of organisms isolated from dye contaminated wastewater has been used as inoculum for this study. As compared to the traditional static incubation method, a rapid decolorization of Remazol navy blue was noticed in the anodic chamber of microbial fuel cell. In low to moderate dye concentrations (25-100mg/L), almost complete decolorization of Remazol navy blue was achieved within 12h of microbial fuel cell operation. The first-order kinetic constant of Remazol navy blue decolorization (k) in microbial fuel cell was found to be considerably higher than that of static incubation condition (K-static (0.3041)Formula: C8H8O2. About 3-Methylbenzoic acid, If you have any questions, you can contact Das, A; Mishra, S or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

SDS of cas: 99-04-7. In 2020 ORG LETT published article about C-H ACTIVATION; BENZOIC-ACIDS; REDUCTIVE ELIMINATION; TRIFLUOROETHYLATION; ANNULATION; FLUORINE; ARENES; PHARMACEUTICALS; CYCLIZATION; INDOLES in [Zhou, Kehan; Zhang, Jingyu] Soochow Univ, Coll Energy, Soochow Inst Energy & Mat Innovat, Suzhou 215006, Peoples R China; [Zhou, Kehan; Geng, Jingyao; Wang, Dongjie; Zhao, Yingsheng] Soochow Univ, Key Lab Organ Synth Jiangsu Prov, Coll Chem Chem Engn & Mat Sci, Suzhou 215123, Peoples R China in 2020, Cited 64. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7.

3-Bromo-1,1,1-trifluoroacetone was first disclosed as an effective indirect trifluoromethylation reagent to construct the important 3-trifluoromethyl isocoumarin skeleton. The reaction proceeds through a ligand-promoted, iridium-catalyzed ortho-selective C-H alkylation of benzoic acid and an intermolecular cyclization reaction promoted by silver acetate. A wide range of 3-trifluoromethyl isocoumarins can be easily obtained in moderate to good yields. Importantly, the isocoumarin skeleton can be easily formed in bioactive compounds, highlighting the importance of this reaction.

About 3-Methylbenzoic acid, If you have any questions, you can contact Zhou, KH; Geng, JY; Wang, DJ; Zhang, JY; Zhao, YS or concate me.. SDS of cas: 99-04-7

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Recently I am researching about C-H BONDS; COPPER-CATALYZED CYANOMETHYLATION; ACTIVATED ALKENES; GRIGNARD-REAGENTS; C(SP(3))-H FUNCTIONALIZATION; UNACTIVATED ALKENES; ALLYLIC ALCOHOLS; ALKYL NITRILES; ACETONITRILE; ESTERIFICATION, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21472134]; Key Laboratory of Organic Chemistry of Jiangsu Province; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD). Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Wang, D; Lu, B; Song, YL; Sun, HM; Shen, Q. The CAS is 99-04-7. Through research, I have a further understanding and discovery of 3-Methylbenzoic acid. Quality Control of 3-Methylbenzoic acid

The first oxidative coupling of alkylnitriles with aromatic carboxylic acids using di-tert-butyl peroxide (DTBP) as oxidant was achieved under the catalysis of ionic Fe(III) complexes bearing an imidazolinium cation. This protocol features nontoxic iron catalysis, direct alpha-C(sp(3))-H bond oxidative esterification of alkylnitriles, non-prefunctionalized starting materials, and a broad substrate scope with outstanding steric hindrance tolerance, providing a novel, straightforward, and green approach toward cyanomethyl ester synthesis. (C) 2019 Elsevier Ltd. All rights reserved.

Quality Control of 3-Methylbenzoic acid. About 3-Methylbenzoic acid, If you have any questions, you can contact Wang, D; Lu, B; Song, YL; Sun, HM; Shen, Q or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Name: 3-Methylbenzoic acid. Recently I am researching about PEPTIDE COUPLING REAGENTS; ALPHA-KETOAMIDES; CARBOXYLIC-ACIDS; OXIDATIVE CLEAVAGE; AMIDATION; BENZAMIDES; SECONDARY; ALDEHYDES; PRODUCTS; ALCOHOLS, Saw an article supported by the Fund for Scientific Research-Flanders (Belgium)FWO; RUDN University Program 5-100. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Song, L; Claessen, S; Van der Eycken, EV. The CAS is 99-04-7. Through research, I have a further understanding and discovery of 3-Methylbenzoic acid

A pyridine-enabled C-N bond activation of peptidomimetics employing cooperative palladium/copper catalysis in water is developed. Diverse amides and 4-pyridylglyoxamides are simultaneously synthesized through two steps from commercially available materials in a rapid, environmentally friendly, and high atom-economical manner.

Name: 3-Methylbenzoic acid. About 3-Methylbenzoic acid, If you have any questions, you can contact Song, L; Claessen, S; Van der Eycken, EV or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Authors Klaimy, S; Lamonier, JF; Casetta, M; Heymans, S; Duquesne, S in ELSEVIER SCI LTD published article about HIGH-DENSITY POLYETHYLENE; FLUIDIZED-BED REACTOR; THERMAL-DEGRADATION; CATALYTIC DEGRADATION; POLYPROPYLENE; POLYSTYRENE; FUEL; TEMPERATURE; RECOVERY in [Klaimy, S.; Casetta, M.; Duquesne, S.] Univ Lille, UMET Unite Mat & Transformat, Cent Lille, CNRS,INRAE,UMR 8207, F-59000 Lille, France; [Klaimy, S.; Lamonier, J-F] Univ Lille, Univ Artois, UCCS Unite Catalyse & Chim Solide, CNRS,Cent Lille,ENSCL,UMR 8181, F-59000 Lille, France; [Heymans, S.] NeoEco, Zone Commerciale, 1 Rue Source, F-59320 Hallennes Lez Haubourdin, France in 2021.0, Cited 44.0. Computed Properties of C8H8O2. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7

Recovery of plastic waste is becoming crucial since the amount of such waste increases continuously. The objective of this study is to investigate the potential of the pyrolysis technique for the recovery of plastic waste. In that frame, the influence of temperature (550 degrees C or 600 degrees C) on the pyrolysis of pure polypropylene (PP), polyethylene (PE), polystyrene (PS) and polyethylene terephthalate (PET) was first studied. It is shown that whatever the type of polymer, aromatic compounds are mainly formed and could reach 55wt.-% of the oil fraction for PP and 31wt.-% for PE at 550 degrees C. In a second step, a PP/PE mixture and a model mixture representative of the packaging plastic waste stream were pyrolyzed to investigate the influence of a combination of polymers on the proportions and composition of the different fractions. The pyrolysis of the polymer mixtures shows that, even if the aromatic compounds formed are similar to those obtained for the virgin polymers, the proportion of aromatic compounds is much more important than when the polymers are pyrolyzed alone. Indeed, mixing PE with PP at a 50/50 ratio does not affect the amount of liquid, gas and solid fractions but leads to the formation of a higher quantity of xylene (39 wt-%) at 550 degrees C. The combination of the plastics in the model mixture has also led to a decrease of the amount of waxy compounds. Furthermore, it was shown that a higher amount of aromatics than expected was formed. As a conclusion, this study demonstrates that pyrolysis is an effective technique to recover plastic waste as aromatic compounds for the petroleum industry. In the specific conditions used in this study (proposed model mixture and pyrolysis conditions), it will favor the idea that sorting is not needed to recover plastic waste through pyrolysis since aromatics formation is favored when the stream is composed of a mixture of polymers. (C) 2021 Published by Elsevier Ltd.

About 3-Methylbenzoic acid, If you have any questions, you can contact Klaimy, S; Lamonier, JF; Casetta, M; Heymans, S; Duquesne, S or concate me.. Computed Properties of C8H8O2

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Name: 3-Methylbenzoic acid. Recently I am researching about CARBOXYLIC-ACID SALTS; CP-H BONDS; PRIMARY ALCOHOLS; UNACTIVATED C(SP(3))-H; AEROBIC OXIDATION; WATER; AMINES; ESTERIFICATION; ALKYLATION; CONVERSION, Saw an article supported by the DST of India [DST EMR/2015/000285]; UGC, IndiaUniversity Grants Commission, India; Indian Institute of Technology Delhi; DST-FISTDepartment of Science & Technology (India); IIT D. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Dolui, P; Hazra, S; Deb, M; Elias, AJ. The CAS is 99-04-7. Through research, I have a further understanding and discovery of 3-Methylbenzoic acid

Picolinamide group assisted sp(3) C-H bond oxidation of methylene groups to the corresponding carbonyl compounds has been achieved by using simple bottle ferrocene as catalyst and Cu(OAc)(2) or tert-butyl peroxybenzoate (TBPB) as oxidant under mild conditions. This method is applicable for picolinamide bound organic as well as organometallic compounds with yields in the range of 46-82%. Control experiments and mechanistic studies indicate that a radical mechanism is responsible for these oxidative transformations in which ferrocene acts as a catalyst.

Name: 3-Methylbenzoic acid. About 3-Methylbenzoic acid, If you have any questions, you can contact Dolui, P; Hazra, S; Deb, M; Elias, AJ or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article Magnesiation of Aryl Fluorides Catalyzed by a Rhodium-Aluminum Complex WOS:000550639000004 published article about C-F BOND; ACTIVATION REACTIONS; CARBON-SULFUR; METAL BONDS; NICKEL; INTERMEDIATE; REACTIVITY; REAGENTS; BEARING; COBALT in [Li, Qiao-Zhi; Sakaki, Shigeyoshi] Kyoto Univ, Fukui Inst Fundamental Chem, Kyoto 6068103, Japan; [Fujii, Ikuya; Semba, Kazuhiko; Nakao, Yoshiaki] Kyoto Univ, Dept Mat Chem, Grad Sch Engn, Kyoto 6158510, Japan in 2020, Cited 74. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7. Computed Properties of C8H8O2

We report the magnesiation of aryl fluorides catalyzed by an Al-Rh heterobimetallic complex. We show that the complex is highly reactive to cleave the C-F bonds across the polarized Al-Rh bond under mild conditions. The reaction allows the use of an easy-to-handle magnesium powder to generate a range of arylmagnesium reagents from aryl fluorides, which are conventionally inert to such metalation compared with other aryl halides.

About 3-Methylbenzoic acid, If you have any questions, you can contact Fujii, I; Semba, K; Li, QZ; Sakaki, S; Nakao, Y or concate me.. Computed Properties of C8H8O2

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Recently I am researching about DIRECT AMIDATION; LARGE-SCALE; ACTIVATION; REAGENTS, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21771057, 21801065]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Miao, YQ; Kang, JX; Ma, YN; Chen, XN. The CAS is 99-04-7. Through research, I have a further understanding and discovery of 3-Methylbenzoic acid. Application In Synthesis of 3-Methylbenzoic acid

Here, a photocatalytic deoxygenative amidation protocol using readily available amine-boranes and carboxylic acids is described. This approach features mild conditions, moderate-to-good yields, easy scale-up, and up to 62 examples of functionalized amides with diverse substituents. The synthetic robustness of this method was also demonstrated by its application in the late-stage functionalization of several pharmaceutical molecules.

Application In Synthesis of 3-Methylbenzoic acid. About 3-Methylbenzoic acid, If you have any questions, you can contact Miao, YQ; Kang, JX; Ma, YN; Chen, XN or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com