Category: 99-04-7

An article Investigation on 4-amino-5-substituent-1,2,4-triazole-3-thione Schiff bases an antifungal drug by characterization (spectroscopic, XRD), biological activities, molecular docking studies and electrostatic potential (ESP) WOS:000487932000019 published article about CRYSTAL-STRUCTURE; CU(II) COMPLEXES; 1,2,4-TRIAZOLE; DERIVATIVES; MANNICH; ANTICANCER; NI(II); CO(II); DFT in [Wu, Shaojie; Zhang, Wenhui; Qi, Le; Ren, Yinghui; Ma, Haixia] Northwest Univ, Sch Chem Engn, Xian 710069, Shaanxi, Peoples R China in 2019.0, Cited 47.0. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7. Application In Synthesis of 3-Methylbenzoic acid

Four novel Schiff bases 4-(2,4-dinitrobenzylideneamino)-5-m-tolyl-2H-1,2,4-triazole-3(4H)-thione) (F-1), 4-(2,4-dinitrobenzylideneamino)-5-(2-methoxyphenyl)-2H-1,2,4-triazole-3(4H)-thione) (F-2), 4-(2,4-dinitrobenzylideneamino)-5-(3-methoxyphenyl)-2H-1,2,4-triazole-3(4H)-thione) (F-3) and 4-(2,4-dinitrobenzylideneamino)-5-(4-methoxyphenyl)-2H-1,2,4-triazole-3(4H)-thione) (F-4) were prepared as new antifungal compounds contributing 4-Amino-5-Substituent-1,2,4-Triazole-3-Thione and 2,4-dinitrobenzaldehyde via a condensation reaction under the mild conditions with excellent yields. The structures of compounds were characterized by elemental analysis (EA), FT-IR, H-1 NMR, C-13 NMR spectra and X-ray analysis. In addition, the compounds were screened for in vitro biological activity, and the bioassay results indicated that the newly synthesized compounds showed different in vitro antifungal activities against five plant fungi. Particularly, compound F-3 (EC50 = 11.16 mg/L) was found to be the most active respectively against Wheat gibberellic, even more effective than Fluconazole (EC50 = 16.03 mg/L). The active compounds were further evaluated for enzyme inhibition efficacy against the receptor CYP51 by docking. Meanwhile, an explicit surface analysis on compounds were carried out theoretically using the wave function analyzer (Multiwfn 3.4.1 software) in order to study the reactivity of the compounds. (C) 2019 Published by Elsevier B.V.

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Reference:
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Recently I am researching about HETEROBICYCLIC ALKENES; BOND ACTIVATION; AROMATIC KETONES; CARBOXYLIC-ACIDS; BENZOIC-ACIDS; 4+2 ANNULATION; ARYL KETONES; FUNCTIONALIZATION; ARYLATION; PALLADIUM, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21961045, 21572198]; Applied Basic Research Project of Yunnan Province [2017FA004, 2018FB021]; Department of Education of Yunnan Province [2019Y0198]; National Innovation and Entrepreneurship Training Program for College Students; Yunnan Provincial Key Laboratory Construction Plan Funding of Universities. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Zhang, KY; Khan, R; Chen, JC; Zhang, XX; Gao, Y; Zhou, YY; Li, KK; Tian, YX; Fan, BM. The CAS is 99-04-7. Through research, I have a further understanding and discovery of 3-Methylbenzoic acid. Application In Synthesis of 3-Methylbenzoic acid

An efficient method for the directing group controlled rhodium-catalyzed addition reaction of oxa/azabicylic alkenes with aromatic ketones and benzoic acids has been developed. The ketones and benzoic acids afforded different addition products when reacted with oxa/azabicyclic alkenes. The reaction between ketones and azabenzonorbornadienes furnished the ring-opening addition products. The reaction between benzoic acids and aza/oxabicyclic alkenes proceeded in the absence of silver salt, giving the 1:2 hydroarylation products in yields up to 96%.

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Reference:
Isothiazole – Wikipedia,
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Category: isothiazole. Recently I am researching about CONVENIENT SYNTHESIS; BOND-CLEAVAGE; N-OXIDES; AMIDATION; ARENES; ACTIVATION; ARYL; 1H-INDAZOLES; INDOLINES; AZIDES, Saw an article supported by the Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21901045]; Guangdong Natural Science FoundationNational Natural Science Foundation of Guangdong Province [2018A030310570]; Foundation of the Department of Education of Guangdong Province [2017KZDXM085, 2018KZDXM070]. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Gao, Y; Nie, JH; Li, YB; Liao, GL; Huo, YP; Hu, XQ. The CAS is 99-04-7. Through research, I have a further understanding and discovery of 3-Methylbenzoic acid

An efficient Rh(III)-catalyzed Csp(2)-H amination protocol of benzoic acids with anthranils was developed for the rapid assembly of valuable anthranilic acid derivatives (AAs). The weakly coordinating carboxyl acted as a directing group and was further transformed to an ester group after facilitating the first C-H amination process. This reaction features good functional group tolerance, mild conditions and operational simplicity. The synthetic potential of this methodology was demonstrated by the synthesis of various useful heterocycles and derivatives.

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An article Heterogeneous Suzuki-Miyaura coupling of heteroaryl ester via chemoselective C(acyl)-O bond activation WOS:000471912700036 published article about CATALYZED C-O; ARYL ESTERS; NICKEL; AZOLES; SILYLATION; AMINATION; CLEAVAGE; KETONES; AMIDE in [Ma, Hongpeng; Bai, Chaolumen; Bao, Yong-Sheng] Inner Mongolia Normal Univ, Coll Chem & Environm Sci, Inner Mongolia Key Lab Green Catalysis, Hohhot 010022, Peoples R China in 2019, Cited 47. Computed Properties of C8H8O2. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7

A site-selective supported palladium nanoparticle catalyzed Suzuki-Miyaura cross-coupling reaction with heteroaryl esters and arylboronic acids as coupling partners was developed. This methodology provides a heterogeneous catalytic route for aryl ketone formation via C(acyl)-O bond activation of esters by successful suppression of the undesired decarbonylation phenomenon. The catalyst can be reused and shows high activity after eight cycles. The XPS analysis of the catalyst before and after the reaction suggested that the reaction might be performed via a Pd-0/Pd-II catalytic cycle that began with Pd-0.

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Isothiazole – Wikipedia,
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Category: isothiazole. I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article 1,3-Dibromo-5,5-dimethylhydantoin as a Precatalyst for Activation of Carbonyl Functionality published in 2019, Reprint Addresses Stavber, S (corresponding author), Jozef Stefan Inst, Dept Phys & Organ Chem, Jamova 39, Ljubljana 1000, Slovenia.; Stavber, S (corresponding author), Jozef Stefan Int Postgrad Sch, Jamova 39, Ljubljana 1000, Slovenia.. The CAS is 99-04-7. Through research, I have a further understanding and discovery of 3-Methylbenzoic acid.

Activation of carbonyl moiety is one of the most rudimentary approaches in organic synthesis and is crucial for a plethora of industrial-scale condensation reactions. In esterification and aldol condensation, which represent two of the most important reactions, the susceptibility of the carbonyl group to nucleophile attack allows the construction of a variety of useful organic compounds. In this context, there is a constant need for development of and improvement in the methods for addition-elimination reactions via activation of carbonyl functionality. In this paper, an advanced methodology for the direct esterification of carboxylic acids and alcohols, and for aldol condensation of aldehydes using widely available, inexpensive, and metal-free 1,3-dibromo-5,5-dimethylhydantoin under neat reaction conditions is reported. The method is air- and moisture-tolerant, allowing simple synthetic and isolation procedures for both reactions presented in this paper. The reaction pathway for esterification is proposed and a scale-up of certain industrially important derivatives is performed.

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Isothiazole – Wikipedia,
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I found the field of Chemistry; Pharmacology & Pharmacy very interesting. Saw the article Synthesis and bioactivities of diamide derivatives containing a phenazine-1-carboxamide scaffold published in 2019.0. Product Details of 99-04-7, Reprint Addresses Du, XY; Wu, QL; Li, JK (corresponding author), Yangtze Univ, Sch Agr, Jingzhou, Peoples R China.; Wu, QL (corresponding author), Yangtze Univ, Minist Educ, Engn Res Ctr Ecol & Agr Use Wetland, Jingzhou, Peoples R China.; Li, JK (corresponding author), Yangtze Univ, Hubei Collaborat Innovat Ctr Grain Ind, Jingzhou, Peoples R China.. The CAS is 99-04-7. Through research, I have a further understanding and discovery of 3-Methylbenzoic acid

Taking natural product phenazine-1-carboxamide (PCN) as a lead compound, a series of novel phenazine-1-carboxylic acid diamide derivatives were designed and synthesised. Their structures were confirmed by H-1-NMR and HRMS. The bioassays showed that some of the target compounds exhibited promising in vitro fungicidal activities, and exhibited excellent and selective herbicidal activities. Particularly, compounds c, h, o and s displayed root length inhibition activities against barnyard grass with the rate of more than 80%. Compound c exhibited the best activity among all the target compounds against barnyard grass stalk length with the IC50 value of 0.158 mmol/L, and compound o exhibited the best and wide spectrum inhibition against barnyard grass root length and rape in both root length and stalk length herbicidal activities with its IC50 values of 0.067, 0.048 and 0.059 mmol/L respectively. The analysis of preliminary Structure-Activity Relationships provides the theoretical basis for further design of phenazine-1-carboxylic acid. [GRAPHICS] .

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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

SDS of cas: 99-04-7. In 2020 J ORGANOMET CHEM published article about ACYL; KETONES; CARBOSTANNYLATION; ACYLSTANNYLATION; ALKYNES; SILYL; TIN in [Chen, Bo; Yuan, Yang; Xu, Jian-Xing; Wu, Xiao-Feng] Univ Rostock, Leibniz Inst Katalyse eV, Albert Einstein Str 29a, D-18059 Rostock, Germany; [Franke, Robert] Evonik Ind AG, Paul Baumann Str 1, D-45772 Marl, Germany; [Franke, Robert] Ruhr Univ Bochum, Lehrstuhl Theoret Chem, Univ Str 150, D-44780 Bochum, Germany in 2020, Cited 21. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7.

In this communication, we describe a new method for the carbonylative synthesis of acylstannanes from aryl iodides and hexamethyldistannane. With Pd(PPh3)(4) as the catalyst and toluene as the solvent at 60 degrees C under 10 bar CO for 16 h, the desired acylstannanes were obtained in good to excellent yields. In order to facilitate isolation and analysis, the obtained acylstannanes were transformed into the corresponding benzoic acids by simply stirring under air for 5 h. (C) 2020 Elsevier B.V. All rights reserved.

SDS of cas: 99-04-7. Bye, fridends, I hope you can learn more about C8H8O2, If you have any questions, you can browse other blog as well. See you lster.

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Isothiazole – Wikipedia,
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An article CO2 activation by electrogenerated divalent samarium for aryl halide carboxylation WOS:000487658900007 published article about CATALYZED DIRECT CARBOXYLATION; CARBON-DIOXIDE; BENZYL CHLORIDES; ELECTROCATALYTIC CARBOXYLATION; RECENT PROGRESS; SILVER CATHODE; ELECTROCARBOXYLATION; REDUCTION; ELECTROSYNTHESIS; PALLADIUM in [Bazzi, Sakna; Schulz, Emmanuelle; Mellah, Mohamed] Univ Paris Saclay, Univ Paris Sud, Inst Chim Mol & Mat Orsay, CNRS,UMR 8182,Equipe Catalyse Mol, 115 Rue Georges Clemenceau, F-91405 Orsay, France; [Le Duc, Gaetan; Gosmini, Corinne] Inst Polytech Paris, Ecole Polytech, CNRS, LCM, F-91228 Palaiseau, France in 2019, Cited 45. Quality Control of 3-Methylbenzoic acid. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7

The reductive carboxylation of aryl halides has been investigated using a samarium electrode as a sacrificial anode to yield the corresponding benzoic acids, providing a smooth strategy for CO2 activation. Carboxylation occurred after an efficient reduction of carbon dioxide mediated by an electrogenerated Sm(ii)-complex acting as a strong monoelectronic reductive reagent.

Quality Control of 3-Methylbenzoic acid. Bye, fridends, I hope you can learn more about C8H8O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
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In 2020 CHINESE J CHEM published article about CAGE B-H; O-CARBORANES; ORTHO-ARYLATION; BORON CLUSTERS; DRUG DISCOVERY; GAMMA-LACTAMS; BENZOIC-ACIDS; BONDS; RHODIUM; FUNCTIONALIZATION in [Quan, Yangjian; Xie, Zuowei] Chinese Univ Hong Kong, Dept Chem, Shatin, Hong Kong, Peoples R China; Chinese Univ Hong Kong, State Key Lab Synthet Chem, Shatin, Hong Kong, Peoples R China in 2020, Cited 89. The Name is 3-Methylbenzoic acid. Through research, I have a further understanding and discovery of 99-04-7. Recommanded Product: 99-04-7

Ir-catalyzed cascade dehydrogenative CH/BH and BH/OH cross-coupling of carboranyl carboxylic acid with readily available benzoic acid has been achieved, leading to the facile synthesis of previously unavailable carborano-coumarin in a simple one-pot process. Two cage B-H, one aryl C-H and one O-H bonds are activated to construct efficiently new B-C and B-O bonds. The cascade cyclization can stop at the first B-H/C-H cross-coupling step by tuning the reaction conditions, resulting in a series of alpha-carboranyl benzoic acid and aryl carborane derivatives. Control experiments indicate that B-H/C-H dehydrocoupling proceeds preferentially over B-H/O-H dehydrocoupling, and both directing groups and oxidants are crucial for this reaction. An iridium(V) intermediate is proposed to be involved in the catalytic cycle.

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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Application In Synthesis of 3-Methylbenzoic acid. I found the field of Chemistry very interesting. Saw the article Copper Salts/TBAB-Catalyzed Chemo- and Regioselective beta-C(sp(3))-H Acyloxylation of Aliphatic Amides published in 2019, Reprint Addresses Zhang, W (corresponding author), Anhui Normal Univ, Coll Chem & Mat Sci, Wuhu 241000, Peoples R China.; Zhang, W (corresponding author), Anhui Normal Univ, Key Lab Funct Mol Solids, Minist Educ, Wuhu 241000, Peoples R China.. The CAS is 99-04-7. Through research, I have a further understanding and discovery of 3-Methylbenzoic acid.

An efficient Cu(II)-catalyzed and tetrabutylammonium bromide (TBAB)-promoted strategy for highly regioselective and chemoselective C(sp(3))-H acyloxylation of aliphatic amides is described. Acyloxylation occurs selectively at the beta position with a broad substrate scope of carboxylic acids and aliphatic amides and good functional group compatibility. Notably, the competing reaction of intramolecular dehydrogenative amidation and intermolecular acyloxylation could be efficiently controlled by the amount of copper salt and the addition of TBAB. The intramolecular dehydrogenative amidation product was obtained in high yield when the amount of copper salts was increased. However, when TBAB was used as an additive, a preference for acyloxylation over intramolecular amidation was observed and the acyloxylated products were obtained in good yield. Preliminary studies were carried out to gain insights into the mechanism.

Application In Synthesis of 3-Methylbenzoic acid. Bye, fridends, I hope you can learn more about C8H8O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com