Category: 93-02-7

Computed Properties of C9H10O3. Shaikh, S; Pavale, G; Dhavan, P; Singh, P; Uparkar, J; Vaidya, SP; Jadhav, BL; Ramana, MMV in [Shaikh, Sarfaraz; Pavale, Ganesh; Uparkar, Jasmin; Ramana, M. M., V] Univ Mumbai, Dept Chem, Santacruz E, Mumbai 400098, Maharashtra, India; [Dhavan, Pratik; Jadhav, B. L.] Univ Mumbai, Dept Life Sci, Santacruz E, Mumbai 400098, Maharashtra, India; [Singh, Pinky; Vaidya, S. P.] Haffkine Inst, Dept Microbiol, Mumbai 400012, Maharashtra, India published Design, synthesis and evaluation of dihydropyranoindole derivatives as potential cholinesterase inhibitors against Alzheimer’s disease in 2021, Cited 41. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7.

A series of novel dihydropyranoindole derivatives containing sulphonamide group were designed, synthesized and evaluated for in-vitro anti-cholinesterase activity. The result showed that all the compounds exhibited potent acetylcholinesterase (AChE) activity (IC50 = 0.41-8.79 mu M) while demonstrated moderate to good activity for butyrylcholinesterase (BuChE) (IC50 = 1.17-30.17 mu M). The tested compounds exhibited selectivity towards AChE over BuChE. Compound 5o was most potent towards both AChE (IC50 = 0.41 mu M) and BuChE (IC50 = 1.17 mu M) when compared to standard galantamine and rivastigmine. Enzyme kinetics and molecular docking studies revealed that compound 5o shows mixed type inhibition and binds to peripheral anionic site (PAS) and the catalytic sites (CAS) of both the enzymes. Furthermore, cell viability studies were also performed against N2a cells along with neuroprotection studies against H2O2 in the same cell line. Antioxidant studies using DPPH radical and H2O2 were also performed which revealed that all compounds possessed some antioxidant activity. Also, DNA damage protection assay for compound 5o was performed implying that compound 5o was protective in nature. ADME studies were also performed which demonstrated good pharmacokinetics. These findings indicated that dihydropyranoindole derivatives could be possible drug lead in the search for new multifunctional AD drugs.

Computed Properties of C9H10O3. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Shaikh, S; Pavale, G; Dhavan, P; Singh, P; Uparkar, J; Vaidya, SP; Jadhav, BL; Ramana, MMV or concate me.

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Product Details of 93-02-7. Authors Moosavi-Zare, AR; Afshar-Hezarkhani, H; Rezaei, MM in TAYLOR & FRANCIS LTD published article about in [Moosavi-Zare, Ahmad R.; Afshar-Hezarkhani, Hadis; Rezaei, Mohammad M.] Sayyed Jamaleddin Asadabadi Univ, Dept Chem, Asadabad, Iran in 2020.0, Cited 32.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7

Aqueous solution of boric acid, as an efficient and green catalytic system, was efficiently utilized tandem four-component condensation reaction of aryl aldehydes with ethyl acetoacetate, malononitrile, and hydrazine hydrate to give pyranopyrazole derivatives. By the reaction of boric acid with water, H+ was prepared and efficiently catalyzed the reaction under mild and green condition.

Product Details of 93-02-7. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Moosavi-Zare, AR; Afshar-Hezarkhani, H; Rezaei, MM or concate me.

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I found the field of Pharmacology & Pharmacy very interesting. Saw the article A Novel Redox Modulator Induces a GPX4-Mediated Cell Death That Is Dependent on Iron and Reactive Oxygen Species published in 2020.0. SDS of cas: 93-02-7, Reprint Addresses Neamati, N (corresponding author), Univ Michigan, Coll Pharm, Dept Med Chem, Rogel Canc Ctr, Ann Arbor, MI 48109 USA.; Sechi, M (corresponding author), Univ Sassari, Dept Chem & Pharm, I-07100 Sassari, Italy.. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde

Redox modulators have been developed as an attractive approach to treat cancer. Herein, we report the synthesis, identification, and biological evaluation of a quinazolinedione reactive oxygen species (ROS) inducer, QD394, with significant cytotoxicity in pancreatic cancer cells. QD394 shows a transcriptomic profile remarkably similar to napabucasin, a cancer stemness inhibitor. Both small molecules inhibit STAT3 phosphorylation, increase cellular ROS, and decrease the GSH/GSSG ratio. Moreover, QD394 causes an iron- and ROS-dependent, GPX4 mediated cell death, suggesting ferroptosis as a major mechanism. Importantly, QD394 decreases the expression of LRPPRC and PNPT1, two proteins involved in mitochondrial RNA catabolic processes and both negatively correlated with the overall survival of pancreatic cancer patients. Pharmacokinetics-guided lead optimization resulted in the derivative QD394-Me, which showed improved plasma stability and reduced toxicity in mice compared to QD394. Overall, QD394 and QD394-Me represent novel ROS-inducing drug-like compounds warranting further development for the treatment of pancreatic cancer.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Hu, S; Sechi, M; Singh, PK; Dai, LP; McCann, S; Sun, DX; Ljungman, M; Neamati, N or concate me.. SDS of cas: 93-02-7

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Product Details of 93-02-7. In 2020.0 BIOORG MED CHEM LETT published article about QUINAZOLINE DERIVATIVES; ANTIBACTERIAL ACTIVITY; MOLECULAR DOCKING; ANTITUMOR; REARRANGEMENT; ANALOGS; SERIES; AGENTS in [Rasapalli, Sivappa; Murphy, Zachary F.; Sammeta, Vamshikrishna Reddy; Golen, James A.] Univ Massachusetts Dartmouth, Dept Chem & Biochem, 285 Old Westport Rd, N Dartmouth, MA 02747 USA; [Weig, Alexander W.; Melander, Roberta J.; Melander, Christian] Univ Notre Dame, Dept Chem & Biochem, 252A McCourtney Hall, Notre Dame, IN 46556 USA; [Macha, Prathyushakrishna; Vasudev, Milana C.] Univ Massachusetts Dartmouth, Dept Biomed Engn, 285 Old Westport Rd, N Dartmouth, MA 02747 USA in 2020.0, Cited 40.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7.

Synthesis of novel 4(3H)-quinazolinonyl aminopyrimidine derivatives has been achieved via quinazolinonyl enones which in turn were obtained from 2-acyl-4(3H)-quinazolinone. They have been assayed for biofilm inhibition against Gram-positive (methicillin-resistant Staphylococcus aureus (MRSA)) and Gram-negative bacteria (Acinetobacter baumannii). The analogues with 2,4,6-trimethoxy phenyl, 4-methylthio phenyl, and 3-bromo phenyl substituents (5h, 5j & 5k) have been shown to inhibit biofilm formation efficiently in MRSA with IC50 values of 20.7-22.4 mu M). The analogues 5h and 5j have demonstrated low toxicity in human cells in vitro and can be investigated further as leads.

Product Details of 93-02-7. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Rasapalli, S; Murphy, ZF; Sammeta, VR; Golen, JA; Weig, AW; Melander, RJ; Melander, C; Macha, P; Vasudev, MC or concate me.

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Recently I am researching about LANOSTEROL 14-ALPHA-DEMETHYLASE; ANTIFUNGAL ACTIVITIES; BIOLOGICAL EVALUATION; CYTOTOXIC ALKALOIDS; DESIGN; SPONGE; EFFICIENT; EUDISTOMINS; TRYPTAMINE; ANTITUMOR, Saw an article supported by the Department of Chemistry, faculty of science, Silpakorn University; Department of Microbiology, faculty of science, Silpakorn University. Published in MDPI in BASEL ,Authors: Buaban, K; Phutdhawong, W; Taechowisan, T; Phutdhawong, WS. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde. Safety of 2,5-Dimethoxybenzaldehyde

A series of tetrahydro-ss-carbolines substituted with an alkyl or acyl side chain was synthesized and screened for its antifungal activity against plant pathogenic fungi (Bipolaris oryzae, Curvularia lunata, Fusarium semitectum, and Fusarium fujikuroi). The structure activity relationship revealed that the substituent at the piperidine nitrogen plays an important role for increasing antifungal activities. In this series, 2-octyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole (3g) displayed potent antifungal activities with a minimum inhibitory concentration of 0.1 mu g/mL, including good inhibitory activity to the radial growth of fungus at a concentration of 100 mu g/mL compared to amphotericin B.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Buaban, K; Phutdhawong, W; Taechowisan, T; Phutdhawong, WS or concate me.. Safety of 2,5-Dimethoxybenzaldehyde

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Recently I am researching about ANTIPROLIFERATIVE ACTIVITY; DRUG DISCOVERY; DESIGN; EXPRESSION; MECHANISM; MOIETIES; GROWTH; ASSAY; PANEL, Saw an article supported by the Deanship of Scientific Research at King Saud UniversityKing Saud University [RG-1439-65]. Published in ACADEMIC PRESS INC ELSEVIER SCIENCE in SAN DIEGO ,Authors: Eldehna, WM; Abdelrahman, MA; Nocentini, A; Bua, S; Al-Rashood, ST; Hassan, GS; Bonardi, A; Almehizia, AA; Alkahtani, HM; Alharbi, A; Gratteri, P; Supuran, CT. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde. Product Details of 93-02-7

In the presented work, we report the synthesis of a series of 4-benzylidene-2-phenyl-5(4H)-imidazolone-based benzenesulfonamides 7a-f via the Erlenmeyer-Plochl reaction. All the prepared imidazolones 7a-f were evaluated as inhibitors of human (h) carbonic anhydrases (CA, EC 4.2.1.1) cytosolic isoforms hCA I and II, as well as transmembrane tumor-associated isoforms hCA IX and XII. All the tested hCA isoforms were inhibited by the prepared imidazolones 7a-f in variable degrees with the following KIs ranges: 673.2-8169 nM for hCA I, 61.2-592.1 nM for hCA II, 23-155.4 nM for hCA XI, and 21.8-179.6 nM for hCA XII. In particular, imidazolones 7a, 7e, and 7f exhibited good selectivity towards the tumor-associated isoforms (CAs IX and XII) over the off-target cytosolic (CAs I and II) with selectivity index (SI) in the range of 6.2-19.4 and 3.3-8, respectively. Moreover, imidazolones 7a-f were screened for their anticancer activity in one dose (10(-5) M) assay against a panel of 60 cancer cell lines according to US-NCI protocol. Furthermore, 7a, 7e and 7f were evaluated for their anti-proliferative activity against colorectal cancer HCT-116 and breast cancer MCF-7 cell lines. Furthermore, 7e and 7f were screened for cell cycle disturbance and apoptosis induction in HCT-116 cells. Finally, a molecular docking study was carried out to rationalize the obtained results.

Product Details of 93-02-7. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Eldehna, WM; Abdelrahman, MA; Nocentini, A; Bua, S; Al-Rashood, ST; Hassan, GS; Bonardi, A; Almehizia, AA; Alkahtani, HM; Alharbi, A; Gratteri, P; Supuran, CT or concate me.

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Recently I am researching about RING-CLOSING METATHESIS; BASE-PROMOTED REARRANGEMENT; CLAISEN REARRANGEMENT; POLYCYCLIC REARRANGEMENTS; ETHYL DIAZOACETATE; CHEMISTRY; SYSTEMS; SYN; CIS; (D3)-TRISHOMOCUBANE, Saw an article supported by the DRDO (Defence Research and Development Organization), New Delhi [ARDB/01/1041849/M/1]; DST (Department of Science and Technology)Department of Science & Technology (India) [SR/S2/JCB-33/2010]; University Grants Commission (UGC), New DelhiUniversity Grants Commission, India. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Kotha, S; Cheekatla, SR. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde. Computed Properties of C9H10O3

The design and synthesis of highly decorated cage [4.3.2] propellanes and D-3-trishomocubanes have been reported via ring-closing metathesis (RCM), [4 + 2] cycloaddition and acid-catalyzed rearrangement as key steps. These cage polycycles were prepared starting with inexpensive synthons such as 2,5-dimethoxybenzaldehyde and endo-dicyclopentadiene. Propellanes containing fused spiro[4.4]nonane ring system was realized by RCM protocol. Interestingly, the dimethoxy cage propellane derivative was observed instead of the rearranged product with Lewis acid such as BF3 center dot MeOH. Several intricate cage structures were synthesized from rearrangement approach that are difficult to generate by conventional routes.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Kotha, S; Cheekatla, SR or concate me.. Computed Properties of C9H10O3

Reference:
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Name: 2,5-Dimethoxybenzaldehyde. Kolli, MK; Palani, E; Govindasamy, C; Katta, VR in [Kolli, Murali Krishna; Palani, Elamathi; Govindasamy, Chandrasekar] VIT Univ, Sch Adv Sci, Div Chem, Chennai 600127, Tamil Nadu, India; [Govindasamy, Chandrasekar] Imam Abdulrahman Bin Faisal Univ, IRMC, Dammam 31441, Saudi Arabia; [Kolli, Murali Krishna; Katta, Vishweshwar Rao] GVK Biosci Pvt Ltd, Dept Med Chem, IDA Nacharam, Hyderabad 500076, Telangana, India published Highly efficient one-pot synthesis of alpha-aminophosphonates using nanoporous AlSBA-15 catalyst in a three-component system in 2020.0, Cited 89.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7.

Nanoporous AlSBA-15 catalysts with different nSi/nAl ratios (41, 129, and 210) were synthesized using a hydrothermal method. These catalysts were characterized by XRD, N-2 sorption, TPD-NH3, FT-IR, SEM and TEM. XRD analyses of AlSBA-15 catalysts confirmed the presence of well-ordered crystalline structure with p6mm symmetry. The specific surface area and specific pore volume of the AlSBA-15 catalysts are in the range of 480 to 757 m(2)/g and 0.65 to 0.95 cm(3)/g, respectively. The catalytic performance of nanoporous AlSBA-15 catalysts are used as an outstanding catalytic system for one-pot synthesis of alpha-aminophosphonates via Kabachnik-Fields reaction in a three-component system using amines (primary/secondary), carbonyl compounds (aldehydes/ketones) and diethyl phosphite. The major advantages of the present contributions are excellent yields, short reaction time, simple experimental technique, high chemo-selectivity, catalyst recyclability, easy work-up procedure and green approach. Three-component synthesis of alpha-aminophosphonates follows first imine formation from amine and aldehyde/ketone followed by phosphate addition. The experimental findings suggest that the nanoporous AlSBA-15 catalysts can be recycled and reused up to six cycles without any loss in the catalytic performance.

Name: 2,5-Dimethoxybenzaldehyde. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Kolli, MK; Palani, E; Govindasamy, C; Katta, VR or concate me.

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Recommanded Product: 93-02-7. In 2020 CHEMISTRYSELECT published article about GREEN FLUORESCENT PROTEIN; GFP CHROMOPHORE ANALOGS; ENHANCEMENT; CHEMISTRY; MIMICS; YLIDES; PROBE in [Sokolov, Anatolii I.; Myasnyanko, Ivan N.; Baleeva, Nadezhda S.; Baranov, Mikhail S.] Russian Acad Sci, Inst Bioorgan Chem, Miklukho Maklaya 16-10, Moscow 117997, Russia; [Baranov, Mikhail S.] Russian Acad Sci, Pirogov Russian Natl Russia Res Med Univ Inst Bio, Miklukho Maklaya 16-10, Moscow 117997, Russia in 2020, Cited 34. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7.

We propose a new protocol for synthesis of the arylidene-1H-imidazol-5(4H)-ones which is based onO-alkylation of amidoacetates using triethyloxonium tetrafluoroborate leading to carboximidates. These imidates have long been used in the synthesis of imidazolones by [2+3] cycloaddition reaction with Schiff bases. However, diversity of carboximidates prepared by the common techniques was limited. The protocol we proposed eliminated these limitations. Using this technique, a number of derivatives of the green fluorescent protein (GFP) and asFP chromophores were synthesized, and influence of the C2 residue on their optical properties was studied.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Sokolov, AI; Myasnyanko, IN; Baleeva, NS; Baranov, MS or concate me.. Recommanded Product: 93-02-7

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Recently I am researching about BETA-HEMATIN FORMATION; IN-VITRO; POTENTIAL ANTIMALARIAL; MOLECULAR-MECHANISM; HEMOZOIN FORMATION; MALARIA; ANTICANCER; QUERCETIN; DERIVATIVES; INHIBITION, Saw an article supported by the CDCH-UCV [PG.06-8276-2011/2]. Published in SPRINGER BIRKHAUSER in NEW YORK ,Authors: Charris, JE; Monasterios, MC; Acosta, ME; Rodriguez, MA; Gamboa, ND; Martinez, GP; Rojas, HR; Mijares, MR; De Sanctis, JB. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde. Safety of 2,5-Dimethoxybenzaldehyde

A series of quinoline-chalcone (E)-1-[3 or 4-(7-chloroquinolin-4-ylamino) phenyl]-3-(phenyl substituted) prop-2-ene-1-one (4, 5), and quinoline-pyrazoline hybrids 7-Chloro-N-[3 or 4-(4,5-dihydro-5-(phenyl-substituted)-1H-pyrazol-3-yl] phenyl) quinoline-4-amine (6, 7) were synthesized with the aim of achieving an antimalarial and anticancer dual action. Most of the compounds showed significant inhibition (%>80) of beta-hematin formation. The existing structures were tested in vivo as potential antimalarials in mice infected with P. berghei ANKA, chloroquine susceptible strain. Some of the compounds exhibited antimalarial activity comparable to that of chloroquine. Moreover, the compounds induce cell death on two human cancer cell lines (Jurkat E6.1 and HL60) without affecting the primary culture of human lymphocytes. Flow cytometry analysis confirmed the increase in apoptotic cell death after 24 h. Based on the structural analysis, these quinoline hybrids represent new compounds potentially useful for malaria end leukemia treatments.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Charris, JE; Monasterios, MC; Acosta, ME; Rodriguez, MA; Gamboa, ND; Martinez, GP; Rojas, HR; Mijares, MR; De Sanctis, JB or concate me.. Safety of 2,5-Dimethoxybenzaldehyde

Reference:
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