What unique challenges do researchers face in 93-02-7

SDS of cas: 93-02-7. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Khan, B; Naiyer, A; Athar, F; Ali, S; Thakur, SC or concate me.

I found the field of Biochemistry & Molecular Biology; Biophysics very interesting. Saw the article Synthesis, characterization and anti-inflammatory activity evaluation of 1,2,4-triazole and its derivatives as a potential scaffold for the synthesis of drugs against prostaglandin-endoperoxide synthase published in 2021. SDS of cas: 93-02-7, Reprint Addresses Thakur, SC (corresponding author), Cent Univ, Jamia Millia Islamia, Ctr Interdisciplinary Res Basic Sci, New Delhi 110025, India.; Thakur, SC (corresponding author), Jamia Hamdard, BIF, DBT BTISNet Bioinformat Infrastruct Facil, New Delhi, India.. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde

Substituted 1,2,4-triazole nucleus is common in several drugs used in a variety of clinical conditions including infections, hypoglycemia, hypertension and cancer. In this study, we synthesized 1,2,4-triazole and its 16 hydrazone derivatives (B1-B16), characterized them by IR, NMR and Mass spectroscopy, and evaluated their radical scavenging and anti-inflammatory activities in vitro and in vivo. Out of 16 derivatives, five (B1, B5, B6, B9, and B13) demonstrated a significant radical scavenging and anti-inflammatory activity in vitro. B6, which possessed two electron-donating hydroxyl groups, was most active among all. Molecular docking and MD simulation of the complex of B6 with prostaglandin-endoperoxide synthase (PTGS) or cyclooxygenase (COX) showed that B6 occupied celecoxib binding site in COX with high affinity (the binding free energy of the complex with COX-1 was -10.5, and -11.2 kcal/mol with COX-2). Maximum anti-inflammatory activity was also shown by the B6 derivative in vivo, in the rat model of carrageenan-induced inflammation. B6, along with four other derivatives (B1, B5, B9 and B13) exhibited 80-90% free radical scavenging activity. The IC50 values of these compounds were >= 40 mu M. Griess nitrite and dichloro-dihydro-fluorescein-diacetate assays suggested a significant inhibition of nitric oxide and reactive oxygen species, especially by B6 and B9. Taken together, out of 16 derivatives, B6 is reported to have highest anti-inflammatory and antioxidant activity at a low dose level, which may be attributed to its two electron-donating hydroxyls. B6 is proposed to be an important scaffold for the synthesis of new drugs against PTGS for use in a myriad of inflammatory and infectious diseases. Communicated by Ramaswamy H. Sarma

SDS of cas: 93-02-7. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Khan, B; Naiyer, A; Athar, F; Ali, S; Thakur, SC or concate me.

Reference:
Isothiazole – Wikipedia,
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About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Taha, M; Alkadi, KAA; Ismail, NH; Imran, S; Adam, A; Kashif, SM; Shah, SAA; Jamil, W; Sidiqqui, S; Khan, KM or concate me.. SDS of cas: 93-02-7

SDS of cas: 93-02-7. Taha, M; Alkadi, KAA; Ismail, NH; Imran, S; Adam, A; Kashif, SM; Shah, SAA; Jamil, W; Sidiqqui, S; Khan, KM in [Taha, Muhammad; Ismail, Nor Hadiani; Imran, Syahrul; Shah, Syed Adnan Ali] Univ Teknol MARA UiTM, Atta Ur Rahman Inst Nat Prod Discovery, Puncak Alam Campus, Bandar Puncak Alam 42300, Selangor, Malaysia; [Taha, Muhammad; Ismail, Nor Hadiani; Imran, Syahrul] Univ Teknol MARA UiTM, Fac Appl Sci, Shah Alam 40450, Selangor, Malaysia; [Alkadi, Khaled A. A.; Adam, Aishah; Shah, Syed Adnan Ali] Univ Teknol MARA UiTM, Fac Pharm, Puncak Alam Campus, Bandar Puncak Alam 42300, Selangor Darul, Malaysia; [Kashif, Syed Muhammad; Jamil, Waqas] Univ Sindh, Inst Adv Res Studies Chem Sci, Jamshoro 76080, Pakistan; [Sidiqqui, Salman; Khan, Khalid Mohammed] Univ Karachi, Int Ctr Chem & Biol Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan published Antiglycation and antioxidant potential of novel imidazo[4,5-b]pyridine benzohydrazones in 2019.0, Cited 45.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7.

A series consisting of 30 novel imidazo[4,5-b]pyridine benzohydrazones have been synthesized and evaluated for their antiglycation activity as well as their antioxidative potential. The synthetic part involves a 3-step reaction in which a pyridine diamine was being converted into a imidazo[4,5-b]pyridine, which was then subjected through another reaction to yield benzohydrazide. Subsequently, the attained benzohydrazide of imidazo[4,5-b]pyridine was used to synthesize the target molecules after treating them with the appropriate benzohydrazone derivatives. The derivatives were evaluated for the antiglycation and antioxidant activities. Result obtained showed that di and trihydroxy substituted compounds showed good activity with compound 25 (140.16 +/- 0.36 mu M) having the most potent antiglycation activity, which is twice lower than Rutin. The results also showed certain correlation between antiglycation activities with DPPH radical scavenging model as well as FRAP which indicated the participation of antioxidative effect in inhibiting glycation activity. (C) 2015 The Authors. Published by Elsevier B.V.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Taha, M; Alkadi, KAA; Ismail, NH; Imran, S; Adam, A; Kashif, SM; Shah, SAA; Jamil, W; Sidiqqui, S; Khan, KM or concate me.. SDS of cas: 93-02-7

Reference:
Isothiazole – Wikipedia,
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What advice would you give a new faculty member or graduate student interested in a career C9H10O3

Safety of 2,5-Dimethoxybenzaldehyde. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Tang, JH; Liu, LL; Yang, SR; Cong, XF; Luo, MM; Zeng, XM or concate me.

An article Chemoselective Cross-Coupling between Two Different and Unactivated C(aryl)-O Bonds Enabled by Chromium Catalysis WOS:000529959000001 published article about CARBON-HETEROATOM BONDS; GRIGNARD-REAGENTS; AROMATIC KETONES; ARYL HALIDES; NI; ETHERS; ACTIVATION; CLEAVAGE; EXPLORATION; ANISOLES in [Tang, Jinghua; Yang, Shangru; Cong, Xuefeng; Luo, Meiming; Zeng, Xiaoming] Sichuan Univ, Coll Chem, Key Lab Green Chem & Technol, Minist Educ, Chengdu 610064, Peoples R China; [Liu, Liu Leo] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA in 2020.0, Cited 60.0. Safety of 2,5-Dimethoxybenzaldehyde. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7

We report here the first example of cross-coupling between two different and unactivated C(aryl)-O bonds with chromium catalysis. The combination of a low-cost Cr(II) salt, 4,4′-di-tart-butyl-2,2′-dipyridyl (dtbpy) as the ligand, and magnesium as the reductant shows high reactivity in promoting the reductive cross-coupling of aryl methyl ether derivatives with aryl esters by cleavage and coupling of two different C(aryl)-O bonds under mild conditions. The formation of active low-valent Cr species by reduction of CrCl2 with Mg can be considered, which prefers to initially activate the C(aryl)-O bond of phenyl methyl ether with the chelation help of dtbpy and an o-imine auxiliary. The subsequent consecutive reduction, second C(aryl)-O activation, and reductive elimination allow for the achievement of selective cross-coupling of C(aryl)-O/C(aryl)-O bonds.

Safety of 2,5-Dimethoxybenzaldehyde. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Tang, JH; Liu, LL; Yang, SR; Cong, XF; Luo, MM; Zeng, XM or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Chemical Properties and Facts of 2,5-Dimethoxybenzaldehyde

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Golla, R; Kumar, PR; Suchethan, PA; Foro, S; Nagaraju, G or concate me.. Recommanded Product: 2,5-Dimethoxybenzaldehyde

Authors Golla, R; Kumar, PR; Suchethan, PA; Foro, S; Nagaraju, G in ELSEVIER published article about SUPRAMOLECULAR INTERACTIONS; RUTHENIUM(II) COMPLEXES; REVERSIBLE REDOX; METAL-COMPLEXES; TERPYRIDINE; LIGAND; HETEROCYCLES in [Golla, Ramesh; Kumar, P. Raghavendra; Suchethan, P. A.] Tumkur Univ, Univ Coll Sci, Dept Studies & Res Chem, Tumakuru 572103, Karnataka, India; [Foro, Sabine] Tech Univ Darmstadt, Inst Mat Sci, Petersenstr 23, D-64287 Darmstadt, Germany; [Nagaraju, G.] Siddaganga Inst Technol, Dept Chem, Tumakuru 572103, Karnataka, India in 2020.0, Cited 55.0. Recommanded Product: 2,5-Dimethoxybenzaldehyde. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7

Four new 4′-dimethoxyphenyl-(2,6-di-2-pyrazinyl) pyridines (1-4) were synthesised by a facile one-pot method using 2-acetylpyrazine and n,n’-dimethoxybanzaldehydes. All compounds (1-4) were characterised by H-1 and C-13{H-1} NMR, and FT-IR spectroscopy. The molecular structure of compounds 1, 2, and 3 was also confirmed by single crystal X-ray diffraction. There exists CH center dot center dot center dot N, CH center dot center dot center dot O and C center dot center dot center dot C aromatic stacking type of intermolecular secondary interactions which resulted into supramolecular structures in compounds 1-3. The Hirshfeld surface analysis was carried out for the confirmation of intermolecular secondary interactions. The dihedral angles between substituted dimethoxyphenyl ring (B) and central pyridine (A) and pyrazine rings (C and D) are in the range of 33-45 degrees. The photophysical properties were studied by UV-Visible and fluorescence spectroscopy and electrochemical properties by cyclic voltammetry. In the UV-Visible spectra, the compounds, 1-4 showed two strong bands at lambda(max), 236-238 and 284-293 nm attributed to the intramolecular charge transfer (pi-pi*) transitions. When these compounds were excited at 350 nm observed emission bands at lambda(em), 463, 511, 462, and 407 nm respectively. The compounds, 1-3 were showed an oxidation peak, (E-OX, 1.18, 1.57 and 1.25 V) but compound 4 showed two oxidation peaks (E-OX, 1.20 and 1.84 V). Astonishingly, only compound, 3 have shown a reduction peak at (E-red, 1.33 V) but there was no reduction peak in 1, 2 and 4. This shows that the compound, 3 undergo reversible redox reaction. (C) 2019 Elsevier B.V. All rights reserved.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Golla, R; Kumar, PR; Suchethan, PA; Foro, S; Nagaraju, G or concate me.. Recommanded Product: 2,5-Dimethoxybenzaldehyde

Reference:
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What unique challenges do researchers face in C9H10O3

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Przhevalskii, NM; Laypanov, RK; Tokmakov, GP; Lukina, IV; Vershinkin, DA; Tafeenko, VA or concate me.. Formula: C9H10O3

Formula: C9H10O3. Authors Przhevalskii, NM; Laypanov, RK; Tokmakov, GP; Lukina, IV; Vershinkin, DA; Tafeenko, VA in SPRINGER published article about in [Przhevalskii, N. M.; Laypanov, R. K.; Tokmakov, G. P.; Lukina, I., V; Vershinkin, D. A.] Russian State Agr Univ, Moscow Timiryazev Agr Acad, 49 Ul Timiryazevskaya, Moscow 127434, Russia; [Tafeenko, V. A.] Lomonosov Moscow State Univ, Dept Chem, Build 3,1 Leninskie Gory, Moscow 119992, Russia in 2021.0, Cited 24.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7

New pyranopyridonotryptamines 3 were synthesized by a three-component reaction of pyridonotryptamines 1, aromatic aldehydes 2, and malononitrile. The structures of compounds 3 were confirmed by X-ray crystallography. A series of compounds 3 underwent primary screening for the effect on the course of mitosis in seeds of plants of the species Allium cepa L.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Przhevalskii, NM; Laypanov, RK; Tokmakov, GP; Lukina, IV; Vershinkin, DA; Tafeenko, VA or concate me.. Formula: C9H10O3

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Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

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About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Teja, C; Khan, FRN or concate me.. Recommanded Product: 2,5-Dimethoxybenzaldehyde

Teja, C; Khan, FRN in [Teja, Chitrala; Khan, Fazlur Rahman Nawaz] Vellore Inst Technol, Sch Adv Sci, Organ & Med Chem Res Lab, Vellore 632014, Tamil Nadu, India published Tetrabutylammonium-Bromide-Promoted Synthesis of Spirooxindoles through Alkyne-Aldehyde C-C Coupling and 1,3-Dipolar Cycloaddition Using Ytterbium Triflate Catalyst in 2020.0, Cited 37.0. Recommanded Product: 2,5-Dimethoxybenzaldehyde. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7.

Tetrabutylammonium-bromide promoted, ytterbium triflate catalyzed one-pot domino synthesis of spirooxindoles is described. The hydration-condensation of alkyne,1aldehyde,2C-C coupling followed by 1,3-dipolar cycloaddition of in-situ generated azomethine ylide from Isatin,3and L-proline,4 aor sarcosine,4 bfurnished novel spirooxindoles,5under solvent-free green-chemical conditions, in high regio and stereo selectivities and yields. The regio and stereochemistry of the synthesized derivatives were characterized by 2D NMR Spectroscopic studies.

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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

What advice would you give a new faculty member or graduate student interested in a career 2,5-Dimethoxybenzaldehyde

Category: isothiazole. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Kadu, VD; Mali, GA; Khadul, SP; Kothe, GJ or concate me.

I found the field of Chemistry very interesting. Saw the article Simple practical method for synthesis of trisubstituted imidazoles: an efficient copper catalyzed multicomponent reaction published in 2021.0. Category: isothiazole, Reprint Addresses Kadu, VD (corresponding author), Punyashlok Ahilyadevi Holkar Solapur Univ, Sch Chem Sci, Solapur 413255, Maharashtra, India.. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde

A rapid practical process has been developed for synthesis of 2,4,5-trisubstituted-imidazoles in excellent yields up to 95% from readily available starting materials. In this CuI catalyzed synthesis, trisubstituted imidazoles were afforded in short reaction times, wherein the substrate scope is well explored with benzoin as well as benzil reacting with different aldehydes in the presence of ammonium acetate as the nitrogen source.

Category: isothiazole. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Kadu, VD; Mali, GA; Khadul, SP; Kothe, GJ or concate me.

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Isothiazole – Wikipedia,
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When did you first realize you had a special interest and talent inC9H10O3

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Abdel-Halim, M; Tinsley, H; Keeton, AB; Weam, M; Atta, NH; Hammam, MA; Hefnawy, A; Hartmann, RW; Engel, M; Piazza, GA; Abadi, AH or concate me.. COA of Formula: C9H10O3

COA of Formula: C9H10O3. In 2020.0 BIOORG CHEM published article about CELL-GROWTH INHIBITORS; CYCLOOXYGENASE-2 INHIBITORS; BIOLOGICAL EVALUATION; ALPHA; CONSEQUENCES; METABOLISM; ANALOGS in [Abdel-Halim, Mohammad; Weam, Mohammed; Atta, Noha H.; Hammam, Mennatallah A.; Hefnawy, Amr; Abadi, Ashraf H.] German Univ Cairo, Fac Pharm & Biotechnol, Dept Pharmaceut Chem, Cairo 11835, Egypt; [Tinsley, Heather] Univ Montevallo, Dept Biol, Montevallo, AL USA; [Keeton, Adam B.; Piazza, Gary A.] Univ S Alabama, Mitchell Canc Inst, Dept Pharmacol, Drug Discovery Res Ctr, Mobile, AL 36608 USA; [Hartmann, Rolf W.; Engel, Matthias] Saarland Univ, Pharmaceut & Med Chem, Campus C2-3, D-66123 Saarbrucken, Germany in 2020.0, Cited 44.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7.

Celecoxib, is a selective cyclooxygenase-2 (COX2) inhibitor with a 1,5-diaryl pyrazole scaffold. Celecoxib has a better safety profile compared to other COX2 inhibitors having side effects of systemic hypertension and thromboembolic complications. This may be partly attributed to an off-target activity involving phosphodiesterase 5 (PDE5) inhibition and the potentiation of NO/cGMP signalling allowing coronary vasodilation and aortic relaxation. Inspired by the structure of celecoxib, we synthesized a chemically diverse series of compounds containing a 1,3,5-trisubstituted pyrazoline scaffold to improve PDE5 inhibitory potency, while eliminating COX2 inhibitory activity. SAR studies for PDE5 inhibition revealed an essential role for a carboxylic acid functionality at the 1-phenyl and the importance of the non-planar pyrazoline core over the planar pyrazole with the 5-phenyl moiety tolerating a range of substituents. These modifications led to new PDE5 inhibitors with approximately 20-fold improved potency to inhibit PDE5 and no COX-2 inhibitory activity compared with celecoxib. PDE isozyme profiling of compound 11 revealed a favorable selectivity profile. These results suggest that trisubstituted pyrazolines provide a promising scaffold for further chemical optimization to identify novel PDE5 inhibitors with potential for less side effects compared with available PDE5 inhibitors used for the treatment of penile erectile dysfunction and pulmonary hypertension.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Abdel-Halim, M; Tinsley, H; Keeton, AB; Weam, M; Atta, NH; Hammam, MA; Hefnawy, A; Hartmann, RW; Engel, M; Piazza, GA; Abadi, AH or concate me.. COA of Formula: C9H10O3

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Chemical Properties and Facts of C9H10O3

Computed Properties of C9H10O3. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Singh, RK; Chaudhary, S; Prasad, DN; Kumar, S or concate me.

An article An Atom-Economic Efficient Synthesis of 1-Amidoalkyl-2-Naphthols Mediated By Hexachlorocyclotriphosphazene (HCCP) as a Novel Catalyst WOS:000483301600008 published article about ONE-POT PREPARATION; REUSABLE CATALYST; RECYCLABLE NANOCATALYST; CHEMISTRY; ACID in [Singh, Rajesh K.; Chaudhary, Shallu; Prasad, D. N.] Shivalik Coll Pharm, Dept Pharmaceut Chem, Nangal 140126, Punjab, India; [Kumar, Sahil] GD Goenka Univ, Sch Med & Allied Sci, Dept Pharm, Sohna 122103, Haryana, India in 2019.0, Cited 25.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7. Computed Properties of C9H10O3

A multicomponent one-pot atom-economic reaction is performed for an efficient synthesis of 1-amidoalkyl-2-naphthol from aromatic aldehydes, beta-naphthol and amide/urea promoted by hexachlorocyclotriphosphazene (HCCP). Various techniques such as stirring, microwave irradiation and thermal technique (hot plate and oil bath) were used in different solvents for the synthesis of 1-amidoalkyl-2-naphthol derivatives with moderate to excellent yield. Among the four methods, microwave irradiation and oil bath heating provide high yield as compared to the hot plate heating and stirring method. The low yield may be due to the formation of undesired side-products due to non-uniform heating.

Computed Properties of C9H10O3. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Singh, RK; Chaudhary, S; Prasad, DN; Kumar, S or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

What advice would you give a new faculty member or graduate student interested in a career 2,5-Dimethoxybenzaldehyde

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact de Oliveira, IM; Esteves, CHA; Darbem, MP; Pimenta, DC; Zukerman-Schpector, J; Ferreira, AG; Stefani, HA; Manarin, F or concate me.. Safety of 2,5-Dimethoxybenzaldehyde

In 2019.0 ADV SYNTH CATAL published article about LITHIUM-SELENIUM EXCHANGE; DIORGANYL DISELENIDES; CARBON-SELENIUM; BOND FORMATION; TELLURIUM; CHROMENES; CATALYSIS; METAL in [de Oliveira, Isadora M.] Univ Sao Paulo, Inst Quim, Dept Quim Fundamental, Sao Paulo, SP, Brazil; [Esteves, C. Henrique A.; Darbem, Mariana P.; Stefani, Helio A.] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Farm, Sao Paulo, SP, Brazil; [Pimenta, Daniel C.] Inst Butantan, Sao Paulo, SP, Brazil; [Zukerman-Schpector, Julio; Ferreira, Antonio G.] Univ Fed Sao Carlos, Dept Quim, Sao Carlos, SP, Brazil; [Manarin, Flavia] Univ Estadual Oeste Parana, CECE, Toledo, PR, Brazil in 2019.0, Cited 36.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7. Safety of 2,5-Dimethoxybenzaldehyde

The iron(III)-promoted synthesis of densely-substituted 4H-chalcogenchromene from organochalcogen propargylamines in the presence of diaryl dichalcogenides is reported. Subsequent C2-functionalization with electrophiles and potassium trifluoroborate salts via Suzuki-Miyaura coupling reaction are also presented. A plausible mechanism based on HRMS experiments is proposed and discussed.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact de Oliveira, IM; Esteves, CHA; Darbem, MP; Pimenta, DC; Zukerman-Schpector, J; Ferreira, AG; Stefani, HA; Manarin, F or concate me.. Safety of 2,5-Dimethoxybenzaldehyde

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com