Category: 93-02-7

Application In Synthesis of 2,5-Dimethoxybenzaldehyde. Authors Gein, VL; Kasimova, NN; Chashchina, SV; Starkova, AV; Syropyatov, BY in SPRINGER published article about in [Gein, V. L.; Kasimova, N. N.; Chashchina, S., V; Starkova, A., V; Syropyatov, B. Ya] Minist Hlth RF, Perm State Pharmaceut Acad, 2 Polevaya St, Perm 614990, Russia in 2019.0, Cited 8.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7

A series of 1-(2-aminopropyl)-5-aryl-4-acyl-3-hydroxy-3-pyrrolin-2-ones were synthesized by three-component reactions of 4-substituted 2,4-dioxobutanoic acid methyl esters with mixtures of an aromatic aldehyde and 1,2-diaminopropane. Products of their reactions with hydrazine, p-phenetidine, and acetic anhydride were obtained. The analgesic, anti-inflammatory, and antimicrobial activities and hemostatic effect of several compounds were studied.

Application In Synthesis of 2,5-Dimethoxybenzaldehyde. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Gein, VL; Kasimova, NN; Chashchina, SV; Starkova, AV; Syropyatov, BY or concate me.

Reference:
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I found the field of Chemistry; Science & Technology – Other Topics very interesting. Saw the article Microwave-assisted one-step rapid synthesis of dicyano imidazoles by HNO3 as a high efficient promoter published in 2021.0. Quality Control of 2,5-Dimethoxybenzaldehyde, Reprint Addresses Kalhor, M (corresponding author), Payame Noor Univ, Dept Chem, POB 19395-4697, Tehran, Iran.. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde

Microwave-activated synthesis is a special and remarkable technique in modern synthetic organic chemistry. In the current research, it is described the microwave-assisted synthesis of 2-aryl-4,5-dicarbonitrile imidazole derivatives via a one-step reaction between aromatic aldehydes and 2,3-diaminomaleonitrile (DAMN) using HNO3 as a metal-free catalyst and a strong oxidizing agent. The present methodology has significant advantages as like as one-step synthesis, shorter reaction times, available starting materials, and higher yields of products with easy purification process, cleaner reaction than the previously reported processes. The valuable benefits of this method have provided a promising prospect for easier, greener, and faster synthesis of diciano imidazoles.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Kalhor, M; Samiei, S; Mirshokraei, SA or concate me.. Quality Control of 2,5-Dimethoxybenzaldehyde

Reference:
Isothiazole – Wikipedia,
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In 2019.0 EUR J MED CHEM published article about RESPONSE-SURFACE METHODOLOGY; KABACHNIK-FIELDS REACTION; ONE-POT SYNTHESIS; ANTITUMOR ACTIVITIES; PHOSPHONATE DERIVATIVES; PLATINUM(II) COMPLEXES; CELL BIOLOGY; CYTOTOXICITY; MECHANISM; TRIFLUOROMETHANESULFONATE in [Ewies, Ewies F.; El-Hussieny, Marwa; El-Sayed, Naglaa F.] Natl Res Ctr, Organometall & Organometalloid Chem Dept, 33 ElBohouth St, Giza 12622, Egypt; [Fouad, Marwa A.] Cairo Univ, Fac Pharm, Pharmaceut Chem Dept, Kasr El Aini St, Cairo 11562, Egypt in 2019.0, Cited 84.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7. Safety of 2,5-Dimethoxybenzaldehyde

alpha-aminophosphonate oxadiazoles (5a-m) were prepared in high yields by reacting of 1,3,4-oxadiazole acetohydrazide (3) with appropriate aldehydes and diethyl phosphite under Kabachnik-Fields conditions using Iron triflate as a catalyst. The reaction conditions were optimized using D-optimal experimental design. Possible reaction mechanisms were considered, and structures of the new products were based upon compatible elementary and spectroscopic evidence. In vitro antitumor activities of these compounds were evaluated against human cancer cell lines of colon (HCT116), breast (MCF7) and liver (HepG2) and compared with anticancer drug, Doxorubicin, employing standard MIT assay. Compounds 5i and 5l demonstrated good antiproliferative activities against HCT116 tumor cells comparable to doxorubicin with low cytotoxicity towards normal fetal colon cell (FHC). Additionally, their capacity to activate apoptosis cascade was studied in HCT116 cell line by investigating the activation of proteolytic caspases cascade, the levels of Cytochrome C, Bax and Bcl-2. Active caspase-3 level was enhanced by 6-8-folds in HCT116 cell line when stimulated with compounds 5i and 5l compared to the control. The level of Caspases 8 & 9 was also increased signifying that intrinsic and extrinsic pathways are both activated. They also induced Bax and down regulated Bcl-2 protein level in addition to over-expressing Cytochrome C level in HCT116 cell line. Also, HCT116 cell cycle was mainly arrested at the Pre-G1 and G2/M phases when treated with compounds 5i and 5l. (C) 2019 Elsevier Masson SAS. All rights reserved.

Safety of 2,5-Dimethoxybenzaldehyde. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Ewies, EF; El-Hussieny, M; El-Sayed, NF; Fouad, MA or concate me.

Reference:
Isothiazole – Wikipedia,
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Godugu, K; Gundala, TR; Bodapati, R; Yadala, VDS; Loka, SS; Nallagondu, CGR in [Godugu, Kumar; Gundala, Thrivikram Reddy; Yadala, Venkata Divya Sri; Loka, Subramanyam Sarma; Nallagondu, Chinna Gangi Reddy] Yogi Vemana Univ, Sch Phys Sci, Dept Chem, Kadapa 516003, Andhra Pradesh, India; [Bodapati, Ramakrishna] Univ Hyderabad, Sch Chem, Cent Univ PO, Hyderabad 500046, India published Synthesis, photophysical and electrochemical properties of donor-acceptor type hydrazinyl thiazolyl coumarins in 2020, Cited 108. COA of Formula: C9H10O3. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7.

A water-mediated MCR strategy has been developed for the synthesis of donor (D)-acceptor(A) type hydrazinyl thiazolyl coumarins (HTCs) (4) in excellent isolated yields (90-98%) from a three component reaction of aromatic aldehydes/ketones (1), thiosemicarbazide (2) and 3-(2-bromoacetyl)-2H-chromen-2-one (3) catalyzed by an environmentally compatible montmorillonite (MMT) K10 clay at RT for 20-40 min. The present MCR strategy has several advantages that include its wide-spread substrate scope, eco-compatibility, short reaction times and products that do not require chromatographic purification. Besides, the method is simple to perform, it is easy to construct C-N, C=N and C-S bonds in one pot and the reaction can be scaled up to a gram level. Moreover, the catalyst can be reused 7 times without significant change of activity. The photophysical properties of the synthesized D-A type HTCs are also studied and it was noticed that the fluorescence properties can be varied with the position of electron donating group on the aromatic ring of aldehyde/ketone of HTCs. Most of the compounds exhibited bright fluorescence in chloroform (1.0 x 10(-5) M) with emission maxima ranging from 409 to 511 nm and large Stokes shifts. Further, the HOMO and LUMO energy levels of the HTCs are found in the range from -5.65 eV to -5.22 eV and -2.67 eV to -2.17 eV, respectively, and in good agreement with the reported hole transporting materials.

COA of Formula: C9H10O3. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Godugu, K; Gundala, TR; Bodapati, R; Yadala, VDS; Loka, SS; Nallagondu, CGR or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

In 2019.0 ORG LETT published article about ASYMMETRIC ALKYLATION; ARYLACETIC ACIDS; PSEUDOEPHEDRINE; OXAZOLIDINONES; DILITHIUM; CARBON in [Yu, Kai; Miao, Bukeyan; Wang, Wenqi; Zakarian, Armen] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA; [Miao, Bukeyan] Univ Michigan, Sch Med, Dept Internal Med Hematol Oncol, 930 N Univ Ave, Ann Arbor, MI 48109 USA in 2019.0, Cited 33.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7. COA of Formula: C9H10O3

Efficient asymmetric alkylation of beta,gamma-unsaturated carboxylic acids without prior functionalization is enabled by chiral lithium amides. Enantioselectivity is imparted by a putative mixed lithium amide-enediolate aggregate that acts a traceless auxiliary formed in situ, allowing for a direct asymmetric alkylation and a simple recovery of the chiral reagent.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Yu, K; Miao, B; Wang, WQ; Zakarian, A or concate me.. COA of Formula: C9H10O3

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Authors Ximenis, M; Mulet, J; Sala, S; Sala, F; Criado, M; Gonzalez-Muniz, R; de Vega, MJP in MDPI published article about in [Ximenis, Marta; Gonzalez-Muniz, Rosario; Perez de Vega, Maria Jesus] CSIC, IQM, Inst Quim Med, Juan Cierva 3, Madrid 28006, Spain; [Mulet, Jose; Sala, Salvador; Sala, Francisco; Criado, Manuel] Univ Miguel Hernandez, CSIC, Inst Neurociencias, Sant Joan dAlacant 03050, Spain in 2021.0, Cited 65.0. SDS of cas: 93-02-7. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7

The alpha 7 nicotinic acetylcholine receptor (alpha 7 nAChR) is a ligand-gated ion channel that is involved in cognition disorders, schizophrenia, pain, and inflammation. Allosteric modulation of this receptor might be advantageous to reduce the toxicity in comparison with full agonists. Our previous results obtained with some hydroxy-chalcones, which were identified as positive allosteric modulators (PAMs) of alpha 7 nAChR, prompted us to evaluate the potential of some structurally related naturally occurring flavonoids and curcuminoids and some synthetic curcumin analogues, with the aim of identifying new allosteric modulators of the alpha 7 nAChR. Biological evaluation showed that phloretin, demethoxycurcumin, and bis-demethoxicurcuming behave as PAMs of alpha 7 nAChR. In addition, some new curcumin derivatives were able to enhance the signal evoked by ACh; the activity values found for the tetrahydrocurcuminoid analog 23 were especially promising.

SDS of cas: 93-02-7. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Ximenis, M; Mulet, J; Sala, S; Sala, F; Criado, M; Gonzalez-Muniz, R; de Vega, MJP or concate me.

Reference:
Isothiazole – Wikipedia,
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An article NH4OAc-Promoted Domino Route to Hydroxyarylated Unsymmetrical Pyridines under Neat Conditions WOS:000516665800033 published article about CYCLIC SULFAMIDATE IMINES; HIGHLY SUBSTITUTED PYRIDINES; N-SULFONYL KETIMINES; BAYLIS-HILLMAN ACETATES; ONE-POT SYNTHESIS; MODULAR SYNTHESIS; TOPOISOMERASE-I; HYDROXYLATION; CYCLOADDITION; CONDENSATION in [Prakash, Meher; Gudimella, Santosh K.; Lodhi, Rajni; Guiri, Soumitra; Samanta, Sampak] Indian Inst Technol Indore, Discipline Chem, Indore 453552, Madhya Pradesh, India in 2020.0, Cited 81.0. Formula: C9H10O3. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7

A new metal-, oxidant-, and solvent-free ecofriendly domino method has been established for modular synthesis of a diverse range of medicinally promising hydroxyarylated unsymmetrical pyridines in good to high chemical yields with an excellent regioselectivity. This domino process involves a range of N-sulfonyl ketimines as C,N-binucleophiles, enolizable ketones, and aromatic/heteroaromatic aldehydes using ammonium acetate as an ideal promoter under neat conditions, which creates two new C-C bonds and one C-N bond. Notably, the neutral reaction conditions are mild enough to tolerate a range of functionalities and cover a variety of substrates, thus bestowing a powerful avenue to access tri- and tetrasubstituted pyridines including carbo- and heterocyclic fused ones. Interestingly, a practical, scalable, and high-yielding synthesis of pyridylphenol derivatives was successfully accomplished by our unique method.

Formula: C9H10O3. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Prakash, M; Gudimella, SK; Lodhi, R; Guiri, S; Samanta, S or concate me.

Reference:
Isothiazole – Wikipedia,
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HPLC of Formula: C9H10O3. Recently I am researching about BIOLOGICAL EVALUATION; NATURAL COMPOUNDS; CYCLE ARREST; FLAVONOIDS; ESTABLISHMENT; APOPTOSIS; INHIBITORS; MODEL, Saw an article supported by the Leading Research Groups support project. Published in MDPI in BASEL ,Authors: Pawlak, A; Henklewska, M; Suarez, BH; Luzny, M; Kozlowska, E; Obminska-Mrukowicz, B; Janeczko, T. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde

Chalcones are interesting candidates for anti-cancer drugs due to the ease of their synthesis and their extensive biological activity. The study presents antitumor activity of newly synthesized chalcone analogues with a methoxy group on a panel of canine lymphoma and leukemia cell lines. The antiproliferative effect of the 2 ‘-hydroxychalcone and its methoxylated derivatives was evaluated in MTT assay after 48 h of treatment in different concentrations. The proapoptotic activity was studied by cytometric analysis of cells stained with Annexin V/FITC and propidium iodide and by measure caspases 3/7 and 8 activation. The DNA damage was evaluated by Western blot analysis of phosphorylated histone H2AX. The new compounds had selective antiproliferative activity against the studied cell lines, the most effective were the 2 ‘-hydroxy-2 ”,5 ”-dimethoxychalcone and 2 ‘-hydroxy-4 ‘,6 ‘-dimethoxychalcone. 2 ‘-Hydroxychalcone and the two most active derivatives induced apoptosis and caspases participation, but some percentage of necrotic cells was also observed. Comparing phosphatidylserine externalization after treatment with the different compounds it was noted that the addition of two methoxy groups increased the proapoptotic potential. The most active compounds triggered DNA damage even in the cell lines resistant to chalcone-induced apoptosis. The results confirmed that the analogues could have anticancer potential in the treatment of canine lymphoma or leukemia.

HPLC of Formula: C9H10O3. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Pawlak, A; Henklewska, M; Suarez, BH; Luzny, M; Kozlowska, E; Obminska-Mrukowicz, B; Janeczko, T or concate me.

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In 2020.0 J ORG CHEM published article about CHLORIDE-SODIUM-IODIDE; CERIUM(III) CHLORIDE; DEMETHYLATING AGENT; BORON-TRICHLORIDE; EFFICIENT; MILD; DEPROTECTION; REAGENTS; REARRANGEMENT; DEALKYLATION in [Sang, Dayong; Yue, Huaxin; Zhao, Zhengdong; Yang, Pengtao; Tian, Juan] Jingchu Univ Technol, Coll Chem Engn & Pharm, Jingmen 448000, Hubei, Peoples R China; [Yue, Huaxin] Wuhan Inst Technol, Sch Chem Engn & Pharm, Wuhan 430205, Hubei, Peoples R China in 2020.0, Cited 67.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7. Computed Properties of C9H10O3

Aluminum triiodide is harnessed by N,N-dimethylformamide dimethyl acetal (DMF-DMA) for the selective cleavage of ethers via neighboring group participation. Various acid-labile functional groups, including carboxylate, allyl, tert-butyldimethylsilyl (TBS), and tert-butoxycarbonyl (Boc), suffer the conditions intact. The method offers an efficient approach to cleaving catechol monoalkyl ethers and to uncovering phenols from acetal-type protecting groups such as methoxymethyl (MOM), methoxyethoxymethyl (MEM), and tetrahydropyranyl (THP) chemoselectively.

About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Sang, DY; Yue, HX; Zhao, ZD; Yang, PT; Tian, J or concate me.. Computed Properties of C9H10O3

Reference:
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Name: 2,5-Dimethoxybenzaldehyde. In 2019.0 CHEMISTRYSELECT published article about MANGANESE-DIOXIDE OXIDATION; ACID ANHYDRIDE MIXTURES; DIMETHYL-SULFOXIDE; SECONDARY ALCOHOLS; HIGHLY EFFICIENT; AEROBIC OXIDATION; MOLECULAR-OXYGEN; IONIC LIQUID; KETONES; CONVERSION in [Sheikhi, Ehsan; Adib, Mehdi; Karajabad, Morteza Akherati; Rezaei, Narjes] Univ Tehran, Sch Chem, Coll Sci, 16 Azar St,POB 14155-6455, Tehran, Iran in 2019.0, Cited 69.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7.

A metal-free and selective oxidation of benzylic alcohols which leads to the direct and sustainable production of benzaldehydes has been developed. Compared with former known oxidation reactions like Swern, Pfitzner-Moffatt, Parikh-Doering, and Corey-Kim oxidations, this oxidation approach introduces the HCA as an easily available, safer and less expensive reagent, and also because of the simple removing of chloroform. In addition, it is not necessary to add any metal, acid or base for the oxidation of benzylic alcohols. The oxidation is proceeded in DMSO and also under solvent-free conditions in excellent yields.

Name: 2,5-Dimethoxybenzaldehyde. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Sheikhi, E; Adib, M; Karajabad, MA; Rezaei, N or concate me.

Reference:
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