Category: 93-02-7

Recently I am researching about ONE-POT SYNTHESIS; MULTICOMPONENT SYNTHESIS; INDAZOLE DERIVATIVES; GREEN SYNTHESIS; CONSTRUCTION, Saw an article supported by the . Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Jadhav, AM; Balwe, SG; Jeong, YT. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde. COA of Formula: C9H10O3

A convenient and highly efficient method for the synthesis of novel polyheterocyclic chromeno pyrimido [1,2-b]indazolone derivatives via a three-component condensation of 1H-indazol-3-amine, aldehydes and 4-hydroxycoumarin catalyzed by Bronsted acid ionic liquid [Et3NH]HSO4] under solvent-free reaction conditions is presented. This ionic liquid is air and water stable and easyto prepare from amine and acid. The main advantages of this protocol includes short reaction time, excellent yield, easy work-up, operational simplicity, a wide range of functional group tolerance and column chromatography-free method. The catalyst can be recovered and reused for at least four runs without any significant impact on the product yields. (C) 2019 Elsevier Ltd. All rights reserved.

COA of Formula: C9H10O3. Welcome to talk about 93-02-7, If you have any questions, you can contact Jadhav, AM; Balwe, SG; Jeong, YT or send Email.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Authors Abdel-Mohsen, HT; Abd El-Meguid, EA; El Kerdawy, AM; Mahmoud, AEE; Ali, MM in WILEY-V C H VERLAG GMBH published article about PROTEIN-KINASE INHIBITORS; DRUG-RESISTANCE; RECEPTOR 2; GROWTH; BENZOTHIAZOLES; ANGIOGENESIS; DISCOVERY; VEGFR-2; POTENT; MECHANISMS in [Abdel-Mohsen, Heba T.; Abd El-Meguid, Eman A.] Natl Res Ctr, Div Pharmaceut & Drug Ind Res, Dept Chem Nat & Microbial Prod, El Buhouth St,POB 12622, Cairo, Egypt; [El Kerdawy, Ahmed M.] Cairo Univ, Fac Pharm, Dept Pharmaceut Chem, Cairo, Egypt; [El Kerdawy, Ahmed M.] New Giza Univ, Fac Pharm, Dept Pharmaceut Chem, Cairo, Egypt; [Mahmoud, Abeer E. E.; Ali, Mamdouh M.] Natl Res Ctr, Div Genet Engn & Biotechnol, Dept Biochem, Cairo, Egypt in 2020.0, Cited 75.0. HPLC of Formula: C9H10O3. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7

A novel series of 2-arylbenzothiazoles 9, 10, and 12 were designed and synthesized as VEGFR-2/FGFR-1/PDGFR-beta multiangiokinase inhibitors targeting breast cancer. Structural elongation of the known 2-phenylbenzothiazole scaffold (type I protein kinase inhibitor [PKI]), was carried out to afford series of type II PKIs 9, 10, and 12. Compounds 9d, 9f, 9i, and 9k exhibited potent multikinase inhibitory activity with IC50 values of 0.19, 0.18, 0.17, and 0.13 mu M, respectively, against VEGFR-2; IC50 values of 0.28, 0.37, 0.19, and 0.27 mu M, respectively, against FGFR-1; and IC50 values of 0.07, 0.04, 0.08, and 0.14 mu M, respectively, against PDGFR-beta. Moreover, the synthesized benzothiazoles demonstrated promising cytotoxic activity against the MCF-7 cell line. The most potent benzothiazoles 9d and 9i exhibited IC50 values of 7.83 and 6.58 mu M, respectively, on the MCF-7 cell line in comparison to sorafenib (III), which showed IC50 = 4.33 mu M. Additionally, 9d and 9i showed VEGFR-2 inhibitory activity in MCF-7 cells of 81% and 83% when compared with sorafenib (III), which showed 88% inhibition. Molecular docking of the designed compounds in the VEGFR-2 and FGFR-1 active sites showed the accommodation of the 2-phenylbenzothiazole moiety, as reported, in the hinge region of the receptor tyrosine kinase (RTK)-binding site, while the amide moiety is involved in hydrogen bond interactions with the key amino acids in the gate area; this in turn directs the aryl group to the hydrophobic allosteric back pocket of the RTKs in a type II-like binding mode. The synthesized benzothiazoles showed satisfactory ADME properties for further optimization in drug discovery.

Welcome to talk about 93-02-7, If you have any questions, you can contact Abdel-Mohsen, HT; Abd El-Meguid, EA; El Kerdawy, AM; Mahmoud, AEE; Ali, MM or send Email.. HPLC of Formula: C9H10O3

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article An efficient protocol for synthesis of novel polyheterocyclic chromeno pyrimido[1,2-b]indazolone derivatives using [Et3NH][HSO4] as a reusable catalyst under solvent-free conditions WOS:000498291800006 published article about ONE-POT SYNTHESIS; MULTICOMPONENT SYNTHESIS; INDAZOLE DERIVATIVES; GREEN SYNTHESIS; CONSTRUCTION in [Jadhav, Amol Maruti; Balwe, Sandip Gangadhar; Jeong, Yeon Tae] Pukyong Natl Univ, Dept Image Sci & Engn, Busan 608737, South Korea in 2019.0, Cited 33.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7. Application In Synthesis of 2,5-Dimethoxybenzaldehyde

A convenient and highly efficient method for the synthesis of novel polyheterocyclic chromeno pyrimido [1,2-b]indazolone derivatives via a three-component condensation of 1H-indazol-3-amine, aldehydes and 4-hydroxycoumarin catalyzed by Bronsted acid ionic liquid [Et3NH]HSO4] under solvent-free reaction conditions is presented. This ionic liquid is air and water stable and easyto prepare from amine and acid. The main advantages of this protocol includes short reaction time, excellent yield, easy work-up, operational simplicity, a wide range of functional group tolerance and column chromatography-free method. The catalyst can be recovered and reused for at least four runs without any significant impact on the product yields. (C) 2019 Elsevier Ltd. All rights reserved.

Application In Synthesis of 2,5-Dimethoxybenzaldehyde. About 2,5-Dimethoxybenzaldehyde, If you have any questions, you can contact Jadhav, AM; Balwe, SG; Jeong, YT or concate me.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

HPLC of Formula: C9H10O3. Authors Wadhwa, P; Jain, P; Jadhav, HR in BENTHAM SCIENCE PUBL LTD published article about in [Wadhwa, Pankaj; Jain, Priti; Jadhav, Hemant R.] Birla Inst Technol & Sci, Dept Pharm, Pilani 333031, Rajasthan, India; [Wadhwa, Pankaj] Lovely Profess Univ, Lovely Sch Pharmaceut Sci, Phagwara 144401, Punjab, India; [Jain, Priti] RC Patel Inst Pharmaceut Educ & Res, Shirpur, Dhule, India in 2021.0, Cited 18.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7

Aim: To design, synthesis and in vitro evaluation of 4-oxo-6-substituted phenyl-2-thioxo 1,2,3,4-tetrahydropyrimidine-5-carbonitrile derivatives as HIV integrase strand transfer inhibitors. Background: Human immunodeficiency virus-1 (HIV-1), a member of retroviridae family, is the primary causative agent of acquired immunodeficiency syndrome (AIDS). Three enzymes viz: integrase (IN), reverse transcriptase (RT) and protease play important role in its replication cycle. HIV-1 integrase is responsible for the incorporation of viral DNA into human chromosomal DNA by catalyzing two independent reactions, 3′-processing (3′-P) and strand transfer (ST), which are observed as the point of no-return in HIV infection. Objective: To develop inhibitors against HIV integrase strand transfer step. Methods: Our previous results indicated that tetrahydro pyrimidine-5-carboxamide derivatives are potent HIV-1 IN inhibitors (unpublished results from our laboratory). Taking clue from above studies and our own experience, we hypothesized 4-oxo-6-substituted phenyl-2-thioxo 1,2,3,4-tetrahydropyrimidine-5-carbonitrile analogues (14a to 14n) as inhibitors of HIV-1 Integrase strand transfer. Prototype compound 14 can be viewed as hybrid structure having characteristics of dihydropyrimidine derivatives 10-12 and tyrphostin 13. Results: A total of fourteen derivatives of 4-oxo-6-substituted phenyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbonitrile (14a-14n) were synthesized and evaluated using HIV-1 Integrase Assay Kit (Xpressbio Life Science Products, USA). The percentage inhibition of all compounds was investigated at 10 mu M concentration and IC50 value of few highly active compounds was studied. The obtained results were validated by in silico molecular docking study using Glide (maestro version 9.3, Schrodinger suite) in extra precision (XP) mode. Conclusion: Fourteen 4-oxo-6-substituted phenyl-2-thioxo 1,2,3,4-tetrahydropyrimidine-5-carbonitrile analogues were synthesized and evaluated for HIV-1 IN inhibitory activity. Three compounds 14a, 14e, and 14h exhibited significant percentage inhibition of HIV-1 IN. There was good in vitro – in silico correlation. However, none of the derivative was active against HIV-1 and HIV-2 below their cytotoxic concentration. It needs to be seen whether these compounds can be explored further for their anti-HIV or cytotoxic potential.

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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Name: 2,5-Dimethoxybenzaldehyde. Authors Krishnaraj, C; Jena, HS; Bourda, L; Laemont, A; Pachfule, P; Roeser, J; Chandran, CV; Borgmans, S; Rogge, SMJ; Leus, K; Stevens, CV; Martens, JA; Van Speybroeck, V; Breynaert, E; Thomas, A; Van der Voort, P in AMER CHEMICAL SOC published article about in [Krishnaraj, Chidharth; Jena, Himanshu Sekhar; Bourda, Laurens; Laemont, Andreas; Leus, Karen; Van der Voort, Pascal] Univ Ghent, COMOC Ctr Ordered Mat Organometall & Catalysis, Dept Chem, B-9000 Ghent, Belgium; [Krishnaraj, Chidharth; Pachfule, Pradip; Roeser, Jerome; Thomas, Arne] Tech Univ Berlin, Dept Chem Funct Mat, D-10623 Berlin, Germany; [Bourda, Laurens] Univ Ghent, Dept Chem, XStruct Bioinorgan Chem, B-9000 Ghent, Belgium; [Chandran, C. Vinod; Martens, Johan A.; Breynaert, Eric] NMRCoRe, B-3001 Leuven, Belgium; [Chandran, C. Vinod; Martens, Johan A.; Breynaert, Eric] Katholieke Univ Leuven, Dept Microbial & Mol Syst M2S, Ctr Surface Chem & Catalysis Characterisat & Appl, B-3001 Leuven, Belgium; [Borgmans, Sander; Rogge, Sven M. J.; Van Speybroeck, Veronique] Univ Ghent, Ctr Mol Modeling CMM, B-9052 Zwijnaarde, Belgium; [Stevens, Christian, V] Univ Ghent, Dept Green Chem & Technol, Synth Bioresources & Bioorgan Chem Res Grp SynBio, B-9000 Ghent, Belgium in 2020.0, Cited 44.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7

Photocatalytic reduction of molecular oxygen is a promising route toward sustainable production of hydrogen peroxide (H2O2). This challenging process requires photoactive semiconductors enabling solar energy driven generation and separation of electrons and holes with high charge transfer kinetics. Covalent organic frameworks (COFs) are an emerging class of photoactive semiconductors, tunable at a molecular level for high charge carrier generation and transfer. Herein, we report two newly designed two-dimensional COFs based on a (diarylamino)benzene linker that form a Kagome (kgm) lattice and show strong visible light absorption. Their high crystallinity and large surface areas (up to 1165 m(2)center dot g(-1)) allow efficient charge transfer and diffusion. The diarylamine (donor) unit promotes strong reduction properties, enabling these COFs to efficiently reduce oxygen to form H2O2. Overall, the use of a metal-free, recyclable photocatalytic system allows efficient photocatalytic solar transformations.

Name: 2,5-Dimethoxybenzaldehyde. Welcome to talk about 93-02-7, If you have any questions, you can contact Krishnaraj, C; Jena, HS; Bourda, L; Laemont, A; Pachfule, P; Roeser, J; Chandran, CV; Borgmans, S; Rogge, SMJ; Leus, K; Stevens, CV; Martens, JA; Van Speybroeck, V; Breynaert, E; Thomas, A; Van der Voort, P or send Email.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Computed Properties of C9H10O3. In 2020.0 INORG CHEM COMMUN published article about ONE-POT SYNTHESIS; MULTICOMPONENT REACTIONS; 3-COMPONENT REACTION; EFFICIENT SYNTHESIS; DESIGN; ALDEHYDES; FACILE in [Maddila, Surya Narayana; Maddila, Suresh; Bhaskaruni, Sandeep V. H. S.; Kerru, Nagaraju; Jonnalagadda, Sreekantha B.] Univ KwaZulu Natal, Sch Chem & Phys, Westville Campus,Chiltern Hills, ZA-4000 Durban, South Africa in 2020.0, Cited 40.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7.

Three different loadings of MnO2 on hydroxyapatite (MnO2/Hap) were synthesized and the hydroxyapatite supported MnO2 materials were characterized by several analytical techniques including FT-IR, P-XRD, TEM and SEM analysis. 3% MnO(2/)HAp material proved highly efficient catalyst for the synthesis of a series of ten pyran-carboxamide derivatives (yield 91-98%) in aqueous medium at room temperature (RT) conditions, via one-pot multi-component reaction, of which nine were new moieties. The prominent features of the protocol are excellent yields, high atom efficiency, short reaction times (15 min), recyclable catalyst and no need for column separation.

Computed Properties of C9H10O3. Bye, fridends, I hope you can learn more about C9H10O3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Safety of 2,5-Dimethoxybenzaldehyde. Authors Wadhwa, P; Jain, P; Jadhav, HR in BENTHAM SCIENCE PUBL LTD published article about in [Wadhwa, Pankaj; Jain, Priti; Jadhav, Hemant R.] Birla Inst Technol & Sci, Dept Pharm, Pilani 333031, Rajasthan, India; [Wadhwa, Pankaj] Lovely Profess Univ, Lovely Sch Pharmaceut Sci, Phagwara 144401, Punjab, India; [Jain, Priti] RC Patel Inst Pharmaceut Educ & Res, Shirpur, Dhule, India in 2021.0, Cited 18.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7

Aim: To design, synthesis and in vitro evaluation of 4-oxo-6-substituted phenyl-2-thioxo 1,2,3,4-tetrahydropyrimidine-5-carbonitrile derivatives as HIV integrase strand transfer inhibitors. Background: Human immunodeficiency virus-1 (HIV-1), a member of retroviridae family, is the primary causative agent of acquired immunodeficiency syndrome (AIDS). Three enzymes viz: integrase (IN), reverse transcriptase (RT) and protease play important role in its replication cycle. HIV-1 integrase is responsible for the incorporation of viral DNA into human chromosomal DNA by catalyzing two independent reactions, 3′-processing (3′-P) and strand transfer (ST), which are observed as the point of no-return in HIV infection. Objective: To develop inhibitors against HIV integrase strand transfer step. Methods: Our previous results indicated that tetrahydro pyrimidine-5-carboxamide derivatives are potent HIV-1 IN inhibitors (unpublished results from our laboratory). Taking clue from above studies and our own experience, we hypothesized 4-oxo-6-substituted phenyl-2-thioxo 1,2,3,4-tetrahydropyrimidine-5-carbonitrile analogues (14a to 14n) as inhibitors of HIV-1 Integrase strand transfer. Prototype compound 14 can be viewed as hybrid structure having characteristics of dihydropyrimidine derivatives 10-12 and tyrphostin 13. Results: A total of fourteen derivatives of 4-oxo-6-substituted phenyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbonitrile (14a-14n) were synthesized and evaluated using HIV-1 Integrase Assay Kit (Xpressbio Life Science Products, USA). The percentage inhibition of all compounds was investigated at 10 mu M concentration and IC50 value of few highly active compounds was studied. The obtained results were validated by in silico molecular docking study using Glide (maestro version 9.3, Schrodinger suite) in extra precision (XP) mode. Conclusion: Fourteen 4-oxo-6-substituted phenyl-2-thioxo 1,2,3,4-tetrahydropyrimidine-5-carbonitrile analogues were synthesized and evaluated for HIV-1 IN inhibitory activity. Three compounds 14a, 14e, and 14h exhibited significant percentage inhibition of HIV-1 IN. There was good in vitro – in silico correlation. However, none of the derivative was active against HIV-1 and HIV-2 below their cytotoxic concentration. It needs to be seen whether these compounds can be explored further for their anti-HIV or cytotoxic potential.

Safety of 2,5-Dimethoxybenzaldehyde. Welcome to talk about 93-02-7, If you have any questions, you can contact Wadhwa, P; Jain, P; Jadhav, HR or send Email.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Sidir, YG; Aslan, C; Berber, H; Sidir, I in [Sidir, Yadigar Gulseven; Sidir, Isa] Bitlis Eren Univ, Dept Phys, Fac Arts & Sci, TR-13000 Bitlis, Turkey; [Aslan, Cebrail] Bitlis Eren Univ, Inst Sci, Dept Phys, TR-13000 Bitlis, Turkey; [Berber, Halil] Anadolu Univ, Dept Chem, Fac Sci, TR-26470 Eskisehir, Turkey published The electronic structure, solvatochromism, and electric dipole moments of new Schiff base derivatives using absorbance and fluorescence spectra in 2019.0, Cited 81.0. COA of Formula: C9H10O3. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7.

The electronic structure and electronic transitions of four new mono Schiff base derivatives are interpreted by using absorption and fluorescence spectra including 28 different solution medium. Electrical dipole moments have been found by means of four different quantum mechanical methods based on solvatochromic shifts like Lippert-Mataga, Bakhshiev, modified Bilot-Kawski, and Reichardt methods. Quantitative researches of solvent-solute interactions are done by using Kamlet-Taft and Catalan parameters. In absorption and fluorescence spectra, bathochromic shift occurs with dispersion-polarization forces effect. The electronic transitions and electronic structure of these molecules have changed to dependent on solvent medium property. HOMO, LUMO, MEP, and SAS were calculated using B3LYP/6-311G(d,p) level of theory. Solvatochromism, photophysical properties, and electronic structure were discussed in detail. The dipole moments in ground-state and excited-state have not almost change.

COA of Formula: C9H10O3. Bye, fridends, I hope you can learn more about C9H10O3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

Category: isothiazole. Recently I am researching about AMIDE BOND FORMATION; AL MIXED OXIDES; N-ARYLATION; MAGNETIC NANOPARTICLES; HYDROTALCITE; ARYL; COPPER; EFFICIENT; AMINOCARBONYLATION; FORMAMIDES, Saw an article supported by the Vinati Organics Ltd.; Godrej Consumer Products Limited (GCPL); IICT-RMIT Joint Research program; J.C. Bose grant; GCPL; J.C. Bose National Fellowship (DST, GoI). Published in ELSEVIER in AMSTERDAM ,Authors: Samudrala, PS; Nakhate, AV; Gupta, SSR; Rasal, KB; Deshmukh, GP; Gadipelly, CR; Theegala, S; Dumbre, DK; Periasamy, S; Komandur, VRC; Bhargava, SK; Mannepalli, LK. The CAS is 93-02-7. Through research, I have a further understanding and discovery of 2,5-Dimethoxybenzaldehyde

Hydrotalcite-derived (HT-derived) oxide catalysts were synthesised from hydrotalcite-like (HT-like) materials prepared by co-precipitation method (Cu-Al, Cu-Fe, Mg-Al, Mg-Fe, Ni-Fe and Ni-Al) followed by calcination and their catalytic activity was studied for oxidative amidation of carboxylic acids and substituted benzaldehydes with N,N-dimethylformamide (DMF). Catalyst screening was done using benzoic acid and DMF as a model reaction. Subsequently, we have optimised the reaction with different reaction parameters, catalyst loading, temperatures and oxidants. Cu-Fe HT-derived oxide catalyst showed excellent activity towards oxidative amidation using TBHP as an oxidant at 80 degrees C in 10 h. The fresh and spent catalysts were thoroughly characterised by different analytical techniques; XRD, SEM, HRTEM, TPD, N-2 adsorption-desorption isotherm and XPS. Moreover, the catalyst was easily separated by simple filtration and reused up to four cycles without significant loss in catalytic activity.

Category: isothiazole. Bye, fridends, I hope you can learn more about C9H10O3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

An article Inversion of Enantioselectivity in Allene Gas versus Allyl Acetate Reductive Aldehyde Allylation Guided by Metal-Centered Stereogenicity: An Experimental and Computational Study WOS:000489204000035 published article about C BOND FORMATION; CARBONYL ALLYLATION; QUATERNARY STEREOCENTERS; H FUNCTIONALIZATION; ALCOHOL; HYDROGEN; PARAFORMALDEHYDE; CHEMISTRY in [Kim, Seung Wook; Meyer, Cole C.; Krische, Michael J.] Univ Texas Austin, Dept Chem, Austin, TX 78712 USA; [Mai, Binh Khanh; Liu, Peng] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA in 2019.0, Cited 44.0. The Name is 2,5-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 93-02-7. HPLC of Formula: C9H10O3

The use of gaseous allene as an ally! pronu-cleophile in enantioselective aldehyde reductive coupling is described. Notably, using the same antipode of chiral ligand, (S)-tol-BINAP, an inversion of enantioselectivity is observed for allene versus allyl acetate pronucleophiles. Experimental and computational studies corroborate intervention of diastereo-meric pi-allyliridium-C,O-benzoate complexes, which arise via allene hydrometalation (from a pentacoordinate iridium hydride) versus ally! acetate ionization (from a square planar iridium species).

Bye, fridends, I hope you can learn more about C9H10O3, If you have any questions, you can browse other blog as well. See you lster.. HPLC of Formula: C9H10O3

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com