Category: 91-40-7

Synthetic Route of 91-40-7, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 91-40-7, Name is 2-(Phenylamino)benzoic acid, SMILES is O=C(O)C1=CC=CC=C1NC2=CC=CC=C2, belongs to isothiazole compound. In a article, author is Li, Ling, introduce new discover of the category.

DBU-Promoted Demethoxylative Thioannulation of Alkynyl Oxime Ethers with Sulfur for the Synthesis of Bisisothiazole-4-yl Disulfides

An efficient synthesis of bisisothiazole-4-yl disulfides via the demethoxylative thioannulation of alkynyl oxime ethers with odorless elemental sulfur has been first developed. This transformation involves the N-O bond cleavage, the formation of multiple C-S and N-S bonds, providing an efficient way for constructions of both isothiazoles and disulfides. Straightforward elaboration of the products to isothiazole thioethers expands the synthetic utility of this reaction.

Synthetic Route of 91-40-7, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 91-40-7.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

 

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 91-40-7, Name is 2-(Phenylamino)benzoic acid, molecular formula is C13H11NO2. In an article, author is Fierro, CM,once mentioned of 91-40-7, Formula: C13H11NO2.

The formation and isolation of benzisothiazole rings from the reactions of oxime-thiophenolate ligands

The reaction of [Ni(eftp)] (eftp = N, N-ethylene(6-formyl-4-methyliminatothiophenolato)] with hydroxylamine hydrochloride in the presence of potassium acetate in MeOH resulted in the formation of [Ni(L)(2)], L = 2-mercapto-5-methyl-3-({2-[(5-methylbenzo[d]isothiazol-7-ylmethylene)-amino]-ethylimino)-methyl)-benzonitrile. A single-crystal X-ray diffraction structural determination showed that the oxime groups of the proposed new binucleating ligand had reacted to produce a nitrite and an isothiazole ring, while two ligand molecules combined with one Ni(II) ion to form a new complex with a cis-S2N2 square-planar geometry. Also, the reaction of 2,6-diformyl-4-methylphenyl disulfide with hydroxylamine in MeCN resulted in the synthesis of 5-methyl-2-oxybenzo[d]isothiazole-7-carbaldehyde oxime, where an isothiazole ring had formed via the cleavage of the disulfide bond. Again, a single-crystal X-ray diffraction study confirmed the presence of a benzisothiazole product. (c) 2006 Elsevier B.V. All rights reserved.

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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

 

In an article, author is Kossoski, F., once mentioned the application of 91-40-7, Computed Properties of C13H11NO2, Name is 2-(Phenylamino)benzoic acid, molecular formula is C13H11NO2, molecular weight is 213.2319, MDL number is MFCD00002421, category is isothiazole. Now introduce a scientific discovery about this category.

Low-energy electron scattering from the aza-derivatives of pyrrole, furan, and thiophene

We report elastic integral and differential cross sections for electron scattering from the aza-derivatives of pyrrole, furan, and thiophene, namely, pyrazole, imidazole, isoxazole, oxazole, isothiazole, and thiazole. The calculations were performed within the Schwinger multichannel method with pseudopotentials, with inclusion of static, exchange, and polarization interactions, for energies up to 10 eV. We found two pi* shape resonances and a high-lying sigma* shape resonance in each system. A sharp low-energy sigma* resonance was also identified in isothiazole and thiazole. Pyrazole and imidazole presented yet a broad low-lying sigma* resonance. The positions of the resonances agree very well with existing experimental results. We discuss the similarities and differences among the resonances of these compounds. (C) 2013 AIP Publishing LLC.

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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

 

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Product Details of 91-40-7, 91-40-7, Name is 2-(Phenylamino)benzoic acid, SMILES is O=C(O)C1=CC=CC=C1NC2=CC=CC=C2, belongs to isothiazole compound. In a document, author is Konstantinova, Lidia S., introduce the new discover.

4,6-Dinitrobenzo[c]isothiazole: synthesis and 1,3-dipolar cycloaddition to azomethine ylide

1,3-Dipolar cycloaddition of 4,6-dinitrobenzo[c]isothiazole to (N-methyl-N-methylideneammonio)methanide (2 equiv.) gives 5,8-dimethyl-3b,6b-dinitrodecahydroisothiazolo[3,4-e]pyrrolo[3,4-g]isoindole, whose structure was confirmed by X-ray diffraction analysis.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 91-40-7. Product Details of 91-40-7.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

 

In an article, author is Swiatek, Piotr, once mentioned the application of 91-40-7, Name is 2-(Phenylamino)benzoic acid, molecular formula is C13H11NO2, molecular weight is 213.2319, MDL number is MFCD00002421, category is isothiazole. Now introduce a scientific discovery about this category, Quality Control of 2-(Phenylamino)benzoic acid.

One of the main challenges for nowadays medicine is drugs selectivity. In COX-1 and COX-2, the active sites are composed of the same group of amino acids with the exception of the only one residue in position 523, in COX-1 is an isoleucine, while in COX-2 is a valine. Here, we presented a series of isothiazolopyridine/ benzisothiazole derivatives substituted differently into an isothiazole ring, which were synthesized and investigated for their potencies to inhibit COX-1 and COX-2 enzymes by colorimetric inhibitor screening assay. All the tested compounds inhibited the activity of COX-1, the effect on COX2 activity was differential. The mode of binding was characterized by a molecular docking study. Comparing biological activity of the investigated compounds, it was observed that compounds sharing the most similar position to flurbiprofen and meloxicam, representing the two main enzyme subdomains, achieved higher biological activity than others. It is directly related to the fit to the enzyme’s active site, which prevents too early dissociation of the compounds. (C) 2016 Elsevier Ltd. All rights reserved.

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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

 

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, 91-40-7, Name is 2-(Phenylamino)benzoic acid, SMILES is O=C(O)C1=CC=CC=C1NC2=CC=CC=C2, belongs to isothiazole compound. In a document, author is Duan, XG, introduce the new discover, HPLC of Formula: C13H11NO2.

Reaction of trithiazyl trichloride with active methylene compounds

Activated allylic compounds react with trithiazyl trichloride, (NSCl),, to give 1,2,5-thiadiazoles 1 and isothiazoles 2. An allylic 2-substituent normally prevents formation of an aromatic 1,2,5-thiadiazole, and isothiazole formation becomes the major pathway. Simple allylic compounds are not very reactive towards (NSCl)(3) but a terminal electron withdrawing group (CO2Et) enhances the reactivity. With unsymmetrical allylic compounds, isothiazole formation is regiospecific placing the more electron withdrawing group adjacent to the ring sulfur. 1,3-Diketones give 3-acyl-1,2,5-thiadiazoles; unsymmetrical 1,3-diketones give these thiadiazoles regiospecifically, explicable by cyclisation of an intermediate onto the more reactive carbonyl group. 1,4-Diketones give 3,4-diacyl-1,2,5-thiadiazoles; thus 1,2-dibenzoyl-ethane, -ethene and -ethyne all give 3,4-dibenzoylthiadiazole (40-44%). Many of these trithiazyl trichloride reactions provide attractive one-step routes to 1,2,5-thiadiazoles and isothiazoles.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 91-40-7 is helpful to your research. HPLC of Formula: C13H11NO2.

Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com