Category: 877265-23-1

877265-23-1,877265-23-1, 6-Bromobenzo[d]isothiazole is a isothiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

D. Benzo[d]isothiazole-6-carbonitrile. To a solution of 6-bromobenzo[d]isothiazole (205 mg, 0.96 mmol) in DMF (5 mL) was added dioxane (1 mL), tetrakis(triphenylphosphine)palladium(0) (167 mg, 0.144 mmol), and zinc cyanide (113 mg, 0.958 mmol). The reaction was heated to 95 C. with stirring for 2 hours, cooled, and the dioxane evaporated. The resulting solution was diluted with water and brine then extracted four times with dichloromethane. The organic solution was dried over anhydrous sodium sulfate, filtered, and volatiles evaporated. The resulting material was purified using chromatography on a normal phase silica gel column with 0 to 10% ethyl acetate in hexanes. Fractions containing clean product were combined and the solvent evaporated. The material was dried under vacuum at room temperature to give the title compound (118 mg, 77%).

As the paragraph descriping shows that 877265-23-1 is playing an increasingly important role.

Reference£º
Patent; D’Sidocky, Neil R.; Harris, Roy L.; Hegde, Sayee G.; Hilgraf, Robert; McCarrick, Margaret A.; McKie, Jeffrey A.; Mortensen, Deborah S.; Nadolny, Lisa; Perin-Ninkovic, Sophie M.; Sapienza, John J.; Wright, Jonathan L.; US2008/242694; (2008); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

6-Bromobenzo[d]isothiazole, cas is 877265-23-1, it is a common heterocyclic compound, the isothiazole compound, its synthesis route is as follows.,877265-23-1

6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]isothiazole. To a mixture of 6-bromobenzo[d]isothiazole (0.86 g, 4.0 mmol)(prepared as described in WO 2008/036308), potassium acetate (0.38 mL, 6.0 mmol), bis(pinacolato)diboron (1.3 g, 5.2 mmol), tris(dibenzylideneacetone)dipalladium (0) (0.18 g, 0.20 mmol), and tricyclohexylphosphine (0.12 g, 0.44 mmol) was added dioxane (5 mL). The resulting mixture was sealed and heated at 1 10C for 30 minutes under microwave irradiation. The mixture was cooled and passed through a short path of Celite, washing with DCM (3 x 10 mL). The combined organic phases were concentrated to give a residue that was purified by chromatography on silica gel (hexanes – 50 % EtOAc in hexanes) and triturat on with hexanes provided the product as a white powder (0.59 g, 56 %). LCMS (API-ES) m/z (%): 230.2 (100 %, M+H+); 1H NMR (400 MHz, CDCl3) delta ppm 8.95 (s, 1 H) 8.58 (s, 1 H) 7.91 – 8.02 (m, 2 H) 1.41 (s, 12 H).

As the rapid development of chemical substances, we look forward to future research findings about 877265-23-1

Reference£º
Patent; AMGEN INC.; WO2009/11871; (2009); A2;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.877265-23-1,6-Bromobenzo[d]isothiazole,as a common compound, the synthetic route is as follows.

877265-23-1, 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]isothiazole. To a mixture of 6-bromobenzo[d]isothiazole (0.86 g, 4.0 mmol)(prepared as described in WO 2008/036308), potassium acetate (0.38 mL, 6.0 mmol), bis(pinacolato)diboron (1.3 g, 5.2 mmol), tris(dibenzylideneacetone)dipalladium (0) (0.18 g, 0.20 mmol), and tricyclohexylphosphine (0.12 g, 0.44 mmol) was added dioxane (5 mL). The resulting mixture was sealed and heated at 1 10C for 30 minutes under microwave irradiation. The mixture was cooled and passed through a short path of Celite, washing with DCM (3 x 10 mL). The combined organic phases were concentrated to give a residue that was purified by chromatography on silica gel (hexanes – 50 % EtOAc in hexanes) and triturat on with hexanes provided the product as a white powder (0.59 g, 56 %). LCMS (API-ES) m/z (%): 230.2 (100 %, M+H+); 1H NMR (400 MHz, CDCl3) delta ppm 8.95 (s, 1 H) 8.58 (s, 1 H) 7.91 – 8.02 (m, 2 H) 1.41 (s, 12 H).

The synthetic route of 877265-23-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AMGEN INC.; WO2009/11871; (2009); A2;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

The isothiazole compound, cas is 877265-23-1 name is 6-Bromobenzo[d]isothiazole, mainly used in chemical industry, its synthesis route is as follows.,877265-23-1

D. Benzo[d]isothiazole-6-carbonitrile. To a solution of 6-bromobenzo[d]isothiazole (205 mg, 0.96 mmol) in DMF (5 mL) was added dioxane (1 mL), tetrakis(triphenylphosphine)palladium(0) (167 mg, 0.144 mmol), and zinc cyanide (113 mg, 0.958 mmol). The reaction was heated to 95 C. with stirring for 2 hours, cooled, and the dioxane evaporated. The resulting solution was diluted with water and brine then extracted four times with dichloromethane. The organic solution was dried over anhydrous sodium sulfate, filtered, and volatiles evaporated. The resulting material was purified using chromatography on a normal phase silica gel column with 0 to 10% ethyl acetate in hexanes. Fractions containing clean product were combined and the solvent evaporated. The material was dried under vacuum at room temperature to give the title compound (118 mg, 77%).

With the rapid development of chemical substances, we look forward to future research findings about 877265-23-1

Reference£º
Patent; D’Sidocky, Neil R.; Harris, Roy L.; Hegde, Sayee G.; Hilgraf, Robert; McCarrick, Margaret A.; McKie, Jeffrey A.; Mortensen, Deborah S.; Nadolny, Lisa; Perin-Ninkovic, Sophie M.; Sapienza, John J.; Wright, Jonathan L.; US2008/242694; (2008); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com