Category: 87691-88-1

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.87691-88-1,3-Piperazinobenzisothiazole hydrochloride,as a common compound, the synthetic route is as follows.

87691-88-1, N-[4-(2-BROMO-ETHYL)-2-FLUORO-PHENYL]-ACETAMIDE (0.2609 g, 1.00 mmol), 3-piperazin-1-yl-benzo [AGISOTHIAZOLE HYDROCHLORIDE (0.3887 g, 1.52 mmol), potassium carbonate (0.2109 g, 1.53 mmol), potassium iodide (0.1662 g, 1.00 MMOL) and acetonitrile (5.0 mL) were added to a Smith microwave reaction tube containing a magnetic stir bar and then crimped shut. The reaction was run on a Smith Personal Chemistry microwave at 140 C for 0.5 h. After removing the crimped septum, the contents were transferred to a separatory funnel with water (10 mL) and extracted with methylene chloride (2 x 40 mL). The combined organic extracts were dried over anhydrous sodium sulfate, filtered and concentrated to give an oily residue. Purification by MPLC on a 40M silica gel cartridge using a linear gradient over 1 h of 0-3% methanol in methylene chloride provided 0.1230 g (0.309 MMOL) of the product as an off-white solid after drying in vacuo. Several fractions containing product and a by-product (0.1487 g total) were discarded. Yield : 31% ; MS (APCI) : 399.2 [M+H] + ; Anal. Calcd. For C2IH23FN40S’0. 25 H20 : C, 62.59 ; H, 5.88 ; N, 13.90. Found: C, 62.72 ; H, 5.53 ; N, 13.53.

87691-88-1 3-Piperazinobenzisothiazole hydrochloride 11521711, aisothiazole compound, is more and more widely used in various.

Reference£º
Patent; WARNER-LAMBERT COMPANY LLC; WO2004/41793; (2004); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

87691-88-1,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.87691-88-1,3-Piperazinobenzisothiazole hydrochloride,as a common compound, the synthetic route is as follows.

EXAMPLE 121; 3-f4-[2-(3′, 4′-DIHYDRO-1’H-SPI RO [91, 31DIOXOLANE-2. 2′- NAPHTHALEN1-6′-YL)-ETHYL1-PI PERAZI N-1-YLi- BENZOrDlISOTHIAZOLE; A mixture of 3- (piperazin-1-yl) benzo [d] isothiazole hydrochloride (349 mg, 1.36 mmol) and the title compound from Preparation 36 (530 mg, 1.36 mmol) with anhydrous K2CO3 (376 mg, 2.72 mmol) in acetonitrile (20 ml) was heated at reflux for 24 hours. The reaction mixture was filtered and the filtrate was concentrated. The crude product was purified by elution through a flash column (silica gel 60,230-400 mesh, 1: 1 hexanes: EtOAc) to give a clear oil which crystallized on standing, 497 mg (84%). MS (APCI) : (M + 1) + = 436.’H-NMR (CDCI3, a) : 7.89 (d, 1 H, J = 7.8 Hz), 7.80 (d, 1 H, J = 8. 1 Hz), 7.46 (t, 1 H, J = 7. 3,7. 3 Hz), 7.34 (t, 1 H, J = 7. 3, 7.3 Hz), 6.98 (s, 3H), 4.01 (s, 4H), 3.58 (br s, 4H), 2.95-2. 65 (m, 12H), 1.93 (t, 2H, J = 6.8, 6.8 Hz). CHN, calc’d for C25H29N302S : C, 68.94% ; H, 6. 71% ; N, 9.65% ; found: C, 68.75% ; H, 6.70% ; N, 9.54%.

The synthetic route of 87691-88-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; WARNER-LAMBERT COMPANY LLC?; WO2005/56540; (2005); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

87691-88-1, 3-Piperazinobenzisothiazole hydrochloride is a isothiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 3-piperazin-1-yl-benzo[d]isothiazole hydrochloride (1.62 g, 6.34 mmol), product from Example 88B (1.90 g, 7.61 mmol), anhydrous potassium carbonate (1.93 g, 13.9 mmol), and potassium iodide (200 mg) in acetonitrile (80 ml) was refluxed for 48 hours. The reaction mixture was concentrated and the residue was partitioned between methylene chloride and water. The organic layer was dried over magnesium sulfate, filtered, and concentrated. The crude product was eluted through a flash column (silica gel 60, 230-400 mesh, EtOAc) to give a clear, viscous oil which crystallized on standing. Yield = 1.16 g (42%); MS(APCI), (M + 1)+ = 433. 1H-NMR (DMSO-d6, delta) 8.03 (d, 2H, J = 9.0 Hz), 7.53 (t, 1H, J =8.1, 7.8 Hz), 7.40 (t, 1H, J = 8.1, 7.3 Hz), 6.87 (d, 2H, J = 7.3 Hz), 3.69 (t, 2H, J = 5.9, 5.9 Hz), 3.26-3.43 (m, 6H), 2.46-2.78 (m, 12H), 1.78 (m, 2H). CHN: calculated for C25H28N4OS; C, 69.41%, H, 6.52%, N, 12.95%; found C, 69.28%, H, 6.60%, N, 12.65%.

The synthetic route of 87691-88-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; WARNER-LAMBERT COMPANY LLC; WO2004/26864; (2004); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.87691-88-1,3-Piperazinobenzisothiazole hydrochloride,as a common compound, the synthetic route is as follows.

The above intermediate IV (0.01 mol) and the hydrochloride salt of the piperazine compound (V) (0.01 mol) were dissolved in DMF (100 mL).In the middle, K2CO3 (0.02 mol) was added. 3-(4-(3-(5-methoxy-1H-indol-3-yl)propyl)peridine was obtained according to the procedureZyridin-1-yl)benzo[d]isothiazole (VI-9) hydrochloride 3.32 g, yield 75%.

As the paragraph descriping shows that 87691-88-1 is playing an increasingly important role.

Reference£º
Patent; Shanghai Pharmaceutical Industry Institute; China Pharmaceutical Industry Zongyuan; Li Jianqi; Gu Zhengsong; Zhou Ainan; Xiao Ying; (26 pag.)CN109467554; (2019); A;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

87691-88-1, 3-Piperazinobenzisothiazole hydrochloride is a isothiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of the product from step C above (5.0016 g, 17.476 mmol), 3-piperazin-1-yl-benzo[d]isothiazole hydrochloride (4.4811 g, 17.520 mmol), potassium carbonate (4.8299 g, 34.946 mmol) and potassium iodine (0.2903 g, 1.749 mmol) were reacted in acetonitrile (29.0 mL) in a CEM MARS5 microwave reactor for 1 h at 200 C. The reaction was cooled to room temperature, diluted with H2O and filtered. The solid was washed with H2O and hexanes. The resulting solid was purified by MPLC [silica gel, 100 % methylene chloride (CH2CI2) to 3 % MeOH/CH2CI2 over 1 h, then hold at 3 % MeOH/CH2CI2] to give 5.6591 g, (12.065 mmol, 69 %) of the titled compound as an off-white crystalline solid. LC-MS (APCI): (M-1)+ = 469.1, (M+1)+ = 471.0

87691-88-1 3-Piperazinobenzisothiazole hydrochloride 11521711, aisothiazole compound, is more and more widely used in various.

Reference£º
Patent; WARNER-LAMBERT COMPANY LLC; WO2004/26864; (2004); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

87691-88-1, 3-Piperazinobenzisothiazole hydrochloride is a isothiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5. Preparation of ZPR in the melt of Na C03 decahydrate. To the melt of Na2C03 decahydrate (40g) was added BITP HCl (lOg) and CEI (10.35g) and the mixture was heated at 95 C for 10 hours. After 10 h the conversion to ZRP was 88. 2% (% area by HPLC). To the reaction mixture water was added and the solid was filtrated and washed with water. After drying the solid weighs 17.14g (purity by HPLC 88%).; 7. Preparation of ZPR in the presence of NaCl. In a three necked flask was charged 40 ml brine, BITP HC1 (14. 1g), CEI (10.35g) and Na2C03 (14. 1g) ; the mixture was than heated at 90C for 16hours. After this the mixture was cooled, water was added and the solid was filtrated, washed with water and dried. The product weights after drying 16.9g (purity by HPLC 87.5%).

As the paragraph descriping shows that 87691-88-1 is playing an increasingly important role.

Reference£º
Patent; TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.; WO2005/40160; (2005); A2;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.87691-88-1,3-Piperazinobenzisothiazole hydrochloride,as a common compound, the synthetic route is as follows.

EXAMPLES 115-116; N-{5-[2-(4-BENZO[D]ISOTHIAZOL-3-YL-PIPERAZIN-1-YL)-ETHYL]-1, 1- DIMETHYL-INDAN-2-YL}-ACETAMIDE AND M-f6-r2- (4- BENZO [D]ISOTHIAZOL-3-YL-PIPERAZIN-1-YL)-ETHYL]-1,1- DIMETHYL-INDAN-2-YLT-ACETAMIDE; A mixture of compounds N-[5-(2-Chloroethyl)-1,1-dimethyl-indan-2-yl]- acetamide and N-[6-(2-Chloroethyl)-1,1-dimethyl-indan-2-yl]-acetamide (1.63 g, 6.15 mmol), 3-piperazin-1-yl-benzo [? isothiazole hydrochloride (1.96 g, 7.69 mmol), potassium carbonate (2.55 g, 18.4 mmol), sodium iodide (1.02 g, 6.76 mmol) in acetonitrile (120 mL) was stirred at reflux for 60 h. After removal of solvent, the residue was partitioned in CH2Ci2/H2O (200 mU50 mL). The organic layer was separated and the water layer was extracted with CH2Cl2 (60 mL). The combined organic extracts were washed with water, brine, dried over Na2SO4, and evaporated. The residue was purified by chromatography (silica gel, gradient from 1 to 2% MeOH/EtOAc) to provide two regioisomers N-{5-[2-(4-Benzo [? isothiazol- 3-yl-piperazin-1-yl)-ethyl]-1, 1-dimethyl-indan-2-yl}-acetamide (655 mg) and N {6- [2- (4-Benzo [d isothiazol-3-yl-piperazin-1-yl)-ethyl]-1, 1-dimethyl-indan- 2-yl}-acetamide (440 mg). EXAMPLE 115 N-{5-[2-(4-BENZO[D]ISOTHIAZOL-3-YL-PIPERAZIN-1-YL)-ETHYL]-1,1- DIMETHYL-INDAN-2-YLl-ACETAMIDE (655 mg, 24%) as a pale yellow solid : mp 58-68 C ;’H NMR (300 MHz, CDCl3) 67. 92 (d, J = 8.1 Hz, 1 H), 7.82 (d, J = 8.1 Hz, 1 H), 7.47 (td, J = 7.0, 0.9 Hz, 1H), 7.36 (td, J= 8.0, 1.0 Hz, 1H), 7.10-7. 05 (m, 3H), 5.53 (d, J= 9.5 Hz, 1 H), 4.57-4. 49 (m, 1 H), 3.61 (t, J = 4.8 Hz, 4H), 3.27 (dd, J = 7.3, 7.2 Hz, 1H), 2.87-2. 61 (m, 9H), 2.02 (s, 3H), 1.30 (s, 3H), 1.14 (s, 3H); ESI MS m/z 449 [C26H32N4OS + H] + ; Rs0. 25 (40: 1 CH2CI2/MeOH) ; HPLC 98. 1% (AUC), tR = 12.87 min. Anal. Calc’d for C26H32N4OS 0. 5H20: C, 68.24 ; H, 7.27 ; N, 12.24. Found: C, 68.12 ; H, 7.37 ; N, 12.13. EXAMPLE 116 N-{6-[2-(4-BENZO[D]ISOTHIAZOL-3-YL-PIPERAZIN-1-YL)-ETHYL]-1,1- DIMETHYL-INDAN-2-YLT-ACETAMIDE (440 mg, 16%) as a pale yellow solid : mp 62-72 C ;’H NMR (300 MHz, CDCl3) No.7. 92 (d, J = 8. 1 Hz, 1 H), 7.82 (d, J = 8. 1 Hz, 1 H), 7.47 (td, J = 7. 0, 1. 0 Hz, 1 H), 7.36 (td, J = 8. 0,1. 0 Hz, 1 H), 7.13 (d, J = 7.6 Hz, 1H), 7.05 (d, J = 7.6 Hz, 1 H), 7.01 (s, 1 H), 5.53 (d, J = 9.5 Hz, 1 H), 4.57-4. 47 (m, 1 H), 3.61 (t, J = 4.8 Hz, 4H), 3.26 (dd, J = 7.2, 7.2 Hz, 1 H), 2.89-2. 59 (m, 9H), 2.02 (s, 3H), 1.31 (s, 3H), 1.15 (s, 3H); ESI MS m/z449 [C26H32N40S + H] + ; Rf O. 29 (40: 1 CH2CI2/MeOH) ; HPLC 96. 1% (AUC), tR = 12.63 min. Anal. Calc’d for C26H32N40S 0. 5H20: C, 68.24 ; H, 7.27 ; N, 12.24. Found: C, 68. 11 ; H, 7.50 ; N, 11.96.

87691-88-1 3-Piperazinobenzisothiazole hydrochloride 11521711, aisothiazole compound, is more and more widely used in various.

Reference£º
Patent; WARNER-LAMBERT COMPANY LLC?; WO2005/56540; (2005); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

87691-88-1, 3-Piperazinobenzisothiazole hydrochloride is a isothiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 61 3-(4-(1-[1,2-Benzisothiazol-3-yl]-4-piperazinyl)butyl)-5-methyl-4-thiazolidinone A mixture of 3-(4-bromobutyl)-5-methyl-4-thiazolidinone (4.00 g), 1-(1,2-benzisothiazol-3-yl)piperazine hydrochloride (4.46 g), K2 CO3 (8.00 g) and NaI (300 mg) in acetonitrile (210 ml) was heated at 40-45 C. for 64 hours and the product was processed in substantially the same manner as in Example 10 to afford 3.64 g of crystals, m.p. 113-115 C. ANALYSIS: Calculated for C19 H26 N4 OS2: 58.43%C; 6.71%H; 14.34%N. Found: 58.32%C; 6.69%H; 14.29%N.

The synthetic route of 87691-88-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Hoechst-Roussel Pharmaceuticals Incorporated; US5229388; (1993); A;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.87691-88-1,3-Piperazinobenzisothiazole hydrochloride,as a common compound, the synthetic route is as follows.

4. Preparation of ZPR in water containing 10% n-BuOH. In a three necked flask was charged BITP HCl (4. 9g), Na2C03 (6.91g), CEI (4.68g), water (25ml) and n-BuOH (2. 5ml), and the mixture was heated. After about 20 hours reflux, ziprasidone was 75.5% area from the reaction mixture, and after 35h reflux the conversion to ZPR was 88%. The solid was filtrated from the reaction mixture, washed with water and dried. The HPLC purity of the product was 93.6% area.

87691-88-1 3-Piperazinobenzisothiazole hydrochloride 11521711, aisothiazole compound, is more and more widely used in various.

Reference£º
Patent; TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.; WO2005/40160; (2005); A2;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

87691-88-1, 3-Piperazinobenzisothiazole hydrochloride is a isothiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of N- [5-CHLORO-4- (2-CHLORO-ACETYL)-2-METHYL-PHENYL]- acetamide (1.375 g, 5.286 mmol), in acetonitrile (50 mL) was added 3- PIPERAZIN-1-YL-BENZO [d] isothiazole hydrochloride (1.352 g, 5.286 mmol), potassium iodide (1EQ), and potassium carbonate (1.5eq). The reaction was stirred as a suspension at rt overnight. The reaction was diluted with H20 and the filtered. After drying at 50 C under high vacuum overnight, N- {4- [2- (4-BENZO [d] isothiazol-3-yl-peperazin-1-yl)-acetyl]-5-chloro-2- METHYL-PHENYL)-ACETAMIDE was collected as a white solid (2.034 g, 4.598 mmol). Yield = 87%. 100% pure at 254 nM; LCMS (APCI) : 443.3 [M+H] + ; ‘H NMR (400 MHz, DMSO-d6) B 9.41 (s, 1H), 8.02 (d, J = 8. 80HZ, 2H), 7.81 (s, 1H), 7.59 (s, 1H), 7.52 (t, J = 7.34Hz, 1H), 7.39 (t, J = 7.34Hz, 1H), 3.80 (s, 2H), 3.44-3. 37 (m, 4H), 3.30 (s, H20), 2.77-2. 68 (m, 4H), 2.23 (s, 3H), 2.08 (s, 3H).

As the paragraph descriping shows that 87691-88-1 is playing an increasingly important role.

Reference£º
Patent; WARNER-LAMBERT COMPANY LLC; WO2004/41793; (2004); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com