Category: 87691-88-1

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬Which mentioned a new discovery about 87691-88-1, molcular formula is C11H14ClN3S, introducing its new discovery. , 87691-88-1

A PROCESS FOR THE PREPARATION OF OXINDOLE DERIVATIVES

A process for the preparation of oxindole derivative of formula (I) comprising reacting compound of formula (II) with dialkyl malonate, COOR1-COOR1, in the presence of a mild base to give compound of formula (III); and wherein R is selected from hydrogen, linear, branched or cyclic alkyl, aryl, substituted aryl, heteroaryl, haloalkyl like CF3, alkoxy, haloalkoxy, thioalkyl and halogen.; R1 is selected from linear, branched and cyclic alkyl (C1 to C4 groups); and X is selected from chloro, bromo, fluoro and iodo groups;further converting compound of formula (III) to compound of formula (I).

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, 87691-88-1, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 87691-88-1

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Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

87691-88-1, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 87691-88-1, molcular formula is C11H14ClN3S, introducing its new discovery.

A SHORT PROCESS FOR THE PREPARATION OF ZIPRASIDONE AND INTERMEDIATES THEREOF

A process for the preparation of oxindole derivative (Ziprasidone hydrochloride) of formula (I) comprising reacting compound of formula (II) with metal or metal compound mineral acid to give compound of formula (III) in a single step which is converted into compound of formula IV which is a key intermediate for the preparation of compound of compound of formula (I).

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, 87691-88-1, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 87691-88-1

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Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, 87691-88-1, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 87691-88-1, Name is 3-Piperazinobenzisothiazole hydrochloride, molecular formula is C11H14ClN3S. In a Article, authors is Ravilla, Lokesh£¬once mentioned of 87691-88-1

Opioid Receptor Modulators with a Cinnamyl Group

To obtain selective and potent opioid receptor ligands, we synthesized dehydro derivatives of alvimopan and found compound (28f), a selective but modest affinity MOR antagonist weaker than alvimopan (1). We replaced the arylpiperidine unit by an arylpiperazine to obtain the 1-(alpha-carboxycinnamyl)-4-arylpiperazines like 13h, which to our surprise had no MOR or DOR activity but was a KOR agonist with moderate affinity. In contrast, literature examples of arylpiperazines 4 and 5 were reported to be pan opioid receptor antagonists, while 6 was a MOR agonist. Two compounds (13l and 11b) showed analgesic response in tail flick test which was blocked by pretreatment with norbinaltorphimine (norBNI). Among 10 1-(alpha-carboxycinnamyl)-4-arylpiperidines, compound 28g and five others were specific MOR antagonists. Interestingly, compound 26b of this series was found to be more potent than naloxone but weaker than 1. Docking studies have explained differential activities of the above piperazines and piperidines.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 87691-88-1

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Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

87691-88-1, Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬Which mentioned a new discovery about 87691-88-1

PROCESS FOR THE PURIFICATION OF ZIPRASIDONE

Process for the purification of ziprasidone. The present invention concerns a process for the purification of 5- [2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6- chloro-1,3-dihydro-2H-indol-2-one of the formula (I) from a composition comprising said compound, wherein said compound is reacted with maleic acid or acetic acid to obtain an acid addition salt of the following formula (II), wherein R is formula (IV), or formula (V).

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Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

Chemistry is traditionally divided into organic and inorganic chemistry. 87691-88-1, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 87691-88-1

HETEROCYCLIC SUBSTITUTED INDANE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF SCHIZOPHRENIA

This invention relates to compounds of the formula (I) wherein J, M, G, m, X, R”, R2, R4, R5, R6, R7, R8, R9, Y, n, z, and R”” are defined as in the specification, pharmaceutical compositions containing them and their use in the treatment of central nervous system and other disorders.

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Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

87691-88-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3-Piperazinobenzisothiazole hydrochloride, cas is 87691-88-1,the isothiazole compound, it is a common compound, a new synthetic route is introduced below.

EXAMPLES 115-116; N-{5-[2-(4-BENZO[D]ISOTHIAZOL-3-YL-PIPERAZIN-1-YL)-ETHYL]-1, 1- DIMETHYL-INDAN-2-YL}-ACETAMIDE AND M-f6-r2- (4- BENZO [D]ISOTHIAZOL-3-YL-PIPERAZIN-1-YL)-ETHYL]-1,1- DIMETHYL-INDAN-2-YLT-ACETAMIDE; A mixture of compounds N-[5-(2-Chloroethyl)-1,1-dimethyl-indan-2-yl]- acetamide and N-[6-(2-Chloroethyl)-1,1-dimethyl-indan-2-yl]-acetamide (1.63 g, 6.15 mmol), 3-piperazin-1-yl-benzo [? isothiazole hydrochloride (1.96 g, 7.69 mmol), potassium carbonate (2.55 g, 18.4 mmol), sodium iodide (1.02 g, 6.76 mmol) in acetonitrile (120 mL) was stirred at reflux for 60 h. After removal of solvent, the residue was partitioned in CH2Ci2/H2O (200 mU50 mL). The organic layer was separated and the water layer was extracted with CH2Cl2 (60 mL). The combined organic extracts were washed with water, brine, dried over Na2SO4, and evaporated. The residue was purified by chromatography (silica gel, gradient from 1 to 2% MeOH/EtOAc) to provide two regioisomers N-{5-[2-(4-Benzo [? isothiazol- 3-yl-piperazin-1-yl)-ethyl]-1, 1-dimethyl-indan-2-yl}-acetamide (655 mg) and N {6- [2- (4-Benzo [d isothiazol-3-yl-piperazin-1-yl)-ethyl]-1, 1-dimethyl-indan- 2-yl}-acetamide (440 mg). EXAMPLE 115 N-{5-[2-(4-BENZO[D]ISOTHIAZOL-3-YL-PIPERAZIN-1-YL)-ETHYL]-1,1- DIMETHYL-INDAN-2-YLl-ACETAMIDE (655 mg, 24%) as a pale yellow solid : mp 58-68 C ;’H NMR (300 MHz, CDCl3) 67. 92 (d, J = 8.1 Hz, 1 H), 7.82 (d, J = 8.1 Hz, 1 H), 7.47 (td, J = 7.0, 0.9 Hz, 1H), 7.36 (td, J= 8.0, 1.0 Hz, 1H), 7.10-7. 05 (m, 3H), 5.53 (d, J= 9.5 Hz, 1 H), 4.57-4. 49 (m, 1 H), 3.61 (t, J = 4.8 Hz, 4H), 3.27 (dd, J = 7.3, 7.2 Hz, 1H), 2.87-2. 61 (m, 9H), 2.02 (s, 3H), 1.30 (s, 3H), 1.14 (s, 3H); ESI MS m/z 449 [C26H32N4OS + H] + ; Rs0. 25 (40: 1 CH2CI2/MeOH) ; HPLC 98. 1% (AUC), tR = 12.87 min. Anal. Calc’d for C26H32N4OS 0. 5H20: C, 68.24 ; H, 7.27 ; N, 12.24. Found: C, 68.12 ; H, 7.37 ; N, 12.13. EXAMPLE 116 N-{6-[2-(4-BENZO[D]ISOTHIAZOL-3-YL-PIPERAZIN-1-YL)-ETHYL]-1,1- DIMETHYL-INDAN-2-YLT-ACETAMIDE (440 mg, 16%) as a pale yellow solid : mp 62-72 C ;’H NMR (300 MHz, CDCl3) No.7. 92 (d, J = 8. 1 Hz, 1 H), 7.82 (d, J = 8. 1 Hz, 1 H), 7.47 (td, J = 7. 0, 1. 0 Hz, 1 H), 7.36 (td, J = 8. 0,1. 0 Hz, 1 H), 7.13 (d, J = 7.6 Hz, 1H), 7.05 (d, J = 7.6 Hz, 1 H), 7.01 (s, 1 H), 5.53 (d, J = 9.5 Hz, 1 H), 4.57-4. 47 (m, 1 H), 3.61 (t, J = 4.8 Hz, 4H), 3.26 (dd, J = 7.2, 7.2 Hz, 1 H), 2.89-2. 59 (m, 9H), 2.02 (s, 3H), 1.31 (s, 3H), 1.15 (s, 3H); ESI MS m/z449 [C26H32N40S + H] + ; Rf O. 29 (40: 1 CH2CI2/MeOH) ; HPLC 96. 1% (AUC), tR = 12.63 min. Anal. Calc’d for C26H32N40S 0. 5H20: C, 68.24 ; H, 7.27 ; N, 12.24. Found: C, 68. 11 ; H, 7.50 ; N, 11.96.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 3-Piperazinobenzisothiazole hydrochloride, 87691-88-1

Reference£º
Patent; WARNER-LAMBERT COMPANY LLC?; WO2005/56540; (2005); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

 

87691-88-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3-Piperazinobenzisothiazole hydrochloride, cas is 87691-88-1,the isothiazole compound, it is a common compound, a new synthetic route is introduced below.

EXAMPLE 63 3-(4-(1-(1,2-Benzisothiazol-3-yl)-4-piperazinyl)butyl)-5-(2,2,2-trifluoroethyl)-4-thiazolidinone hydrochloride A mixture of 3-(4-bromobutyl)-5-(2,2,2-trifluoroethyl)-4-thiazolidinone (3.20 g), 1-(1,2-benzisothiazol-3-yl)piperazine hydrochloride (2.81 g), K2 CO3 (4.83 g) and NaI (250 mg) in acetonitrile (280 ml) was heated at 70 C. for 15 hours and the product was processed in substantially the same manner as in Example 10 to afford 2.30 g of crystals, m.p. 188-200 C. ANALYSIS: Calculated for C20 H25 F3 N4 OS2 ¡¤HCl: 48.52%C; 5.29%H; 11.32%N; 7.16%Cl. Found: 48.51%C; 5.32%H; 11.20%N; 7.28%Cl.

The chemical industry reduces the impact on the environment during synthesis,87691-88-1,3-Piperazinobenzisothiazole hydrochloride,I believe this compound will play a more active role in future production and life.

Reference£º
Patent; Hoechst-Roussel Pharmaceuticals Incorporated; US5229388; (1993); A;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

 

Name is 3-Piperazinobenzisothiazole hydrochloride, as a common heterocyclic compound, it belongs to isothiazole compound, and cas is 87691-88-1, its synthesis route is as follows.

EXAMPLE 5 The mixture of 2.0 g of 4-(1,2-benzisothiazol-3-yl)piperazine hydrochloride, 2.0 g of 3-(4-chlorobutyryl)-2-methyl-5,6,7,8-tetrahydro-4H-thieno[3,2-c]azepin-4-one, 2.1 g of potassium carbonate and 1.2 g of potassium iodide in 15 ml of N,N-dimethylformamide and 15 ml of toluene was stirred at 60 C. for 3 hours. After the mixture was cooled in a water bath, water was added thereto and the mixture was extracted with ethyl acetate. The organic layer was washed with saline solution, dried over magnesium sulfate and concentrated. The residue was purified by column chromatography on a silica gel, dissolved in isopropyl alcohol and ethanol-maleic acid was added thereto to make maleate. The resulting crystals were recrystallized from ethanol to give 0.90 g of 3-(4-(4-(1,2-benzisothiazol-3-yl) piperazin-1-yl)butyryl)-2-methyl-5,6,7,8-tetrahydro-4H-thieno[3,2-c]azepin-4-one maleate as white crystals, m.p. 150-152 C.

87691-88-1, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,87691-88-1 ,3-Piperazinobenzisothiazole hydrochloride, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; Yoshitomi Pharmaceutical Industries, Ltd.; US5532240; (1996); A;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

 

87691-88-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3-Piperazinobenzisothiazole hydrochloride, cas is 87691-88-1,the isothiazole compound, it is a common compound, a new synthetic route is introduced below.

2. Preparation of ZPR in glycerol In a three necked flask was charged BITP HC1 (25g, 0. 098 mol), glycerol (62 ml), Na2C03 (13g) and the mixture was stirred for 10 minutes. CEI (5.9g) was added and the reaction mixture was heated for 3h at 115-120C. After 3h, the reaction was almost complete; after cooling to room temperature the solid was filtrated and was triturated in water and dried. The dried solid weights 42 g and the purity was 89.03%.

The chemical industry reduces the impact on the environment during synthesis,87691-88-1,3-Piperazinobenzisothiazole hydrochloride,I believe this compound will play a more active role in future production and life.

Reference£º
Patent; TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.; WO2005/40160; (2005); A2;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

 

87691-88-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3-Piperazinobenzisothiazole hydrochloride, cas is 87691-88-1,the isothiazole compound, it is a common compound, a new synthetic route is introduced below.

EXAMPLE 63 3-(4-(1-(1,2-Benzisothiazol-3-yl)-4-piperazinyl)butyl)-5-(2,2,2-trifluorethyl)-4-thiazolidinone hydrochloride A mixture of 3-(4-bromobutyl)-5-(2,2,2-trifluoroethyl)-4-thiazolidinone (3.20 g), 1-(1,2-benzisothiazol-3-yl)piperazine hydrochloride (2.81 g), K2 CO3 (4.83 g) and NaI (250 mg) in acetonitrile (280 ml) was heated at 70 C. for 15 hours and the product was processed in substantially the same manner as in Example 10 to afford 2.30 g of crystals, m.p. 188-200 C. ANALYSIS: Calculated for C20 H25 F3 N4 OS2 ¡¤HCl: 48.52% C; 5.29% H; 11.32% N; 7.16% Cl. Found: 48.51% C; 5.32% H; 11.20 % N; 7.28% Cl.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 3-Piperazinobenzisothiazole hydrochloride, 87691-88-1

Reference£º
Patent; Hoechst-Roussel Pharmaceuticals Inc.; US4933453; (1990); A;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com