Category: 76857-14-2

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 76857-14-2, In a patent£¬Which mentioned a new discovery about 76857-14-2

A and Cefotetan disodium method for the preparation of intermediates (by machine translation)

The invention discloses a Cefotetan disodium method for the preparation of intermediates thereof, the commercial raw material 4 – (1-amino-3-tert-butoxy -1,3-dioxo-2-ene yl) – 1,3-dithio-azetidine-2-carboxylic acid (2) and 7-MAC (3) for a condensation reaction to make compound 4, after deprotection, salification Cefotetan disodium (1). The invention also provides the compound 2 preparation method. The conventional route of the route to avoid pollution of the environment of the use of chloride reagent, with simple process route, process cost reduction, the overall yield of product is improved, friendly characteristic of the environment, is suitable for industrial production. (by machine translation)

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, 76857-14-2, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 76857-14-2

Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 76857-14-2, In a patent£¬Which mentioned a new discovery about 76857-14-2

A and Cefotetan disodium method for the preparation of intermediates (by machine translation)

The invention discloses a Cefotetan disodium method for the preparation of intermediates thereof, the commercial raw material 4 – (1-amino-3-tert-butoxy -1,3-dioxo-2-ene yl) – 1,3-dithio-azetidine-2-carboxylic acid (2) and 7-MAC (3) for a condensation reaction to make compound 4, after deprotection, salification Cefotetan disodium (1). The invention also provides the compound 2 preparation method. The conventional route of the route to avoid pollution of the environment of the use of chloride reagent, with simple process route, process cost reduction, the overall yield of product is improved, friendly characteristic of the environment, is suitable for industrial production. (by machine translation)

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, 76857-14-2, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 76857-14-2

Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

As a common heterocyclic compound, it belongs to isothiazole compound, name is Sodium 3-oxido-5-sulfidoisothiazole-4-carboxylate, and cas is 76857-14-2, its synthesis route is as follows.

Into reactor cooling water was sequentially added purified water, intermediate II, start stirring. Drop 5% sodium bicarbonate solution, adjusting the pH value 5.7-6.0, stirring to make the solid completely dissolved. Then according to the feeding sequentially adding EDTA disodium, sodium bicarbonate. The reaction liquid pump CO2 gas, and drop trisodium salt aqueous solution, control reaction system pH value 7.5-8.5. Temperature 0-5 C. After dropping, control system pH value 7.9 – 8.1, reaction 8 hours.Then inject the CO2Gas, adjusting the pH value of the reaction solution of 7.5 – 7.8, HPLC monitoring isomerization, until the isomer ? 5.0%. The filtrate 9% hydrochloric acid aqueous solution to pH adjusting system 0.7 – 1.0, separating solid, centrifugal filtration, obtain cefotetan wet product.

76857-14-2, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,76857-14-2 ,Sodium 3-oxido-5-sulfidoisothiazole-4-carboxylate, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; Jichuan Pharmaceutical Group Co., Ltd.; Cao Longxiang; Dong Zibo; Niu Ben; Ding Xiaohua; Shao Jianguo; Zhu Jia; Li Ping; (15 pag.)CN106478670; (2017); A;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

 

Name is Sodium 3-oxido-5-sulfidoisothiazole-4-carboxylate, as a common heterocyclic compound, it belongs to isothiazole compound, and cas is 76857-14-2, its synthesis route is as follows.,76857-14-2

The second intermediate obtained in step (4) is added in portions to the aqueous solution of 4-carboxy-3-hydroxy-5-mercaptoisothiazole trisodium in acetone at a low temperature of 2 to 8C.Then, the pH of the mixed solution was adjusted with sodium bicarbonate to be 7.5 to 9, and allowed to react at 15 to 30 C. and a stirring rate of 30 to 80 r/min for 3 to 8 hours.After filtering, the filter cake is washed with a small amount of deionized water to neutrality, and then dried under reduced pressure to obtain crude cefotetan acid; The cefotetan acid crude product obtained in step (5) is configured as an aqueous acetone suspension, and the excess sodium bicarbonate is stirred and dissolved in batch at room temperature.Then use activated carbon to stir for more than 1h, filter, -5 ~ 5 C,Stir and add 5 ~ 8mol/L hydrochloric acid solution to adjust the pH to less than 3, stir, filter and dry to obtain purified cefotetanic acid; The method for adding sodium bicarbonate is as follows: first, sodium bicarbonate is added in an amount of 30 to 50 g per batch, and after each batch is added,After stirring for 1-3 hours to dissolve, add the next batch, and so on, until the added sodium bicarbonate does not dissolve; At a low temperature of -5 to 10C, cefotetan obtained in step (6) is dissolved in purified water, and then sodium bicarbonate is added in portions.Stir and dissolve and adjust the pH of the solution to below 6, then add the activated carbon to stir for more than 1h, filter,The filtrate is first filtered through a 0.25 mum nylon filter and then filtered through a 0.2-0.3 mum filter.Finally, it is filtered through a nanofiltration membrane of 10 to 50 nm, then sterilized in a sterilization chamber, and freeze-dried at -40 C. to -15 C. for more than 12 hours to obtain the disodium cefotetan.

With the complex challenges of chemical substances, we look forward to future research findings about Sodium 3-oxido-5-sulfidoisothiazole-4-carboxylate

Reference£º
Patent; Jiangsu Han Sitong Pharmaceutical Co., Ltd.; Wang Duoping; Wei Genghu; Shi Jiagui; Lu Lihuan; (9 pag.)CN107540694; (2018); A;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

 

As a common heterocyclic compound, it belongs to isothiazole compound, name is Sodium 3-oxido-5-sulfidoisothiazole-4-carboxylate, and cas is 76857-14-2, its synthesis route is as follows.,76857-14-2

4-carboxy-5-mercapto-3-hydroxy-isothiazolium trisodium (5) (24.31 g, 0.10 mol) was added to a solution of(About 65ml) hydrochloric acid stirring, the pH to 2-3, by adding 297mgDMAPStirring was continued for 20 minutes,Followed by addition of 50 ml of tert-butanol,6 ml of pyridine, Boc2O (21.83 g, 0.10 mol),In a dry environmentThe reaction was stirred at room temperature for 18 h. The reaction was complete by HPLC and the solvent was removed by rotary evaporation to give an oil which was chromatographed on ethyl acetate, The organic layer was dried over anhydrous magnesium sulfate, concentrated, and recrystallized from ethanol to give Intermediate 6 (24.11 g) in a molar yield87%, HPLC purity 99.2%.

With the complex challenges of chemical substances, we look forward to future research findings about 76857-14-2,belong isothiazole compound

Reference£º
Patent; Shandong Luoxin Pharmaceutical Group Co Ltd; Sun, Song; Xu, Qinyan; Chang, Zhicheng; (7 pag.)CN105646544; (2016); A;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.76857-14-2,Sodium 3-oxido-5-sulfidoisothiazole-4-carboxylate,as a common compound, the synthetic route is as follows.,76857-14-2

The second intermediate obtained in step (4) is added in portions to the aqueous solution of 4-carboxy-3-hydroxy-5-mercaptoisothiazole trisodium in acetone at a low temperature of 2 to 8C.Then, the pH of the mixed solution was adjusted with sodium bicarbonate to be 7.5 to 9, and allowed to react at 15 to 30 C. and a stirring rate of 30 to 80 r/min for 3 to 8 hours.After filtering, the filter cake is washed with a small amount of deionized water to neutrality, and then dried under reduced pressure to obtain crude cefotetan acid; The cefotetan acid crude product obtained in step (5) is configured as an aqueous acetone suspension, and the excess sodium bicarbonate is stirred and dissolved in batch at room temperature.Then use activated carbon to stir for more than 1h, filter, -5 ~ 5 C,Stir and add 5 ~ 8mol/L hydrochloric acid solution to adjust the pH to less than 3, stir, filter and dry to obtain purified cefotetanic acid; The method for adding sodium bicarbonate is as follows: first, sodium bicarbonate is added in an amount of 30 to 50 g per batch, and after each batch is added,After stirring for 1-3 hours to dissolve, add the next batch, and so on, until the added sodium bicarbonate does not dissolve; At a low temperature of -5 to 10C, cefotetan obtained in step (6) is dissolved in purified water, and then sodium bicarbonate is added in portions.Stir and dissolve and adjust the pH of the solution to below 6, then add the activated carbon to stir for more than 1h, filter,The filtrate is first filtered through a 0.25 mum nylon filter and then filtered through a 0.2-0.3 mum filter.Finally, it is filtered through a nanofiltration membrane of 10 to 50 nm, then sterilized in a sterilization chamber, and freeze-dried at -40 C. to -15 C. for more than 12 hours to obtain the disodium cefotetan.

76857-14-2 Sodium 3-oxido-5-sulfidoisothiazole-4-carboxylate 136151974, aisothiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Jiangsu Han Sitong Pharmaceutical Co., Ltd.; Wang Duoping; Wei Genghu; Shi Jiagui; Lu Lihuan; (9 pag.)CN107540694; (2018); A;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

 

76857-14-2, Sodium 3-oxido-5-sulfidoisothiazole-4-carboxylate is a isothiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

76857-14-2, 4-carboxy-5-mercapto-3-hydroxy-isothiazolium trisodium (5) (24.31 g, 0.10 mol) was added to a solution of(About 65ml) hydrochloric acid stirring, the pH to 2-3, by adding 297mgDMAPStirring was continued for 20 minutes,Followed by addition of 50 ml of tert-butanol,6 ml of pyridine, Boc2O (21.83 g, 0.10 mol),In a dry environmentThe reaction was stirred at room temperature for 18 h. The reaction was complete by HPLC and the solvent was removed by rotary evaporation to give an oil which was chromatographed on ethyl acetate, The organic layer was dried over anhydrous magnesium sulfate, concentrated, and recrystallized from ethanol to give Intermediate 6 (24.11 g) in a molar yield87%, HPLC purity 99.2%.

76857-14-2 Sodium 3-oxido-5-sulfidoisothiazole-4-carboxylate 136151974, aisothiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Shandong Luoxin Pharmaceutical Group Co Ltd; Sun, Song; Xu, Qinyan; Chang, Zhicheng; (7 pag.)CN105646544; (2016); A;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

 

76857-14-2, Sodium 3-oxido-5-sulfidoisothiazole-4-carboxylate is a isothiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

76857-14-2, Into reactor cooling water was sequentially added purified water, intermediate II, start stirring. Drop 5% sodium bicarbonate solution, adjusting the pH value 5.7-6.0, stirring to make the solid completely dissolved. Then according to the feeding sequentially adding EDTA disodium, sodium bicarbonate. The reaction liquid pump CO2 gas, and drop trisodium salt aqueous solution, control reaction system pH value 7.5-8.5. Temperature 0-5 C. After dropping, control system pH value 7.9 – 8.1, reaction 8 hours.Then inject the CO2Gas, adjusting the pH value of the reaction solution of 7.5 – 7.8, HPLC monitoring isomerization, until the isomer ? 5.0%. The filtrate 9% hydrochloric acid aqueous solution to pH adjusting system 0.7 – 1.0, separating solid, centrifugal filtration, obtain cefotetan wet product.

The synthetic route of 76857-14-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Jichuan Pharmaceutical Group Co., Ltd.; Cao Longxiang; Dong Zibo; Niu Ben; Ding Xiaohua; Shao Jianguo; Zhu Jia; Li Ping; (15 pag.)CN106478670; (2017); A;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.76857-14-2,Sodium 3-oxido-5-sulfidoisothiazole-4-carboxylate,as a common compound, the synthetic route is as follows.

76857-14-2, To the reaction solution B, 2000 ml of a saturated sodium hydrogencarbonate solution was added, and the mixture was stirred, and the phases were separated. The aqueous phase was taken and the temperature was lowered to 5 C or lower. To the solution was added 60 g / 400 ml of 4-carboxy-3-hydroxy-5-mercaptoisothiazolium trisodium (CHMT) aqueous solution. The pH of the reaction solution is controlled to be 6.0 to 9.0, the content of the cefotetan tautomer is less than or equal to 6.0%, the pH is adjusted to 6.5, 50g of active alumina is added, stirred for 1 hour, filtered, hydrochloric acid to adjust the pH of the filtrate is 1.5 to 2.5, filtration, in the original cefotetan acid.

As the paragraph descriping shows that 76857-14-2 is playing an increasingly important role.

Reference£º
Patent; Shenzhen Salubris Pharmaceuticals Co., Ltd.; Lei, Jiangang; Liang, Guilin; Yang, Siyuan; Zhao, Li; (11 pag.)CN103724359; (2016); B;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com