Category: 76857-14-2

It is a common heterocyclic compound, the isothiazole compound, Sodium 3-oxido-5-sulfidoisothiazole-4-carboxylate, cas is 76857-14-2 its synthesis route is as follows.

4-carboxy-5-mercapto-3-hydroxy-isothiazolium trisodium (5) (24.31 g, 0.10 mol) was added to a solution of(About 65ml) hydrochloric acid stirring, the pH to 2-3, by adding 297mgDMAPStirring was continued for 20 minutes,Followed by addition of 50 ml of tert-butanol,6 ml of pyridine, Boc2O (21.83 g, 0.10 mol),In a dry environmentThe reaction was stirred at room temperature for 18 h. The reaction was complete by HPLC and the solvent was removed by rotary evaporation to give an oil which was chromatographed on ethyl acetate, The organic layer was dried over anhydrous magnesium sulfate, concentrated, and recrystallized from ethanol to give Intermediate 6 (24.11 g) in a molar yield87%, HPLC purity 99.2%.

76857-14-2, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,76857-14-2 ,Sodium 3-oxido-5-sulfidoisothiazole-4-carboxylate, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; Shandong Luoxin Pharmaceutical Group Co Ltd; Sun, Song; Xu, Qinyan; Chang, Zhicheng; (7 pag.)CN105646544; (2016); A;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

 

Electric Literature of 76857-14-2, Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter. In a Patent£¬Which mentioned a new discovery about 76857-14-2

A head spore for the Tanzania acid new crystalline and its preparation method (by machine translation)

A head spore for the Tanzania acid new crystalline and its preparation method. The present invention provides a [6R – (6a, 7 alpha)] – 7 – [[ [4 – (2 – amino – 1 – carboxyl – 2 – oxo ethylidene) – 1, 3 – dithio-azetidine – 2 – yl] carbonyl] amino] – 7 – methoxy – 3 – [[ (1 – methyl – 1H – tetrazol – 5 – yl) thio] methyl] – 8 – oxo – 5 – thia – 1 – azabicyclo [4, 2, 0] Oct – 2 – ene – 2 – carboxylic acid the new crystalline form, this crystalline form X – ray powder diffraction pattern of a reflection angle of the 2 theta in the 11.66 ¡À 0.1 , 17 . 53 ¡À 0.1 , 17 . 72 ¡À 0.1 , 18 . 91 ¡À 0.1 , 20 . 01 ¡À 0.1 , 21 . 02 ¡À 0.1 , 22 . 24 ¡À 0.1 , 23 . 33 ¡À 0.1 and has a characteristic peak. Such a compound is crystalline form has good stability, and its preparation process is simple, lower cost, can be used in industrial production. (by machine translation)

Electric Literature of 76857-14-2, If you are hungry for even more, make sure to check my other article about 76857-14-2

Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

Application of 76857-14-2, Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about Application of 76857-14-2

A amorphous head spore for the Tanzania acid and prepared cefotetan disodium method and containing the cefotetan disodium pharmaceutical composition (by machine translation)

The invention discloses a head-spore for the Tanzania acid new crystal and prepared cefotetan disodium method and containing cefotetan disodium pharmaceutical composition. The new crystalline form X – ray diffraction pattern in the X – ray diffraction does not occur, and in the differential thermal analysis endothermic peak for the Atlas 158.3 C, exothermic peak at 144.6 C. The new crystalline form of the present invention solved in the prior art by the header spore for the Tanzania acid prepared cefotetan disodium is unstable. The invention the preparation method used good operability, organic less solvent residue, is very suitable for large-scale industrial production. (by machine translation)

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about is helpful to your research. Application of 76857-14-2

Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

Synthetic Route of 76857-14-2, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.76857-14-2, Name is Sodium 3-oxido-5-sulfidoisothiazole-4-carboxylate, molecular formula is C4NNa3O3S2. In a Patent£¬once mentioned of 76857-14-2

Cefotetan disodium preparation method (by machine translation)

The invention discloses a cefotetan disodium preparation method, comprises the following steps: (1) preparing 1st intermediate; (2) the extraction separation; (3) preparing 2nd intermediate; (4) crystallization separation; (5) the crude preparation head spore for the tanzania acid; (6) head spore for the tanzania acid purification; (7) preparation head spore for the tanzania acid disodium. The invention relates to a cefotetan disodium preparation method, the process is simple, mild reaction conditions, the reaction process of the good controllability, the product yield is high, the resulting cefotetan disodium high purity, low impurity content, good appearance quality, stable property, clinical it has broad application prospects. (by machine translation)

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 76857-14-2 is helpful to your research. Synthetic Route of 76857-14-2

Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, the author is and a compound is mentioned, COA of Formula: C4NNa3O3S2, Sodium 3-oxido-5-sulfidoisothiazole-4-carboxylate, introducing its new discovery. COA of Formula: C4NNa3O3S2

A and Cefotetan disodium method for the preparation of intermediates (by machine translation)

The invention discloses a Cefotetan disodium method for the preparation of intermediates thereof, the commercial raw material 4 – (1-amino-3-tert-butoxy -1,3-dioxo-2-ene yl) – 1,3-dithio-azetidine-2-carboxylic acid (2) and 7-MAC (3) for a condensation reaction to make compound 4, after deprotection, salification Cefotetan disodium (1). The invention also provides the compound 2 preparation method. The conventional route of the route to avoid pollution of the environment of the use of chloride reagent, with simple process route, process cost reduction, the overall yield of product is improved, friendly characteristic of the environment, is suitable for industrial production. (by machine translation)

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about is helpful to your research. COA of Formula: C4NNa3O3S2

Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

Electric Literature of 76857-14-2, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 76857-14-2, Name is Sodium 3-oxido-5-sulfidoisothiazole-4-carboxylate, molecular formula is C4NNa3O3S2. In a Patent£¬once mentioned of 76857-14-2

Process for obtaining compounds usable in the production of cefotetan, and new compounds obtained thereby

A process for obtaining salts of 4-carboxy-3-hydroxy-5-mercapto-isothiazole which are compounds usable in the production of Cefotetan, and new compounds obtained thereby, in which R1 = R2 = R3 = Na or K; R1 = Na or K and R2 = R3 = H; or R1 = R2 = Na or K and R3 = H.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 76857-14-2

Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

Electric Literature of 76857-14-2, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 76857-14-2, Sodium 3-oxido-5-sulfidoisothiazole-4-carboxylate, introducing its new discovery.

Cefotetan disodium preparation method (by machine translation)

The invention discloses a cefotetan disodium preparation method, comprises the following steps: (1) preparing 1st intermediate; (2) the extraction separation; (3) preparing 2nd intermediate; (4) crystallization separation; (5) the crude preparation head spore for the tanzania acid; (6) head spore for the tanzania acid purification; (7) preparation head spore for the tanzania acid disodium. The invention relates to a cefotetan disodium preparation method, the process is simple, mild reaction conditions, the reaction process of the good controllability, the product yield is high, the resulting cefotetan disodium high purity, low impurity content, good appearance quality, stable property, clinical it has broad application prospects. (by machine translation)

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Electric Literature of 76857-14-2. In my other articles, you can also check out more blogs about 76857-14-2

Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

Related Products of 76857-14-2, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.76857-14-2, Name is Sodium 3-oxido-5-sulfidoisothiazole-4-carboxylate, molecular formula is C4NNa3O3S2. In a article£¬once mentioned of 76857-14-2

A amorphous head spore for the Tanzania acid and prepared cefotetan disodium method and containing the cefotetan disodium pharmaceutical composition (by machine translation)

The invention discloses a head-spore for the Tanzania acid new crystal and prepared cefotetan disodium method and containing cefotetan disodium pharmaceutical composition. The new crystalline form X – ray diffraction pattern in the X – ray diffraction does not occur, and in the differential thermal analysis endothermic peak for the Atlas 158.3 C, exothermic peak at 144.6 C. The new crystalline form of the present invention solved in the prior art by the header spore for the Tanzania acid prepared cefotetan disodium is unstable. The invention the preparation method used good operability, organic less solvent residue, is very suitable for large-scale industrial production. (by machine translation)

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 76857-14-2

Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

Reference of 76857-14-2, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.76857-14-2, Name is Sodium 3-oxido-5-sulfidoisothiazole-4-carboxylate, molecular formula is C4NNa3O3S2. In a Patent£¬once mentioned of 76857-14-2

A head spore for the Tanzania acid new crystalline and its preparation method (by machine translation)

A head spore for the Tanzania acid new crystalline and its preparation method. The present invention provides a [6R – (6a, 7 alpha)] – 7 – [[ [4 – (2 – amino – 1 – carboxyl – 2 – oxo ethylidene) – 1, 3 – dithio-azetidine – 2 – yl] carbonyl] amino] – 7 – methoxy – 3 – [[ (1 – methyl – 1H – tetrazol – 5 – yl) thio] methyl] – 8 – oxo – 5 – thia – 1 – azabicyclo [4, 2, 0] Oct – 2 – ene – 2 – carboxylic acid the new crystalline form, this crystalline form X – ray powder diffraction pattern of a reflection angle of the 2 theta in the 11.66 ¡À 0.1 , 17 . 53 ¡À 0.1 , 17 . 72 ¡À 0.1 , 18 . 91 ¡À 0.1 , 20 . 01 ¡À 0.1 , 21 . 02 ¡À 0.1 , 22 . 24 ¡À 0.1 , 23 . 33 ¡À 0.1 and has a characteristic peak. Such a compound is crystalline form has good stability, and its preparation process is simple, lower cost, can be used in industrial production. (by machine translation)

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 76857-14-2, and how the biochemistry of the body works.Reference of 76857-14-2

Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

Reference of 76857-14-2, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 76857-14-2, Name is Sodium 3-oxido-5-sulfidoisothiazole-4-carboxylate, molecular formula is C4NNa3O3S2. In a Patent£¬once mentioned of 76857-14-2

Process for obtaining compounds usable in the production of cefotetan, and new compounds obtained thereby

A process for obtaining salts of 4-carboxy-3-hydroxy-5-mercapto-isothiazole which are compounds usable in the production of Cefotetan, and new compounds obtained thereby, in which R1 = R2 = R3 = Na or K; R1 = Na or K and R2 = R3 = H; or R1 = R2 = Na or K and R3 = H.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Reference of 76857-14-2. In my other articles, you can also check out more blogs about 76857-14-2

Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com