Category: 677304-75-5

Analyzing the synthesis route of 677304-75-5

The synthetic route of 677304-75-5 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.677304-75-5,6-Bromobenzo[d]isothiazole-3-carboxylic acid,as a common compound, the synthetic route is as follows.

677304-75-5, The following procedure was used to prepare benzisothiazole tert-butyl esters: Di-tert-butyldicarbonate (128 mmol) was added to a suspension of 6-bromo-1,2-benzisothiazole-3-carboxylic acid (46.5 mmol) and 4-dimethylaminopyridine (4.26 mmol) in tert-butyl alcohol (40.0 mL) and tetrahydrofuran (40.0 mL) and the reaction mixture was heated at 65 C. for 16 hours. There was vigorous carbon dioxide evolution which gradually subsided as the mixture become homogeneous. The reaction mixture was concentrated and the residue was dissolved in dichloromethane. The dichloromethane solution was filtered through silica gel (ca. 50 g) and the eluent was concentrated to provide the ester product in 99% yield.

The synthetic route of 677304-75-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Schumacher, Richard; Danca, Mihaela Diana; Ma, Jianguo; Herbert, Brian; Nguyen, True Minh; Xie, Wenge; Tehim, Ashok; US2007/78147; (2007); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

 

Downstream synthetic route of 677304-75-5

As the paragraph descriping shows that 677304-75-5 is playing an increasingly important role.

677304-75-5, 6-Bromobenzo[d]isothiazole-3-carboxylic acid is a isothiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

677304-75-5, The following acids were prepared using this method: -Bromobenzisothiazole-S-carboxylic acid. 5-Bromobenzisothiazole-3-carboxy lie acid. 6-Methoxybenzisothiazole-3-carboxylic acid.The following esters were prepared from the acid using ethanol and sulfuric acid:Ethyl 6-bromobenzisothiazole-3-carboxylate. Ethyl 5-bromobenzisothiazole-3-carboxylate. Ethyl 6-methoxybenzisothiazole-3-carboxylate.

As the paragraph descriping shows that 677304-75-5 is playing an increasingly important role.

Reference£º
Patent; MEMORY PHARMACEUTICALS CORPORATION; WO2007/56582; (2007); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

 

New learning discoveries about 677304-75-5

As the paragraph descriping shows that 677304-75-5 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.677304-75-5,6-Bromobenzo[d]isothiazole-3-carboxylic acid,as a common compound, the synthetic route is as follows.

677304-75-5, Step 5[00200] Sulfuryl dichloride (86.7 mg, 728 mumol) was added to a solution of 6- bromobenzo[d]-isothiazole-3-carboxylic acid (188 mg, 728 mumol). The reaction mixture was stirred for 30 min before removing the volatiles by rotovap. The residue was taken up in CH2Cl2 (0.587 ml) and a solution of 2-propylamine (62.5 muL, 728 mumol) and triethylamine (101 mul, 728 mumol) in CH2Cl2 (1.2 ml) was added. The reaction mixture was stirred at room temperature until LCMS analysis indicated complete conversion to the desired product. The reaction mixture was diluted with distilled water and ethyl acetate. The layers were separated and the aqueous was extracted with ethyl acetate. The combined organics were washed with brine and dried over Na2SO4, filtered and concentrated to give 6-bromo-N- isopropylbenzo[d]isothiazole-3-carboxamide.

As the paragraph descriping shows that 677304-75-5 is playing an increasingly important role.

Reference£º
Patent; AMGEN INC.; MEMORY PHARMACEUTICALS CORPORTION; WO2007/98169; (2007); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

 

Brief introduction of 677304-75-5

The synthetic route of 677304-75-5 has been constantly updated, and we look forward to future research findings.

677304-75-5, 6-Bromobenzo[d]isothiazole-3-carboxylic acid is a isothiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 3: DIEA (11.7 mL, 67.4 mmol) and HBTU (7.03 g, 18.5 mmol) were added to a solution of 6-bromobenzo[d]isothiazole-3-carboxylic acid (4.35 g, 16.9 mmol) and N,O-dimethylhydroxylamine hydrochloride (2.14 g, 21.9 mmol) in DMF (100 mL). The reaction was stirred at room temperature for 2 hours. The mixture was partitioned between water and EtOAc. The organic layer was washed with aqueous NaHCO3 solution and brine, dried and concentrated. The residue was purified by column chromatography (hexane:EtOAc, 3:1) to give 6-bromo-N-methoxy-N-methylbenzo[d]isothiazole-3- carboxamide (4.60 g, 91%) as a solid. 1H NMR (CDCl3, 400 MHz) delta 8.12 (m, 2H), 8.59 (d, J = 8.8 Hz, IH), 3.83 (s, 3H), 3.49 (s, 3H).

The synthetic route of 677304-75-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ARRAY BIOPHARMA INC.; GENENTECH, INC.; WO2009/89462; (2009); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

 

Some tips on 677304-75-5

677304-75-5 6-Bromobenzo[d]isothiazole-3-carboxylic acid 53401192, aisothiazole compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.677304-75-5,6-Bromobenzo[d]isothiazole-3-carboxylic acid,as a common compound, the synthetic route is as follows.

The following esters were prepared from the acid using ethanol and sulfuric acid: Ethyl 6-bromobenzisothiazole-3-carboxylate. Ethyl 6-methoxybenzisothiazole-3-carboxylate. tert-Butyl 5-bromo-1,2-benzisothiazole-3-carboxylate.

677304-75-5 6-Bromobenzo[d]isothiazole-3-carboxylic acid 53401192, aisothiazole compound, is more and more widely used in various.

Reference£º
Patent; Schumacher, Richard; Danca, Mihaela Diana; Ma, Jianguo; Herbert, Brian; Nguyen, True Minh; Xie, Wenge; Tehim, Ashok; US2007/78147; (2007); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com