Category: 677304-75-5

As a common heterocyclic compound, it belongs to isothiazole compound, name is 6-Bromobenzo[d]isothiazole-3-carboxylic acid, and cas is 677304-75-5, its synthesis route is as follows.,677304-75-5

Step 5[00200] Sulfuryl dichloride (86.7 mg, 728 mumol) was added to a solution of 6- bromobenzo[d]-isothiazole-3-carboxylic acid (188 mg, 728 mumol). The reaction mixture was stirred for 30 min before removing the volatiles by rotovap. The residue was taken up in CH2Cl2 (0.587 ml) and a solution of 2-propylamine (62.5 muL, 728 mumol) and triethylamine (101 mul, 728 mumol) in CH2Cl2 (1.2 ml) was added. The reaction mixture was stirred at room temperature until LCMS analysis indicated complete conversion to the desired product. The reaction mixture was diluted with distilled water and ethyl acetate. The layers were separated and the aqueous was extracted with ethyl acetate. The combined organics were washed with brine and dried over Na2SO4, filtered and concentrated to give 6-bromo-N- isopropylbenzo[d]isothiazole-3-carboxamide.

With the complex challenges of chemical substances, we look forward to future research findings about 677304-75-5,belong isothiazole compound

Reference£º
Patent; AMGEN INC.; MEMORY PHARMACEUTICALS CORPORTION; WO2007/98169; (2007); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO188,mainly used in chemical industry, its synthesis route is as follows.,677304-75-5

Intermediate Preparation 40A- 1; Methyl 6-bromobenzord”|isothiazole-3-carboxylate; To a solution of 6-bromobenzo[solid. 1H NMR (400 MHz, MeOD) delta 4.04 (s, 3H), 7.73 (dd, J= 8.8, 1.6 Hz, IH), 8.41 (s, IH), 8.61 (d, J= 8.8 Hz, IH).

With the complex challenges of chemical substances, we look forward to future research findings about 6-Bromobenzo[d]isothiazole-3-carboxylic acid,belong isothiazole compound

Reference£º
Patent; ELI LILLY AND COMPANY; WO2009/12125; (2009); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO328,mainly used in chemical industry, its synthesis route is as follows.,677304-75-5

Step 5; Sulfuryl dichloride (86.7 mg, 728 mumol) is added to a solution of6-bromobenzo[d]-isothiazole-3-carboxylic acid (188 mg, 728 mumol). The reaction mixture is stirred for 30 min before removing the volatiles by rotovap. The residue is taken up in CH2Cl2 (0.587 ml) and a solution of 2-prorhoylamine (62.5 muL, 728 mumol) and triethylamine (101 mul, 728 mumol) in CHjCl2 (1.2 ml) is added. The reaction mixture is stirred at room temperature until LC/MS analysis indicates complete conversion to the desired product. The reaction mixture is diluted with distilled water and ethyl acetate. The layers are separated and the aqueous is extracted with ethyl acetate. The combined organics are washed with brine and dried over Na2SO4, filtered and concentrated to give 6-bromo-N-isopropylbenzo[d]isothiazole- 3-carboxamide.

With the synthetic route has been constantly updated, we look forward to future research findings about 6-Bromobenzo[d]isothiazole-3-carboxylic acid,belong isothiazole compound

Reference£º
Patent; AMGEN INC.; MEMORY PHARMACEUTICALS CORPORATION; WO2007/100880; (2007); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

As a common heterocyclic compound, it belongs to isothiazole compound, name is 6-Bromobenzo[d]isothiazole-3-carboxylic acid, and cas is 677304-75-5, its synthesis route is as follows.,677304-75-5

The following procedure was used to prepare benzisothiazole tert-butyl esters: Di-tert-butyldicarbonate (128 mmol) was added to a suspension of 6-bromo-1,2-benzisothiazole-3-carboxylic acid (46.5 mmol) and 4-dimethylaminopyridine (4.26 mmol) in tert-butyl alcohol (40.0 mL) and tetrahydrofuran (40.0 mL) and the reaction mixture was heated at 65 C. for 16 hours. There was vigorous carbon dioxide evolution which gradually subsided as the mixture become homogeneous. The reaction mixture was concentrated and the residue was dissolved in dichloromethane. The dichloromethane solution was filtered through silica gel (ca. 50 g) and the eluent was concentrated to provide the ester product in 99% yield.

With the complex challenges of chemical substances, we look forward to future research findings about 677304-75-5,belong isothiazole compound

Reference£º
Patent; Schumacher, Richard; Danca, Mihaela Diana; Ma, Jianguo; Herbert, Brian; Nguyen, True Minh; Xie, Wenge; Tehim, Ashok; US2007/78147; (2007); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

As a common heterocyclic compound, it belongs to isothiazole compound, name is 6-Bromobenzo[d]isothiazole-3-carboxylic acid, and cas is 677304-75-5, its synthesis route is as follows.,677304-75-5

Step 3: DIEA (11.7 mL, 67.4 mmol) and HBTU (7.03 g, 18.5 mmol) were added to a solution of 6-bromobenzo[d]isothiazole-3-carboxylic acid (4.35 g, 16.9 mmol) and N,O-dimethylhydroxylamine hydrochloride (2.14 g, 21.9 mmol) in DMF (100 mL). The reaction was stirred at room temperature for 2 hours. The mixture was partitioned between water and EtOAc. The organic layer was washed with aqueous NaHCO3 solution and brine, dried and concentrated. The residue was purified by column chromatography (hexane:EtOAc, 3:1) to give 6-bromo-N-methoxy-N-methylbenzo[d]isothiazole-3- carboxamide (4.60 g, 91%) as a solid. 1H NMR (CDCl3, 400 MHz) delta 8.12 (m, 2H), 8.59 (d, J = 8.8 Hz, IH), 3.83 (s, 3H), 3.49 (s, 3H).

With the complex challenges of chemical substances, we look forward to future research findings about 677304-75-5,belong isothiazole compound

Reference£º
Patent; ARRAY BIOPHARMA INC.; GENENTECH, INC.; WO2009/89462; (2009); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.677304-75-5,6-Bromobenzo[d]isothiazole-3-carboxylic acid,as a common compound, the synthetic route is as follows.

677304-75-5, Intermediate Preparation 40A- 1; Methyl 6-bromobenzord”|isothiazole-3-carboxylate; To a solution of 6-bromobenzo[solid. 1H NMR (400 MHz, MeOD) delta 4.04 (s, 3H), 7.73 (dd, J= 8.8, 1.6 Hz, IH), 8.41 (s, IH), 8.61 (d, J= 8.8 Hz, IH).

677304-75-5 6-Bromobenzo[d]isothiazole-3-carboxylic acid 53401192, aisothiazole compound, is more and more widely used in various fields.

Reference£º
Patent; ELI LILLY AND COMPANY; WO2009/12125; (2009); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

6-Bromobenzo[d]isothiazole-3-carboxylic acid, cas is 677304-75-5, it is a common heterocyclic compound, the isothiazole compound, its synthesis route is as follows.,677304-75-5

The following acids were prepared using this method: -Bromobenzisothiazole-S-carboxylic acid. 5-Bromobenzisothiazole-3-carboxy lie acid. 6-Methoxybenzisothiazole-3-carboxylic acid.The following esters were prepared from the acid using ethanol and sulfuric acid:Ethyl 6-bromobenzisothiazole-3-carboxylate. Ethyl 5-bromobenzisothiazole-3-carboxylate. Ethyl 6-methoxybenzisothiazole-3-carboxylate.

As the rapid development of chemical substances, we look forward to future research findings about 677304-75-5

Reference£º
Patent; MEMORY PHARMACEUTICALS CORPORATION; WO2007/56582; (2007); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

677304-75-5, 6-Bromobenzo[d]isothiazole-3-carboxylic acid is a isothiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,677304-75-5

Step 5; Sulfuryl dichloride (86.7 mg, 728 mumol) is added to a solution of6-bromobenzo[d]-isothiazole-3-carboxylic acid (188 mg, 728 mumol). The reaction mixture is stirred for 30 min before removing the volatiles by rotovap. The residue is taken up in CH2Cl2 (0.587 ml) and a solution of 2-prorhoylamine (62.5 muL, 728 mumol) and triethylamine (101 mul, 728 mumol) in CHjCl2 (1.2 ml) is added. The reaction mixture is stirred at room temperature until LC/MS analysis indicates complete conversion to the desired product. The reaction mixture is diluted with distilled water and ethyl acetate. The layers are separated and the aqueous is extracted with ethyl acetate. The combined organics are washed with brine and dried over Na2SO4, filtered and concentrated to give 6-bromo-N-isopropylbenzo[d]isothiazole- 3-carboxamide.

As the paragraph descriping shows that 677304-75-5 is playing an increasingly important role.

Reference£º
Patent; AMGEN INC.; MEMORY PHARMACEUTICALS CORPORATION; WO2007/100880; (2007); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

677304-75-5, 6-Bromobenzo[d]isothiazole-3-carboxylic acid is a isothiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,677304-75-5

The following procedure was used to prepare benzisothiazole fer/-butyl esters:Di-ferz’-butyldicarbonate (128 mmol) was added to a suspension of 6-bromo-l,2- benzisothiazole-3-carboxyIic acid (46.5 mmol) and 4-dimethylaminopyridine (4.26 mmol) in tert-buty alcohol (40.0 mL) and tetrahydrofuran (40.0 mL) and the reaction mixture was heated at 65 0C for 16 hours. There was vigorous carbon dioxide evolution which gradually subsided as the mixture become homogeneous. The reaction mixture was concentrated and the residue was dissolved in dichloromethane. The dichloromethane solution was filtered through silica gel (ca. 5Og) and the eluent was concentrated to provide the ester product in 99% yield.The following ester was prepared using this method:tert-Butyl S-brorno-l^-benzisothiazole-S-carboxylate. tert-Butyl -bromo-l^-benzisothiazole-S-carboxylate.

677304-75-5 6-Bromobenzo[d]isothiazole-3-carboxylic acid 53401192, aisothiazole compound, is more and more widely used in various fields.

Reference£º
Patent; MEMORY PHARMACEUTICALS CORPORATION; WO2007/56582; (2007); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

677304-75-5,677304-75-5, 6-Bromobenzo[d]isothiazole-3-carboxylic acid is a isothiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation 45; 6-(4-Hvdroxy-2-methyl-phenyl)-benzordlisothiazole-3-carboxylic acid; To a degassed solution of 6-Bromo-benzo[d]isothiazole-3-carboxylic acid (0.42g, 1.54mmol), 3-Methyl-4-(4,4,5,5-tetramethyl-[l,3,2]dioxaborolan-2-yl-phenol (0.54, 2.3 lmmol), 2-Dicyclohexylphosphino-2′,6′-dimethoxy- 1 , 1 ‘-biphenyl (0.064g, 0.154mmol), and potassium phosphate (0.7 Ig, 3. lmmol) in dioxane (8mL) and water (4mL) is added Pd(OAc)2 (6.5mg, 0.03mmol). The reaction is degassed again and heated to 80 degrees for 18 h. The reaction is cooled to room temperature and concentrated under reduced pressure. The material is diluted with EtOAc and IN HCl. The layers are separated and concentrated under reduced pressure. The crude material is diluted with 20 mL of MeOH and 2 mL H2SO4 and heated to reflux for 2 h. The reaction is concentrated onto silica and purified using a gradient of 20 to 50% EtOAc in Hexanes to yield the title compound (0.12g, 26% yield). ES/MS m/e 300.0 (M+l).

The synthetic route of 677304-75-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ELI LILLY AND COMPANY; WO2007/140174; (2007); A2;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com