Category: 6307-44-4

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 6307-44-4, is researched, Molecular C5H7N3S, about The chemistry of pyrimidinethiols. II. The preparation and reactions of some 2-arenecarbonylmethylthiopyrimidines, the main research direction is pyrimidinone phenacylthio; phenacylthiopyrimidinone.Recommanded Product: 6307-44-4.

2-Pyrimidinethiones were treated with phenacyl halides to give (phenacylthio)pyrimidines I (R1= Ph, tolyl, halophenyl, anisyl, dimethyoxyphenyl, O2NC6H4, biphenyl, Cl2C6H3, naphthyl; R2 = Me, H, Ph, Pr, NH2). Some I were heated in Ph2O to give phenacylidenepyrimidinones II (R3 = Ph, tolyl, halophenyl, anisyl, dimethyoxyphenyl, O2NC6H4, biphenylyl, naphthyl; R4 = Me, H, Pr).

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Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

HPLC of Formula: 6307-44-4. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 2-Amino-6-methylpyrimidine-4-thiol, is researched, Molecular C5H7N3S, CAS is 6307-44-4, about Synthesis and antibacterial activities of novel C(3)-aminopyrimidinyl substituted cephalosporins. Author is Lee, Chang-Seok; Oh, Seong Ho; Ryu, Eun-Jung; Kim, Mu-Yong; Paek, Kyung-Sook.

A new class of cephalosporins with C(3)-aminopyrimidinylthio substituents was prepared and found to exhibit well balanced activities against Gram-neg. and Gram-pos. bacteria. The MIC data on some of these new β-lactams, e.g., I and II, prove that this type of cephalosporin deserves further evaluation as new antibiotics against respiratory tract pathogens.

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Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Lee, Chang-Seok; Oh, Seong Ho; Ryu, Eun-Jung; Kim, Mu-Yong; Paek, Kyung-Sook published the article 《Synthesis and antibacterial activities of novel C(3)-aminopyrimidinyl substituted cephalosporins》. Keywords: cephalosporin aminopyrimidinylthio antibacterial antimicrobial preparation; beta lactam aminopyrimidinylthio preparation.They researched the compound: 2-Amino-6-methylpyrimidine-4-thiol( cas:6307-44-4 ).COA of Formula: C5H7N3S. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:6307-44-4) here.

A new class of cephalosporins with C(3)-aminopyrimidinylthio substituents was prepared and found to exhibit well balanced activities against Gram-neg. and Gram-pos. bacteria. The MIC data on some of these new β-lactams, e.g., I and II, prove that this type of cephalosporin deserves further evaluation as new antibiotics against respiratory tract pathogens.

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Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Aryl ethers of 4-[(2-hydroxyethyl)sulfanyl]pyrimidine derivatives: Pathways of synthesis and fungicidal activity of their salt forms, published in 2016-06-30, which mentions a compound: 6307-44-4, Name is 2-Amino-6-methylpyrimidine-4-thiol, Molecular C5H7N3S, Name: 2-Amino-6-methylpyrimidine-4-thiol.

2-Amino-4-[(2-aryloxyethyl)sulfanyl]-6-methylpyrimidines were obtained by S-alkylation of 2-amino-6-methylpyrimidin-4(3H)-thione with 2-aryloxyethyl chlorides. Since 2-amino-4-[(2-chloroethyl)sulfanyl]-6-methylpyrimidine is prone to in situ intramol. cyclization it cannot be used in Claisen reaction. The bromination of the target compounds provided 5-bromo derivatives; some of their hydrochlorides exhibited fungicidal activity.

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Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Recommanded Product: 2-Amino-6-methylpyrimidine-4-thiol. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2-Amino-6-methylpyrimidine-4-thiol, is researched, Molecular C5H7N3S, CAS is 6307-44-4, about Aryl ethers of 4-[(2-hydroxyethyl)sulfanyl]pyrimidine derivatives: Pathways of synthesis and fungicidal activity of their salt forms.

2-Amino-4-[(2-aryloxyethyl)sulfanyl]-6-methylpyrimidines were obtained by S-alkylation of 2-amino-6-methylpyrimidin-4(3H)-thione with 2-aryloxyethyl chlorides. Since 2-amino-4-[(2-chloroethyl)sulfanyl]-6-methylpyrimidine is prone to in situ intramol. cyclization it cannot be used in Claisen reaction. The bromination of the target compounds provided 5-bromo derivatives; some of their hydrochlorides exhibited fungicidal activity.

From this literature《Aryl ethers of 4-[(2-hydroxyethyl)sulfanyl]pyrimidine derivatives: Pathways of synthesis and fungicidal activity of their salt forms》,we know some information about this compound(6307-44-4)Recommanded Product: 2-Amino-6-methylpyrimidine-4-thiol, but this is not all information, there are many literatures related to this compound(6307-44-4).

Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Synthesis and Plant Growth Stimulating Action of 2-Amino-6-methylpyrimidine-4(3H)-thione Derivatives》. Authors are Hambardzumyan, E. N.; Vorskanyan, A. S.; Shahbazyan, L. V.; Yengoyan, A. P..The article about the compound:2-Amino-6-methylpyrimidine-4-thiolcas:6307-44-4,SMILESS:SC1=CC(C)=NC(N)=N1).HPLC of Formula: 6307-44-4. Through the article, more information about this compound (cas:6307-44-4) is conveyed.

A series of new pyrimidine derivatives, e.g., I including those containing an azole or azine heterocycle linked through a sulfur atom or a thiomethylene group, was synthesized based on 2-amino-6-methylpyrimidine-4(3H)-thione. The synthesized compounds exhibited a pronounced stimulating effect on plants growth in the range of 43-96% compared to heteroauxin.

There is still a lot of research devoted to this compound(SMILES：SC1=CC(C)=NC(N)=N1)HPLC of Formula: 6307-44-4, and with the development of science, more effects of this compound(6307-44-4) can be discovered.

Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Synthetic Route of C5H7N3S. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2-Amino-6-methylpyrimidine-4-thiol, is researched, Molecular C5H7N3S, CAS is 6307-44-4, about N-(3-Sulfanylmethyl-4H-1,2,4-triazol-4-yl)-2-sulfanylacetamide Containing Terminal 2-Amino-6-methylpyrimidin-4-yl Fragments. Synthesis from 2-[(2-Amino-6-methylpyrimidin-4-yl)sulfanyl]acetohydrazide and Triethyl Orthoformate.

2-[(2-Amino-6-methylpyrimidin-4-yl)sulfanyl]acetohydrazide reacted with tri-Et orthoformate at a molar ratio of 1:1 to give 2-[(2-amino-6-methylpyrimidin-4-yl)sulfanyl]-N-{3-[(2-amino-6-methylpyrimidin-4-yl)sulfanylmethyl]-4H-1,2,4-triazol-4-yl}acetamide.

There is still a lot of research devoted to this compound(SMILES：SC1=CC(C)=NC(N)=N1)Synthetic Route of C5H7N3S, and with the development of science, more effects of this compound(6307-44-4) can be discovered.

Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Quantum Chemistry, NMR Spectroscopy, and Single-Crystal Diffractometry Methods in the Analysis of Protonation Pathways of 2-Amino-4-benzylsulfanyl-6-methylpyrimidines, published in 2019-01-31, which mentions a compound: 6307-44-4, mainly applied to aminomethyl pyrimidinethione benzyl chloride protonation mechanism NMR chem shift, Application In Synthesis of 2-Amino-6-methylpyrimidine-4-thiol.

Protonation pathways of 2-amino-4-benzylsulfanyl-6-methylpyrimidines have been investigated by means of semiempirical PM3 quantum-chem. simulation, 13C NMR spectroscopy, and single-crystal diffractometry methods. In the gas phase and in the bipolar aprotic solvent, the protonation involves the N1 atom. The protonation in the crystalline state is characterized by the formation of a branched system of H-bonds, involving the protons of the amino group besides the mentioned nitrogen atom.

If you want to learn more about this compound(2-Amino-6-methylpyrimidine-4-thiol)Application In Synthesis of 2-Amino-6-methylpyrimidine-4-thiol, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(6307-44-4).

Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Name: 2-Amino-6-methylpyrimidine-4-thiol. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2-Amino-6-methylpyrimidine-4-thiol, is researched, Molecular C5H7N3S, CAS is 6307-44-4, about Aryl ethers of 4-[(2-hydroxyethyl)sulfanyl]pyrimidine derivatives: Pathways of synthesis and fungicidal activity of their salt forms. Author is Erkin, A. V.; Klaptyuk, I. V.; Gurzhii, V. V.; Yuzikhin, O. S.; Krutikov, V. I..

2-Amino-4-[(2-aryloxyethyl)sulfanyl]-6-methylpyrimidines were obtained by S-alkylation of 2-amino-6-methylpyrimidin-4(3H)-thione with 2-aryloxyethyl chlorides. Since 2-amino-4-[(2-chloroethyl)sulfanyl]-6-methylpyrimidine is prone to in situ intramol. cyclization it cannot be used in Claisen reaction. The bromination of the target compounds provided 5-bromo derivatives; some of their hydrochlorides exhibited fungicidal activity.

If you want to learn more about this compound(2-Amino-6-methylpyrimidine-4-thiol)Name: 2-Amino-6-methylpyrimidine-4-thiol, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(6307-44-4).

Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Ganatra, Sunil H.; Bodhe, Manoj N.; Tatode, P. N. published the article 《Inhibition studies of Pyrimidine class of compounds on Enoyl-ACP reductase enzyme》. Keywords: enoyl ACP reductase pyrimidine antileprosy mol docking modeling leprosy.They researched the compound: 2-Amino-6-methylpyrimidine-4-thiol( cas:6307-44-4 ).Related Products of 6307-44-4. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:6307-44-4) here.

Present work is aimed to identify and understand the inhibiting nature of Pyrimidine class of compounds to enoyl acyl carrier protein reductase (Enoyl-ACP reductase), which is one of the main receptor proteins used in drug discovery for screening anti-leprosy agents. Series of Pyrimidine based compounds are virtually designed using the mol. mechanic technique. The designed mols. were docked using with crystal structure of Enoyl-ACP reductase (PDB ID: 2NTV) using Autodock mol. docking software. The method uses rigid-protein and flexible ligand-techniques to acquire maximum conformations of ligand mols. The docking results were evaluated using the acquired binding energy values for each ligand-protein complex. Those mols. having higher neg. binding energy values with higher hydrogen bonds are selected for further anal. The selected mols. show better hydrophobic, electrostatic and steric interactions with receptor protein. It is reported that the presence of -CH2OH at R1 and -C6H5 at R2 and R3 positions enhance the neg. binding energy (ΔG kcal mol-1) values. Particularly -OC6H5 at R1 and -OH at R2 help in increasing the interactions between ligand and protein. The results show the mol. level interactions and inhibit the receptor protein.

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Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com