Category: 560-09-8

Safety of (1S,3R)-1,2,2-Trimethylcyclopentane-1,3-dicarboxylic acid. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: (1S,3R)-1,2,2-Trimethylcyclopentane-1,3-dicarboxylic acid, is researched, Molecular C10H16O4, CAS is 560-09-8, about Stereo- and enantio-selective hydrogenation of ketones using iridium catalysts containing a carboxylate ligand. Author is Heil, Balint; Kvintovics, Pal; Tarszabo, Laszlo; James, Brian R..

Cyclohexanone I and PhCOMe were hydrogenated in Me2CHOH under Ar in the presence of a catalyst formed from [IrCl(C8H14)2]2, a carboxylic acid, and P(OR2)3 (R2 = Bu, Ph, Me). For I the best carboxylic acids were BzOH, AcOH, (R)-(-)-PhCH(OH)CO2H (II) (R)-(+)-HO2CCH2CH(OH)CO2H, MeCH:CHCO2H and PhCH:CHCO2H. (RS)-PhCH(OAc)CO2H, EtCO2H and (1S,3R)-camphoric acid gave lower conversions. Conversion was increased to 78% when Et3N was added and the catalyst contained BzOH and P(OMe)3. The cis/trans ratio was 1.8. The cis/trans ratio increased as the P(OMe)3-Ir ratio increased to ∼4, and then decreased. PhCOMe conversion to (S)-PhCH(OH)Me was 75% and an optical yield of 1.0% was obtained by P(OMe)3, II, and NaOMe. Using (S)-(+)-PhCH(OH)CO2H an excess of (R)-PhCH(OH)Me was obtained. (R)-(-)-PhCH(OAc)CO2H gave 12% enantiomeric excess of S-isomer with 20% conversion.

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Reference:
Isothiazole – Wikipedia,
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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Camphane derivatives. VII. Syntheses and structure of 3-methyl-3aβ,7aβ-bornano[3,2-d]oxazolidin-2-one and its derivatives》. Authors are Hamashima, Yoshio; Tori, Kazuo; Takamizawa, Akira.The article about the compound:(1S,3R)-1,2,2-Trimethylcyclopentane-1,3-dicarboxylic acidcas:560-09-8,SMILESS:CC1(C)[C@@H](CC[C@]1(C)C(O)=O)C(O)=O).Product Details of 560-09-8. Through the article, more information about this compound (cas:560-09-8) is conveyed.

cf. CA 62, 4055b. In connection with the elucidation of the structure of I and II, obtained by the reaction of 3α-methylaminocamphor (III) with COCl2, 3-methyl-3aβ,7aβ-(IV) and 3aα,7α-bornano[3,2-d]oxazolidin-2-one (V) and their derivatives were synthesized and studied stereochem. Their N.M.R. spectra were also investigated (tabulated and discussed). Excess COCl2 in C6H6 added dropwise with stirring to a boiling suspension of 10 g. III.HCl in dry C6H6 until dissolution gave 7 g. VI, m. 82° (Et2O-hexane), [α]25D 142° (CHCl3), showing a pos. Cotton effect on optical rotatory dispersion (ORD), 0.36 g. II, m. 193° (MeOH-Et2O), [α]25D 127.7° (CHCl3), showing a pos. Cotton effect on ORD, and 0.3 g. unchanged III.HCl. The resinous oil obtained on concentration redissolved in C6H6, the solution washed with 10% aqueous Na2CO3, dried, and concentrated, the oily residue kept several days (HCl evolved), the resulting solid extracted with Et2O, and the Et2O-soluble fraction washed with dilute aqueous Na2CO3, chromatographed on neutral Al2O3, and eluted with Et2O gave 5 g. I, m. 82° (Et2O-hexane), [α]25D -22° (CHCl3), showing a neg. plain curve on ORD; the product eluted with MeOH and the Et2O-insoluble solid combined and recrystallized from MeOH gave 0.40 g. II. VI (0.2 g.) refluxed 2 hrs. with 5 ml. 25% MeOH-HCl gave 0.092 g. I and 0.046 g. VII, m. 122°. VI(0.5 g.) refluxed 5 hrs. with 3 ml. SOCl2 gave 0.35 g. I, m. 82°. (VII,R=Me); (IX,R=Et); (X,R=Ac); (XI,R=Bz); A suspension of I in 4 ml. 2% HCl heated 30 min. at 80° on a steam bath until CO2 evolution ceased and the resulting solution concentrated to dryness gave 15 mg. III.HCl, m. 238° (decomposition). ClCO2Me (1 mole) added dropwise to 2 moles III in Et2O with stirring and ice cooling and the mixture stirred 1 hr. at room temperature, gave VIII, b1, 130-40°, m. 53-4°. A mixture of 100 mg. I and 200 mg. KOH in 10 ml. MeOH refluxed 10 hrs. gave VIII, b1 135°, m. 50°. I (480 mg.) in 5 ml. MeOH containing 500 mg. Na heated 30 min. at 70° gave 400 mg. VIII, b1, 130-40°. I (1 g.) in 15 ml. 30% MeOH-HCl refluxed 10 hrs. gave 0.6 g. VII, m. 122°. I (1 mole) in C5H5N heated 2 hrs. at 70° with 1.2 moles AgNO3 in MeOH also gave VII, m. 122°. I (1 g.) refluxed with 25% EtOH-HCl and worked up like VII gave 0.9 g. IX, b0.07 145°. Both VII and IX were easily hydrolyzed to III by concentrated HCl. A mixture of 2.44 g. I and 2 g. AgOAc in AcOH refluxed 8 hrs. gave 2.1 g. X, m. 107° (hexane), showing a plain neg. curve on ORD. I (240 g.) mixed with 230 mg. AgOBz and 2 g. BzOH, and the mixture heated 10 hrs. at 150-60° and cooled, and the product isolated by extraction with C6H6 gave 200 mg. XI, m. 153-4°, [α]23D -47.2° (CHCl3). Acid hydrolysis of both X and XI led to III, no other products or intermediates being obtained. I (100 mg.) in 10 ml. MeOH containing 200 mg. KOH hydrogenated over 100 mg. 10% Pd-C at room temperature and atm. pressure with stirring (9 ml. H absorbed during 1 hr.) gave 60 mg. IV, m. 119° (Et2O), [α]28D 108.2° (CHCl3), showing a pos. plain curve on ORD. IV was also obtained in fairly good yield by hydrogenation with Raney Ni in alk. medium. 3α-Aminoborneol (XII) (300 mg.) and 3 ml. 98% HCO2H heated 6 hrs. at 110° gave 150 mg. XIII, m. 143° (EtOH). XII (100 mg.) and 100 mg. HCONH2 heated 10 min. at 120° gave 100 mg. XIII, m. 143°. (XII,R=H); (XIII,R=CHO); (XIV,R=Me); (XVIII,R=Cl); (XIX,R=OH); (XXII,R=OAc); (XXIII,R=OMe); XIII (300 mg.) in tetrahydrofuran (THF) added dropwise to 200 mg. LiAlF4 in THF with ice water cooling and the mixture refluxed and stirred 4 hrs. gave 200 mg. XIV, m. 85-6° (hexane). III (3 g.) in Et2O added to 300 mg. LiAlH4 in Et2O and the mixture stirred 2 hrs. at room temperature gave 1.0 g. XIV, m. 85° (hexane). To a mixture of 500 mg. XIV, 10 ml. C6H6, and 10 ml. 10% aqueous Na2CO3 was added 20% C6H6COCl2 with stirring until the organic layer became clear (the mixture was kept alk. throughout the reaction) gave 510 mg. IV, m. 119° (Et2O), [α]26D 108° (CHCl3), IV (10 mg.) refluxed 6 hrs. with 2 ml. MeOH containing 200 mg. KOH gave 6 mg. XIV, m. 80-2°. XIV (200 mg.) and 2 ml. CS2 in 15 ml. EtOH refluxed until no more H2S was evolved (15 hrs.) (during the reaction addnl. CS2 was added) gave 120 mg. XV, m. 206° (MeOH). A suspension of 120 mg. XV and 500 mg. Raney Ni (WII) in EtOH stirred 3 hrs. at room temperature and kept overnight gave 50 mg. XIV, m. 80-2°. To 100 mg. XV in 1 ml. AcOH was added dropwise 35% H2O2 until no more turbidity occurred and the mixture let stand 2 hrs. at room temperature to give IV, m. 119°. 3α-Aminoisoborneol (200 mg.) and 1 ml. 98% HCO2H refluxed 5 hrs. gave 150 mg. 3α-formamido analog, m. 162° (Me2CO-Et2O), which (480 mg.) reduced with LiAlH4 in Et2O gave 300 mg. 3α-methylaminoisoborneol (XVI), m. 66-7° (Et2O-hexane) (HCl salt m. >310°). II (70 mg.) treated with 2 ml. C5H5N and 1 ml. Ac2O under ice water cooling and the solution kept ∼1 week at room temperature gave 60 mg. XVII, m. 120.5° (Et2O), [α]30D 150.3°, showing a pos. plain curve on ORD. XVII on hydrolysis with NaOH or HCl gave II. II(100 mg.) and 2 ml. SOCl2 refluxed 20 hrs. until gas evolution ceased gave 100 mg. XVIII, m. 132° (Et2O-hexane), [α]28D -21.5° (CHCl3), showing a pos. plain curve on ORD. II (100 mg.) and 500 mg. PCl5 in 2 ml. POCl3 refluxed 20 hrs. gave 80 mg. XVIII, m. 130-1°. XVIII (400 mg.) suspended in 10 ml. 10% HCl heated 15 hrs. at 100° gave quant. XIX, m. 254° (decomposition) (MeOH-Et2O), [α]24D 13.3° (CHCl3), showing a pos. plain curve on ORD. XVIII (260 mg.) in 10 ml. MeOH containing 620 mg. KOH heated 4 hrs. at 75° and kept overnight at room temperature gave 100 mg. camphor-quinone (XX), m. 190-5°, and 100 mg. XIX. XIX (130 mg.) in 3 ml. absolute MeOH containing 200 mg. Na kept 1 week at room temperature gave 40 mg. D-camphoric acid (XXI), m. 187° (Et2O-hexane), [α]25D 46.1° (EtOH), and a small amount XX. XXI (10 mg.) heated 4 hrs. at 140° with 10 mg. ZnCl2 and 500 mg. Ac2O gave 3 mg. camphoric anhydride, m. 220°. XIX (50 mg.) in 10 ml. MeOH containing 50 mg. KOH hydrogenated over 100 mg. Raney Ni at room temperature and atm. pressure with stirring (6 ml. H absorbed, during 1 hr.) gave 37 mg. II, m. 188-90°. Zn (600 mg.) added to 130 mg. XIX in 6 ml. AcOH at 100° with stirring, after 2 hrs. 600 mg. Zn added, and the mixture heated and stirred 2 hrs. gave 20 mg. unchanged XIX, and 45 mg. II, m. 190-2°. XVIII (40 mg.), 60 mg. AgOAc; and 1 ml. C5H5N in 1 ml. AcOH heated 3 hrs. at 100° gave 25 mg. XXII, m. 84-5° (Et2O-hexane), [α]22D 67.2° (CHCl3), showing a pos. plain curve on ORD. To 50 mg. XIX in 5 ml. C5H5N was added 1 ml. Ac2O with cooling and the solution kept 1 week at room temperature to give 50 mg. XXII, m. 84° (Et2O-hexane). Treatment of either XVIII or XIX with excess AgOAc in C5H5N gave XXII. XXII (20 mg.) heated 4 hrs. on a steam bath with 2 ml. 10% HCl gave XIX, m. 254° (decomposition) (Et2O). XIX (50 mg.) and 2 ml. SOCl2 refluxed 20 hrs. gave XVIII, m. 132° (Et2O-hexane). A mixture of 40 mg. XVIII, 60 mg. AgNO3; 2 ml. C5H5N, and 2 ml. MeOH heated 1.5 hrs. on a steam bath until no further precipitation of solid occurred gave XXIII, b0.05 110-20°, m. 76-8° (hexane), showing a small pos. plain curve on ORD. XVIII (20 mg.) in 2 ml. 25% MeOH-HCl heated 5 hrs. gave 12 mg. XXIII, b0.05 115°. XXIII (50 mg.) in MeOH hydrogenated over 100 mg. Raney Ni at room temperature and atm. pressure (1 mol. equivalent H was absorbed) gave XXIV, b0.15 120-30°, m. 48-50°. To 260 mg. XIX in AcOD (prepared from 10 ml. Ac2O and 3 ml. D2O) was added 1 g. Zn at 110° with stirring, after 1.5 hrs. 1.5 g. Zn added, and the mixture heated 4.5 hrs. to give XXV, m. 192-3°. XVIII (100 mg.) in 10 ml. MeOH containing 200 mg. KOH hydrogenated over 100 mg. 10% Pd-C at room temperature and atm. pressure (2 mol. equivalents H absorbed in 15 min.) gave 60 mg. IV, m. 119° (Et2O-hexane), and 13 mg. XIV, m. 84-5°. XVIII (55 mg.) in 10 ml. MeOH containing 100 mg. KOH hydrogenated over 200 mg. Raney Ni at room temperature and atm. pressure (2 mot. equivalents H absorbed in 15 min.) gave 28 mg. V, m. 123° (Et2O), [α]27D -33.3° (CHCl3), showing a neg. plain curve on ORD. The N.M.R. spectral evidence confirmed the assignment of the configurations of most of the compounds prepared Pertinent ir data were given and the N.M.R. spectra of IV and V recorded.

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Isothiazole – Wikipedia,
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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (1S,3R)-1,2,2-Trimethylcyclopentane-1,3-dicarboxylic acid( cas:560-09-8 ) is researched.HPLC of Formula: 560-09-8.Rahman, Mohammad Arifur; Hopke, Philip K. published the article 《Mechanistic Pathway of Carbon Monoxide Off-Gassing from Wood Pellets》 about this compound( cas:560-09-8 ) in Energy & Fuels. Keywords: mechanistic pathway carbon monoxide off gassing wood pellet storage. Let’s learn more about this compound (cas:560-09-8).

The off-gassing of carbon monoxide (CO) from stored wood pellets was identified as a significant problem, potentially resulting in adverse occupational and residential exposures. The mechanism for the production of CO from wood pellets was not fully identified. A multiple step process was hypothesized. The reaction is initiated by the autoxidation of unsaturated compounds, including fatty acids and terpenes, by mol. oxygen. As a byproduct of these reactions, hydroxyl radicals are formed. Then, the bulk of CO results from the reactions of hemicellulose and hydroxyl radicals. To understand the mechanistic pathway of CO off-gassing, a number of experiments were conducted in which CO was measured and evolved organic compounds were analyzed using gas chromatog.-mass spectrometry (GC-MS). These studies identified a number of short- and long-chain aldehydes from the evolved gases that indicates the autoxidation mechanism. However, there is insufficient mass of these unsaturated compounds in wood to support the observed mass of off-gassed CO. However, autoxidation would form hydroxyl radicals. The role of hydroxyl radicals was studied using a radical scavenger, and its role in CO production was confirmed. Thus, if the autoxidation initiation can be eliminated, then CO off-gassing from pellets would be substantially reduced. Destruction of the reactive compounds with ozone led to a suppression of CO formation, suggesting an approach to process the wood fiber that would result in low or no CO emission wood pellets.

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Isothiazole – Wikipedia,
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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Journal of Molecular Structure called Investigation on two homologus series of ferroelectric hydrogen bond liquid crystals derived from camphoric acid and alkyloxy/alkyl benzoic acids, Author is Mohan, M. L. N. Madhu; Pal, Kaushik, which mentions a compound: 560-09-8, SMILESS is CC1(C)[C@@H](CC[C@]1(C)C(O)=O)C(O)=O, Molecular C10H16O4, HPLC of Formula: 560-09-8.

Two ferroelec. series comprising of 12 mesogens are investigated. In the first homologous series, Camphoric acid abbreviated as CA which is a ferroelec. ingredient, formed hydrogen bonds with benzoic acids with oxygen atom abbreviated as nBAO. The carbon chain of the benzoic acids varied from 5 to 12 atoms. Thus eight homologous members are synthesized. This mesogenic homologous series is represented as CA+nBAO. Similarly, Camphoric acid formed hydrogen bonds with alkyl benzoic acids abbreviated as nBA. The carbon number of the benzoic acids varied from 5 to 8. This mesogenic homologous series is represented as CA+nBA. Phases observed includes a new phase variant Smectic X*, and conventional phases C*, I* and G*. DSC thermograms exposed the Tc and corresponding ΔH magnitudes. Dielec. relaxations in smectic C* are discussed for a selected mesogen. The existence of oxygen in CA+nBAO facilitated presence of abundance poly phase morphism.

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Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (1S,3R)-1,2,2-Trimethylcyclopentane-1,3-dicarboxylic acid( cas:560-09-8 ) is researched.Synthetic Route of C10H16O4.Chen, Shu-Mei; Chang, Li-Mei; Yang, Xue-Kang; Luo, Ting; Xu, Hai; Gu, Zhi-Gang; Zhang, Jian published the article 《Liquid-Phase Epitaxial Growth of Azapyrene-Based Chiral Metal-Organic Framework Thin Films for Circularly Polarized Luminescence》 about this compound( cas:560-09-8 ) in ACS Applied Materials & Interfaces. Keywords: LPE azapyrene chiral metalorganic framework film circularly polarized luminescence; epitaxy liquid phase azapyrene chiral metalorganic framework polarized luminescence; circularly polarized luminescence; enantioselective adsorption; homochiral; layer by layer; liquid-phase epitaxial growth; metal−organic framework; oriented film. Let’s learn more about this compound (cas:560-09-8).

Development of chiral metal-organic frameworks (MOFs) for circularly polarized luminescence (CPL) is a challenging but important task. An example of azapyrene-based chiral MOF thin films [Zn2Cam2DAP]n grown on functionalized substrates (named SURchirMOF-4) for CPL property is reported. By using a liquid-phase epitaxial layer-by-layer method, the resulted SURchirMOF-4 was constructed from chiral camphoric acid and 2,7-diazapyrene ligand, which has high orientation and homogeneity. The CD, CPL, and enantioselective adsorption results show that SURchirMOF-4 has strong chirality and CPL property as well as good enantioselective adsorption toward enantiomers of Me-lactate. The synthesis of azapyrene-based chiral MOF thin films not only represents an ideal model for studying the enantioselective adsorption, but also will be a valuable approach for development of the chiral thin film exhibiting CPL property.

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Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: (1S,3R)-1,2,2-Trimethylcyclopentane-1,3-dicarboxylic acid, is researched, Molecular C10H16O4, CAS is 560-09-8, about Vitamin D3: synthesis of seco C-9,11,21-trisnor-17-methyl-1α, 25-dihydroxyvitamin D3 analogues, the main research direction is vitamin D3 analog antiproliferative antitumor calcemic effect preparation; trisnormethyldihydroxyvitamin D3 D ring analog preparation.Formula: C10H16O4.

The synthesis and biol. activities of seco C-9,11,21-trisnor-17-methyl-1α,25-dihydroxyvitamin D3 analogs (D-ring analogs) are described. Synthesized analogs were evaluated for their affinity for the vitamin D receptor, in vivo calcemic effects in mice, and anti-proliferative activity in various cell lines.

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Isothiazole – Wikipedia,
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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 560-09-8, is researched, Molecular C10H16O4, about Two Homochiral Bimetallic Metal-Organic Frameworks Composed of a Paramagnetic Metalloligand and Chiral Camphorates: Multifunctional Properties of Sorption, Magnetism, and Enantioselective Separation, the main research direction is solvothermal preparation homochiral cobalt tristriazolylborate copper camphorate porous MOF; crystal structure homochiral cobalt tristriazolylborate copper camphorate porous MOF; thermal decomposition homochiral cobalt tristriazolylborate copper camphorate porous MOF; gas adsorption homochiral cobalt tristriazolylborate copper camphorate porous MOF; magnetic property homochiral cobalt tristriazolylborate copper camphorate porous MOF.HPLC of Formula: 560-09-8.

Two porous metal-organic frameworks [Co(Tt)2][Cu4(D-cam)4]·5H2O·DMF (1; Tt = tris(triazolyl)borate, D-H2cam = D-(+)-camphoric acid or (1R,3S)-1,2,2-trimethyl-1,3-cyclopentanedicarboxylic acid) and [Co(Tt)2][Cu4(L-cam)4]·5H2O·2DMF (2; L-H2cam = L-(-)-camphoric acid or (1S,3R)-1,2,2-trimethyl-1,3-cyclopentanedicarboxylic acid) were prepared by mixing Cu2+, Co(Tt), and camphoric acid under solvothermal conditions. The structures of 1 and 2 reveal that the two-dimensional layers composed of chiral ligands and Cu-Cu paddlewheel units are connected through the metalloligands to form three-dimensional networks. These solids show multifunctional properties such as gas adsorption onto the pores of the frameworks, antiferromagnetic coupling between spin carriers, and a small enantioselective separation of racemic alcs.

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Isothiazole – Wikipedia,
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Safety of (1S,3R)-1,2,2-Trimethylcyclopentane-1,3-dicarboxylic acid. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (1S,3R)-1,2,2-Trimethylcyclopentane-1,3-dicarboxylic acid, is researched, Molecular C10H16O4, CAS is 560-09-8, about Highly selective biotransformation of (+)-(1S)- and (-)-(1R)-camphorquinone by Aspergillus wentii.

To clarify the structures of biotransformation products and metabolic pathways, the biotransformation of monoterpenoids, (+)- and (-)-camphorquinone (1a and b), has been investigated using Aspergillus wentii as a biocatalyst. Compound 1a was converted to (-)-(2S)-exo-hydroxycamphor (2a), (-)-(2S)-endo-hydroxycamphor (3a), (-)-(3S)-exo-hydroxycamphor (4a), (-)-(3S)-endo-hydroxycamphor (5a), and (+)-camphoric acid (6a). Compound 1b was converted to (+)-(2R)-exo-hydroxycamphor (2b), (+)-(2R)-endo-hydroxycamphor (3b), (+)-(3R)-exo-hydroxycamphor (4b), (+)-(3R)-endo-hydroxycamphor (5b), and (-)-camphoric acid (6b). Compound 1a mainly produced 2a (65.0%) with stereoselectivity, whereas 1b afforded 3b (84.3%) with high stereoselectivity. These structures were confirmed by gas chromatog.-mass spectrometry, IR, 1H NMR (NMR), and 13C NMR spectral data. The products illustrate the marked ability of A. wentii for enzymic oxidation and ketone reduction

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Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (1S,3R)-1,2,2-Trimethylcyclopentane-1,3-dicarboxylic acid( cas:560-09-8 ) is researched.Reference of (1S,3R)-1,2,2-Trimethylcyclopentane-1,3-dicarboxylic acid.Liu, Bo; Shekhah, Osama; Arslan, Hasan K.; Liu, Jinxuan; Woell, Christof; Fischer, Roland A. published the article 《Enantiopure Metal-Organic Framework Thin Films: Oriented SURMOF Growth and Enantioselective Adsorption》 about this compound( cas:560-09-8 ) in Angewandte Chemie, International Edition. Keywords: enantiopure metalorganic framework oriented film growth enantioselective adsorption. Let’s learn more about this compound (cas:560-09-8).

The LPE growth of [Zn2[(+)cam]2(dabco)n] [(+)cam = (1R,3S)-(+)-camphoric acid, dabco = 1,4-diazabicyclo[2.2.2]octane] and its enantiomeric form and their application to the direct QCM (quartz crystal microbalance) monitoring of the uptake of a pair of enantiomeric guest mols., namely (2R,5R)-2,5-hexanediol (R-HDO) and (2S,5S)-2,5-hexanediol (S-HDO) from the gas phase under flow conditions are described. As examined by surface X-ray diffraction in out-of-plane and in-plane modes, the SURMOFs (surface-attached MOFs) were grown in (110) and (001) orientations on SAMs of MHDA and PPMT, with MHDA = 16-mercaptohexadecanoic acid; PPMT = (4,(4-pyridyl)phenyl)methanethiol, resp., on Au-coated QCM substrates. The difference of absolute uptake and absorption rate for each of the chosen enantiomeric probe mols. R-HDO and S-HDO is clear, and show significant enantioselectivity.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Inorganic Chemistry Communications called Homochiral ferroelectric three-dimensional cadmium(II) frameworks from racemic camphoric acid and 3,5-di(imidazol-1-yl)benzoic acid, Author is Su, Zhi; Lv, Gao-Chao; Fan, Jian; Liu, Guang-Xiang; Sun, Wei-Yin, which mentions a compound: 560-09-8, SMILESS is CC1(C)[C@@H](CC[C@]1(C)C(O)=O)C(O)=O, Molecular C10H16O4, Application In Synthesis of (1S,3R)-1,2,2-Trimethylcyclopentane-1,3-dicarboxylic acid.

Two three-dimensional (3D) chiral frameworks, [Cd6(L)4(D-Cam)4(H2O)4]·2H2O (1D) and [Cd6(L)4(L-Cam)4(H2O)4]·2H2O (1L) [HL = 3,5-di(imidazol-1-yl)benzoic acid, D-H2Cam = D-camphoric acid, L-H2Cam = L-camphoric acid], were synthesized under hydrothermal conditions, which represent a nice example of enantioselectivity of organic racemic ligands (DL-camphorates) during the self-assembly process and formation of the metal complexes. Compounds 1D and 1L feature 3-dimensional framework with chiral chains constructed by Cd(II) cations and camphorate anions. Solid-state CD spectra of 1D and 1L revealed that they are enantiomers. Also, the complexes with chiral C2 space group display ferroelec. behavior with a remnant elec. polarization (Pr) of ∼0.140 μC/cm2 and an elec. coercive field (Ec) of ∼17.11 kV/cm.

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Isothiazole – Wikipedia,
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