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Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 455-19-6, Name is 1-Formyl-4-trifluoromethylbenzene, molecular formula is C8H5F3O. In an article, author is Zhao, MX,once mentioned of 455-19-6, Recommanded Product: 455-19-6.

Reaction of ketene aminals with aryl isothiocyanates – A simple route to isothiazole compounds

Cyclic and acyclic ketene aminals with different electron withdrawing groups reacted with aryl isothiocyanates to give the corresponding alpha – carbon adducts in high yield which underwent oxidative cyclization with bromine to afford isothiazole compounds in moderate yield.

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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

 

More research is needed about C8H5F3O

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Related Products of 455-19-6, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 455-19-6, Name is 1-Formyl-4-trifluoromethylbenzene, SMILES is O=CC1=CC=C(C(F)(F)F)C=C1, belongs to isothiazole compound. In a article, author is Clerici, F, introduce new discover of the category.

Isothiazoles .6. Cycloaddition of azides to isothiazole dioxides: Synthesis of thiadiazabicyclo[3.1.0]hexene derivatives and their thermal rearrangement to thiazete dioxides, 1,2,6-thiadiazine dioxides and pyrazoles.

3-Diethylamino-4-(4-methoxyphenyl)-isothiazole 1,1-dioxide(1) was made to react with arylalkyl- and arylazides 2. Cycloadducts 3, which could he isolated in some cases, afforded N-arylalkyl or N-aryl-thiadiazabicyclo[3.1.0]hexene derivatives 4 through N-2-elimination. Thermal rearrangements of N-aryl- and N-beta-phenylethyl substituted compounds 4b-e, produced derivatives of 1,2-thiazete 1,1-dioxide 5, 1,2,6-thiadiazine 1,1-dioxide 6 and pyrazole 7. The reaction can be optimized to afford compounds 6 in synthetically useful yield. In the case of N-benzyl-thiadiazabicyclo[3.1.0]hexene derivative 4a the different substitution on the aziridine nitrogen produced a different reaction course, affording the thiadiazine derivative 6a and the pyrimidine derivative 8. Copyright (C) 1996 Elsevier Science Ltd

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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

 

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Synthesis and antiproliferative activity of benzo[d]isothiazole hydrazones

Several benzo[d]isothiazole hydrazones have been evaluated for their potential antiretroviral activity. Since a number of these compounds were found to be inactive against viruses, but showed cytotoxicity at micromolar concentrations against the human CD4(+) lymphocytes (MT-4) that were used to support HIV-1 growth, they were further tested for antiproliferative activity. The compounds resulted as being cytotoxic for MT-4 cells and new derivatives which were rationally designed and synthesized, were tested for antiproliferative activity against several leukaemia and solid, tumour cell lines. In addition, these compounds were evaluated against normal cell lines. Compound 2h proved to be the most active compound and the fragment -CO-NH-N=CH-2-hydroxyphenyl was identified as being very important for biological activity, suggesting intramolecular, hydrogen bond formation or favourable mutual disposition between two important centres in the pharmacophore. H-1-NMR spectra have been explained with the support of a conformational analysis. (c) 2006 Elsevier SAS. All rights reserved.

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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

 

Discovery of 1-Formyl-4-trifluoromethylbenzene

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Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 455-19-6, Name is 1-Formyl-4-trifluoromethylbenzene, molecular formula is C8H5F3O, belongs to isothiazole compound, is a common compound. In a patnet, author is GEWALD, K, once mentioned the new application about 455-19-6, Recommanded Product: 455-19-6.

ON THE CHEMISTRY OF 4-AMINO-THIAZOLINE-2-THIONES .2.

6-Amino-thiazolo[4,5-c]isothiazole derivatives 4 are obtained by addition of hydrogen sulfide to the 4-Amino-thiazoline-5-carbonitrile 2 followed by cyclooxidation of the intermediate thioamides 3. In the presence of sodium sulfite the hydrolysis of the 4-amino-2-methylthio-thiazolium salts 5 derived from the title compounds 1 yields the 4-amino-thiazolin-2-ones 6. By their further hydrolysis the 2,4-dioxo-thiazolidin-5-carboxamides 8 are formed. The 2-oxo-and 2-thioxo-thiazolo [4,5-d]pyrimidin-7-ones and -thiones available from 1 undergo ring opening by hydrolysis to give the substituted 4-amino-6-oxo- and 4-amino-6-thioxo-pyrimidine-5-thiols 15a-h and 13i-e. They have been isolated as their disulfides 14 or 5-alkyl derivatives i.e. the substituted 4-amino-5-alkylthiopyrimidin-6-ones and -thiones 16. In analogy, the intermediate 6-amino-7-oxo-thiazolo[4,5-d] pyrimidin-2-thione 18 and the 7-amino-thiazolo[4,5-d]-pyrimidin-2-thione 24 derived from 1 react by ring cleavage to yield the 1,4- and 4,6-diamino-pyrimidin-5-thiole derivatives 22 and 27, respectively, isolated as their disulfides or alkylthio-derivatives. From the pyrimidine 16b the pyrimido[5,4-b]1,4-thiazine derivative 18 can be obtained.

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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

 

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Process development and scale-up of cefotetan synthesis

Cefotetan (YM09330) is a semi-synthetic injectable antibiotic which was discovered and developed by Yamanouchi Pharmaceutical Co.,Ltd. and has been on the market since 1983. This compound shows a strong and wide spectrum of antibacterial activity and high stability against beta-lactamase. This paper outlines the optimization of the synthetic process, the replacement of the trifluoroacetic acid used for the cleavage method of benzhydryl ester, work on the stability of diphenyldiazomethane, an alternative synthetic route to Cefotetan, the method for synthesizing the isothiazole derivative and the scale-up of Cefotetan synthesis.

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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

 

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SYNTHESIS OF ISOTHIAZOLE DERIVATIVES WITH POTENTIAL BIOLOGICAL-ACTIVITY

The synthesis of acyl and ureido derivatives of substituted amides of 3-methyl-5-aminoisothiazole-4-carboxylic acid is presented. The structures of the compounds obtained were established on the basis of IR, H-1 NMR and elemental analysis. The influence on the circulatory system of the derivatives was investigated.

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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com

 

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Application of 455-19-6, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 455-19-6, Name is 1-Formyl-4-trifluoromethylbenzene, SMILES is O=CC1=CC=C(C(F)(F)F)C=C1, belongs to isothiazole compound. In a article, author is GUILLOTEAU, F, introduce new discover of the category.

A CONVENIENT REGIOSPECIFIC SYNTHESIS OF ISOTHIAZOL-4-YL DERIVATIVES

Synthesis of derivatives resulting from the formation of a carbon-carbon bond in 4-position of the isothiazole is easily obtained by using the 4-magnesioisothiazole prepared via metal halogen exchange.

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Reference:
Isothiazole – Wikipedia,
,Isothiazole – ScienceDirect.com