Category: 400777-00-6

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: tert-Butyl (6-chloro-4-iodopyridin-3-yl)carbamate(SMILESS: O=C(OC(C)(C)C)NC1=C(I)C=C(Cl)N=C1,cas:400777-00-6) is researched.Category: isothiazole. The article 《Discovery of potent, balanced and orally active dual NK1/NK3 receptor ligands》 in relation to this compound, is published in Bioorganic & Medicinal Chemistry Letters. Let’s take a look at the latest research on this compound (cas:400777-00-6).

During a program directed at selective NK1 receptor antagonists, we serendipitously discovered an NK1 receptor ligand with addnl. affinity for the NK3 receptor. Recognising an opportunity for a drug discovery program aiming for dual NK1/NK3 receptor antagonists, we prepared a series of analogs from a novel, versatile building block. From this series emerged compounds with high and balanced affinities for the NK1 and the NK3 receptors. Typical representatives of this series were active in the gerbil foot tapping assay after oral administration.

After consulting a lot of data, we found that this compound(400777-00-6)Reference of tert-Butyl (6-chloro-4-iodopyridin-3-yl)carbamate can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Inorganic Chemistry called A Ruthenium(II) Complex as a Luminescent Probe for DNA Mismatches and Abasic Sites, Author is Boynton, Adam N.; Marcelis, Lionel; McConnell, Anna J.; Barton, Jacqueline K., which mentions a compound: 400777-00-6, SMILESS is O=C(OC(C)(C)C)NC1=C(I)C=C(Cl)N=C1, Molecular C10H12ClIN2O2, Product Details of 400777-00-6.

[Ru(bpy)2(BNIQ)]2+ (BNIQ = Benzo[c][1,7]naphthyridine-1-isoquinoline), which incorporates the sterically expansive BNIQ ligand, is a highly selective luminescent probe for DNA mismatches and abasic sites, possessing a 500-fold higher binding affinity toward these destabilized regions relative to well-matched base pairs. As a result of this higher binding affinity, the complex exhibits an enhanced steady-state emission in the presence of DNA duplexes containing a single base mismatch or abasic site compared to fully well-matched DNA. Luminescence quenching experiments with Cu(phen)22+ and [Fe(CN)6]3- implicate binding of the complex to a mismatch from the minor groove via metalloinsertion. The emission response of the complex to different single base mismatches, binding preferentially to the more destabilized mismatches, is also consistent with binding by metalloinsertion. This work shows that high selectivity toward destabilized regions in duplex DNA can be achieved through the rational design of a complex with a sterically expansive aromatic ligand.

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Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 400777-00-6, is researched, Molecular C10H12ClIN2O2, about A Ruthenium(II) Complex as a Luminescent Probe for DNA Mismatches and Abasic Sites, the main research direction is ruthenium complex luminescence DNA mismatch.Product Details of 400777-00-6.

[Ru(bpy)2(BNIQ)]2+ (BNIQ = Benzo[c][1,7]naphthyridine-1-isoquinoline), which incorporates the sterically expansive BNIQ ligand, is a highly selective luminescent probe for DNA mismatches and abasic sites, possessing a 500-fold higher binding affinity toward these destabilized regions relative to well-matched base pairs. As a result of this higher binding affinity, the complex exhibits an enhanced steady-state emission in the presence of DNA duplexes containing a single base mismatch or abasic site compared to fully well-matched DNA. Luminescence quenching experiments with Cu(phen)22+ and [Fe(CN)6]3- implicate binding of the complex to a mismatch from the minor groove via metalloinsertion. The emission response of the complex to different single base mismatches, binding preferentially to the more destabilized mismatches, is also consistent with binding by metalloinsertion. This work shows that high selectivity toward destabilized regions in duplex DNA can be achieved through the rational design of a complex with a sterically expansive aromatic ligand.

There is still a lot of research devoted to this compound(SMILES：O=C(OC(C)(C)C)NC1=C(I)C=C(Cl)N=C1)Product Details of 400777-00-6, and with the development of science, more effects of this compound(400777-00-6) can be discovered.

Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called A Ruthenium(II) Complex as a Luminescent Probe for DNA Mismatches and Abasic Sites, published in 2017-07-17, which mentions a compound: 400777-00-6, Name is tert-Butyl (6-chloro-4-iodopyridin-3-yl)carbamate, Molecular C10H12ClIN2O2, Recommanded Product: 400777-00-6.

[Ru(bpy)2(BNIQ)]2+ (BNIQ = Benzo[c][1,7]naphthyridine-1-isoquinoline), which incorporates the sterically expansive BNIQ ligand, is a highly selective luminescent probe for DNA mismatches and abasic sites, possessing a 500-fold higher binding affinity toward these destabilized regions relative to well-matched base pairs. As a result of this higher binding affinity, the complex exhibits an enhanced steady-state emission in the presence of DNA duplexes containing a single base mismatch or abasic site compared to fully well-matched DNA. Luminescence quenching experiments with Cu(phen)22+ and [Fe(CN)6]3- implicate binding of the complex to a mismatch from the minor groove via metalloinsertion. The emission response of the complex to different single base mismatches, binding preferentially to the more destabilized mismatches, is also consistent with binding by metalloinsertion. This work shows that high selectivity toward destabilized regions in duplex DNA can be achieved through the rational design of a complex with a sterically expansive aromatic ligand.

There is still a lot of research devoted to this compound(SMILES：O=C(OC(C)(C)C)NC1=C(I)C=C(Cl)N=C1)Recommanded Product: 400777-00-6, and with the development of science, more effects of this compound(400777-00-6) can be discovered.

Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 400777-00-6, is researched, SMILESS is O=C(OC(C)(C)C)NC1=C(I)C=C(Cl)N=C1, Molecular C10H12ClIN2O2Journal, Article, Inorganic Chemistry called A Ruthenium(II) Complex as a Luminescent Probe for DNA Mismatches and Abasic Sites, Author is Boynton, Adam N.; Marcelis, Lionel; McConnell, Anna J.; Barton, Jacqueline K., the main research direction is ruthenium complex luminescence DNA mismatch.Product Details of 400777-00-6.

[Ru(bpy)2(BNIQ)]2+ (BNIQ = Benzo[c][1,7]naphthyridine-1-isoquinoline), which incorporates the sterically expansive BNIQ ligand, is a highly selective luminescent probe for DNA mismatches and abasic sites, possessing a 500-fold higher binding affinity toward these destabilized regions relative to well-matched base pairs. As a result of this higher binding affinity, the complex exhibits an enhanced steady-state emission in the presence of DNA duplexes containing a single base mismatch or abasic site compared to fully well-matched DNA. Luminescence quenching experiments with Cu(phen)22+ and [Fe(CN)6]3- implicate binding of the complex to a mismatch from the minor groove via metalloinsertion. The emission response of the complex to different single base mismatches, binding preferentially to the more destabilized mismatches, is also consistent with binding by metalloinsertion. This work shows that high selectivity toward destabilized regions in duplex DNA can be achieved through the rational design of a complex with a sterically expansive aromatic ligand.

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Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Synthetic Route of C10H12ClIN2O2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: tert-Butyl (6-chloro-4-iodopyridin-3-yl)carbamate, is researched, Molecular C10H12ClIN2O2, CAS is 400777-00-6, about Discovery of potent, balanced and orally active dual NK1/NK3 receptor ligands.

During a program directed at selective NK1 receptor antagonists, we serendipitously discovered an NK1 receptor ligand with addnl. affinity for the NK3 receptor. Recognising an opportunity for a drug discovery program aiming for dual NK1/NK3 receptor antagonists, we prepared a series of analogs from a novel, versatile building block. From this series emerged compounds with high and balanced affinities for the NK1 and the NK3 receptors. Typical representatives of this series were active in the gerbil foot tapping assay after oral administration.

There is still a lot of research devoted to this compound(SMILES：O=C(OC(C)(C)C)NC1=C(I)C=C(Cl)N=C1)Synthetic Route of C10H12ClIN2O2, and with the development of science, more effects of this compound(400777-00-6) can be discovered.

Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Bioorganic & Medicinal Chemistry Letters called Discovery of potent, balanced and orally active dual NK1/NK3 receptor ligands, Author is Peters, Jens-Uwe; Hoffmann, Torsten; Schnider, Patrick; Stadler, Heinz; Koblet, Andreas; Alker, Andre; Poli, Sonia Maria; Ballard, Theresa M.; Spooren, Will; Steward, Lucinda; Sleight, Andrew J., which mentions a compound: 400777-00-6, SMILESS is O=C(OC(C)(C)C)NC1=C(I)C=C(Cl)N=C1, Molecular C10H12ClIN2O2, Synthetic Route of C10H12ClIN2O2.

During a program directed at selective NK1 receptor antagonists, we serendipitously discovered an NK1 receptor ligand with addnl. affinity for the NK3 receptor. Recognising an opportunity for a drug discovery program aiming for dual NK1/NK3 receptor antagonists, we prepared a series of analogs from a novel, versatile building block. From this series emerged compounds with high and balanced affinities for the NK1 and the NK3 receptors. Typical representatives of this series were active in the gerbil foot tapping assay after oral administration.

If you want to learn more about this compound(tert-Butyl (6-chloro-4-iodopyridin-3-yl)carbamate)Synthetic Route of C10H12ClIN2O2, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(400777-00-6).

Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com