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Screen-printed electrodes for quality control of liquid (Bio)fuels

Energy demand for modern society is ubiquitous and the liquid fuels play important role in this context. The market acceptance of liquid fuels depends on a highly rigorous quality control, which requires accurate and precise analytical methods to monitor the chemical parameters established by regulatory agencies. Fast and on-site monitoring of the quality parameters of fuels can be achieved by electrochemical techniques using disposable sensors, such as screen-printed electrodes (SPEs). This revision is devoted to recent development and application of SPEs to monitor quality parameters of liquid fuels (fossil fuels and biofuels), including the determination of organic and inorganic analytes using voltammetric or amperometric detection. Trends of SPE technology for quality control of fuels, based on the reported electrochemical methods that may be considered by regulatory agencies, are highlighted.

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Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

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Design, synthesis and evaluation of phenethylaminoheterocycles as Kv1.5 inhibitors

Phenethylaminoheterocycles have been prepared and assayed for inhibition of the Kv1.5 potassium ion channel as a potential approach to the treatment of atrial fibrillation. A diverse set of heterocycles were identified as potent Kv1.5 inhibitors and were advanced to pharmacodynamic evaluation based on selectivity and pharmacokinetic profile. Heterocycle optimization and template modification lead to the identification of compound 24 which demonstrated increased atrial effective refractory period in the rabbit pharmacodynamic model with mild effects on blood pressure and heart rate.

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Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

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Volatile compounds of six species of edible seaweed: A review

Seaweeds are widely distributed throughout the world. Many seaweeds are of commercial importance with some consumed directly or used as an ingredient as they have functional, nutritional and/or organoleptic properties. Consumer acceptance of food is closely related to its sensory properties, of which flavor is of prime importance. A significant contributor to flavor is the aromatic volatile components present. This review focusses on the volatile components identified in commercially important edible macroalgae species consisting of four brown (Himanthalia elongata, Laminaria spp. including L. ochroleuca, and Undaria pinnatifida) and two red species (Porphyra umbilicalis and Palmaria palmata). In excess of 200 volatile compounds have been identified consisting of hydrocarbons, alcohols, aldehydes, ketones, acids, esters, furans, phenols and sulfur- containing compounds, among others present in minor quantities. The extraction/concentration conditions, chromatography and detection methodologies applied varied and impacted on the volatiles identified due to differences in their hydrophobicity, molecular weight and vapor pressure. This review highlights that considerable more information is required to identify volatile aromatic compounds in edible macroalgae and to identify those most likely to impact sensory perception. Such information could be used to aid new product development or widen applications of these seaweeds in the food or beverage sectors.

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Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

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Reference of 272-16-2, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.272-16-2, Name is Benzo[d]isothiazole, molecular formula is C7H5NS. In a article£¬once mentioned of 272-16-2

Free and bound volatile compounds as markers of aromatic typicalness of Moravia Dulce, Rojal and Tortosi red wines

Rojal, Moravia Dulce and Tortosi are three red minority grape varieties grown in La Mancha region (Spain). In this work, wines from these grape varieties were elaborated across four harvests (2006-2009). The aroma of wines was studied by instrumental and sensory analysis to determine their typicality and quality. Free and glycosidically-bound aroma compounds were isolated by solid phase extraction (SPE) and analysed using gas chromatography-mass spectrometry (GC-MS). GC-MS analysis of wines identified 75, 78 and 80 free aroma compounds and 59, 62 and 62 bound aroma compounds in Moravia Dulce, Rojal and Tortosi wines, respectively. C6 and benzenic compounds were the major components of free varietal aroma. Bound aroma fraction was characterised by a larger concentration of benzenic and C 13-norisoprenoid compounds, which suggest that these wines possess a great aroma potential.

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Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

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N-(AMIDINOPHENYL) CYCLOUREA ANALOGS AS FACTOR XA INHIBITORS

The present application describes N-(amidinophenyl)cyclourea analogs of formula I: STR1 which are useful as inhibitors of factor Xa.

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Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

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Processes for producing isothiazole derivatives

A method for producing a 1,2-benzisothiazole characterized by treating a 2-(alkylthio)benzaldehyde oxime with a halogen compound; a method for producing a 3-halo-1,2-benzisothiazole characterized by treating a 1,2-benzisothiazole with a halogenating agent; and a method for producing a 1-(1,2-benzisothiazol-3-yl)piperazine characterized by reacting the obtained 3-halo-1,2-benzisothiazoles with a piperazine. By the method of the present invention, 1,2-benzisothiazoles and 3-halo-1,2-benzisothiazoles, which are useful as intermediates for pharmaceutical compositions such as psychotropic agents, and 1-(1,2-benzisothiazole-3-yl)piperazines synthesized therefrom can be obtained in a high yield without using expensive starting materials by shorter and simpler process than conventional methods.

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Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

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Electric Literature of 272-16-2, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.272-16-2, Name is Benzo[d]isothiazole, molecular formula is C7H5NS. In a article£¬once mentioned of 272-16-2

Benzimidazolinones, benzoxazolinones, benzopiperazinones, indanones, and derivatives thereof as inhibitors of factor Xa

The present application describes inhibitors of factor Xa of formula I: or pharmaceutically acceptable salt forms thereof, wherein W, W1, W2, and W3 may be N or C and J, Ja, and Jb combine to form a substituted carbocycle or heterocycle.

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Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

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Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Review, the author is Kettle, Jason G. and a compound is mentioned, name: Benzo[d]isothiazole, Benzo[d]isothiazole, introducing its new discovery. name: Benzo[d]isothiazole

Covalent inhibitors of the GTPase KRASG12C: a review of the patent literature

Introduction: KRAS is one of the most important oncology drug targets, playing a pivotal role in the initiation and progression of many human tumors. It has long been held undruggable due to many previously failed attempts to both directly and indirectly target this challenging GTPase protein family. Areas covered: This review covers patent applications claiming inhibitors of the mutant GTPase KRASG12C that act via covalent modification of cysteine at codon 12 in the period of 2014 to the present. A total of 37 PCT applications from 9 applicants are evaluated, with the discussion organized alphabetically by assignee name. Expert opinion: The last 5 years have seen an explosion in interest around this important target with many companies aiming to capitalize on the breakthrough discovery of covalent allosteric inhibitors of the glycine to cysteine mutant form of the enzyme. The first agents from this effort have now entered clinical trials and preliminary data are encouraging with responses seen in both lung adenocarcinoma and colorectal cancer patients.

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Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

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The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 272-16-2 is helpful to your research. Formula: C7H5NS

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, the author is Liu, Yaran and a compound is mentioned, Formula: C7H5NS, Benzo[d]isothiazole, introducing its new discovery. Formula: C7H5NS

Data on free and bound volatile compounds in six Ribes nigrum L. blackcurrant cultivars

The data investigated 198 volatile compounds of six currant cultivars grown in China which is analyzed by SPME?GC?MS. Volatile compounds in these currant samples were identified by two methods, comparing retention indices with reference standards and matching mass spectrum in the NST11 library. A synthetic currant matrix prepared according to the currant juice condition were extracted and analyzed using the same extraction procedure as the currant samples. The standard curve was generated for quantification of volatile compounds. For the volatiles without the available standard, the data provided consulting standards that had the same carbon atom or the similar functional structure for quantification. Further interpretation and discussion can be seen in article entitled ?Characterization of Free and Bound Volatile Compounds in Six Ribes nigrum L. Blackcurrant Cultivars? (Liu et al., 2018) [1].

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Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

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Related Products of 272-16-2, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 272-16-2, Name is Benzo[d]isothiazole, molecular formula is C7H5NS. In a Article£¬once mentioned of 272-16-2

Lurasidone: efficacy and safety in the treatment of psychotic and mood disorders

Introduction: Lurasidone ([3aR,4S,7R,7aS]-2-[(1R,2R)-2-[4-(1,2-benzisothiazol-3-yl)piperazin-1yl-methyl] cyclohexylmethyl]-hexahydro-4,7-methano-2H-isoindole-1,3-dione hydrochloride; Latuda) is a novel benzisothiazole, second-generation antipsychotic drug developed by Dainippon Sumitomo Pharma Corporation in Japan. Similar to other atypical antipsychotics it has a distinctive pharmacodynamic profile, Areas covered: This review updates reported research findings on the efficacy, safety and tolerability of LRSD for treatment of psychotic and major affective disorders, with meta-analyses. Short-term efficacy of LRSD in schizophrenia is supported by several randomized, controlled trials with daily doses of 40?160?mg, yielding relatively modest symptomatic improvements. Lurasidone has regulatory approval for treatment of undefined duration in schizophrenia. Long-term benefits and effects in schizophrenia, and both short- and long-term use for other psychotic disorders and mania have not been tested. LRSD shows unusual efficacy in acute bipolar depression even without psychotic features. However, trials of adding LRSD to lithium or valproate for bipolar disorder have yielded inconsistent findings. Expert opinion: Available research findings indicate that LRSD is effective and well-tolerated for short-term treatment of schizophrenia, and for acute bipolar depression. It has low risk of inducing weight-gain, metabolic, or cardiac abnormalities, but its risk of akathisia may exceed that of other modern antipsychotics. Needed is adequate long-term testing in schizophrenia and bipolar disorder and testing for other indications, including against alternative treatments.

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Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com