Category: 26172-54-3

On March 31, 1995, Suzuki, Tetsuya published a patent.Safety of 2-Methylisothiazol-3(2H)-one hydrochloride The title of the patent was Photographic emulsions containing isothiazolin-3-ones. And the patent contained the following:

Photog. emulsions are prepared by addition of isothiazolin-3-ones I (R1 = H, alkyl, cycloalkyl, alkenyl, alkoxy, aryl, heterocycle, CONH2, etc.; R2-3 = H, halo, alkyl,, cycloalkyl, aryl, cyano, alkylthio, etc.; R2 and R3 may form a benzene ring) during the period from nucleation of emulsion grains to the termination of chem. ripening. The photog. materials show little dependence on humidity and little change in sensitivity from the time lapse from exposure to processing. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Safety of 2-Methylisothiazol-3(2H)-one hydrochloride

The Article related to emulsion photog isothiazolinone stabilizer, Radiation Chemistry, Photochemistry, and Photographic and Other Reprographic Processes: Silver Halide Photographic Chemistry and Processes and other aspects.Safety of 2-Methylisothiazol-3(2H)-one hydrochloride

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On April 29, 2009, Jin, Yuechun; Li, Kezhong; Lu, Xueting; Zhang, Xiaolin; Wang, Yu; Zhou, Shuailin; Li, Chao published a patent.Application of 26172-54-3 The title of the patent was Method for continuous production of 3-isothiazolinone derivatives. And the patent contained the following:

The method comprises allowing to react Me acrylate (I) with sulfur and H2S in the first reactor, filtering the reaction liquid to obtain solid, water phase and organic phase containing (SCH2CH2CO2CH3)2 (II) and S(SCH2CH2CO2CH3)2 (III), introducing the solid and water phase to the first reactor, introducing the organic phase into the first counter-current extraction tower, allowing to react compound III with Na2SO3 aqueous solution to obtain compound II, aminating compound II with primary amine (compound IV; NH2R; here: R = C1-C18 alkyl or C3-C18 cycloalkyl) to obtain (SCH2CH2CONHR)2 (compound V; R is defined as above); reacting compound V with Cl2 to obtain the title compound VI (IT-HCl; here: IT is 2-R-4-R1-5-R2-3-isothiazolinone; R is defined as above; R1 and R2 are H or Cl). The method has the advantages of less production equipment, low energy consumption, simplified operation, and suitability for industrialized production The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Application of 26172-54-3

The Article related to isothiazolinone derivative preparation, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Application of 26172-54-3

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On June 30, 1988, Lindner, Wolfgang published a patent.Category: isothiazole The title of the patent was Process for isolation of isothiazolinone derivatives using strong acids. And the patent contained the following:

Isothiazolinone compounds I (R = C1-3 alkyl; X = halogen; or R = C1-16 alkyl, C5-6 cycloalkyl; X = H) are isolated from tech. mixtures containing ≥1 I compound and/or 4-halo-2-alkyl-3-isothiazolinone and/or 4,5-dihalo-2-alkyl-3-isothiazolinones and/or their halogen addition compounds and/or nitroso compounds, by dissolving the wet mixture in an organic solvent which is slightly miscible or immiscible with water, drying the organic solution, treating with a strong acid, recovering the precipitated I salt, and hydrolyzing it if desired. A 100 g portion of an aqueous tech. solution containing 2-methyl-3-isothiazolinone(II) 4.41, 5-chloro-2-methyl-3-isothiazolinone(III) 10.27, and 4,5-dichloro-2-methyl-3-isothiazolinone (IV) ≈0.3%, was mixed with 100 g AcOEt, the organic layer separated, dried over Na2SO4, the organic solution saturated with HCl, the precipitated salts separated by filtration, and dissolved with stirring in the aqueous phase to give a formulation containing II 4.35, III 9.96, and IV <0.01 g. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Category: isothiazole

The Article related to isothiazolinone derivative isolation process, polychloroisothiazolinone separation isothiazolinone purification, acid isothiazolinone purification, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Category: isothiazole

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On August 17, 2016, there was a patent about fireproofing agents.Category: isothiazole The title of the patent was Flame retardant used in waterborne flame-retarding coating. And the patent contained the following:

A cyano- and amino group-containing fireproofing agent is applied in coating material. A coating is prepared from waterborne polyurethane resin 30-80, dispersing wetting agent 10-20, defoaming agent 1-5, antiseptic 1-5, film-forming aid 10-20, flame retardant 1-10, and water 50-150 weight parts. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Category: isothiazole

The Article related to cyano amino containing fireproofing agent coating polyurethane, Coatings, Inks, and Related Products: Drying Oils, Solvents, Plasticizers, and Other Additives and other aspects.Category: isothiazole

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On November 27, 2020, Zeng, Xiangxi published a patent.Safety of 2-Methylisothiazol-3(2H)-one hydrochloride The title of the patent was Preparation of high washing fastness bronzing pulp. And the patent contained the following:

Title bronzing pulp is prepared from (a) 45-60 parts of ethylene-vinyl acetate copolymer emulsion, (b) 10-20 parts of styrene-acrylic emulsion, (c) 0.5-2 parts of odorless kerosene, (d) 5-8 parts of microsphere foaming powder, (e) 2-6 parts of fatty alc. polyoxyethylene ether, (f) 4-6 parts of hot melt powder, (g) 0.02-0.1 part of preservative, and (h) 1-5 parts of water; the preservative is a compound of 5-chloro-2-methylisothiazolin-3-one hydrochloride and 2-methyl-4-isothiazolin-3-one hydrochloride; and the solid content of the ethylene-vinyl acetate copolymer emulsion is 52-55% and the solid content of the styrene-acrylic emulsion is 45-55%. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Safety of 2-Methylisothiazol-3(2H)-one hydrochloride

The Article related to washing fastness bronzing pulp ethylene vinyl acetate copolymer emulsion, Coatings, Inks, and Related Products: Acrylic and Water-Sol (Electrophoretic) Resin Coatings and other aspects.Safety of 2-Methylisothiazol-3(2H)-one hydrochloride

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On December 13, 1977, Weiler, Ernest D.; Miller, George A. published a patent.COA of Formula: C4H6ClNOS The title of the patent was Halogenated 3-isothiazolidinone 1-oxide and 1,1-dioxides. And the patent contained the following:

The title compounds I (R1 = H, C1-18 unsubstituted alkyl, HO, halo, C1-4 carbalkoxy, cyano or carboxy-monosubstituted C1-18 alkyl, C3-8 cycloalkyl, PhCH2, halo C1-4 alkyl, C1-4 alkoxy, nitro or cyano-substituted benzyl, Ph, naphthyl, nitro-substituted Ph or naphthyl; R1, R2 = H, halo; R3 = halo; n = 0, 1) were prepared by halogenation of the corresponding 4-isothiazolin-3-one. Thus, 4-isothiazolin-3-one 1-oxide was brominated with Br to give I (R = R1 = R2 = H, R3 = Br, n = 1) (II). II was fungicidal at 500 ppm, bactericidal at 123 ppm and at 10 lbs/acre controlled monocotyledons by 72%. At 150 ppm II controlled rice blast by 70-89%. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).COA of Formula: C4H6ClNOS

The Article related to bactericide haloisothiazolidinone oxide, fungicide isothiazolidinone oxide, herbicide isothiazolidinone oxide, algicide isothiazolidinone oxide, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.COA of Formula: C4H6ClNOS

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On October 2, 1979, Weiler, Ernest D. published a patent.Quality Control of 2-Methylisothiazol-3(2H)-one hydrochloride The title of the patent was Isothiazolidin-3-ones. And the patent contained the following:

Isothiazolidinones I (R = H, optionally substituted C1-18 alkyl, phenylalkyl, Ph, naphthyl, cycloalkyl; R1, R3 = halogen, alkyl; R2 = halogen) were prepared Thus 2,4-dimethyl-3-isothiazolinone was chlorinated with Cl to give 68% I (R = R1 = Me, R2 = R3 = Cl), which had a min. inhibitory concentration of 125 ppm against Escherichia coli, Staphylococcus aureus, Aspergillus niger, and Rhizopus stolonifer. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Quality Control of 2-Methylisothiazol-3(2H)-one hydrochloride

The Article related to haloisothiazolidinone, bactericide haloisothiazolidinone, fungicide haloisothiazolidinone, isothiazolinone halogenation, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Quality Control of 2-Methylisothiazol-3(2H)-one hydrochloride

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On July 28, 1998, Onishi, Toshimasa; Morita, Takashi; Yamamoto, Yoshi; Tojo, Tamaki; Tanaka, Ikuya published a patent.COA of Formula: C4H6ClNOS The title of the patent was Preparation of 3-isothiazolones as microbicides. And the patent contained the following:

Title compounds I [X, Z = H, halo, C1-4 alkyl; Y = C1-8 alkyl, C5-6 cycloalkyl, C≤8 aralkyl, C6 aryl, (substituted) aryl], useful as microbicides (no data), not containing alkali metal salts and H2O produced in neutralization are prepared by neutralization of I hydrohalides with alkali metal bases in organic solvents having solubility of I and no solubility of alkali metal salts in the presence of small amount of H2O, dehydration of the reaction mixtures, and removal of alkali metal salts by solid-liquid separation, recovery of I. 3-Isothiazolone hydrochloride AcOEt solution (5-chloro-2-methyl-4-isothiazolin-3-one (II)/2-methyl-4-isothiazolin-3-one (III) ratio of 4.4/1) was treated with NaHCO3 in the presence of H2O at room temperature for 1 h, dried, separation of a solid from the reaction mixture, and distilled to give 85% 3-isothiazolone with II/III ratio of 4.8/1 containing ≤0.1% H2O and NaCl. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).COA of Formula: C4H6ClNOS

The Article related to isothiazolone preparation purification microbicide, neutralization isothiazolone hydrohalide alkali metal base, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.COA of Formula: C4H6ClNOS

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On January 19, 1999, Kim, Sang-Hwan; Park, Jong-Ho; Kim, Jin-Mae; Choi, Ki-Sung; Chow, Myang-Ho; Han, Seung-Jon published a patent.Electric Literature of 26172-54-3 The title of the patent was Preparation of anhydrous isothiazolones as microbicides. And the patent contained the following:

Anhydrous isothiazolones, useful as microbicides (no data), are prepared by extraction from solutions using halo hydrocarbons or nitro hydrocarbons and removal of the halo or nitro hydrocarbons from the extracts An aqueous solution containing ∼3:1 5-chloro-2-methyl-3-isothiazolone.HCl and 2-methyl-3-isothiazolone.HCl was mixed with CH2Cl2 and then the organic layer was evaporated and dissolved into ethylene glycol to give a solution showing H2O content 500 ppm (H2O content of ethylene glycol 450 ppm) and complete storage stability at 65° for ≥16 days. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Electric Literature of 26172-54-3

The Article related to isothiazolone anhydrous preparation microbicide, extraction isothiazolone halo nitro hydrocarbon, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Electric Literature of 26172-54-3

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On July 17, 1991, Petigara, Ramesh Balubhai; Woodruff, Robert Alva; Pendell, Barry Jack; Leister, Norman Andrew published a patent.COA of Formula: C4H6ClNOS The title of the patent was Preparation of salt- and water-free 3-isothiazolones. And the patent contained the following:

The title compounds [I; X = H, alkyl; X1 = H, Cl, alkyl; Y = (un)substituted alkyl] were prepared by neutralization of Im.HmZ (Z = Cl, Br, SO4, FSO3; m = 1, 2) with anhydrous NH3 in an organic solvent. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).COA of Formula: C4H6ClNOS

The Article related to isothiazolone anhydrous base preparation, ammonia neutralization isothiazolone acid salt, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.COA of Formula: C4H6ClNOS

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com