Category: 26172-54-3

On January 1, 2007, Cuixart Grande, Jesus Maria published a patent.Quality Control of 2-Methylisothiazol-3(2H)-one hydrochloride The title of the patent was Procedure for preparing 2-alkylisothiazolones and their formulation in stable form alone or in association to other molecules with biocidal activity. And the patent contained the following:

This invention relates to a procedure for preparing 2-alkylisothiazolones of formula I and their formulations in stable forms alone or in association to other mols. with biocidal activity. 2-Alkylisothiazolones may be used as industrial biocides. A procedure for preparing compounds of formula I wherein R is C1-8 alkyl; X and X1 are independently H and Cl; are claimed. These compounds were obtained by cyclization of 3,3′-dithiopropionamides. Several example on formulations of these compounds are also provided. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Quality Control of 2-Methylisothiazol-3(2H)-one hydrochloride

The Article related to alkylisothiazolone preparation formulation, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Quality Control of 2-Methylisothiazol-3(2H)-one hydrochloride

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On December 22, 2020, Gu, Zhenpeng; Yang, Zhaohui; Zhang, Xiaona; Zhao, Lin; Liu, Wei; Chen, Qi published a patent.SDS of cas: 26172-54-3 The title of the patent was Preparation of 2-methyl-4-isothiazolin-3-one (MIT) aqueous solution by using dipolar aprotic solvent. And the patent contained the following:

The title method includes (1) mixing 3,3′-dithiobis(N-methylpropionamide) or 3-mercapto-N-methylpropanamide with solvent, and adding halogenating agent (chlorine gas, sulfuryl chloride, etc.) for a halogenation ring-closing reaction. (2) Filtering to obtain a product, washing the filter cake with Et acetate, and drying to obtain 2-methyl-4-isothiazolin-3-one hydrochloride solid. (3) Dissolving with a sodium carbonate aqueous solution to obtain an aqueous solution having pH of 5.0-7.0 and the mass content of 2-methyl-4-isothiazolin-3-one of 50%. The solvent comprises chlorination solvent (dichloromethane, chloroform, etc.) and dipolar aprotic solvent (acetonitrile, DMF, etc.). The prepared 2-methyl-4-isothiazolin-3-one has the purity up to above 99.9% and the content of 5-chloro-2-methyl-4-isothiazolin-3-one controlled at below 100 ppm. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).SDS of cas: 26172-54-3

The Article related to methyl isothiazolinone preparation, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.SDS of cas: 26172-54-3

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On April 12, 2007, Kyriatsoulis, Apostolos; Feldmann, Susanne; Huber, Erasmus; Kobold, Uwe; Puhlmann, Angela; Von Proff, Leopold; Waechter, Nicole published a patent.Synthetic Route of 26172-54-3 The title of the patent was Release reagent for vitamin D compounds. And the patent contained the following:

The present invention concerns a reagent composition for releasing vitamin D compounds bound to vitamin D-binding protein, a method for the detection of a 25-hydroxyvitamin D compound in which the 25-hydroxyvitamin D compound is released from vitamin D-binding protein using this reagent and the mixture obtained in this manner is analyzed, the use of the reagent to release vitamin D compounds, as well as a kit for detecting 25-hydroxyvitamin D which contains the reagent for releasing vitamin D compounds in addition to the usual immunol. reagents. 25-Hydroxyvitamin D3-3-hemisuccinate-keyhole hemocyanin conjugates were prepared and used to generate antibodies in sheep. An affinity chromatog. stationary phase was prepared to purify the antibodies. Immunoassay reagents were prepared and used to determine 25-hydroxyvitamin D in serum samples from humans of Caucasian descent and of African descent. When release reagent contained 10 % DMSO, DMF, or N-methylpyrrolidone, the values from the immunoassay correlated very well with values from LC-MS-MS and were independent of the phenotype of the vitamin D-binding protein. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Synthetic Route of 26172-54-3

The Article related to reagent releasing binding protein vitamin d compound assay, dmso release reagent hydroxyvitamin d immunoassay blood serum, dmf release reagent hydroxyvitamin d immunoassay blood serum, n methylpyrrolidone release reagent hydroxyvitamin d immunoassay blood serum, caucassian african human hydroxyvitamin d release reagent immunoassay and other aspects.Synthetic Route of 26172-54-3

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On August 8, 1978, Lewis, Sheldon N.; Miller, George A.; Law, Andrew B. published a patent.Formula: C4H6ClNOS The title of the patent was 3-Isothiazolones as biocides. And the patent contained the following:

Isothiazolones I (R, R1 = H, halogen, C1-4 alkyl; R2 = optionally substituted C1-18 alkyl, alkenyl, alkynyl, cycloalkyl, aralkyl, aryl) (106 compounds) were prepared Thus 79 g (SCH2CH2CONHMe)2 was cyclized in the presence of SO2Cl2 to give 11.5 g I (R = H, R1 = Cl, R2 = Me). I have bactericidal, fungicidal, and algicidal activity. Their use in lubricating oils, cooling water, paints, polymer emulsions, laundry detergents, soaps, cosmetics, paper, leather, textiles, and wood products is illustrated. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Formula: C4H6ClNOS

The Article related to algicides, coating materials, cosmetics and personal care products, detergents, drinking waters, fungicides, leather, lubricating oils, paper, polymers role: uses (uses), soaps role: rct (reactant), ract (reactant or reagent), textiles, wood preservatives and other aspects.Formula: C4H6ClNOS

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On November 1, 2015, De, Bibekananda; Gupta, Kuldeep; Mandal, Manabendra; Karak, Niranjan published an article.Recommanded Product: 26172-54-3 The title of the article was Biocide immobilized OMMT-carbon dot reduced Cu2O nanohybrid/hyperbranched epoxy nanocomposites: Mechanical, thermal, antimicrobial and optical properties. And the article contained the following:

The present work demonstrated a transparent thermosetting nanocomposite with antimicrobial and photoluminescence attributes. The nanocomposites are fabricated by incorporation of different weight% (1, 2 and 3) of a biocide immobilized OMMT-carbon dot reduced Cu2O nanohybrid (MITH-NH) in the hyperbranched epoxy matrix. MITH-NH is obtained by immobilization of 2-methyl-4-isothiazolin-3-one hydrochloride (MITH) at room temperature using sonication on OMMT-carbon dot reduced Cu2O nanohybrid. The nanohybrid is prepared by reduction of cupric acetate using carbon dot as the reducing agent in the presence of OMMT at 70°. The significant improvements in tensile strength (∼ 2 fold), elongation at break (3 fold), toughness (4 fold) and initial thermal degradation temperature (30°) of the pristine hyperbranched epoxy system are achieved by incorporation of 3 weight% of MITH-NH in it. The nanocomposites exhibit strong antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Klebsiella pneumoniae and Pseudomonas aeruginosa bacteria and Candida albicans, a fungus. The nanocomposite also shows significant activity against biofilm formation compared to the pristine thermoset. Further, the nanocomposite films emit different colors on exposure of different wavelengths of UV light. The properties of these nanocomposites are also compared with the same nanohybrid without OMMT. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Recommanded Product: 26172-54-3

The Article related to epoxy resin copper oxide ommt nanocomposite thermal mech property, antimicrobial activity, biocide immobilization, carbon dot reduced cu(2)o-ommt nanohybrid, hyperbranched epoxy nanocomposite, mechanical, optical property and other aspects.Recommanded Product: 26172-54-3

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On April 30, 2019, Luna, Breanna L.; Garcia, Javier A.; Huang, Min; Ewing, Peter J.; Valentine, Sonya C.; Chu, Yi-Ming; Ye, Qi-Zhuang; Xu, H. Howard published an article.Quality Control of 2-Methylisothiazol-3(2H)-one hydrochloride The title of the article was Identification and characterization of novel isothiazolones with potent bactericidal activity against multi-drug resistant Acinetobacter baumannii clinical isolates. And the article contained the following:

Acinetobacter baumannii has emerged as a globally important nosocomial pathogen characterized by an increased multi-drug resistance (MDR), leaving limited options for treating its infection. To identify novel antibacterial compounds with activity against clin. isolates of A. baumannii, we performed high-throughput screening against a chem. library of 42,944 compounds using nonpathogenic Escherichia coli MG1655 and identified 55 hit compounds The antibacterial activities of 30 pure compounds were determined against MDR clin. isolates of A. baumannii obtained from Los Angeles County hospitals. Two isothiazolones identified, 5-chloro-2-(4-chloro-3-methylphenyl)-4-methyl-3(2H)-isothiazolone and 5-chloro-2-(4-chlorophenyl)-4-methyl-3(2H)-isothiazolone (I), possess novel structure and exhibited consistent, potent and cidal activity against all 46 MDR A. baumannii clin. isolates and reference strains. Addnl., structure-activity relation anal. involving several addnl. isothiazolones supports the link between a chloro-group on the heterocyclic ring or a fused benzene ring and the cidal activity. Attempts to obtain isothiazolone resistant mutants failed, consistent with the rapid cidal action and indicative of a complex mechanism of action. While cytotoxicity was observed with I, it had a therapeutic index value of 28 suggesting future therapeutic potential. Our results indicate that high-throughput screening of compound libraries followed by in vitro biol. evaluations is a viable approach for the discovery of novel antibacterial agents to contribute in the fight against MDR bacterial pathogens. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Quality Control of 2-Methylisothiazol-3(2H)-one hydrochloride

The Article related to antibacterial activity isothiazolone derivative structure acinetobacter, acinetobacter baumannii, antimicrobial susceptibility testing, cytotoxicity, high-throughput screening, isothiazolone, time-kill assay and other aspects.Quality Control of 2-Methylisothiazol-3(2H)-one hydrochloride

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On November 23, 1972, Miller, George Allen; Weiler, Ernest Dieter published a patent.Formula: C4H6ClNOS The title of the patent was Pesticidal isothiazolinone metal salt complexes. And the patent contained the following:

Fifty-six title compounds [Im.MXn; R = H or Cl; R1 = H or Me; RR1 = CH:CHCH:CH; R2 = H, C1-10 normal or branched alkyl, Ph, m-ClC6H4, p-MeC6H4CH2, or p-ClC6H4CH2CH2; M = Ca, Cd, Co, Cr, Cu, Fe, Hg, Mg, Mn, Ni, Sn, or Zn; X = e.g., Cl, SO4, or Br; m = 1 or 2; n = 1-3] were prepared in .leq.100% yield by reaction of I or I-HX with MXn or MO, resp. I were used as algicides, bactericides, fungicides, herbicides, insecticides, and slimicides, e.g., in cooling towers and paper mills or against mildew in paints. Thus, 2-methyl-3-isothiazolone [2682-20-4] in EtOH was added to ZnCl2 in EtOH and the mixture stirred 30 min to give 92% bis(2-methyl-3-isothiazolone zinc (II) chloride (II) [38897-06-2]. 2-Methyl-3-isothiazolone-HCl [26172-54-3] and ZnO in MeOH were stirred 24 hr to give 94% II. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Formula: C4H6ClNOS

The Article related to isothiazolinone salt pesticide, algicide isothiazolinone, bactericide isothiazolinone, fungicide isothiazolinone, herbicide isothiazolinone, insecticide isothiazolinone, slimicide isothiazolinone and other aspects.Formula: C4H6ClNOS

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On December 21, 1984, Mine, Kyomitsu; Irie, Soichiro; Hirao, Yotaro; Nagumo, Toshio; Kawaguchi, Yasushi; Kobayashi, Yayoi published a patent.SDS of cas: 26172-54-3 The title of the patent was Antiseptic treatment of silver halide photographic hydrophilic colloid layers. And the patent contained the following:

A phenol derivative I (R = halo, C1-6 alkyl, lower alkoxycarbonyl, CO2H; n = 0-5) and a compound of formula II (R1 = H, alkyl, cycloalkyl, alkenyl, aralkyl, aryl, heterocyclyl, alkylamido, arylthioamido, alkylthioamido, alkysulfamido, arylsulfamido; R2,R3 = H, halo, alkyl, cycloalkyl, aryl, heterocyclyl, CN, alkylthio, arylthio, alkylsulfoxy, alkylsulfonyl) are added to Ag halide photog. hydrophilic colloid layers as antiseptic agents. Thus, phenol and II (R1 = CONHMe; R2 = Br; R3 = H) were added to a Ag(Br, I) emulsion for x-ray films. The emulsion showed excellent antiseptic property (tested by using Acinetobacters) without degradation of sensitivity and other photog. characteristics. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).SDS of cas: 26172-54-3

The Article related to antiseptic treatment photog emulsion, phenol photog emulsion antiseptic, isothiazolone photog emulsion antiseptic, Radiation Chemistry, Photochemistry, and Photographic and Other Reprographic Processes: Silver Halide Photographic Chemistry and Processes and other aspects.SDS of cas: 26172-54-3

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On May 9, 1990, Metoki, Iku; Sato, Kiyoshi published a patent.Electric Literature of 26172-54-3 The title of the patent was Photographic material with excellent antislatic properties. And the patent contained the following:

A high-sensitivity photog. material having improved antistatic properties at high humidity is composed of a support and ≥1 Ag halide photosensitive layer spectrally sensitized by adding a spectral sensitizer during the grain formation process, the phys. ripening process, and the desalting process, and also containing a 3-isothiazolinone derivative (I; R1 = H, alkyl, cycloalkyl, alkenyl, aralkyl, alkoxy, aryl, heterocyclyl, carbamoyl, thiocarbamoyl, and sulfamoyl; R2, R3 = H, halogen, alkyl, cycloalkyl, aryl, CN, alkylthio, arylthio, alkylsulfoxide, alkylsulfonyl, heterocyclyl, or R2 and R3 together can form a benzene ring). Thus, a PET film was coated with a gelatin-Ag halide emulsion (the spectral sensitizer was added after the grain growth process) containing II. The resultant emulsion showed a relative sensitivity of 130 and a surface sp. resistance (at 20° and 55% relative humidity) of 7 × 1011. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Electric Literature of 26172-54-3

The Article related to isothiazolinone derivative photog antistatic property, film photog antistatic isothiazolinone derivative, Radiation Chemistry, Photochemistry, and Photographic and Other Reprographic Processes: Silver Halide Photographic Chemistry and Processes and other aspects.Electric Literature of 26172-54-3

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On July 14, 1995, Takahashi, Shigeaki published a patent.Name: 2-Methylisothiazol-3(2H)-one hydrochloride The title of the patent was High-sensitivity silver halide photographic material. And the patent contained the following:

The material is spectrally sensitized with ≥1 sensitizer which is dispersed in solid fine particles with particle size ≤1 μm and contains ≥1 isothiazolin-3-one compound I (R1 = H, alkyl, alicyclic group, alkenyl, aralkyl, alkoxy, aryl, heterocyclic group, carbamoyl, thiocarbamoyl, sulfamoyl; R2-3 = H, halo, alkyl, alicyclic group, aryl, cyano, alkylthio, arylthio, alkylsulfoxide, alkylsulfonyl, heterocyclic group; R2 and R3 may form benzene ring) between nucleation and chem. sensitization. The material gave stain-free images. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Name: 2-Methylisothiazol-3(2H)-one hydrochloride

The Article related to silver halide photog isothiazolinone sensitizer, Radiation Chemistry, Photochemistry, and Photographic and Other Reprographic Processes: Silver Halide Photographic Chemistry and Processes and other aspects.Name: 2-Methylisothiazol-3(2H)-one hydrochloride

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com