Category: 26172-54-3

On November 8, 1988, Grove, Scott L. published a patent.Quality Control of 2-Methylisothiazol-3(2H)-one hydrochloride The title of the patent was Wood preservatives containing transition metal carboxylates and isothiazolones. And the patent contained the following:

Wood preservatives comprise a transition metal carboxylate and a isothiazolone I [R1 = C1-18 alkyl, alkenyl, or alkynyl, C≤12 cycloalkyl (C3-6 ring); R2, R3 = H, halo, lower alkyl]. A slurry of dithio-N,N-dimethylpropionamide in ethylene dichloride was treated with SO2Cl2 to give I (R1 = Me, R2 = R3 = H)-HCl and I (R1 = Me, R2 = H, R3 = Cl). A wood preservative composition comprised Cu naphthenate 8, I (R1 = octyl, R2 = R3 = Cl) 2, Atlas G 1096 10, Atlas G 3300 2% and the balance mineral spirits. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Quality Control of 2-Methylisothiazol-3(2H)-one hydrochloride

The Article related to metal carboxylate isothiazolone wood preservative, Agrochemical Bioregulators: Invertebrate and other aspects.Quality Control of 2-Methylisothiazol-3(2H)-one hydrochloride

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On February 28, 2011, Kato, Masaru; Hida, Kazuo; Fujihara, Takashi; Nagasawa, Akira published an article.Product Details of 26172-54-3 The title of the article was Ferromagnetic Spin Ladder System: Stack of Chlorido-Bridged Dinuclear Copper(II) Complexes with 2-Methylisothiazol-3(2H)-one. And the article contained the following:

A dinuclear copper(II) complex, [{CuIICl(O-mi)}2(μ-Cl)2] [mi = 2-methylisothiazol-3(2H)-one], has been synthesized and its mol. structure in the solid state determined by single-crystal X-ray anal. The crystal consists of centrosym. dinuclear copper(II) units in which each copper(II) ion is doubly bridged by two chloride ions and has a slightly distorted square-planar geometry with a terminal chlorido ligand and a terminal mi ligand coordinated through the oxygen atom. The dinuclear units stack one on top of another to form a one-dimensional two-leg ladder structure. The magnetic susceptibility of the powder was measured in the temperature range 3.0-302 K. It was found that there are ferromagnetic interactions along the rung (in the same direction of the intramol.; Jrung = +5.03 ± 0.03 cm-1) and the leg (in the same direction of the intermol.; Jleg = +1.96 ± 0.02 cm-1) and an antiferromagnetic interaction along the diagonal (Jx = -1.36 ± 0.02 cm-1), the exptl. data being fitted by the numerical calculation for a twelve-site ladder Hamiltonian. In addition, DFT calculations with the UB3LYP functional on the model complex [{CuIICl(O-mi)}2(μ-Cl)2] gave an intramol. magnetic coupling constant J = +28.6 cm-1 and indicated that the spin-d. distribution on O in mi is less than that on the terminal Cl. We conclude that the O-donor ligand at the terminal position plays an essential role in the emerging intramol. ferromagnetic interaction. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Product Details of 26172-54-3

The Article related to dinuclear copper complex spin ladder magnetic susceptibility crystal structure, Magnetic Phenomena: Magnetic Properties and other aspects.Product Details of 26172-54-3

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On January 30, 2013, Li, Chengbei published a patent.Recommanded Product: 2-Methylisothiazol-3(2H)-one hydrochloride The title of the patent was Antiseptic and antimildew composition special for wet tissue, and production method thereof. And the patent contained the following:

The antiseptic and antimildew composition is composed of 10-50% antiseptic aqueous solution 2-15 weight%, antimildew agent 2-6 weight%, rapid germicide 2-5 weight%, solvent 65-80 weight%, additive 0.5-5 weight%, stabilizing agent 0-5 weight%, and addnl. water. The antiseptic is from 2-methylisothiazolinone, 5-chloro-2-methylisothiazolinone, and/or bronopol. The antimildew agent is from 3-iodo-2-propargyl Bu carbamate, and/or p-hydroxybenzoate. The rapid germicide is from p-chloro-3,5-dimethylphenol, and/or 2,4-dichloro-3,5-dimethylphenol. The solvent is from 1,2-propanediol, glycerol, glycol, and/or dipropylene glycol. The additive is from hydrogenated castor oil, nonylphenol polyoxyethylene ether, fatty alc. polyoxyethylene ether, sodium dodecyl ether sulfate, and/or alkyl glycoside. The stabilizing agent is from sodium nitrate, lithium nitrate, potassium nitrate, and/or benzoyl peroxide. The antiseptic and antimildew composition is produced by (1) dissolving antiseptic in deionized water, neutralizing with base to pH 2-4, adding stabilizing agent under stirring, filtering to obtain antiseptic aqueous solution, (2) dissolving antimildew agent in solvent, adding rapid germicide and additive in that order under stirring to obtain antimildew germicide solution, and (3) mixing uniformly both solutions under stirring. The antiseptic and antimildew composition can be specially used in wet tissue, with reasonable formula, and good antiseptic and antimildew effects. The method has the advantages of simple and advanced production process, low cost and suitability for industrialized production The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Recommanded Product: 2-Methylisothiazol-3(2H)-one hydrochloride

The Article related to antiseptic antimildew composition wet tissue, Agrochemical Bioregulators: Microbial and other aspects.Recommanded Product: 2-Methylisothiazol-3(2H)-one hydrochloride

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On January 22, 1992, Hoss, Gerhard; Pappert, Gunter; Schmidt, Axel published a patent.Safety of 2-Methylisothiazol-3(2H)-one hydrochloride The title of the patent was Preservation of diagnostic test reagents and kits. And the patent contained the following:

Diagnostic test kits and the reagents therein are preserved from microbial degradation by a combination of ≥2 of 2-methyl-4-isothiazolin-3-one-HCl, 2-hydroxypyridine N-oxide, chloroacetamide, N,N-methylenebis[N-(1-hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]urea (I), and 5-bromo-5-nitro-1,3-dioxane. Thus, the reagents in a kit for automated determination of albumin (succinate buffer, pH 4.2; bromcresol green; Brij 35; and preservatives 2-hydroxypyridine N-oxide and I) were incubated with a mixture of bacteria, fungi, and yeasts for 6 wk at 23°. After this time, the bacterial count was reduced by 1.6 x 104 and the count of fungi and yeasts by 8.3 x 104. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Safety of 2-Methylisothiazol-3(2H)-one hydrochloride

The Article related to preservative diagnostic reagent solution, Biochemical Methods: Reagents and other aspects.Safety of 2-Methylisothiazol-3(2H)-one hydrochloride

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On June 20, 2017, Bao, Xingyan; Luo, Weixiao; Tan, Baiqing; Li, Zhiming published a patent.Reference of 2-Methylisothiazol-3(2H)-one hydrochloride The title of the patent was Reagent for detecting glucose by hexokinase method with high stability and low cost. And the patent contained the following:

The present invention relates to the field of detection technol. for detecting blood GLU by hexokinase method, and provides liquid dual reagent composed of reagent 1 and reagent 2. Reagent 1 mainly includes buffer solution, Mg2+, ionic equilibrium agent, preservative, NAD (oxidized coenzyme I), and protective agent, and surfactant, and reagent 2 includes buffer solution, protective agent, surfactant, preservative, hexokinase (HK), glucose-6-phosphate dehydrogenase (G6P-DH) and ATP-Na2. The invention targetedly adds various protective agents including polyethylene glycol, Tween-80 and FAD to ensure stability of enzymes in reagent, adds various surfactants in order to reduce cost, particularly usage of enzymes, and to improve emulsification to enzymes and use efficiency of enzymes, thus greatly reduces reagent cost, and is very convenient for application and promotion clin. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Reference of 2-Methylisothiazol-3(2H)-one hydrochloride

The Article related to blood glucose hexokinase dehydrogenase blood diagnostic reagent, Biochemical Methods: Reagents and other aspects.Reference of 2-Methylisothiazol-3(2H)-one hydrochloride

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On July 17, 2018, Luo, Weixiao; Hu, Xiaofei; Wang, Meili published a patent.HPLC of Formula: 26172-54-3 The title of the patent was Reagent with high interference resistance for detecting uric acid with enzyme. And the patent contained the following:

The reagent with high interference resistance for detecting uric acid with enzymes comprises reagent R1 and reagent R2. The reagent R1 comprises buffer 20, 4-aminoantipyrine 1.2, sodium nitrite 4-8, ion balancer 5-10 mmol/L, ascorbic acid oxidase 3-5 KU/L, heavy metal ion chelating agent 1-2 mmol/L, bovine serum albumin 1-5 g/L, dodecyl tri-Me betaine 1-3, triton-305 1-3 mL/L, and preservative 0.2-0.5 g/L. The reagent R2 comprises buffer 100, N-ethyl-N-(2-hydroxy-3-sulfopropyl)-3,5-dimethoxyaniline (F-DAOS) 8-12 mmol/L, uricase 1-2 KU/L, bovine serum albumin 1-5 g/L, peroxidase 5-10 KU/L and preservative 0.2-0.5 g/L. The reagent has very good interference resistance, and can realize very accurate detection, especially for newborn samples. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).HPLC of Formula: 26172-54-3

The Article related to interference uric acid ascorbic oxidase uricase peroxidase spectrometry, Biochemical Methods: Reagents and other aspects.HPLC of Formula: 26172-54-3

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On May 12, 2010, Oh, Seok published a patent.Name: 2-Methylisothiazol-3(2H)-one hydrochloride The title of the patent was Purification of 2-methyl-4-isothiazolin-3-one. And the patent contained the following:

The title purification method comprises: (1) dispersing a product containing 2-methyl-4-isothiazolin-3-one (I) salts and 5-chloro-2-methyl-4-isothiazolin-3-one (II) salts (byproduct) in an organic solvent, (2) adding amines to the solution to generate I and II, further decomposing II at (-20)-30° for 3-72 h, and (3) removing II by filtration and distilling the solution to obtain pure I. I is used as a preservative. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Name: 2-Methylisothiazol-3(2H)-one hydrochloride

The Article related to methylisothiazolinone purification, Pharmaceuticals: Pharmaceutics and other aspects.Name: 2-Methylisothiazol-3(2H)-one hydrochloride

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On January 31, 2020, Ma, Lei; Zhuang, Luyang; Chen, Xiaoling; Chen, Fei; Yang, Min; Qiao, Xiaofang; Li, Xiaoxia; Fu, Guangyu; Wu, Xuewei published a patent.Product Details of 26172-54-3 The title of the patent was High precision quantitative detection kit for insulin-like growth factor binding protein 3. And the patent contained the following:

A quant. detection kit having good accuracy, improved sensitivity and detection rate of pos. sample, and shortened detection time is provided. The quant. detection kit comprises: magnetic particles coated with insulin-like growth factor binding protein 3 (IGFBP-3) monoclonal antibody, enzyme-labeled IGFBP-3 monoclonal antibody, sample dilution, wherein sample diluent is any one of hydrochloric acid, citric acid, malic acid, phosphoric acid, and sulfosalicylic acid. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Product Details of 26172-54-3

The Article related to insulin growth factor binding protein 3 detection kit, Biochemical Methods: Apparatus and other aspects.Product Details of 26172-54-3

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On November 16, 2016, Yang, Zhiting; Wei, Hong; Liu, Xuemei; Chen, Yong; Gao, Aiju; Xu, Yang published a patent.Electric Literature of 26172-54-3 The title of the patent was A glycocholic acid detection kit capable of eliminating chyle interference. And the patent contained the following:

The present invention discloses a glycocholic acid detection kit capable of eliminating chyle interference. The detection kit comprises reagent R1, reagent R2 and calibrator, and described reagent R1 comprises buffer solution a, chyle elimination agent, stabilizer a, surfactant a, reaction promotor a and preservative a; described reagent R2 comprises buffer solution b, latex particle of anti-human glycocholic acid monoclonal antibody, stabilizer b, surfactant b, preservative b and reaction promotor b; described calibrator comprises buffer solution c, glycocholic acid standard product, stabilizer c, surfactant c, reaction promotor c and preservative c. This detection kit is short in detection time, strong in interference tolerance, good in stability, good in repeatability, high in accuracy and high in detection sensitivity. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Electric Literature of 26172-54-3

The Article related to glycocholic acid kit chyle interference analytical reagent, Biochemical Methods: Immunological and other aspects.Electric Literature of 26172-54-3

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

On March 30, 2021, Xu, Junyan; Zhuang, Luyang; Wang, Dan; Yang, Min published a patent.Category: isothiazole The title of the patent was Chemiluminescence immunoassay detection kit for metanephrine. And the patent contained the following:

The invention relates to a chemiluminescence immunoassay detection kit for metanephrine, which has the advantages of high detection efficiency, high sensitivity and specificity. The kit comprises a sample pretreatment reagent and a detection reagent; the sample pretreatment reagent comprises an acidification solution, an acylation buffer solution and an acylating agent solution; the acylating agent in the acylating agent solution is one or more of acetic anhydride, succinic anhydride, butyric anhydride, caproic anhydride, octanoic anhydride, acetylchloride and glacial acetic acid; the detection reagent comprises a magnetic particle coated with metanephrine, specific antibody solution of metanephrine, enzyme conjugate solution containing horseradish peroxidase labeled antibody, and calibration product. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Category: isothiazole

The Article related to chemiluminescence immunoassay test kit metanephrine diagnosis, Biochemical Methods: Immunological and other aspects.Category: isothiazole

Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com