Category: 18480-53-0

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 18480-53-0, name is 3,4-Dichloroisothiazole-5-carboxylic acid, introducing its new discovery. 18480-53-0

A class of 3, 4 – improvement of the thiazole – 5 – carboxamidine derivative and its preparation and use (by machine translation)

The invention provides 3,4-dichloroisothiazolyl-5-formamidine derivatives, and a preparation method and application thereof, relating to isothiazolyl formamidine compounds of which the chemical structure general formula is disclosed as IV. The invention discloses a structural general formula and synthesis method of the compounds, application of the compounds as a bactericide, plant antiviral agent or plant activator, application of a combination of the compounds or agriculturally acceptable assistants or synergists thereof and the commercial pesticide, bactericide, plant antiviral agent or plant activator in controlling diseases, pests and virus diseases in agriculture, forestry and horticulture and a preparation method thereof.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.18480-53-0, you can also check out more blogs about18480-53-0

Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

18480-53-0, Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬Which mentioned a new discovery about 18480-53-0

Isothiazolecarboxylic acid derivatives, rice blast control agents containing the same as active ingredients, and rice blast control method applying the control agents

Application of a rice blast control agent containing an isothiazolecarboxylic acid derivative of the below-described formula, which shows excellent activity against rice blast (Pyricularia oryzae) in rice cultivation, to the water surface of a paddy rice field results in the absorption of the derivative through roots of rice plants, so that the resistance of the rice plants can be enhanced. STR1 wherein R1 and R2 independently mean a hydrogen or halogen atom or a particular group, and Y stands for an OR3 group (R3 being a hydrogen or alkali metal atom or a particular group), an NHR4 group (R4 being a hydrogen atom or a particular group), or a morpholino group.

18480-53-0, Interested yet? Read on for other articles about 18480-53-0!

Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

18480-53-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3,4-Dichloroisothiazole-5-carboxylic acid, cas is 18480-53-0,the isothiazole compound, it is a common compound, a new synthetic route is introduced below.

EXAMPLE 5 Synthesis of isopropyl 3,4-dicloroisothiazole-5-carboxylate (Compound No. 6) Thionyl chloride (20 g) was added to 1.5 g of 3,4-dichloroisothiazole-5-carboxylic acid and the resultant mixture was heated under reflux for 1 hour. After excess thionyl chloride was distilled off under reduced pressure, a small amount of benzene was added, and the solvent was again distilled off under reduced pressure to remove a trace amount of thionyl chloride. Dry diethyl ether (10 ml) was added to the residue, whereby an acid chloride solution was obtained. 2-Propanol (0.54 g) and triethylamine (0.92 g) were dissolved in dry diethyl ether, to which the above-prepared acid chloride solution was added dropwise under ice cooling. They were then reacted at 30¡ã C. for 30 minutes and, after insoluble matter was filtered off, the filtrate was concentrated and then purified by chromatography on a silica gel column (n-hexane:ethyl acetate=9:1) to obtain 1.02 g of the title compound.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 3,4-Dichloroisothiazole-5-carboxylic acid, 18480-53-0

Reference£º
Patent; Mitsui Toatsu Chemicals, Incorporated; US5240951; (1993); A;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

 

As a common heterocyclic compound, it belongs to isothiazole compound, name is 3,4-Dichloroisothiazole-5-carboxylic acid, and cas is 18480-53-0, its synthesis route is as follows.

To 4.0 g (20.3 mmol) of 3,4-dichloroisothiazole-5-carboxylic acid were added 8 ml of oxalyl chloride and a catalytic amount of DMF, followed by stirring at 50¡ãC for 30 minutes to give rise to a reaction. The reaction mixture was concentrated under vacuum to obtain 3,4-dichloroisothiazole-5-carbonyl chloride. 1.9 g (50.5 mmol) of sodium borohydride was suspended in 40 ml of water. To the resulting suspension was dropwise added, at 10 to 15¡ãC, a solution of the 3,4-dichloroisothiazole-5-carbonyl chloride dissolved in THF (4 ml). Stirring was conducted at 15¡ãC for 30 minutes. Then, an aqueous citric acid solution was added to make the mixture weakly acidic and extraction with ethyl acetate was conducted. The organic layer was washed with water, dried over anhydrous magnesium sulfate, and concentrated. The resulting crystals were washed with hexane to obtain 3.0 g (yield: 81percent) of (3,4-dichloroisothiazol-5-yl)methanol as colorless crystals (melting point: 94 to 95¡ãC). 1H-NMR (CDCl3) delta: 2.28 (1H, bs), 4.96 (2H, s) ppm In 6 ml of acetonitrile were dissolved 0.62 g (3.10 mmol) of 3-chloro-1,2-benzoisothiazole 1,1-dioxide and 0.57 g (3.10 mmol) of the (3,4-dichloroisothiazol-5-yl)methanol. To the resulting solution was dropwise added 0.34 g (3.4 mmol) of triethylamine, followed by stirring at room temperature for 5 hours to give rise to a reaction. After the completion of the reaction, 12 ml of water was added. The resulting crystals were obtained by filtration. The crystals were washed with water and isopropyl alcohol to obtain 0.89 g (yield: 82percent) of 3-(3,4-dichloroisothiazol-5-ylmethoxy)-1,2-benzoisothiazole 1,1-dioxide as a colorless powder (melting point: 165 to 167¡ãC). 1H-NMR (CDCl3) delta: 5.79 (2H, s), 7.73-7.94 (4H, m) ppm.

18480-53-0, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,18480-53-0 ,3,4-Dichloroisothiazole-5-carboxylic acid, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; KUMIAI CHEMICAL INDUSTRY CO., LTD.; IHARA CHEMICAL INDUSTRY CO., LTD.; EP2017268; (2009); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

 

18480-53-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3,4-Dichloroisothiazole-5-carboxylic acid, cas is 18480-53-0,the isothiazole compound, it is a common compound, a new synthetic route is introduced below.

In a 250 ml single-mouth round bottom flask, 7.8 g of 3,4-dichloroisothiazole-5-carboxylic acid and 50 ml of thionyl chloride were added.The NaOH lye was inserted above the return pipe to absorb volatile thionyl chloride and refluxed at 80¡ãC for 5 hours.The solution turns light yellowRemove unreacted thionyl chloride by atmospheric pressure at 74¡ãC,Then vacuum distillation to collect 128 ¡ãCThe fraction yielded 5.9 g of colorless 3,4-dichloroisothiazole-5-formyl chloride,Using the resulting pure product to calculate the yield,Yield 69.3percent;

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 3,4-Dichloroisothiazole-5-carboxylic acid, 18480-53-0

Reference£º
Patent; Nankai University; Fan Zhijin; Zong Guangning; Ma Liuyong; Li Fengyun; Zhu Yujie; Chen Lai; Wang Haixia; Qian Xiaolin; Guo Xiaofeng; Pei Yu; Xu Jinghua; (21 pag.)CN104974150; (2018); B;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

 

It is a common heterocyclic compound, the isothiazole compound, 3,4-Dichloroisothiazole-5-carboxylic acid, cas is 18480-53-0 its synthesis route is as follows.

730mg of 3,4-dichloroisothiazole-5-carboxylic acid (3.7 mmol) were dissolved in 10 ml of dichloromethane and a drop of dimethylformamide was added. 1.4 g of oxalyl chloride (11.1 mmol) were added dropwise at room temperature. After stirring for 1 h at room temperature, the solution was evaporated to dryness on a rotary evaporator. The residue was taken up in 3 ml ofdichloromethane and slowly added dropwise to a solution of 626 mg of 1- cyclohexylmethanamine (5.5 mmol) and 746 mg of triethylamine (7.4 mmol) in 10 ml of dichloromethane. The mixture was stirred at room temperature for 1 h. The reaction mixture was then added to water and extracted repeatedly with dichloromethane. The concentrated extracts were dried over MgSO4, concentrated and purified by column chromatography. Yield:1.05 g (97percent of theory).?H-NMR (400 MHz, CDC13 , ppm) 6.86 (br, 1H), 3.34 (tr, 2H), 1.77 (m, 4H), 1.66 (m, 1H), 1.58 (m, 1H), 1.3-1.15 (m, 3H), 1.0 (m, 2H).

18480-53-0, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,18480-53-0 ,3,4-Dichloroisothiazole-5-carboxylic acid, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; BAYER CROPSCIENCE AKTIENGESELLSCHAFT; BERNIER, David; CRISTAU, Pierre; TSUCHIYA, Tomoki; RINOLFI, Philippe; DROeGE, Thomas; MAECHLING, Simon; SCHMIDT, Jan Peter; TELSER, Joachim; DOeLLER, Uwe; MOSRIN, Marc; REY, Jullien; TIEBES, Joerg; WACHENDORFF-NEUMANN, Ulrike; (467 pag.)WO2016/102435; (2016); A2;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

 

As a common heterocyclic compound, it belong isothiazole compound,3,4-Dichloroisothiazole-5-carboxylic acid,18480-53-0,Molecular formula: C4HCl2NO2S,mainly used in chemical industry, its synthesis route is as follows.,18480-53-0

After 10 g of 50 mmol of 3,4-dichloro-isothiazole carboxylic acid II was added to 100 ml flask was added 30 ml of thionylchloride, refluxed for 5 hours, thionyl chloride was distilled off at atmospheric pressure, the residue was water pump vacuumdistillation at 100-110 degrees C compound fraction collected between 10.6 g yellow solid 3,4-dichloro-isothiazole carboxylicacid chloride III, a yield of 96.3percent, 3,4-dichloro-isothiazole carboxylic acid chloride III prepared a pro rata amount of expanded orreduced, the volume of the reaction vessel according to the corresponding scaled up or down, a commercially availablecompound II has the same effect.

With the synthetic route has been constantly updated, we look forward to future research findings about 3,4-Dichloroisothiazole-5-carboxylic acid,belong isothiazole compound

Reference£º
Patent; Jiangxi Tianren Ecology Co., Ltd.; Nankai University; Chen, Xiaoyan; Liu, Xiping; Fan, Zhijin; Liang, Xiaowen; Li, Yuedong; Mao, Wutao; Li, Juanjuan; Wang, Dun; Wang, Shuhua; Zhou, Lifeng; Ji, Xiaotian; HUA, XUEWEN; (23 pag.)CN102942565; (2016); B;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

 

Name is 3,4-Dichloroisothiazole-5-carboxylic acid, as a common heterocyclic compound, it belongs to isothiazole compound, and cas is 18480-53-0, its synthesis route is as follows.,18480-53-0

0.75 mmol of 3,4-dichloroisothiazole-5-carboxylic acid I-1 was added to a 100 ml two-neck round bottom flask.1-(3-Methylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDCI) was 0.9 mmol, 1-hydroxybenzotriazole (HOBT) was 0.77 mmol, dissolved in dichloro Methane (25 mL) was stirred in an ice bath for 15 minutes.A solution of the amine II-1 in dichloromethane (25 mL) was added to the reaction mixture, then 0.90 mmol of Et3N was added, and the reaction mixture was stirred at room temperature for 16 hours.After the reaction was completed, the organic layer was washed with water (2¡Á30 mL) and brine (40 mL).The organic layer was dried over MgSO 4 and concentrated under reduced vacuo.The residue is purified by silica gel column chromatography on 100~200 mesh to give compound III-1.The eluent was petroleum ether: ethyl acetate at 60 to 90 C, and the volume ratio was 5:1, and the yield was 56%; the amount of the compound III-1 prepared and the volume of the reaction vessel were expanded or reduced in a corresponding ratio.

With the complex challenges of chemical substances, we look forward to future research findings about 3,4-Dichloroisothiazole-5-carboxylic acid

Reference£º
Patent; Nankai University; Fan Zhijin; Yang Dongyan; Li Zhengming; Zhu Yilin; Zhou Jinghui; Guo Xiaofeng; Zhang Nailou; Wu Qifan; Yu Bin; Zhou Shuang; (19 pag.)CN110041324; (2019); A;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

 

As a common heterocyclic compound, it belong isothiazole compound,3,4-Dichloroisothiazole-5-carboxylic acid,18480-53-0,Molecular formula: C4HCl2NO2S,mainly used in chemical industry, its synthesis route is as follows.,18480-53-0

730mg of 3,4-dichloroisothiazole-5-carboxylic acid (3.7 mmol) were dissolved in 10 ml of dichloromethane and a drop of dimethylformamide was added. 1.4 g of oxalyl chloride (11.1 mmol) were added dropwise at room temperature. After stirring for 1 h at room temperature, the solution was evaporated to dryness on a rotary evaporator. The residue was taken up in 3 ml ofdichloromethane and slowly added dropwise to a solution of 626 mg of 1- cyclohexylmethanamine (5.5 mmol) and 746 mg of triethylamine (7.4 mmol) in 10 ml of dichloromethane. The mixture was stirred at room temperature for 1 h. The reaction mixture was then added to water and extracted repeatedly with dichloromethane. The concentrated extracts were dried over MgSO4, concentrated and purified by column chromatography. Yield:1.05 g (97percent of theory).?H-NMR (400 MHz, CDC13 , ppm) 6.86 (br, 1H), 3.34 (tr, 2H), 1.77 (m, 4H), 1.66 (m, 1H), 1.58 (m, 1H), 1.3-1.15 (m, 3H), 1.0 (m, 2H).

With the synthetic route has been constantly updated, we look forward to future research findings about 3,4-Dichloroisothiazole-5-carboxylic acid,belong isothiazole compound

Reference£º
Patent; BAYER CROPSCIENCE AKTIENGESELLSCHAFT; BERNIER, David; CRISTAU, Pierre; TSUCHIYA, Tomoki; RINOLFI, Philippe; DROeGE, Thomas; MAECHLING, Simon; SCHMIDT, Jan Peter; TELSER, Joachim; DOeLLER, Uwe; MOSRIN, Marc; REY, Jullien; TIEBES, Joerg; WACHENDORFF-NEUMANN, Ulrike; (467 pag.)WO2016/102435; (2016); A2;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

 

As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO201,mainly used in chemical industry, its synthesis route is as follows.,18480-53-0

To a solution of S^-dichloroisothiazole-delta-carboxylic acid (4.0Og, 20.1 mmol) in dichloromethane (75 ml_), cooled with an ice-brine bath, was added N,N-dimethylformamide (78 mul_, 1 mmol) followed dropwise by oxalyl chloride (1.94 ml_, 22.2 mmol). After stirring at room temperature for 2h, meanwhile gas evolution had completely stopped, all volatiles were removed in vacuo to affor the crude acid chloride (4.30 g).

With the complex challenges of chemical substances, we look forward to future research findings about 3,4-Dichloroisothiazole-5-carboxylic acid,belong isothiazole compound

Reference£º
Patent; BAYER CROPSCIENCE SA; WO2009/130193; (2009); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com