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18480-53-0, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,18480-53-0 ,3,4-Dichloroisothiazole-5-carboxylic acid, other downstream synthetic routes, hurry up and to see

As a common heterocyclic compound, it belongs to isothiazole compound, name is 3,4-Dichloroisothiazole-5-carboxylic acid, and cas is 18480-53-0, its synthesis route is as follows.

SYNTHESIS EXAMPLE 1 Process (a): After thionyl chloride (10 ml) had been added to 3,4-dichloro-5-isothiazole-carboxylic acid (0.99 g), the mixture was refluxed by heating for 2 hours. The excess of thionylchloride was then distilled off under reduced pressure, and 3,4-dichloro-5-isothiazolecarboxylic acid chloride was obtained.

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Reference£º
Patent; Assmann, Lutz; Kitagawa, Yoshinori; Ishikawa, Koichi; Yamazaki, Daiei; Sawada, Haruko; Araki, Yasuo; Sakuma, Haruhiko; Kinbara, Taro; Imanishi, Kinya; US2003/13750; (2003); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

 

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The chemical industry reduces the impact on the environment during synthesis,18480-53-0,3,4-Dichloroisothiazole-5-carboxylic acid,I believe this compound will play a more active role in future production and life.

18480-53-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3,4-Dichloroisothiazole-5-carboxylic acid, cas is 18480-53-0,the isothiazole compound, it is a common compound, a new synthetic route is introduced below.

Preparation of the starting material: At room temperature, 146 g (1.23 mol) of thionyl chloride are added dropwise with stirring over a period of 5 minutes to 8.92 g (0.045 mol) of 3,4-dichloro-isothiazole-5-carboxylic acid. 4 drops of dimethylformamide are then added, and the reaction mixture is heated at reflux for one hour. The reaction mixture is subsequently cooled to room temperature and concentrated under reduced pressure. This gives 12.19 g of 3,4-dichloro-isothiazole-5-carbonyl chloride in the form of an orange oil. The compounds of the formula (I) listed in the table below are also prepared by the method given above.

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Reference£º
Patent; Bayer Aktiengesellschaft; US6191155; (2001); B1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

 

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A class of 3, 4 – improvement of the thiazole – 5 – carboxamidine derivative and its preparation and use (by machine translation)

The invention provides 3,4-dichloroisothiazolyl-5-formamidine derivatives, and a preparation method and application thereof, relating to isothiazolyl formamidine compounds of which the chemical structure general formula is disclosed as IV. The invention discloses a structural general formula and synthesis method of the compounds, application of the compounds as a bactericide, plant antiviral agent or plant activator, application of a combination of the compounds or agriculturally acceptable assistants or synergists thereof and the commercial pesticide, bactericide, plant antiviral agent or plant activator in controlling diseases, pests and virus diseases in agriculture, forestry and horticulture and a preparation method thereof.

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Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

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A kind of 3,4-dichloro-thiazole derivatives and process for their preparation and use (by machine translation)

The invention provides 3,4-dichloro isothiazole derivatives, their preparation method and application. The invention relates to a heterocyclic compound containing 3,4-dichloro isothiazol, and the compound is represented by the following chemical structural general formula. The invention discloses the structural general formula of the compound, a synthetic method of the compound and applications of the compound as pesticide, bactericide, anti-plant virus agent, and plant activator, and a technology of mixing the compound with agriculturally acceptable auxiliary agents or synergists for preparing pesticide, bactericide, anti-plant virus agent, and plant activator. The invention further discloses the combined application of the compound and the commercial pesticide, bactericide, anti-plant virus agent, and plant activator in controlling diseases, insect pests, and virus diseases in agriculture, forestry and gardening, and a preparation method of the compound and the commercial pesticide, bactericide, anti-plant virus agent, and plant activator.

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Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

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ACTIVE COMPOUND COMBINATIONS

The invention relates to active compound combinations, in particular within a fungicide composition, which comprises (A) a compound of formula (I) and at least one further respiratory chain complex in inhibitor (B). Moreover, the invention relates to a method for curatively or preventively controlling the phytopathogenic fungi of plants or crops, to the use of a combination according to the invention for the treatment of seed, to a method for protecting a seed and not at least to the treated seed.

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Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

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Method of manufacturing benzisothiazol compd. (by machine translation)

[Problem to be Solved] To provide an industrially preferred process for producing an isothiazole compound, particularly 3,4-dichloro-5-cyanoisothiazole. For example, to provide a safer industrial production process by avoiding the simultaneous use of an aprotic polar solvent such as N,N-dimethylformamide and chlorine. In addition, to provide a production process which is economically preferred because an aprotic polar solvent, which is highly likely to become a part of waste, is not used. [Solution] A process for producing an isothiazole compound represented by a general formula (3), wherein R is a cyano group or the like; and X is a chlorine atom or the like, which comprises heating a nitrile compound represented by a general formula (1), wherein R is as defined above, and sulfur, and then carrying out a reaction between the nitrile compound represented by the general formula (1), the sulfur and a halogen represented by a general formula (2), wherein X is as defined above.

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Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

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Thiadiazole and isothiazole amide derivative as well as preparation method and application thereof (by machine translation)

The invention provides thiadiazole, isothiazole amide derivatives and a preparation method and application, and relates to thiadiazole, isothiazole amide derivatives, and the chemical structural general formula is shown in the formula III: The invention discloses a structural general, a synthetic method and an application of the compound as an insecticide, a bactericide, an anti-plant virus agent and application of the compound to agricultural, forestry, horticultural plant insect pests, diseases, virus diseases and a preparation method thereof together with commercial insecticides, bactericides, plant pathogens, acaricides, and the like, and a preparation method. (by machine translation)

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Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

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1,2-BENZISOTHIAZOLE DERIVATIVE, AND AGRICULTURAL OR HORTICULTURAL PLANT DISEASE-CONTROLLING AGENT

[Task] The present invention is to provide a 1,2-benzoisothiazole derivative or a salt thereof which is not harmful to a crop and is remarkably effective on an agricultural or horticultural plant disease such as Pyricularia oryzae, Septoria nodorum, Pseudoperonospora cubensis and Colletotrichum orbiculare, and, an agricultural or horticultural plant disease-controlling agent containing the derivative or its salt as an active ingredient. [Means] A 1,2-benzoisothiazole derivative represented by the general formula [I] (wherein R1 is a hydrogen atom or a halogen atom, and R2 is a methyl group or a halogen atom), or a salt thereof.

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Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

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FUNGICIDE HYDROXIMOYL-HETEROCYCLES DERIVATIVES

The present invention relates to hydroximoyl-heterocycle derivatives, their process of preparation, intermediate compounds for their preparation, their use as fungicide active agents, particularly in the form of fungicide compositions, and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions.

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Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

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3,4-DIHALOGENOISOTHIAZOLE DERIVATIVE AND AGENT FOR CONTROLLING AGRICULTURAL OR HORTICULTURAL PLANT DISEASE

[Task] The present invention is to provide a 3,4-dihalogenoisothiazole derivative or a salt thereof which is not harmful to a crop and is remarkably effective on an agricultural or horticultural plant disease such as rice blast disease, cucumber anthracnose, wheat powdery mildew and wheat glume blotch, etc., and, an agricultural or horticultural plant disease-controlling agent containing the derivative or its salt as an active ingredient. [Means] A 3,4-dihalogenoisothiazole derivative represented by the general formula [I] (wherein R1 is a halogen atom; A is an oxygen atom or a sulfur atom; and R is a C1-C6 alkyl group, a C2-C5 alkenyl group, a C2-C5 alkynyl group, a C3-C6 cycloalkyl group, a phenyl group or a 5- to 10-membered heterocyclic group containing at least one of oxygen atom, sulfur atom and nitrogen atom), or a salt thereof.

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Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com