Category: 111248-89-6

1,3-Dihydrobenzo[c]isothiazole 2,2-dioxide, cas is 111248-89-6, it is a common heterocyclic compound, the isothiazole compound, its synthesis route is as follows.,111248-89-6

4f. 5-bromo-1 ,3-dihydrobenzo[c]isothiazole 2,2-dioxide 1,3-Dihydro-benzo[c]isothiazole 22-dioxide (0.50 g, 3.14 mmol, 1.00 eq.)was solubilized in acetic acid (5 mL) at RT under nitrogen atmosphere.Bromine (0.45 g, 3.14 mmol, 1.00 eq.) in acetic acid (5 mL) was added dropwise over 5 minutes and the reaction mixture was stirred for 0.5 h. Potassium, acetate (0.28 g, 3.14 mmol, 1.00 eq.) was added and the reaction mixture was concentrated to dryness. The residue was taken in 2 % NaHCO3 solution and stirred for 10 minutes. This solution wasacidified to pH 2 using conc. HCI (2.5 mL) and extracted with MTBE (50 mL). The MTBE layer was washed with water (50 mL), brine solution (25 mL), dried over Na2SO4 and concentrated to get the crude product as brown solid. The crude product was triturated with petroleum ether (10 mL), filtered to a light brown solid (HPLC purity app. 86 %) which was further purified by column chromatography using 60-1 20 mesh silica gel, 15 %ethyl acetate in petroleum ether as eluent to get a yellow solid (HPLC purity app.90 %). The resulting product was then triturated with ethanol (5 mL), filtered and dried to get the title compounds as light yellow solid (0.35 g, 47.7 %, 94% purity).

111248-89-6 is used more and more widely, we look forward to future research findings about 1,3-Dihydrobenzo[c]isothiazole 2,2-dioxide

Reference£º
Patent; MERCK PATENT GMBH; CANCER RESEARCH TECHNOLOGY LIMITED; SCHIEMANN, Kai; STIEBER, Frank; CALDERINI, Michel; BLAGG, Julian; MALLINGER, Aurelie; WAALBOER, Dennis; RINK, Christian; CRUMPLER, Simon Ross; (127 pag.)WO2015/144290; (2015); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

111248-89-6, 1,3-Dihydrobenzo[c]isothiazole 2,2-dioxide is a isothiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To 1,3-dihydro-2,1-benzisothiazoline 2,2-dioxide (Chiarino et al, J. Heterocycl. Chem. 23(6), 1645-9, 1986) (0.74 g, 4.4 mmol) in anhydrous dichloromethane (minimum amount) at room temperature was added sequentially N,N-diisopropylethylamine (0.76 mL, 4.4 mmol) and 2-(trimethylsilyl)ethoxymethyl chloride (0.77 mL, 4.4 mmol). After 30 min, the reaction was poured into water (50 mL), the layers were separated, and the aqueous phase was extracted with ethyl acetate (2*50 mL). The organic layers were combined, washed with brine (30 mL), dried over magnesium sulfate, filtered and concentrated in vacuo to give 1, 3-dihydro-I-(2′-trimethylsilylethyl)-2, 1-benzisothiazoline 2,2-dioxide (1.3 g, 99%) as an off-white solid. 1H NMR (CDCl3, 300 MHz) delta0.02 (s, 9 H), 0.97 (dd, 2 H, J=8.3, 8.2 Hz), 3.73 (dd, 2 H, J=8.2, 8.3 Hz), 4.40 (s, 2 H), 5.08 (s, 2 H), 7.05 (d, 1 H, J=7.4 Hz), 7.07 (dd, 1 H), 7.26 (d, 1 H, J=7.4 Hz), 7.35 (‘t’, 1H, J=7.6, 7.6 Hz). MS ((+) APCI m/z 317 [M+NH4]+.

111248-89-6, As the paragraph descriping shows that 111248-89-6 is playing an increasingly important role.

Reference£º
Patent; American Home Products Corporation; Ligand Pharmaceuticals, Inc.; US6339098; (2002); B1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

111248-89-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1,3-Dihydrobenzo[c]isothiazole 2,2-dioxide, cas is 111248-89-6,the isothiazole compound, it is a common compound, a new synthetic route is introduced below.

To a suspension of 1 ,3-dihydrobenzo[c]isothiazole-2,2-dioxide (280 mg, 1.655 mmol) and potassium carbonate (229 mg, 1.66 mmol) in DMF (5 mL) was added iodomethane (414 pL, 6.62 mmol). The reaction was stirred for 6 h at RT and was then quenched with a saturated solution of ammonium chloride. The reaction mixture was concentrated and purified by column chromatography (cyclohexane/acetone) to afford the title compound as a white solid (270 mg, 89%). 1H NMR (500 MHz, CDCl3) ppm = 7.37 – 7.32 (m, 1 H), 7.27 – 7.24 (m, 1 H), 7.02 (td, J=7.6, 1.0, 1 H), 6.73 (d, J=8.0, 1 H), 4.34 (s, 2H), 3.14 (s, 3H). Rt = 2.07 min (HPLC method C).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1,3-Dihydrobenzo[c]isothiazole 2,2-dioxide, 111248-89-6

Reference£º
Patent; MERCK PATENT GMBH; CANCER RESEARCH TECHNOLOGY LIMITED; SCHIEMANN, kai; STIEBER, Frank; BLAGG, Julian; MALLINGER, Aurelie; WAALBOER, Dennis; RINK, Christian; CRUMPLER, Simon Ross; WO2014/63778; (2014); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO97,mainly used in chemical industry, its synthesis route is as follows.,111248-89-6

c. 1-Methyl-1,3-dihydrobenzo[c]isothiazole-2,2-dioxide To a suspension of 1,3-dihydrobenzo[c]isothiazole-2,2-dioxide (280 mg, 1.655 mmol) and potassium carbonate (229 mg, 1.66 mmol) in DMF (5 mL) was added iodomethane (414 muL, 6.62 mmol). The reaction was stirred for 6 h at rt and was then quenched with a sat. NH4Cl solution. The reaction mixture was concentrated and purified by column chromatography (CyHex/acetone) to afford the title compound as a white solid (270 mg, 89%).

With the complex challenges of chemical substances, we look forward to future research findings about 1,3-Dihydrobenzo[c]isothiazole 2,2-dioxide,belong isothiazole compound

Reference£º
Patent; Merck Patent GmbH; Cancer Research Technology, Ltd.; SCHIEMANN, Kai; BLAGG, Julian; MALLINGER, Aurelie; RINK, Christian; SEJBERG, Jimmy; HONEY, Mark; (139 pag.)US2016/16951; (2016); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

Name is 1,3-Dihydrobenzo[c]isothiazole 2,2-dioxide, as a common heterocyclic compound, it belongs to isothiazole compound, and cas is 111248-89-6, its synthesis route is as follows.,111248-89-6

4c. 1-Methyl-i ,3-dihydrobenzo[c]isothiazole-2 ,2-dioxide To a suspension of I ,3-dihydrobenzo[c]isothiazole-2,2-dioxide (280 mg,1.655 mmol) and potassium carbonate (229 mg, 1.66 mmol) in DMF (5 mL) was added iodomethane (414 pL, 6.62 mmol). The reaction was stirred for 6 hr at RT andwas then quenched with a sat. NH4CI solution. The reaction mixture was concentratedand purified by column chromatography (CyHex/acetone) to afford the title compound asa white solid (270 mg, 89%). 1H NMR (500 MHz, CDCI3) ppm = 7.37-7.32 (m, 1H), 7.27-7.24 (m, 1H), 7.02 (td, J=7.6, 1.0, IH), 6.73 (d, J8.0, IH), 4.34 (s, 2H), 3.14 (s, 3H); Rt= 2.07 mm (H PLC method F).

With the complex challenges of chemical substances, we look forward to future research findings about 1,3-Dihydrobenzo[c]isothiazole 2,2-dioxide

Reference£º
Patent; MERCK PATENT GMBH; CANCER RESEARCH TECHNOLOGY LIMITED; SCHIEMANN, Kai; STIEBER, Frank; CALDERINI, Michel; BLAGG, Julian; MALLINGER, Aurelie; WAALBOER, Dennis; RINK, Christian; CRUMPLER, Simon Ross; (127 pag.)WO2015/144290; (2015); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.111248-89-6,1,3-Dihydrobenzo[c]isothiazole 2,2-dioxide,as a common compound, the synthetic route is as follows.

4f. 5-bromo-1 ,3-dihydrobenzo[c]isothiazole 2,2-dioxide 1,3-Dihydro-benzo[c]isothiazole 22-dioxide (0.50 g, 3.14 mmol, 1.00 eq.)was solubilized in acetic acid (5 mL) at RT under nitrogen atmosphere.Bromine (0.45 g, 3.14 mmol, 1.00 eq.) in acetic acid (5 mL) was added dropwise over 5 minutes and the reaction mixture was stirred for 0.5 h. Potassium, acetate (0.28 g, 3.14 mmol, 1.00 eq.) was added and the reaction mixture was concentrated to dryness. The residue was taken in 2 % NaHCO3 solution and stirred for 10 minutes. This solution wasacidified to pH 2 using conc. HCI (2.5 mL) and extracted with MTBE (50 mL). The MTBE layer was washed with water (50 mL), brine solution (25 mL), dried over Na2SO4 and concentrated to get the crude product as brown solid. The crude product was triturated with petroleum ether (10 mL), filtered to a light brown solid (HPLC purity app. 86 %) which was further purified by column chromatography using 60-1 20 mesh silica gel, 15 %ethyl acetate in petroleum ether as eluent to get a yellow solid (HPLC purity app.90 %). The resulting product was then triturated with ethanol (5 mL), filtered and dried to get the title compounds as light yellow solid (0.35 g, 47.7 %, 94% purity).

111248-89-6, The synthetic route of 111248-89-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK PATENT GMBH; CANCER RESEARCH TECHNOLOGY LIMITED; SCHIEMANN, Kai; STIEBER, Frank; CALDERINI, Michel; BLAGG, Julian; MALLINGER, Aurelie; WAALBOER, Dennis; RINK, Christian; CRUMPLER, Simon Ross; (127 pag.)WO2015/144290; (2015); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

111248-89-6, 1,3-Dihydrobenzo[c]isothiazole 2,2-dioxide is a isothiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

f. 5-bromo-1,3-dihydrobenzo[c]isothiazole 2,2-dioxide 1,3-Dihydro-benzo[c]isothiazole 2,2-dioxide (0.50 g, 3.14 mmol, 1.00 eq.) was solubilized in acetic acid (5 mL) at rt under nitrogen atmosphere. Bromine (0.45 g, 3.14 mmol, 1.00 eq.) in acetic acid (5 mL) was added dropwise over 5 minutes and the reaction mixture was stirred for 0.5 h. Potassium acetate (0.28 g, 3.14 mmol, 1.00 eq.) was added and the reaction mixture was concentrated to dryness. The residue was taken in 2% NaHCO3 solution and stirred for 10 minutes. This solution was acidified to pH 2 using conc. HCl (2.5 mL) and extracted with MTBE (50 mL). The MTBE layer was washed with water (50 mL), brine solution (25 mL), dried over Na2SO4 and concentrated to get the crude product as brown solid. The crude product was triturated with petroleum ether (10 mL), filtered to a light brown solid (HPLC purity app. 86%) which was further purified by column chromatography using 60-120 mesh silica gel, 15% ethyl acetate in petroleum ether as eluent to get a yellow solid (HPLC purity app. 90%). The resulting product was then triturated with ethanol (5 mL), filtered and dried to get the title compounds as light yellow solid (0.35 g, 47.7%, 94% purity)., 111248-89-6

111248-89-6 1,3-Dihydrobenzo[c]isothiazole 2,2-dioxide 15536009, aisothiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Merck Patent GmbH; Cancer Research Technology, Ltd.; SCHIEMANN, Kai; BLAGG, Julian; MALLINGER, Aurelie; RINK, Christian; SEJBERG, Jimmy; HONEY, Mark; (139 pag.)US2016/16951; (2016); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.111248-89-6,1,3-Dihydrobenzo[c]isothiazole 2,2-dioxide,as a common compound, the synthetic route is as follows.

c. 1-Methyl-1,3-dihydrobenzo[c]isothiazole-2,2-dioxide To a suspension of 1,3-dihydrobenzo[c]isothiazole-2,2-dioxide (280 mg, 1.655 mmol) and potassium carbonate (229 mg, 1.66 mmol) in DMF (5 mL) was added iodomethane (414 muL, 6.62 mmol). The reaction was stirred for 6 h at rt and was then quenched with a sat. NH4Cl solution. The reaction mixture was concentrated and purified by column chromatography (CyHex/acetone) to afford the title compound as a white solid (270 mg, 89%)., 111248-89-6

111248-89-6 1,3-Dihydrobenzo[c]isothiazole 2,2-dioxide 15536009, aisothiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Merck Patent GmbH; Cancer Research Technology, Ltd.; SCHIEMANN, Kai; BLAGG, Julian; MALLINGER, Aurelie; RINK, Christian; SEJBERG, Jimmy; HONEY, Mark; (139 pag.)US2016/16951; (2016); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com