Category: 111248-89-6

As a common heterocyclic compound, it belongs to isothiazole compound, name is 1,3-Dihydrobenzo[c]isothiazole 2,2-dioxide, and cas is 111248-89-6, its synthesis route is as follows.

f. 5-bromo-1,3-dihydrobenzo[c]isothiazole 2,2-dioxide 1,3-Dihydro-benzo[c]isothiazole 2,2-dioxide (0.50 g, 3.14 mmol, 1.00 eq.) was solubilized in acetic acid (5 mL) at rt under nitrogen atmosphere. Bromine (0.45 g, 3.14 mmol, 1.00 eq.) in acetic acid (5 mL) was added dropwise over 5 minutes and the reaction mixture was stirred for 0.5 h. Potassium acetate (0.28 g, 3.14 mmol, 1.00 eq.) was added and the reaction mixture was concentrated to dryness. The residue was taken in 2% NaHCO3 solution and stirred for 10 minutes. This solution was acidified to pH 2 using conc. HCl (2.5 mL) and extracted with MTBE (50 mL). The MTBE layer was washed with water (50 mL), brine solution (25 mL), dried over Na2SO4 and concentrated to get the crude product as brown solid. The crude product was triturated with petroleum ether (10 mL), filtered to a light brown solid (HPLC purity app. 86%) which was further purified by column chromatography using 60-120 mesh silica gel, 15% ethyl acetate in petroleum ether as eluent to get a yellow solid (HPLC purity app. 90%). The resulting product was then triturated with ethanol (5 mL), filtered and dried to get the title compounds as light yellow solid (0.35 g, 47.7%, 94% purity).

111248-89-6, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,111248-89-6 ,1,3-Dihydrobenzo[c]isothiazole 2,2-dioxide, other downstream synthetic routes, hurry up and to see

Reference£º
Patent; Merck Patent GmbH; Cancer Research Technology, Ltd.; SCHIEMANN, Kai; BLAGG, Julian; MALLINGER, Aurelie; RINK, Christian; SEJBERG, Jimmy; HONEY, Mark; (139 pag.)US2016/16951; (2016); A1;,
Isothiazole – Wikipedia
Isothiazole – ScienceDirect.com

 

Reference of 111248-89-6, In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, Reference of 111248-89-6, name is 1,3-Dihydrobenzo[c]isothiazole 2,2-dioxide, introducing its new discovery.

2,1-benzisothiazoline 2,2-dioxides

This invention provides a progesterone receptor antagonist of formula 1 having the structure STR1wherein R 1, and R 2 are each, independently, hydrogen, alkyl, substituted alkyl, hydroxy, alkoxy, substituted alkoxy, aryl, substituted aryl, heteroaryl, substituted heteroaryl, arylalkyl, heteroarylalkyl, and alkynyl. R 1 and R 2 may be taken together to form a ring and together contain –CH 2 (CH 2) n CH 2 –, –CH 2 CH 2 CMe 2 CH 2 CH 2 –, –O(CH 2) P CH 2 –, O(CH 2) q O–, –CH 2 CH 2 OCH 2 CH 2 –, –CH 2 CH 2 NR 7 CH 2 CH 2 –. R 1 and R 2 may be taken together to form a double bond, the double bond having two methyl groups bonded to the terminal end, having a cycloalkyl group bonded to the terminal end, having an oxygen bonded to the terminal end, or having a cycloether bonded to the terminal end; or a double bond. R 3 is hydrogen, hydroxyl, NH 2, alkyl, substituted alkyl, alkenyl, alkynyl, substituted or, COR A. R 4 is hydrogen, halogen, –CN, –NH 2, alkyl, substituted alkyl, alkoxy, alkoxy, aminoalkyl, or substituted aminoalkyl; R 5 is a trisubstituted phenyl ring having the structure, STR2or is a five or six membered heteroaryl ring, containing 1, 2, or 3 heteroatoms selected from the group consisting of O, S, SO, SO 2 and NR 6, or pharmaceutically acceptable salt thereof.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 111248-89-6, and how the biochemistry of the body works.Reference of 111248-89-6

Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

Application of 111248-89-6, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.111248-89-6, Name is 1,3-Dihydrobenzo[c]isothiazole 2,2-dioxide, molecular formula is C7H7NO2S. In a article£¬once mentioned of 111248-89-6

2,1-Benzisothiazoline 2,2-Dioxide and Derivatives

Synthesis of new 2,1-benzisothiazoline 2,2-dioxides 1 and some of its benzene ring substitution derivatives was accomplished by two different methods of cyclisation.Also a number of new N-substituted derivatives, obtained by treatment of 1 and analogues with aliphatic and aromatic acid chlorides are described.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Application of 111248-89-6. In my other articles, you can also check out more blogs about 111248-89-6

Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

Reference of 111248-89-6, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.111248-89-6, Name is 1,3-Dihydrobenzo[c]isothiazole 2,2-dioxide, molecular formula is C7H7NO2S. In a Patent£¬once mentioned of 111248-89-6

2-AMINOPYRIDINE COMPOUNDS

The invention provides novel substituted 2-aminopyridine compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases such as cancer, inflammatory or degenerative diseases.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 111248-89-6

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Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Product Details of 111248-89-6, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 111248-89-6, name is 1,3-Dihydrobenzo[c]isothiazole 2,2-dioxide. In an article£¬Which mentioned a new discovery about 111248-89-6

CARBAZOLE-CONTAINING SULFONAMIDES AS CRYPTOCHROME MODULATORS

The subject matter herein is directed to carbazole-containing sulfonamide derivatives and pharmaceutically acceptable salts or hydrates thereof of structural formula I wherein the variable R1, R2, R3, R4, R5, R6, R7, A, B, C, D, E, F, G, H, a, and b are accordingly described. Also provided are pharmaceutical compositions comprising the compounds of formula I to treat a Cry-mediated disease or disorder, such as diabetes, obesity, metabolic syndrome, Cushing’s syndrome, and glaucoma.

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Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

Application of 111248-89-6, In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, Application of 111248-89-6, name is 1,3-Dihydrobenzo[c]isothiazole 2,2-dioxide, introducing its new discovery.

Application of photoelectron spectroscopy to molecular properties, 57[?] UV photoelectron spectroscopy studies of the products of thermal extrusion of sulfur dioxide from benzosultams

An aza-ortho-xylylene system is produced by thermal degradation of N- alkylbenzosultam, which can be directly studied by coupling the system to a UV/photoelectron spectrometer. These thermodynamically unstable xylylene derivatives rearrange to give aldimine by a [1,5] hydrogen shift.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 111248-89-6, and how the biochemistry of the body works.Application of 111248-89-6

Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, COA of Formula: C7H7NO2S, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 111248-89-6, Name is 1,3-Dihydrobenzo[c]isothiazole 2,2-dioxide, molecular formula is C7H7NO2S

NOVEL NAPHTHYRIDINES AND ISOQUINOLINES AND THEIR USE AS CDK8/19 INHIBITORS

The present invention relates to naphthyridine and isoquinoline compounds, and pharmaceutically acceptable compositions thereof, useful as inhibitors of CDK8/19, and for the treatment of CDK8/19-related disorders.

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, COA of Formula: C7H7NO2S, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 111248-89-6

Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

Related Products of 111248-89-6, Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter. In a Patent£¬Which mentioned a new discovery about 111248-89-6

PYRIDYL PIPERIDINES

The invention provides novel substituted pyridyl piperidine compounds according to Formula (I) which are Wnt pathway inhibitors, their manufacture and use for the treatment of hyperproliferative diseases such as cancer, inflammatory or degenerative diseases.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Related Products of 111248-89-6, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 111248-89-6

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Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

Electric Literature of 111248-89-6, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. Electric Literature of 111248-89-6, Name is 1,3-Dihydrobenzo[c]isothiazole 2,2-dioxide, molecular formula is C7H7NO2S. In a Article, authors is Wilkening£¬once mentioned of Electric Literature of 111248-89-6

Synthesis and activity of 2-(sulfonamido)methylcarbapenems: Discovery of a novel, anti-MRSA 1,8-naphthosultam pharmacophore

A series of 1beta-methyl carbapenems substituted at the 2-position with lipophilic, acyclic and cyclic (sulfonamido)methyl groups was prepared and evaluated for activity against resistant gram-positive bacteria. From these studies, the 1,8-naphthosultamyl group emerged as a novel, PBP2a-binding, anti-MRSA pharmacophore worthy of further exploration.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 111248-89-6

Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com

 

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.Quality Control of 1,3-Dihydrobenzo[c]isothiazole 2,2-dioxide, Name is 1,3-Dihydrobenzo[c]isothiazole 2,2-dioxide, molecular formula is C7H7NO2S, Quality Control of 1,3-Dihydrobenzo[c]isothiazole 2,2-dioxide. In a Article, authors is Abramovitch, Rudolph A.£¬once mentioned of Quality Control of 1,3-Dihydrobenzo[c]isothiazole 2,2-dioxide

FLASH VACUUM PYROLYSIS OF alpha-TOLUENESULFONYL AZIDE

The flash vacuum pyrolysis of alpha-toluenesulfonyl azide (1) gave bibenzyl (2), 2-(beta-phenethyl)pyridine (3), and 2,1-benzisothiazole 2,2-dioxide (4); an authentic sample of the latter was prepared from 2-bromo-alpha-toluenesulfonamide and potassium amide in liquid ammonia.FVP of benzenesulfonyl azide using benzene as carrier gas gave some diphenylamine, but not in the absence of benzene.

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about is helpful to your research. Quality Control of 1,3-Dihydrobenzo[c]isothiazole 2,2-dioxide

Reference£º
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com