High-yield synthesis of pyrrolidinyl PNA monomers was written by Merino, Pedro;Greco, Graziella;Tejero, Tomas;Chiacchio, Ugo;Corsaro, Antonino;Pistara, Venerando;Romeo, Giovanni. And the article was included in Tetrahedron Letters in 2011.Product Details of 94594-91-9 This article mentions the following:
Two monomers for the syntheses of conformationally restricted peptide nucleic acids were synthesized through a simple procedure, involving an asym. 1,3-dipolar cycloaddition chem. as a key step, from common starting materials in 3 and 5 steps, and 58.8% and 30.5% overall yields, resp. In the experiment, the researchers used many compounds, for example, 1-((3aS,6R,7aR)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one (cas: 94594-91-9Product Details of 94594-91-9).
1-((3aS,6R,7aR)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one (cas: 94594-91-9) belongs to isothiazole derivatives. Isothiazole is a good solvent for many organic substances but should be used with caution because it is more toxic than pyridine. In general, isothiazole undergoes nitration in the presence of HNO3, sulfuric acid, and sulfonation by using sulfuric acid under thermal conditions to generate corresponding 4-nitro- and 4-sulfonic acid derivatives, respectively.Product Details of 94594-91-9
Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com