Diastereoselective cycloadditions of nitrilimines to enantiopure acrylamides was written by Garanti, Luisa;Molteni, Giorgio;Pilati, Tullio. And the article was included in Tetrahedron: Asymmetry in 2002.Safety of 1-((3aS,6R,7aR)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one This article mentions the following:
The diastereoselective cycloaddition of the nitrilimine, generated from hydrazonoyl chloride 4-MeC6H4NHN:C(Cl)CO2Me, with enantiopure pyrrolidine, oxazolidine, or camphorsultam substituted acrylamides, e.g. I (R = Me2CH, Ph), gave separable mixtures of isomeric 4,5-dihydropyrazoles, e.g. II. Basic hydrolysis of the cycloadducts gave the corresponding dicarboxy derivatives, e.g. III, which are of potential interest as new chiral building blocks. In the experiment, the researchers used many compounds, for example, 1-((3aS,6R,7aR)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one (cas: 94594-91-9Safety of 1-((3aS,6R,7aR)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one).
1-((3aS,6R,7aR)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one (cas: 94594-91-9) belongs to isothiazole derivatives. Isothiazoles and benzisothiazoles are usually liquids or low-melting-point solids; polar substituents increase the melting points because of the possibility of hydrogen bonding and other interactions in the crystalline state. It has been found that isothiazole-based compounds show synergistic effects when used with other biocidal compounds.Safety of 1-((3aS,6R,7aR)-8,8-Dimethyl-2,2-dioxidohexahydro-1H-3a,6-methanobenzo[c]isothiazol-1-yl)prop-2-en-1-one
Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com