Octylisothiazolinone, an additional cause of allergic contact dermatitis caused by leather: case series and potential implications for the study of cross-reactivity with methylisothiazolinone was written by Aerts, Olivier;Meert, Hans;Romaen, Elien;Leysen, Julie;Matthieu, Lucretia;Apers, Sandra;Lambert, Julien;Goossens, An. And the article was included in Contact Dermatitis in 2016.Synthetic Route of C3H3NOS This article mentions the following:
Summary : Background : Octylisothiazolinone (OIT) is used as an antifungal agent by the leather industry. Objectives : To show sensitization to OIT from leather, and to highlight the potential implications when cross-reactivity between OIT and methylisothiazolinone (MI) is studied. Methods : Two patients with allergic contact dermatitis caused by a leather belt and shoes, resp., were patch tested with methylchloroisothiazolinone (MCI)/MI, MI, MCI, OIT, and benzisothiazolinone (BIT). High-performance liquid chromatog. with UV detection (HPLC-UV) was used to detect isothiazolinone derivatives in leather goods. Addnl., files of OIT-sensitized patients, observed at the KU Leuven department during the period 1990-2015, were retrospectively analyzed. Results : Both patients had been primarily sensitized to OIT, but the diagnosis in one of them could be achieved only when a higher patch test concentration of OIT (1000 ppm pet.) was used. HPLC-UV confirmed the presence of OIT in their leather goods. Non-relevant sensitization to MI was noted in both cases. Four addnl. cases of OIT sensitization from leather could be retrieved from the KU Leuven database. Conclusions : Non-occupational sensitization to OIT from leather may occur. Patch test concentrations of >250 ppm pet. may be necessary for diagnosis, and to show cross-reactivity with MI. Safer use limits for OIT in the leather industry may be needed. In the experiment, the researchers used many compounds, for example, Isothiazol-3(2H)-one (cas: 1003-07-2Synthetic Route of C3H3NOS).
Isothiazol-3(2H)-one (cas: 1003-07-2) belongs to isothiazole derivatives. Some representatives of isothiazoles have proven to be synergists of bioactive substances, which opens the way to lower the doses of drugs used and is especially important in cancer chemotherapy. Many compounds with an isothiazole scaffold demonstrated a wide range of biological profiles. Some of these molecules have been efficiently used in the treatment of Alzheimer’s disease.Synthetic Route of C3H3NOS
Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com