On June 30, 2007, Aleksic, Maja; Thain, Emma; Gutsell, Stephen J.; Pease, Camilla K.; Basketter, David A. published an article.Computed Properties of 26172-54-3 The title of the article was The role of non-covalent protein binding in skin sensitization potency of chemicals. And the article contained the following:
Skin sensitization is a delayed hypersensitivity reaction caused by repeated exposure to common natural and synthetic chem. allergens. It is thought that small chem. sensitizers (haptens) are required to form a strong irreversible bond with a self protein/peptide and generate an immunogenic hapten-protein complex in order to be recognized by the immune system and stimulate T cell proliferation. The sensitizers are usually electrophilic chems. that are directly reactive with proteins or reactive intermediates (metabolites) of chem. inert compounds (prohaptens). Sensitizing chems. are also capable of weak, non-covalent association with proteins and there is an ongoing debate about the role of weak interactions of chems. and proteins in the chem. of allergy. The non-covalent interactions are reversible and thus have a major impact on skin/epidermal bioavailability of chem./reactive metabolites. We investigated the relationship between the relative level of non-covalent association to a model protein and their relative potencies as determined by the EC3 values in the murine local lymph node assay (LLNA) for a number of chems. Using human serum albumin as a model protein, we determined that no observable relationship exists between the two parameters for the chems. tested. Therefore, at least for this model protein, non-covalent interactions appear not to be a key determinant of allergen potency. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Computed Properties of 26172-54-3
The Article related to skin sensitization potency noncovalent protein binding, Toxicology: Chemicals (Household, Industrial, General) and other aspects.Computed Properties of 26172-54-3
Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com