On December 22, 2020, Gu, Zhenpeng; Yang, Zhaohui; Zhang, Xiaona; Zhao, Lin; Liu, Wei; Chen, Qi published a patent.SDS of cas: 26172-54-3 The title of the patent was Preparation of 2-methyl-4-isothiazolin-3-one (MIT) aqueous solution by using dipolar aprotic solvent. And the patent contained the following:
The title method includes (1) mixing 3,3′-dithiobis(N-methylpropionamide) or 3-mercapto-N-methylpropanamide with solvent, and adding halogenating agent (chlorine gas, sulfuryl chloride, etc.) for a halogenation ring-closing reaction. (2) Filtering to obtain a product, washing the filter cake with Et acetate, and drying to obtain 2-methyl-4-isothiazolin-3-one hydrochloride solid. (3) Dissolving with a sodium carbonate aqueous solution to obtain an aqueous solution having pH of 5.0-7.0 and the mass content of 2-methyl-4-isothiazolin-3-one of 50%. The solvent comprises chlorination solvent (dichloromethane, chloroform, etc.) and dipolar aprotic solvent (acetonitrile, DMF, etc.). The prepared 2-methyl-4-isothiazolin-3-one has the purity up to above 99.9% and the content of 5-chloro-2-methyl-4-isothiazolin-3-one controlled at below 100 ppm. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).SDS of cas: 26172-54-3
The Article related to methyl isothiazolinone preparation, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.SDS of cas: 26172-54-3
Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com