On August 8, 1978, Lewis, Sheldon N.; Miller, George A.; Law, Andrew B. published a patent.Formula: C4H6ClNOS The title of the patent was 3-Isothiazolones as biocides. And the patent contained the following:
Isothiazolones I (R, R1 = H, halogen, C1-4 alkyl; R2 = optionally substituted C1-18 alkyl, alkenyl, alkynyl, cycloalkyl, aralkyl, aryl) (106 compounds) were prepared Thus 79 g (SCH2CH2CONHMe)2 was cyclized in the presence of SO2Cl2 to give 11.5 g I (R = H, R1 = Cl, R2 = Me). I have bactericidal, fungicidal, and algicidal activity. Their use in lubricating oils, cooling water, paints, polymer emulsions, laundry detergents, soaps, cosmetics, paper, leather, textiles, and wood products is illustrated. The experimental process involved the reaction of 2-Methylisothiazol-3(2H)-one hydrochloride(cas: 26172-54-3).Formula: C4H6ClNOS
The Article related to algicides, coating materials, cosmetics and personal care products, detergents, drinking waters, fungicides, leather, lubricating oils, paper, polymers role: uses (uses), soaps role: rct (reactant), ract (reactant or reagent), textiles, wood preservatives and other aspects.Formula: C4H6ClNOS
Referemce:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com