Name: 2-(tert-Butyl)isothiazol-3(2H)-one 1,1-dioxide. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2-(tert-Butyl)isothiazol-3(2H)-one 1,1-dioxide, is researched, Molecular C7H11NO3S, CAS is 119639-24-6, about Benzothiazole benzimidazole (S)-isothiazolidinone derivatives as protein tyrosine phosphatase-1B inhibitors. Author is Sparks, Richard B.; Polam, Padmaja; Zhu, Wenyu; Crawley, Matthew L.; Takvorian, Amy; McLaughlin, Erin; Wei, Min; Ala, Paul J.; Gonneville, Lucie; Taylor, Nancy; Li, Yanlong; Wynn, Richard; Burn, Timothy C.; Liu, Phillip C. C.; Combs, Andrew P..
Benzothiazole benzimidazole (S)-isothiazolidinone ((S)-IZD) derivatives 5 were discovered through a peptidomimetic modification of the tripeptide (S)-IZD protein tyrosine phosphatase 1B (PTP1B) inhibitor 1. These derivatives are potent, competitive, and reversible inhibitors of PTP1B with improved caco-2 permeability. An X-ray co-crystal structure of inhibitor 5/PTP1B at 2.2 Å resolution demonstrated that the benzothiazole benzimidazole forms bi-dentate H-bonds to Asp48, and the benzothiazole interacts with the surface of the protein in a solvent exposed region towards the C-site. The design, synthesis, and SAR of this novel series of benzothiazole benzimidazole containing (S)-IZD inhibitors of PTP1B are presented herein.
After consulting a lot of data, we found that this compound(119639-24-6)Name: 2-(tert-Butyl)isothiazol-3(2H)-one 1,1-dioxide can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Isothiazole – Wikipedia,
Isothiazole – ScienceDirect.com